Hub : Genes

EML4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0460	0.0180	1.3e-03	0.042	0.011	0.030	0.018	0.030	6.3e-06	1.5e-02	1.2e-04	2.7e-03	1.4e-04
2	GTEx	Adipose Subcutaneous	0.1730	0.0540	8.6e-07	0.143	NA	0.114	NA	0.145	9.6e-12	NA	1.4e-09	NA	6.9e-12
3	GTEx	Cells Transformed fibroblasts	0.4340	0.0630	1.3e-11	0.093	NA	0.305	NA	0.248	1.8e-07	NA	3.1e-23	NA	1.2e-18
4	GTEx	Esophagus Muscularis	0.0980	0.0410	1.3e-03	0.077	NA	0.010	NA	0.056	2.1e-05	NA	7.4e-02	NA	2.4e-04
5	GTEx	Muscle Skeletal	0.1334	0.0444	5.5e-05	0.029	NA	0.023	NA	0.038	7.6e-04	NA	2.1e-03	NA	1.1e-04
6	GTEx	Nerve Tibial	0.2404	0.0630	2.3e-08	0.094	NA	0.134	NA	0.132	3.6e-07	NA	9.7e-10	NA	1.4e-09
7	GTEx	Skin Sun Exposed Lower leg	0.3220	0.0830	8.9e-06	0.100	NA	0.069	NA	0.075	1.3e-08	NA	2.2e-06	NA	8.1e-07
8	GTEx	Thyroid	0.1260	0.0380	6.7e-07	0.089	NA	0.113	NA	0.106	2.4e-07	NA	5.4e-09	NA	1.8e-08
9	METSIM	Adipose	0.1056	0.0296	5.4e-10	0.080	0.085	0.080	0.085	0.078	5.0e-12	9.5e-13	5.2e-12	9.9e-13	8.5e-12
10	NTR	Blood	0.0655	0.0196	2.0e-05	0.029	0.018	0.042	0.033	0.038	7.6e-10	9.7e-07	1.3e-13	8.2e-11	3.0e-12
11	ROSMAP	Brain Pre-frontal Cortex	0.0485	0.0185	3.6e-04	0.038	0.021	0.034	0.024	0.037	9.9e-06	7.6e-04	3.3e-05	3.8e-04	1.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.6	1.0	1.9	-1.1	-0.7	1.4	-1.0	-0.9	-1.1	-0.8	-1.1	-1.4	0.1	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.3	1.8	-0.1	0.5	1.3	0.1	0.1	0.3	-0.9	0.4	-0.3	-0.2	0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.9	0.5	-0.2	0.1	-0.3	-0.4	-0.2	0.9	-0.6	0.3	0.0	0.3
Depression (Nagel 2018)	0.3	0.4	0.9	-0.1	1.0	0.4	0.9	-0.3	0.7	0.5	0.3	0.6	-0.9	0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.6	-1.6	0.8	1.2	-0.4	-0.1	0.5	1.0	0.2	0.4	-1.4	-0.9
Neuroticism (Nagel 2018)	0.3	0.8	2.5	1.0	0.0	1.1	0.5	0.5	0.6	1.4	0.1	0.8	0.5	1.6
Schizophrenia (2018)	0.4	0.9	1.8	0.7	1.3	0.6	0.9	0.9	1.3	-0.5	1.3	0.7	-0.4	1.1
Schizophrenia vs Biploar Disorder	2.9	3.8	9.2	1.7	2.1	-1.1	3.0	1.2	2.4	-0.4	2.3	2.2	1.5	2.1
Worry (Nagel 2018)	0.4	0.7	3.2	0.6	-0.3	1.8	-0.1	0.5	0.4	1.5	0.1	0.4	0.8	1.0
Alzheimer’s Disease (in mother)	0.9	1.1	2.9	0.4	-1.4	-1.7	0.0	-0.6	-0.9	-1.7	-0.5	-1.0	-0.9	0.8
Alzheimer’s Disease (in father)	1.8	2.0	6.6	-2.0	1.9	0.6	0.6	2.6	1.4	1.1	1.6	0.8	-0.8	0.2
Alzheimer’s Disease (including proxy)	1.1	1.5	5.8	-0.7	-2.4	-0.6	-1.3	-0.8	-1.3	-1.3	-1.0	-1.7	-0.7	-0.4
Crohns Disease (2017)	0.7	1.6	5.9	2.2	-0.1	-1.1	1.3	0.1	0.5	-0.8	1.4	-0.3	-0.9	2.4
Irritable Bowel Disease (IBD)	0.3	0.8	2.7	1.6	-1.2	-0.5	-0.2	-1.4	-0.6	-0.0	-0.0	-1.1	-0.7	0.8
Ulcerative Colitis (UC)	0.6	1.1	3.6	0.9	-1.6	-0.1	-1.0	-1.9	-1.3	0.6	-0.9	-1.1	-0.4	-0.6
Major Depression (MDD)	2.7	3.3	11.7	1.9	0.9	-0.0	2.7	0.8	2.0	-0.5	1.9	2.0	0.8	3.4
Reaction Time	2.8	5.4	13.4	2.4	2.2	1.4	3.7	1.9	2.9	1.0	2.3	2.6	-0.1	3.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	2.1	-0.4	0.2	-0.5	-0.1	-0.4	0.1	0.2	-0.0	-0.1	-1.5	-0.4
Breast Cancer	0.6	1.4	4.8	0.1	-2.2	-0.1	-1.3	-0.1	-1.5	0.2	-1.3	-2.2	-0.3	-0.5
Ovarian Cancer	0.8	1.0	4.5	0.4	-0.3	-1.1	0.4	-1.1	-1.0	1.0	-1.1	-0.1	-2.1	-1.1
Prostate Cancer	0.3	0.4	1.5	-0.5	-0.1	0.2	-1.0	0.1	0.1	-1.2	0.3	-0.0	-1.2	0.2
Age at First Birth	0.3	0.5	1.5	-0.8	0.0	1.0	-0.9	-0.5	-0.7	-1.2	-0.8	-0.1	-0.0	-0.3
Bipolar Disorder (2011)	0.9	0.9	2.3	-0.6	-0.5	0.5	-1.2	-0.9	-1.1	0.2	-1.5	-0.7	0.1	-1.5
Body Mass Index (BMI) (2010)	2.8	3.9	8.5	-0.0	2.3	-0.9	2.9	2.4	2.3	-0.0	2.7	1.9	-1.6	2.0
Coronary Artery Disease (CAD)	0.2	0.3	1.3	-0.4	0.5	0.4	0.0	1.1	0.6	-0.0	0.1	0.6	-0.5	0.0
Crohns Disease (2012)	0.4	0.7	1.6	0.4	0.5	0.5	0.3	0.4	0.7	1.1	1.2	-0.1	-1.2	1.3
Mean Putamen Volume	1.4	1.6	5.7	2.4	-0.0	1.9	1.3	0.8	0.9	0.2	0.5	1.3	0.4	1.6
Fasting Glucose	3.9	4.7	10.1	-0.2	-2.7	-0.6	-2.4	-3.2	-2.6	-2.0	-1.9	-2.9	0.3	-2.3
HbA1C	2.9	3.2	7.9	1.8	-2.3	-1.6	-0.8	-2.8	-2.3	0.2	-2.2	-1.3	-1.5	-1.3
HDL Cholesterol	0.9	1.5	6.1	-0.6	-0.6	2.5	-1.4	-1.5	-0.7	-1.7	-0.9	-0.4	0.0	-0.9
LDL Cholesterol	1.3	2.0	6.9	2.6	-1.4	-1.4	0.7	-1.1	-1.1	-1.4	0.0	-1.7	-1.7	0.6
Lupus	0.8	1.3	5.2	2.3	-0.4	-1.1	0.9	0.3	-0.3	-2.0	-0.2	-0.0	0.2	1.5
