Best TWAS P=1.91e-16 · Best GWAS P=9.44e-27 conditioned to 6.23e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EML4 | 0.05 | 0.04 | enet | 12 | 0.03 | 1.2e-04 | -5.7 | -6.5 | 1.1e-10 | 0.08 | 0.03 | 0.97 | TRUE |
| 2 | GTEx | Artery Aorta | PREPL | 0.07 | 0.04 | lasso | 2 | 0.03 | 1.1e-02 | 5.5 | -5.4 | 7.8e-08 | -0.44 | 0.27 | 0.36 | FALSE |
| 3 | GTEx | Artery Coronary | PREPL | 0.33 | 0.01 | enet | 7 | 0.00 | 4.2e-01 | 5.0 | -6.9 | 4.1e-12 | -0.57 | 0.11 | 0.12 | FALSE |
| 4 | GTEx | Artery Tibial | PREPL | 0.04 | 0.02 | lasso | 5 | 0.01 | 2.7e-02 | 5.4 | -5.3 | 1.3e-07 | -0.52 | 0.51 | 0.10 | FALSE |
| 5 | GTEx | Artery Tibial | PLEKHH2 | 0.49 | 0.17 | enet | 48 | 0.29 | 2.6e-23 | -1.5 | 5.9 | 3.2e-09 | 0.08 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | CAMKMT | 0.15 | 0.06 | lasso | 4 | 0.03 | 1.7e-03 | 7.6 | 6.7 | 2.0e-11 | 0.31 | 0.65 | 0.07 | TRUE |
| 7 | GTEx | Colon Transverse | PREPL | 0.18 | 0.08 | lasso | 7 | 0.06 | 1.0e-03 | 5.5 | -5.4 | 7.9e-08 | -0.44 | 0.43 | 0.03 | FALSE |
| 8 | GTEx | Heart Left Ventricle | PREPL | 0.10 | 0.05 | lasso | 4 | 0.02 | 3.5e-02 | 5.8 | -5.2 | 2.6e-07 | -0.46 | 0.30 | 0.03 | FALSE |
| 9 | GTEx | Pancreas | PREPL | 0.12 | 0.03 | lasso | 4 | 0.02 | 6.7e-02 | 5.5 | -5.2 | 2.4e-07 | -0.49 | 0.50 | 0.05 | FALSE |
| 10 | METSIM | Adipose | PREPL | 0.04 | 0.05 | lasso | 3 | 0.04 | 1.7e-06 | 5.4 | -5.5 | 4.2e-08 | -0.46 | 0.99 | 0.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | CAMKMT | 0.06 | 0.06 | lasso | 4 | 0.05 | 1.6e-06 | 7.4 | -7.2 | 4.5e-13 | 0.09 | 1.00 | 0.00 | TRUE |
| 12 | The Cancer Genome Atlas | Glioblastoma Multiforme | PPM1B | 0.14 | 0.04 | blup | 65 | 0.04 | 2.4e-02 | 2.0 | 8.2 | 1.9e-16 | 0.65 | 0.02 | 0.35 | TRUE |