Neuroticism (2016)	1.1	1.6	4.4	2.1	0.6	1.1	1.7	-0.3	1.3	1.7	0.6	1.2	0.4	1.5
Primary Biliary Cirrhosis	0.8	1.1	3.2	-0.7	-0.4	1.4	-1.8	0.3	-0.8	1.8	-1.0	-0.3	0.3	-1.0
Rheumatoid Arthritis	0.3	0.4	1.4	-0.6	-0.0	0.6	-0.5	-0.1	-0.4	0.9	-0.3	0.1	1.2	-1.0
Schizophrenia (2014)	0.3	0.6	0.8	0.8	0.9	0.8	0.8	0.3	0.9	-0.7	0.9	0.3	-0.6	0.9
Triglycerides	0.8	1.3	2.9	1.5	0.6	-0.5	1.7	1.2	0.9	1.2	1.6	0.5	-0.8	1.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.7	-0.4	1.6	1.2	0.5	1.9	1.1	-0.0	0.8	0.9	0.1	0.5
Ulcerative Colitis	0.6	0.9	3.0	0.6	-1.3	1.1	-1.1	-1.7	-0.6	0.5	-0.3	-0.9	0.6	-0.2
Blood Eosinophil Count	0.5	3.6	10.0	-2.3	3.2	-0.4	2.2	2.6	2.1	-0.8	2.3	0.9	-1.1	-0.2
Blood Platelet Count	0.3	3.1	9.0	2.1	-2.5	-2.0	-0.4	-3.0	-1.9	-1.1	-1.2	-1.7	-0.5	-1.0
Blood Red Count	0.7	7.1	13.8	0.1	2.2	-0.4	3.5	3.1	3.2	-0.9	3.7	2.8	3.5	2.6
Blood White Count	0.6	4.3	8.9	2.7	-2.2	-1.8	-0.5	-2.4	-2.3	-3.0	-1.7	-2.4	0.7	-1.8
Heel T-Score	0.3	2.1	12.1	0.2	0.7	2.1	1.0	-3.5	0.1	-1.6	0.7	0.2	-0.1	-1.3
BMI	1.1	6.3	14.4	-1.8	3.3	-1.6	2.2	3.8	2.7	2.8	2.6	3.1	-0.4	1.4
Height	0.8	15.7	106.1	-10.3	2.7	1.8	-4.6	-0.6	0.1	3.1	-0.9	0.5	-1.0	-4.8
Waist Hip Ratio (WHR)	0.6	2.8	8.1	2.4	1.3	1.9	2.9	0.6	1.8	1.2	1.2	1.3	-1.6	1.3
Systolic Blood Pressure	0.4	1.8	5.5	1.8	-0.1	2.4	0.3	0.1	0.9	-1.9	-0.0	0.9	0.8	2.0
Smoking Status	1.4	3.4	5.3	2.3	-2.1	-2.2	-1.1	-1.9	-1.9	-2.2	-2.1	-1.8	-0.5	-0.8
Allergy or Eczema	1.0	2.7	8.1	0.6	-2.4	-0.1	-1.4	-2.8	-1.6	-1.4	-1.8	-2.0	-1.0	-1.1
Cardiovascular Disease	0.4	1.2	2.3	1.2	0.8	0.2	1.5	0.5	1.4	-1.1	0.9	1.3	0.3	1.5
Hypothyroidism (self reported)	0.7	1.7	3.0	-0.5	-1.3	-1.0	-1.6	-1.7	-1.5	-0.1	-1.7	-1.6	-0.5	-1.5
Respiratory disease	0.4	0.9	2.8	1.3	0.2	-0.7	1.2	0.9	0.8	-0.7	1.2	-0.1	0.0	1.7
Type 2 Diabetes (T2D) (2018)	1.1	2.0	5.3	-2.3	1.9	-0.3	1.0	1.8	1.1	1.9	1.2	0.8	1.2	-0.9
Lung FEV1/FVC ratio	10.5	53.2	100.0	-0.2	-9.1	-2.2	-9.7	-8.6	-10.0	-4.3	-8.8	-9.4	-2.5	-6.1
Lung FVC	0.7	3.4	10.6	1.2	-2.0	-3.3	-1.5	-0.8	-2.6	-1.6	-1.6	-2.6	-0.2	-0.1
Neuroticism	0.4	1.0	3.6	1.6	0.1	0.9	0.7	0.2	0.7	1.2	0.7	0.8	0.6	1.9
Chronotype (morning person)	0.2	0.4	2.2	-0.2	0.4	-0.8	-0.2	1.5	0.3	0.4	0.4	0.6	-0.3	0.1
Hair Pigment	0.2	6.0	38.8	0.1	-1.4	-3.1	-1.1	6.2	-1.7	-0.6	-1.4	-1.7	2.3	-0.8
Tanning	0.3	4.1	12.7	-1.3	-2.0	1.9	-3.6	-2.6	-1.9	-0.9	-2.1	-2.2	-0.2	-1.8
Hand grip strength (left)	1.8	4.6	15.4	-3.9	2.2	3.5	-0.2	2.7	2.0	1.5	1.1	1.7	0.5	-0.6
Number of treatments/medications taken	0.5	0.8	3.1	-1.8	0.9	-1.4	-0.5	0.2	-0.0	1.1	-0.4	0.3	0.2	-1.3
Average weekly spirits intake	3.2	4.0	10.6	1.1	-3.3	1.0	-2.5	-2.6	-2.2	-0.9	-2.5	-2.1	-1.1	-1.2
Sensitivity / hurt feelings	0.5	0.8	2.9	0.6	0.1	1.4	0.5	0.5	0.2	-0.1	0.3	0.2	-1.7	1.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.5	0.6	0.1	-0.6	1.2	-0.5	0.1	-0.7	0.5	0.3	-0.1	0.5
Hearing difficulty/problems: Yes	1.0	1.6	4.7	-0.3	1.0	0.9	1.4	0.9	1.5	2.2	1.2	1.3	-0.9	1.4
Relative age of first facial hair	1.4	2.9	6.5	0.8	1.6	2.6	2.2	1.0	2.0	1.6	1.7	2.0	-0.3	1.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.9	-1.1	0.9	-0.7	0.2	1.0	0.4	1.4	0.4	0.7	0.4	-0.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.4	1.8	0.1	-0.3	1.2	-0.1	0.5	0.3	0.5	0.2	0.7	1.5
Ever had hysterectomy (womb removed)	0.8	0.9	3.0	1.7	0.2	1.3	1.0	0.4	0.9	-0.2	0.8	0.7	-0.5	1.4
Systolic blood pressure, automated reading	0.2	0.6	2.0	1.4	-0.6	1.1	0.2	-0.0	0.5	-0.1	0.3	0.3	0.8	1.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	-0.7	0.2	-0.9	0.5	-0.5	0.1	0.5	0.0	0.2	0.7	-0.7
Angina	1.8	2.4	4.0	-1.5	1.9	1.1	1.3	1.2	1.8	2.0	1.8	2.0	0.9	0.8
Medication for hormone replacement therapy	0.3	0.4	1.8	-0.7	0.3	1.1	-0.2	0.4	0.3	1.3	-0.1	0.0	-0.6	-0.1
Vitamin and mineral supplements	1.2	1.6	3.1	0.4	1.1	-0.7	1.4	1.4	1.5	-1.1	1.4	1.6	-1.3	1.8
Supplements: Zinc	1.6	1.7	4.6	-0.9	-1.3	-0.1	-2.1	-0.9	-2.1	-0.9	-1.5	-1.5	-0.3	-1.2
Medication: Co-codamol	0.2	0.3	1.1	0.5	0.7	-0.5	0.9	-0.0	0.4	-0.4	0.1	-0.0	-1.0	-0.3
Medication: Metformin	1.2	1.6	3.3	-0.6	1.7	-0.9	1.8	1.7	1.3	1.3	1.4	1.2	-0.8	0.6
Diabetes (father)	1.1	1.4	4.0	-1.6	0.8	-0.5	-0.1	0.9	0.2	1.9	-0.2	1.3	2.0	-1.3
Diabetes (mother)	1.0	1.3	2.6	0.2	-1.4	0.1	-1.2	-0.1	-1.5	-0.9	-1.6	-1.4	-1.1	-1.3
Severe depression (siblings)	0.6	0.7	4.1	-2.0	0.5	0.1	-0.9	0.2	-0.1	1.1	0.8	-0.1	-0.6	-0.5
Pack years adult smoking proportion	1.4	2.2	5.2	0.5	1.9	-1.6	1.5	2.3	1.4	-1.0	1.1	1.8	0.5	1.6
Impedance of leg (right)	0.2	1.2	4.1	1.9	0.2	0.6	1.1	-0.5	0.7	-0.3	0.6	0.6	2.0	1.5
Leg fat-free mass (left)	0.5	2.6	16.6	-4.1	1.7	-0.5	-1.1	1.7	0.3	0.7	-0.1	0.9	-0.9	-1.3
Trunk fat percentage	1.1	4.3	12.1	1.1	1.9	-3.5	2.9	1.9	1.6	2.2	1.6	2.4	1.0	1.7
Hand grip strength (right)	1.1	3.1	10.2	-3.2	1.9	2.8	-0.0	2.0	1.6	0.5	0.9	1.7	1.2	-0.7
Townsend deprivation index at recruitment	1.0	1.4	2.1	1.1	0.7	1.4	1.3	0.6	1.4	0.7	1.3	1.4	-1.0	1.4
Current tobacco smoking	0.1	0.1	0.6	0.4	-0.1	-0.1	-0.0	0.2	-0.1	-0.6	-0.8	-0.3	-0.4	0.3
Average weekly fortified wine intake	1.9	2.2	5.7	-0.3	-1.6	-0.9	-1.4	-1.4	-1.8	-1.5	-1.1	-2.4	-1.4	-1.4
Maternal smoking around birth	2.8	4.1	7.7	0.5	-2.7	-0.4	-2.5	-1.8	-2.8	-0.2	-2.8	-2.8	-0.7	-2.1
Fed-up feelings	0.5	0.9	4.2	2.1	0.1	0.0	1.3	-0.2	0.3	-0.4	0.4	0.3	-0.7	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.0	-0.0	1.3	0.5	1.4	0.1	1.0	0.5	0.7	1.0	-0.8	0.6
Relative age voice broke	0.4	0.5	1.4	-0.6	0.2	1.0	-0.2	0.7	0.3	-0.1	-1.1	1.0	1.2	-0.5
Taking other prescription medications	1.7	2.7	5.7	-0.6	2.0	-1.8	1.5	1.7	1.9	2.4	1.1	2.2	-0.9	0.2
Age when periods started (menarche)	0.4	0.8	6.4	-0.8	0.2	-0.1	-0.8	0.7	0.1	0.3	-0.9	0.3	2.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	0.6	1.1	-0.7	1.4	0.4	0.6	-0.8	0.5	1.1	-0.2	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.1	0.6	-0.9	1.1	-0.4	-2.0	-0.9	-0.8	-1.1	-0.3	-0.3	-0.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.0	-1.3	1.7	-0.2	0.3	1.5	1.6	1.0	1.1	1.7	0.8	0.4
Qualifications: CSEs or equivalent	0.8	1.0	2.7	0.7	-0.7	1.3	-0.7	-0.1	-1.1	-1.4	-0.9	-0.7	1.6	-0.9
Serious illness, injury or assault to yourself	0.6	0.8	2.2	-1.4	0.0	0.3	-1.3	-0.3	-0.4	0.8	-0.5	-0.1	-1.0	-1.5
High blood pressure	0.2	0.5	1.5	1.0	0.1	0.3	0.7	0.3	0.7	-0.0	0.2	1.2	1.0	1.0
Hayfever, allergic rhinitis or eczema	1.6	3.6	8.4	1.0	-2.8	0.2	-1.3	-2.9	-1.8	-2.1	-2.0	-2.3	-1.4	-1.1
Multivitamins +/- minerals	1.3	1.6	2.9	0.2	-1.3	0.5	-1.4	-1.7	-1.7	1.0	-1.4	-1.4	1.2	-1.4
Stomach or abdominal pain in last month	1.3	1.6	4.6	1.5	0.4	-1.3	2.0	-0.1	0.5	-0.3	1.9	0.9	2.1	0.2
Supplements: Glucosamine	4.2	5.4	11.6	-0.7	-2.7	-1.0	-2.8	-3.2	-2.8	0.4	-3.4	-1.8	-0.1	-3.2
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	5.5	0.3	-2.3	0.8	-2.1	-1.9	-2.1	-0.3	-1.4	-2.3	0.9	-1.9
Medication: Atenolol	2.5	3.2	6.2	-0.5	1.7	0.5	1.7	2.4	2.1	0.9	2.5	2.0	2.1	1.7
Medication: Levothyroxine sodium	0.8	1.4	2.6	-1.1	-0.7	-1.3	-1.6	-1.3	-1.2	1.0	-1.2	-1.1	-0.1	-1.5
Sitting height	1.3	9.4	22.6	-4.8	4.5	2.5	1.0	3.3	3.6	-0.6	3.7	3.4	1.5	1.4
Chronic bronchitis/emphysema (father)	0.8	1.0	5.2	0.8	0.7	-0.2	0.9	0.6	1.2	0.1	1.1	0.6	-0.3	2.3
High blood pressure (mother)	1.2	1.8	4.8	0.2	1.6	-0.8	2.2	1.8	1.4	0.0	1.6	1.7	0.0	0.6
Body mass index (BMI)	0.4	1.9	3.7	0.1	1.4	-1.6	1.7	1.9	1.2	1.3	1.3	1.8	-0.0	1.2
Impedance of leg (left)	0.2	0.9	4.1	1.8	-0.4	0.5	0.6	-1.1	0.1	-0.4	0.2	0.2	2.0	0.9
Leg predicted mass (left)	0.5	2.6	17.0	-4.1	1.7	-0.5	-1.1	1.7	0.3	0.8	-0.2	0.9	-0.8	-1.3
Trunk fat mass	0.7	3.2	6.6	-0.7	2.1	-2.6	1.8	2.0	1.5	2.3	1.4	2.4	0.5	0.8
Waist circumference	0.4	1.3	2.8	-0.7	1.5	-1.7	1.1	1.4	0.8	1.6	0.5	1.4	-0.5	-0.1
Number of incorrect matches in round	1.3	2.1	5.8	1.0	-2.4	0.6	-1.4	-1.3	-1.9	-0.4	-1.7	-2.3	0.6	-0.2
Past tobacco smoking	1.2	2.3	4.0	-1.6	1.9	2.0	1.0	1.7	1.6	1.3	1.4	1.7	1.0	1.0
Alcohol usually taken with meals	0.2	0.3	1.6	-0.2	-0.8	0.6	-1.3	0.1	-0.6	0.5	-0.6	-0.1	-0.1	-0.4
Nervous feelings	1.0	1.8	3.6	1.0	0.9	0.2	1.5	1.4	1.5	1.1	1.9	1.1	1.6	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	7.9	0.9	1.8	-0.8	2.8	1.1	1.7	-0.4	2.0	1.8	-0.4	1.8
Hearing difficulty/problems with background noise	0.4	0.7	2.0	-0.4	0.8	0.8	0.9	0.8	1.0	0.3	1.1	0.3	-1.4	0.7
Hair/balding pattern: Pattern 2	0.7	0.9	7.0	0.7	-0.4	2.6	0.2	-0.5	0.4	0.0	0.8	-0.3	-0.3	0.7
Had menopause	0.9	1.1	3.4	1.5	-0.5	-1.1	1.3	-0.1	0.5	1.4	0.6	0.3	-1.0	1.8
Had other major operations	0.1	0.2	1.1	0.1	-0.1	-1.1	0.2	-0.3	0.0	0.0	-0.5	0.3	-0.3	0.1
Forced vital capacity (FVC)	0.3	1.1	3.6	-1.9	0.5	-1.7	-1.2	0.3	-0.9	-1.3	-0.1	-0.7	0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.7	0.8	-0.7	-0.6	0.2	-1.9	-0.9	-1.7	-0.9	-0.4	0.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.5	-0.6	1.6	1.9	0.4	1.3	1.3	-0.3	0.4	0.9	-0.1	0.4
Qualifications: None of the above	0.3	0.7	2.4	1.6	-0.9	-0.6	-0.3	-0.4	-0.9	0.9	-0.3	-1.1	-0.3	0.3
Financial difficulties in last 2 years	1.1	1.4	3.6	-0.8	1.8	0.6	0.9	1.2	1.4	1.0	0.7	1.9	-1.5	0.5
Mouth/teeth dental problems	0.8	1.2	2.8	-1.3	-0.6	0.6	-1.4	-1.7	-1.2	0.0	-1.0	-0.9	0.3	-1.7
Heart attack	1.3	1.7	3.2	-0.0	1.4	0.7	1.5	1.3	1.5	1.3	1.8	1.6	0.7	1.3
Allergy	0.9	2.1	4.8	-1.0	2.2	0.2	0.9	2.2	1.2	2.0	1.4	1.9	1.1	0.4
Pain all over the body in last month	0.4	0.5	1.5	-0.3	-0.3	-1.2	-0.4	-0.6	-0.8	-0.2	-1.1	-0.1	0.1	-1.1
Diabetes (self-reported)	0.5	0.8	1.8	-1.1	1.1	-0.5	1.0	0.8	0.7	1.4	1.1	0.8	0.8	0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.2	-0.4	0.9	-0.9	-0.2	-0.3	-0.7	-0.5	-0.5	0.6	-0.9
Medication: Ramipril	0.5	0.7	1.3	0.2	-1.1	0.8	-1.1	-1.1	-0.7	-0.3	-1.0	-0.6	-0.1	-1.0
Medication: Simvastatin	1.2	1.8	3.1	-0.9	1.8	0.4	1.5	1.4	1.6	0.5	1.7	1.7	0.6	1.6
Fluid intelligence score	0.4	0.8	1.5	0.8	0.7	-0.0	1.1	0.4	1.1	-0.8	1.0	0.5	-1.1	1.2
Illnesses of siblings	1.1	1.5	4.0	0.1	-1.7	0.7	-1.5	-1.4	-1.5	0.7	-2.0	-1.2	-0.0	-0.9
Neuroticism score	0.5	1.1	3.9	1.9	0.2	0.3	1.3	0.3	0.8	0.2	1.2	0.8	0.4	2.0
Weight	0.5	2.2	7.1	-2.7	2.1	-1.1	0.2	1.8	1.2	1.4	0.8	2.0	0.1	-0.2
Impedance of arm (right)	0.6	2.6	10.4	2.9	0.4	-3.2	2.7	-0.7	0.2	-0.1	0.3	0.5	0.8	0.6
Arm fat percentage (right)	0.8	3.0	12.9	1.6	1.1	-3.6	2.6	1.3	0.9	1.4	1.0	1.6	0.1	1.3
Trunk fat-free mass	1.0	5.9	37.6	-6.1	1.0	1.8	-3.7	0.5	-0.5	0.5	-0.9	0.1	-0.4	-2.7
Hip circumference	0.3	1.4	5.9	-2.4	1.1	-2.0	-0.6	1.4	0.0	0.8	-0.2	0.8	0.5	-0.8
Time employed in main current job	0.6	0.7	3.7	-0.5	0.8	0.6	0.3	0.5	0.5	0.5	-0.2	1.9	1.4	-0.4
Alcohol intake versus 10 years previously	0.8	1.2	4.0	-1.8	1.4	-0.0	0.1	1.4	0.7	-0.3	0.8	0.9	2.0	-0.6
Father’s age at death	0.2	0.3	1.2	0.9	-1.1	0.2	-0.1	0.3	-0.3	1.0	-0.3	-0.5	0.1	-0.3
Worrier / anxious feelings	0.2	0.5	1.8	-1.1	0.1	0.9	-0.7	0.6	0.2	1.3	0.1	-0.0	-0.5	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	10.0	1.9	1.6	-0.1	3.2	0.6	1.6	-0.7	2.1	1.7	-1.0	2.5
Falls in the last year	0.4	0.5	3.5	0.3	0.4	-1.9	1.1	0.2	0.0	0.2	0.0	0.9	0.1	-0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.8	-0.1	0.5	-0.6	0.6	0.9	0.2	0.3	0.1	-0.1	-0.6	-0.0
Number of live births	0.3	0.5	1.8	0.5	-1.4	-0.2	0.1	-0.7	-0.5	0.7	0.1	-0.7	0.5	1.0
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	12.0	-1.5	-1.9	-1.6	-3.5	-2.0	-3.3	-2.0	-2.2	-3.1	-0.8	-2.3
Pulse rate	0.2	0.4	1.2	-0.9	0.4	0.4	0.0	0.4	0.6	0.8	0.5	0.1	-0.5	-1.1
Happiness	0.6	0.8	1.8	-0.2	0.9	-0.1	1.1	1.4	1.1	0.2	1.1	1.1	0.3	0.6
Noisy workplace	0.3	0.3	1.5	0.8	-0.3	0.9	0.1	-0.4	0.2	0.2	0.1	0.2	1.2	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.0	-1.4	0.7	-1.1	-0.1	0.4	-0.4	-1.1	-0.4	-0.0	-0.3	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.9	-1.4	1.7	0.2	1.0	0.6	1.6	-1.0	1.6	1.5	0.7	-0.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	1.1	-0.0	-1.3	1.3	0.1	0.8	0.3	0.8	0.8	-1.1	0.5
Asthma	0.5	1.0	4.3	2.1	-0.4	-1.0	1.3	-0.0	0.3	-1.4	0.6	-0.3	-0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	10.6	-1.3	-2.0	1.4	-3.2	-2.5	-2.3	0.0	-2.8	-1.7	0.2	-2.2
Medication: Cholesterol lowering	2.4	3.7	7.0	-2.5	2.6	-1.1	1.3	2.3	2.3	1.3	2.2	2.5	-0.2	0.7
Depression (self-reported)	0.5	0.6	3.5	1.9	-0.1	-0.5	0.7	-0.8	-0.1	0.0	0.4	-0.5	-0.9	0.9
Medication: Lansoprazole	0.4	0.4	1.8	0.0	-0.0	-1.4	0.3	-0.4	0.0	1.1	-0.1	0.7	0.7	-0.4
Prospective memory result	1.5	1.9	4.3	-0.4	-1.7	-0.7	-1.4	-1.3	-2.1	0.5	-1.7	-1.4	-0.1	-2.0
Lung cancer (father)	1.3	1.5	5.8	1.6	0.4	-0.5	1.9	0.2	0.6	-1.1	1.6	0.3	-0.6	2.4
Illnesses of mother	2.3	2.8	6.1	0.5	-2.1	0.6	-2.2	-2.5	-1.8	0.9	-2.0	-2.1	0.6	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	15.7	-1.6	-1.9	-2.2	-4.0	-2.1	-3.4	-2.6	-2.6	-3.0	0.2	-3.0
Pulse wave Arterial Stiffness index	1.2	1.4	2.8	0.4	-1.3	-0.8	-1.2	-1.5	-1.5	-0.7	-0.8	-1.7	0.1	-1.7
Impedance of arm (left)	0.7	3.3	10.6	3.1	0.7	-3.3	3.1	-0.2	0.6	-0.1	0.8	1.1	1.5	0.9
Arm fat mass (right)	0.5	2.1	4.9	-0.5	1.8	-2.2	1.6	1.8	1.2	1.4	1.0	1.9	0.1	0.8
Trunk predicted mass	1.0	5.8	36.2	-6.0	0.9	1.8	-3.7	0.4	-0.5	0.5	-1.0	0.0	-0.4	-2.7
Standing height	0.6	6.2	41.6	-6.5	1.8	1.1	-3.3	0.1	0.0	0.5	-0.9	0.6	0.6	-3.0
Length of working week for main job	1.6	1.7	4.4	0.8	1.3	-0.6	2.1	1.4	1.5	-1.6	1.4	0.8	0.2	1.5
Exposure to tobacco smoke at home	0.5	0.5	2.0	-0.6	0.4	-0.6	0.0	0.3	0.7	1.4	1.0	1.1	0.4	-0.2
Breastfed as a baby	0.2	0.3	1.3	1.1	-0.7	0.1	-0.2	-0.5	-0.1	-0.6	0.1	0.0	0.8	0.4
Tense / ‘highly strung’	0.5	0.9	4.0	0.8	-0.2	0.7	1.0	0.2	0.3	1.3	1.0	0.4	2.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.6	0.1	0.4	-1.9	0.5	0.1	-0.1	1.1	-0.2	0.1	-1.7	0.1
Hair/balding pattern: Pattern 4	0.9	2.1	7.0	-1.8	2.2	0.5	0.7	2.6	1.7	-0.1	1.3	1.6	0.1	0.7
Birth weight of first child	1.3	2.4	4.6	-1.8	2.0	0.7	1.3	1.3	2.1	1.3	1.5	1.8	-0.7	1.5
Peak expiratory flow (PEF)	2.5	5.8	13.5	-1.9	-1.9	-0.1	-3.7	-2.6	-3.0	-0.3	-2.2	-2.9	-2.3	-3.0
Pulse wave reflection index	1.1	1.4	3.3	0.3	-1.5	-0.5	-1.4	-0.7	-1.8	-1.2	-1.4	-1.0	1.3	-1.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	4.4	1.5	1.2	-0.1	2.1	0.4	1.5	-0.4	1.1	1.8	0.7	1.2
Loud music exposure frequency	3.0	3.2	8.5	0.5	-2.3	-1.2	-1.5	-1.8	-1.9	-1.9	-2.1	-2.9	-1.1	-1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	10.2	-3.2	1.3	-0.5	-1.1	1.4	0.2	-0.1	-0.3	0.3	0.2	-1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.6	0.9	-0.3	0.9	-0.2	0.5	-0.2	-1.2	-0.3	-0.4	0.6	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.9	-1.0	0.3	-0.1	-0.2	0.3	-0.2	-0.1	-0.3	0.0	-0.6	-0.8
Medication: Paracetamol	1.7	2.8	6.5	-1.4	-1.2	-0.9	-2.5	-1.6	-2.3	-0.9	-1.6	-1.7	-0.6	-2.5
Headache pain in last month	0.3	0.5	1.4	0.3	1.2	0.6	0.7	0.7	0.5	-0.7	0.6	0.7	-0.9	0.8
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.9	1.7	-1.4	1.2	-1.0	-1.5	-1.1	-0.8	-1.2	-1.6	-0.1	-0.3
Glaucoma (self-reported)	2.6	3.1	7.7	-0.2	-1.7	-0.6	-2.8	-2.1	-1.9	-0.2	-2.4	-2.1	-0.3	-2.0
Gout (self-reported)	0.2	0.3	1.6	-0.1	0.6	-1.0	-0.1	0.4	-0.0	-0.1	-0.2	-0.1	-0.4	-1.3
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.3	-1.1	-1.1	-1.5	-1.4	-1.6	-1.4	0.7	-1.7	-1.6	-0.6	-2.1
Medication: Amlodipine	0.1	0.1	0.3	0.4	-0.1	0.5	0.5	0.3	0.0	0.1	-0.0	0.3	0.4	-0.4
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.6	1.2	1.0	0.2	1.9	1.7	1.5	-0.5	1.0	1.2	0.7	1.0
Birth weight	1.1	2.5	5.3	-1.1	2.1	0.5	1.6	1.6	2.2	1.1	1.9	2.3	-0.2	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	3.1	-0.3	0.5	1.8	-0.0	0.5	0.7	0.1	0.9	0.5	0.3	0.8
High blood pressure (siblings)	0.8	1.1	3.0	-0.3	1.7	-1.3	1.1	1.2	1.2	0.2	1.1	1.3	-0.6	-0.3
Forced vital capacity (FVC), Best measure	0.5	1.9	4.4	-1.8	0.0	-1.8	-2.1	-0.0	-1.2	-1.8	-0.9	-0.8	1.1	-1.7
Body fat percentage	1.0	3.9	9.0	1.3	1.6	-3.0	2.9	1.7	1.5	2.1	1.6	2.3	0.9	1.9
Leg fat percentage (right)	0.8	3.0	5.9	1.1	1.3	-1.4	2.4	1.3	1.7	2.3	1.6	2.3	0.7	2.2
Arm fat-free mass (right)	0.7	3.8	26.5	-5.2	1.3	1.6	-2.6	1.3	0.2	0.4	-0.2	0.5	-0.2	-1.5
Exposure to tobacco smoke outside home	1.8	2.4	6.1	1.2	1.5	1.1	2.5	1.5	2.0	0.1	1.9	1.3	-0.4	2.1
Comparative body size at age 10	1.4	3.9	9.4	0.1	1.9	-1.5	3.1	2.1	2.4	-0.8	2.3	2.2	-0.8	2.3
Number of full brothers	0.8	1.0	3.8	0.3	0.4	0.9	0.5	0.8	0.7	-0.4	1.0	1.2	1.9	1.3
Worry too long after embarrassment	1.9	3.2	13.1	3.0	0.4	0.9	2.1	1.1	1.4	-0.3	1.9	0.9	0.6	3.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	1.5	-0.0	-0.9	-0.9	-0.9	-1.2	-0.8	0.1	-1.0	-1.2	-1.1	-1.0
Wheeze or whistling in the chest in last year	0.9	1.6	4.2	1.9	0.6	0.6	2.0	1.4	1.0	-0.5	1.1	0.7	-0.6	1.9
Number of children fathered	0.5	0.6	1.6	-0.7	-0.4	1.3	-1.2	-0.2	-0.4	0.9	-0.2	-0.4	0.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.1	-1.4	-0.3	-0.0	-0.7	-0.2	-0.5	-0.7	-0.8	-0.6	-0.7	-0.6
Age at first live birth	0.3	0.6	1.7	-1.2	-0.4	0.8	-1.3	-0.4	-0.3	-0.5	-0.8	-0.8	-0.1	-0.7
Pulse wave peak to peak time	1.3	1.5	3.1	-0.7	1.4	0.8	1.2	1.5	1.6	0.6	0.9	1.8	-0.1	1.7
Health satisfaction	1.1	1.5	2.9	0.4	1.2	-0.6	1.6	1.2	1.4	-0.3	1.7	1.3	0.7	1.6
Shortness of breath walking on level ground	0.2	0.3	1.4	0.2	0.5	-0.0	0.4	0.1	0.5	1.2	0.0	0.5	0.3	0.7
Qualifications: College or University degree	0.2	0.7	2.4	-1.0	-0.9	0.1	-0.9	-0.7	-0.8	-0.1	-1.5	-0.5	0.2	-1.0
Eye problems/disorders: None of the above	0.6	0.7	3.4	0.6	-0.7	0.6	0.6	0.1	-0.6	-1.2	0.2	-0.9	-1.8	0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	3.0	0.8	-0.3	-1.3	0.4	0.5	-0.2	-1.7	0.1	-0.3	-0.2	0.8
Emphysema/chronic bronchitis	0.3	0.3	1.0	-1.0	-0.1	-0.2	-0.8	0.8	-0.3	0.0	-0.8	-0.7	0.3	-0.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.4	1.1	0.1	-0.4	1.2	0.8	0.8	0.6	0.9	0.4	0.4	1.1
Neck or shoulder pain in last month	0.9	1.2	4.9	2.2	0.7	-0.0	1.4	0.2	0.7	0.4	1.1	0.7	-1.7	1.0
Medication: Blood pressure	0.2	0.4	1.2	-0.6	0.4	-1.1	0.4	1.0	0.3	0.2	0.3	0.9	0.9	-0.1
Angina (self-reported)	2.0	2.6	4.6	-1.5	1.9	1.2	1.4	1.5	2.0	1.9	1.8	2.1	0.8	0.7
Migraine (self-reported)	1.0	1.3	2.6	0.1	1.4	0.0	1.2	1.4	1.6	-0.2	1.0	1.4	-1.1	1.4
Medication: Ibuprofen	2.9	3.4	8.6	-0.7	-1.9	0.6	-2.9	-2.1	-2.3	-0.7	-2.8	-1.4	0.9	-2.0
Medication: Allopurinol	0.4	0.5	1.5	-0.0	1.0	-1.1	0.5	0.6	0.3	0.1	0.5	0.5	-1.2	-0.9
Medication: Omeprazole	2.2	2.6	6.0	-1.0	2.1	-0.6	1.4	0.6	1.8	2.4	2.2	1.8	-1.6	0.6
Medication: Seretide 50 evohaler	0.4	0.5	1.4	1.0	-0.7	-0.3	-0.4	0.4	-0.8	-0.6	-0.4	-1.2	0.9	-0.6
Mean time to correctly identify matches	1.9	3.6	8.4	2.1	1.5	1.0	2.9	1.1	2.4	1.5	1.6	2.1	-0.6	2.7
Heart disease (mother)	1.3	1.6	3.6	-1.1	1.6	-1.0	1.4	1.4	1.5	-0.7	1.9	1.5	-0.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	0.3	0.1	1.0	0.7	0.2	0.4	0.8	0.6	0.6	-0.0	1.0
Whole body fat mass	0.7	2.9	5.3	-0.6	2.0	-2.1	1.8	1.9	1.6	2.1	1.4	2.3	0.6	1.1
Leg fat mass (right)	0.7	2.6	5.6	-0.6	1.9	-1.3	1.7	1.9	1.7	2.1	1.3	2.4	0.5	1.3
Arm predicted mass (right)	0.8	3.9	26.2	-5.1	1.4	1.6	-2.5	1.4	0.3	0.6	-0.0	0.6	-0.5	-1.5
Pulse rate, automated reading	0.4	1.4	3.2	-1.2	1.7	1.0	0.8	1.7	1.3	0.4	1.8	0.9	-0.3	0.7
Alcohol intake frequency.	1.4	3.2	6.2	0.5	2.4	-0.0	2.5	1.6	2.2	1.8	2.1	2.2	-1.2	1.4
Comparative height size at age 10	0.5	2.8	12.8	-3.6	0.6	0.2	-2.5	-0.1	-1.0	1.4	-1.2	-0.7	-0.5	-2.5
Number of full sisters	1.4	1.7	4.2	1.4	0.9	0.3	1.9	1.3	1.1	1.6	1.0	1.3	-0.2	2.1
Suffer from ‘nerves’	0.2	0.3	2.4	0.2	0.0	0.6	0.0	0.4	0.0	-0.2	-0.3	-0.1	-1.5	-0.1
Overall health rating	2.5	5.4	13.4	0.6	2.5	-0.3	3.7	2.4	2.8	0.7	2.9	2.9	0.7	2.7
Chest pain or discomfort	1.1	1.6	3.7	-0.2	1.5	0.0	1.5	1.8	1.9	0.7	1.4	1.7	0.2	0.7
Had major operations	0.4	0.5	2.2	-1.5	0.3	1.1	-0.8	0.1	0.3	-0.6	0.1	0.6	-0.3	-0.0
Age at last live birth	0.3	0.5	0.9	0.1	-0.8	0.9	-0.7	-0.8	-0.4	1.0	-0.8	-0.8	0.0	-0.1
Family relationship satisfaction	1.6	2.0	5.0	-0.5	2.2	-0.7	1.7	1.6	1.5	-0.0	1.5	1.9	0.5	1.6
Leg pain on walking	0.5	0.6	3.1	0.4	0.4	0.7	0.3	-0.3	0.7	1.8	0.7	0.9	-0.9	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	0.2	1.0	-0.8	0.7	1.4	0.6	-0.5	0.9	0.3	-0.6	1.1
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.6	-1.6	1.6	-0.7	0.3	0.4	0.6	0.7	1.1	1.0	1.4	-0.8
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	5.3	-0.7	-1.9	-0.9	-2.1	-0.7	-2.0	0.1	-2.1	-2.3	1.3	-1.2
Medication: Aspirin	2.3	3.0	7.6	-0.9	2.8	-0.6	2.5	1.9	2.3	0.3	2.0	2.0	-0.0	1.2
Supplements: Vitamin C	0.7	0.8	1.8	-0.6	-0.6	1.0	-1.2	-0.6	-0.5	-0.2	-1.2	-1.1	0.7	-1.4
Knee pain experienced in last month	0.2	0.3	0.8	0.0	0.6	0.8	0.5	-0.1	0.4	0.1	0.7	0.6	-0.2	0.9
Hypertension (Self-reported)	0.2	0.7	2.2	0.5	0.4	0.8	0.4	0.5	0.9	0.5	0.3	1.5	1.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	0.1	-0.8	-0.0	-1.0	-1.2	-0.9	0.5	-1.2	-0.7	-0.8	-0.5
Illnesses of father: Heart disease	0.1	0.1	0.6	-0.8	-0.1	-0.1	-0.3	0.6	-0.1	0.4	0.1	0.4	0.2	-0.2
Illnesses of siblings: Diabetes	0.1	0.2	0.6	0.6	-0.2	0.3	0.6	0.0	0.1	0.3	0.8	-0.2	0.3	-0.1
Smoking status: Previous	1.3	2.0	4.1	1.6	-2.0	-1.7	-0.9	-1.8	-1.6	-0.7	-1.0	-1.6	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	8.4	-2.9	1.3	-0.5	-2.0	0.2	-0.2	-0.6	-1.0	0.2	-0.8	-1.6
Whole body fat-free mass	0.8	4.3	30.1	-5.5	1.2	1.0	-2.8	0.9	-0.2	0.5	-0.7	0.3	-0.5	-2.2
Leg fat-free mass (right)	0.5	2.6	17.8	-4.2	1.3	-0.6	-1.5	1.3	-0.1	0.6	-0.5	0.6	-0.9	-1.9
Arm fat percentage (left)	1.0	4.1	12.2	1.7	1.6	-3.5	3.2	1.8	1.3	1.6	1.5	2.2	0.4	1.6
Average weekly red wine intake	0.3	0.5	1.9	-1.4	0.1	1.4	-0.4	0.6	0.5	0.0	-0.0	0.4	0.8	-0.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.6	-1.9	1.0	-0.1	-0.0	1.6	0.6	1.6	0.0	0.4	0.1	-1.0
Mood swings	0.4	0.7	2.3	0.8	-0.9	-0.2	-0.6	-1.5	-1.0	0.1	-1.0	-0.5	0.5	-1.0
Loneliness, isolation	3.0	4.2	8.4	0.1	2.5	0.8	2.5	1.7	2.9	1.5	2.2	2.4	-1.6	2.4
Long-standing illness, disability or infirmity	1.3	2.0	5.5	-1.9	2.1	-1.0	0.9	2.3	1.2	0.4	1.1	1.3	1.5	0.1
Ever had bowel cancer screening	0.6	0.7	4.1	-0.1	-0.2	0.5	-0.8	-0.9	-0.2	2.0	-0.2	-0.4	1.2	-0.3
Diabetes diagnosed by doctor	1.3	2.1	4.3	-2.0	1.9	-0.8	1.3	1.4	1.4	2.1	1.6	1.4	0.6	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.2	0.5	0.2	-0.1	0.6	0.6	0.7	-0.7	0.1	0.9	0.1	1.5
Friendships satisfaction	2.4	3.0	7.9	0.4	1.9	0.3	1.9	1.9	2.1	-0.5	2.0	2.2	0.8	2.8
Qualifications: nursing, teaching	0.2	0.4	2.4	-0.8	0.1	-0.7	0.0	0.1	0.1	-1.6	0.1	0.2	0.4	0.2
Commuting to job workplace: Walk	0.6	0.6	2.2	0.4	-1.2	0.8	-0.5	-0.4	-0.6	-0.3	-0.9	-0.8	-1.5	-0.2
Eye problems/disorders: Cataract	0.4	0.5	1.4	-0.5	1.2	-0.5	0.1	0.3	0.9	1.0	0.4	1.2	0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.0	-0.5	1.3	-0.4	1.0	2.0	1.6	2.0	1.0	1.8	-0.1	1.4
Medication for cholesterol	1.9	2.9	5.8	-0.1	-2.2	-0.5	-2.1	-1.4	-2.4	-0.8	-2.3	-2.1	-0.2	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.2	1.1	-1.8	1.0	-1.2	-1.0	-1.3	0.2	-1.3	-1.1	1.5	0.4
Back pain experienced in last month	0.5	0.7	2.3	0.8	0.6	0.5	1.3	0.0	0.9	-0.4	1.5	0.2	-0.2	1.2
Mineral and other dietary supplements	4.5	6.0	11.1	1.3	2.5	1.4	3.0	2.9	3.2	-0.0	3.3	2.5	0.6	3.2
Breast cancer (self-reported)	0.3	0.4	1.1	1.0	-0.2	-0.4	0.1	-0.9	-0.4	-0.2	-0.1	0.3	-1.0	1.0
Asthma (self-reported)	0.4	0.8	3.2	1.8	-0.2	-0.6	1.4	0.2	0.6	-0.9	0.7	0.0	-0.2	1.1
Osteoporosis (self-reported)	1.0	1.3	7.9	-0.4	-0.6	0.3	-1.1	0.0	-0.5	2.8	-1.1	0.0	0.2	-1.6
Osteoarthritis (self-reported)	0.8	1.0	5.5	-0.6	0.2	1.7	-0.8	0.7	0.3	2.4	-0.4	0.7	0.5	-0.2
Medication: Aspirin	1.6	2.1	5.0	-0.3	2.1	-0.2	2.2	1.4	1.9	0.2	1.7	1.6	-0.4	1.4
Medication: Gliclazide	0.5	0.5	3.3	-0.3	-0.0	0.3	0.3	0.1	0.7	1.8	1.0	0.4	-0.7	0.5
Illnesses of father: None of the above (group 1)	1.1	1.4	4.5	0.7	-1.0	-1.0	-0.4	-1.6	-1.2	-2.1	-0.8	-1.5	-0.9	-0.7
Smoking status: Current	0.1	0.2	0.8	0.9	0.2	-0.3	0.5	0.4	0.3	-0.6	-0.4	0.0	-0.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	7.1	0.6	-2.1	-1.8	-2.3	-2.2	-2.6	-2.2	-2.1	-2.7	0.6	-1.0
Whole body water mass	0.8	4.4	30.6	-5.5	1.2	0.9	-2.9	1.0	-0.2	0.5	-0.7	0.2	-0.7	-2.2
Leg predicted mass (right)	0.5	2.7	18.0	-4.2	1.3	-0.6	-1.6	1.3	-0.1	0.7	-0.6	0.6	-0.9	-1.8
Arm fat mass (left)	0.6	2.5	5.9	-0.4	1.9	-2.4	1.7	2.0	1.3	1.5	1.2	2.2	0.2	0.7
Number of self-reported non-cancer illnesses	0.5	0.8	2.2	0.2	1.0	0.2	0.9	0.7	1.2	0.6	1.3	0.9	0.6	1.5
Average weekly champagne plus white wine intake	1.3	1.7	3.1	0.1	-1.6	-1.0	-1.6	-1.5	-1.4	0.8	-1.3	-1.2	-1.3	-1.8
Miserableness	0.3	0.6	1.1	0.8	0.5	-0.6	1.0	0.3	0.6	-0.6	0.6	1.1	1.0	0.7
Guilty feelings	0.9	1.3	2.7	-0.5	1.4	-0.6	1.0	1.5	1.1	1.6	1.1	1.0	-0.3	1.5
Wears glasses or contact lenses	0.8	1.0	2.6	-1.6	-0.3	-0.5	-1.2	-0.3	-0.7	1.3	-0.9	-0.8	-0.4	-1.6
Ever taken oral contraceptive pill	0.2	0.2	1.1	-0.0	-0.3	0.6	0.2	-0.3	0.5	1.0	0.1	0.3	0.3	0.2
Hearing aid user	1.1	1.3	2.9	-1.1	1.0	-1.1	0.2	1.5	1.1	1.4	1.3	1.7	0.2	-0.4
Mother’s age at death	0.9	1.1	4.4	-1.7	0.7	1.7	-0.2	0.2	0.6	2.1	0.7	0.1	0.4	-0.9
Financial situation satisfaction	0.7	0.8	3.5	-0.2	0.8	0.5	1.3	-0.1	1.2	0.9	0.2	1.9	0.3	0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	4.8	-1.1	0.4	0.5	0.1	0.2	0.5	2.2	0.3	0.4	-1.2	-0.4
Commuting to job workplace: Public transport	0.6	0.7	2.9	1.7	-1.4	-0.1	-0.7	-0.9	-0.4	-0.7	-0.9	-0.6	0.1	0.3
Eye problems/disorders: Glaucoma	1.4	1.7	3.8	0.0	-1.3	-0.8	-2.0	-1.9	-1.3	-0.1	-1.5	-1.4	-0.3	-1.6
Medication: Blood pressure	0.6	1.2	2.9	1.1	1.0	-0.1	1.7	0.5	1.4	0.1	1.3	1.4	0.4	1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-1.0	-0.3	0.1	-0.6	-0.5	-0.3	-0.2	-0.5	-0.9	-1.1	0.2
Supplements: Fish oil (including cod liver oil)	2.7	3.5	7.5	-0.8	-1.9	-1.4	-2.3	-1.6	-2.6	-0.5	-2.7	-2.2	0.3	-2.3
High cholesterol (Self-reported)	0.2	0.4	1.6	-0.6	0.6	-0.4	0.3	0.0	0.7	-0.3	1.3	0.5	0.8	0.4
Medication: Bendroflumethiazide	1.2	1.8	4.7	-0.4	1.4	-0.2	1.5	1.2	2.0	0.5	1.9	2.2	0.5	1.2
Medication: Paracetamol	1.0	1.6	4.6	-1.2	-0.4	-0.8	-1.8	-1.1	-1.6	-1.2	-1.0	-1.2	0.4	-2.1
Medication: Lisinopril	1.6	2.1	6.1	-0.2	1.7	-2.5	1.7	1.8	1.0	-0.2	1.9	1.1	0.9	0.9
Medication: Atorvastatin	1.6	1.9	4.6	-1.4	1.9	-0.9	1.2	1.0	2.2	0.4	1.6	1.9	1.1	0.3
Illnesses of father: High blood pressure	1.2	1.5	4.8	-0.8	1.8	-0.8	0.7	2.2	0.8	0.7	0.7	1.5	0.9	-1.3
Alcohol drinker status: Never	0.3	0.3	2.0	0.1	0.1	1.4	-0.0	-0.3	0.6	0.5	0.6	0.4	-0.7	0.1
Ever smoked	3.2	5.6	9.1	1.1	-3.0	-2.0	-2.5	-2.4	-2.9	-2.2	-2.9	-2.9	-1.0	-2.1
Basal metabolic rate	0.6	3.4	24.1	-4.9	1.5	0.4	-2.1	1.2	0.1	0.7	-0.4	0.7	-0.4	-1.8
Leg fat percentage (left)	0.6	2.3	4.4	1.0	0.9	-1.7	2.1	0.9	1.2	2.1	1.3	2.0	0.8	1.9
Arm fat-free mass (left)	0.7	3.6	25.2	-5.0	1.3	1.2	-2.6	1.0	0.2	0.5	-0.4	0.5	-0.5	-1.5
Number of operations (self-reported)	0.4	0.5	1.4	-0.6	0.5	0.6	0.0	0.4	0.8	1.2	0.7	1.0	-1.0	0.5
Average weekly beer plus cider intake	0.9	1.3	3.1	1.8	-1.1	-0.8	0.5	-1.2	-1.4	-1.8	-0.8	-1.4	-0.2	-0.3
Irritability	0.6	1.1	6.9	2.6	-0.9	0.5	0.8	-1.4	-0.5	0.0	-0.3	-0.5	0.6	0.7
Risk taking	1.0	1.5	3.5	0.5	1.4	0.3	1.9	0.6	1.3	-1.5	1.0	1.8	-0.5	1.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	13.8	-2.0	0.4	1.5	-1.8	-0.2	-0.3	2.2	-0.3	0.6	3.7	-2.2
Fractured/broken bones in last 5 years	1.3	1.6	3.5	0.8	-1.9	-0.6	-1.1	-0.9	-1.6	0.4	-1.6	-1.4	1.2	-1.6
Age started oral contraceptive pill	0.5	0.6	2.7	0.5	0.2	-0.9	0.8	0.1	0.9	1.6	0.6	0.7	0.0	0.8
Diastolic blood pressure, automated reading	0.4	1.3	4.1	0.3	1.0	0.4	0.3	2.0	1.0	-1.2	0.8	1.6	0.5	1.6
Ever depressed for a whole week	0.5	0.6	3.5	-0.7	0.9	1.9	-0.3	0.8	0.8	-0.2	-0.2	0.5	0.2	0.3
Unable to work because of sickness or disability	0.7	0.9	3.2	0.7	0.8	-0.4	0.9	0.5	1.0	1.8	1.1	1.1	-0.1	0.5
Commuting to job workplace: Cycle	0.3	0.4	1.4	1.1	-0.5	1.2	0.5	0.4	0.2	0.1	-0.0	-0.4	-1.0	0.4
Myopia	0.7	0.9	2.8	0.4	1.1	0.8	1.3	-0.4	1.2	1.3	1.7	0.5	-0.4	0.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.2	-0.8	-0.8	-0.1	-1.4	-0.8	-1.5	-0.1	-0.8	-2.1	-0.5	-1.7
Cholesterol lowering medication	1.6	2.4	4.6	0.8	1.3	-0.5	2.1	0.4	1.9	-0.6	2.0	1.7	1.8	2.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.4	-0.9	1.4	-0.7	1.0	0.7	1.2	1.4	1.8	1.2	-1.2	0.3
Pain experienced in last month	1.1	1.8	4.2	-0.4	-1.7	-1.3	-1.6	-0.8	-1.7	-0.0	-2.0	-1.5	0.4	-1.6
Supplements: Calcium	1.7	1.8	4.2	-1.5	-1.3	0.9	-2.0	-1.1	-1.4	0.9	-1.6	-0.8	0.7	-2.0
Basal cell carcinoma (self-reported)	1.1	1.3	3.0	-0.4	1.5	-0.1	1.7	0.8	1.5	0.2	1.5	1.1	-1.0	1.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.5	-0.2	1.2	0.9	1.2	1.2	1.4	1.4	1.6	1.5	0.7	1.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.5	-1.2	0.6	-0.0	-0.0	0.5	-0.2	-0.3	-0.1	0.1	-0.7	-0.7
Heart disease (siblings)	2.0	2.4	5.2	-1.2	1.9	-0.4	1.4	2.1	1.6	0.3	2.3	1.9	1.5	1.2
Alcohol drinker status: Previous	0.8	0.9	4.4	1.3	-0.4	-0.4	0.7	-0.8	-0.1	-1.0	-0.5	-0.1	-2.1	1.2
Pack years of smoking	1.8	2.6	5.9	0.1	2.2	-1.2	1.7	2.4	1.7	-0.5	1.5	2.2	0.7	1.8
Impedance of whole body	0.4	2.1	7.3	2.7	0.7	-1.4	2.4	-0.2	0.9	0.0	0.8	1.1	1.8	1.3
Leg fat mass (left)	0.5	2.0	4.4	-0.6	1.5	-1.5	1.4	1.7	1.3	2.1	1.1	2.0	0.4	1.0
Arm predicted mass (left)	0.7	3.6	24.7	-5.0	0.9	1.2	-2.9	0.8	-0.2	0.6	-0.7	0.2	-0.2	-1.7