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chr2:46,021,381-47,829,230

Best TWAS P=1.74e-25 · Best GWAS P=5.05e-25 conditioned to 0.0146

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
32	GTEx	Skin Not Sun Exposed Suprapubic	PIGF	0.14	0.08	lasso	4	0.07	1.7e-04	10.19	-10.4	1.7e-25	-0.88	0.01	0.97	TRUE
9	GTEx	Brain Frontal Cortex BA9	ATP6V1E2	0.40	-0.01	enet	35	0.06	1.4e-02	5.50	-8.2	2.8e-16	-0.44	0.09	0.27	FALSE
25	GTEx	Heart Left Ventricle	ATP6V1E2	0.38	0.05	enet	32	0.20	1.1e-10	5.50	-8.1	4.5e-16	-0.48	0.33	0.65	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	AC016722.2	0.30	0.07	lasso	4	0.11	7.7e-05	5.71	-8.0	1.3e-15	-0.37	0.25	0.05	FALSE
17	GTEx	Colon Sigmoid	ATP6V1E2	0.25	0.08	enet	17	0.13	3.3e-05	6.39	-7.9	2.2e-15	-0.37	0.61	0.12	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	CRIPT	0.27	-0.01	enet	8	0.02	1.2e-01	7.19	7.8	5.5e-15	0.41	0.12	0.08	FALSE
2	GTEx	Adipose Subcutaneous	CRIPT	0.12	0.10	lasso	3	0.09	7.1e-08	6.52	7.6	2.7e-14	0.45	0.96	0.03	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATP6V1E2	0.04	0.02	lasso	3	0.02	4.6e-03	7.57	-7.6	3.1e-14	-0.34	0.02	0.97	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CRIPT	0.11	0.11	lasso	3	0.10	1.7e-06	7.08	7.4	1.6e-13	0.38	0.78	0.19	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	ATP6V1E2	0.11	0.04	blup	75	0.06	2.0e-04	5.49	-7.2	4.1e-13	-0.38	0.09	0.86	FALSE
4	GTEx	Adrenal Gland	CRIPT	0.16	0.10	enet	11	0.13	2.3e-05	7.08	7.2	5.0e-13	0.38	0.68	0.04	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	CRIPT	0.21	0.14	enet	9	0.18	6.4e-07	6.00	7.2	7.9e-13	0.38	0.76	0.02	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	CRIPT	0.13	0.13	lasso	3	0.15	1.2e-15	7.19	7.2	8.8e-13	0.41	0.82	0.18	FALSE
42	GTEx	Whole Blood	CRIPT	0.11	0.04	enet	18	0.05	1.2e-05	6.37	7.1	1.0e-12	0.37	0.88	0.04	FALSE
54	The Cancer Genome Atlas	Esophageal Carcinoma	CRIPT	0.20	0.10	enet	10	0.16	1.3e-05	5.31	7.1	1.0e-12	0.38	0.18	0.40	FALSE
70	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CRIPT	0.13	0.07	enet	13	0.10	7.9e-05	6.37	7.0	2.4e-12	0.40	0.10	0.35	FALSE
22	GTEx	Esophagus Mucosa	ATP6V1E2	0.26	0.17	lasso	9	0.18	5.4e-12	5.49	-7.0	3.0e-12	-0.44	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CRIPT	0.14	0.05	blup	66	0.07	8.2e-04	6.37	7.0	3.5e-12	0.38	0.10	0.53	FALSE
46	NTR	Blood	CRIPT	0.04	0.05	lasso	6	0.05	3.0e-15	6.37	-7.0	3.7e-12	-0.37	1.00	0.00	FALSE
5	GTEx	Artery Aorta	CRIPT	0.16	0.06	lasso	6	0.06	3.8e-04	7.19	6.9	4.3e-12	0.41	0.85	0.02	FALSE
77	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRIPT	0.13	0.09	blup	66	0.06	5.1e-03	6.57	6.9	4.3e-12	0.30	0.11	0.09	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	CRIPT	0.16	0.19	enet	8	0.21	9.7e-12	6.37	6.9	7.0e-12	0.34	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CRIPT	0.23	0.23	lasso	5	0.24	6.2e-29	6.52	6.8	8.3e-12	0.34	1.00	0.00	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	ATP6V1E2	0.43	0.33	lasso	5	0.30	2.3e-10	6.39	-6.8	1.2e-11	-0.37	0.96	0.03	FALSE
26	GTEx	Muscle Skeletal	CRIPT	0.14	0.05	enet	25	0.08	1.8e-08	5.33	6.8	1.5e-11	0.40	0.99	0.01	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	CRIPT	0.36	0.31	enet	24	0.32	1.3e-41	6.37	6.7	1.8e-11	0.37	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRIPT	0.06	0.05	enet	11	0.06	8.0e-12	6.00	6.7	2.3e-11	0.38	0.95	0.05	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	CRIPT	0.10	0.06	blup	66	0.07	5.6e-05	5.21	6.7	2.6e-11	0.38	0.46	0.24	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATP6V1E2	0.07	0.04	enet	6	0.04	1.6e-05	5.50	-6.5	5.7e-11	-0.39	0.89	0.06	FALSE
23	GTEx	Esophagus Muscularis	CRIPT	0.15	0.21	lasso	4	0.20	2.1e-12	6.52	6.5	6.2e-11	0.33	1.00	0.00	FALSE
48	YFS	Blood	CRIPT	0.42	0.51	lasso	5	0.52	1.1e-203	6.37	6.5	6.3e-11	0.34	1.00	0.00	FALSE
30	GTEx	Pituitary	ATP6V1E2	0.33	0.05	enet	19	0.14	2.6e-04	6.27	-6.5	6.8e-11	-0.26	0.20	0.09	FALSE
34	GTEx	Skin Sun Exposed Lower leg	CRIPT	0.19	0.09	lasso	6	0.10	8.6e-09	6.52	6.5	7.1e-11	0.36	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PIGF	0.18	0.10	enet	7	0.08	9.3e-04	6.00	6.5	7.3e-11	0.38	0.10	0.33	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CRIPT	0.13	0.12	lasso	5	0.11	5.5e-12	6.52	6.5	7.5e-11	0.35	0.99	0.01	FALSE
36	GTEx	Stomach	CRIPT	0.14	0.14	lasso	2	0.16	5.0e-08	6.00	6.5	7.6e-11	0.31	0.92	0.02	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	CRIPT	0.07	0.08	lasso	2	0.08	3.6e-09	6.37	6.5	7.6e-11	0.31	1.00	0.00	FALSE
37	GTEx	Testis	CRIPT	0.32	0.25	lasso	5	0.24	7.3e-11	6.52	6.5	8.4e-11	0.33	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	CRIPT	0.11	0.03	lasso	3	0.01	2.9e-02	6.00	6.5	8.6e-11	0.35	0.32	0.22	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	ATP6V1E2	0.22	0.18	lasso	9	0.19	8.8e-11	5.49	-6.5	1.0e-10	-0.40	1.00	0.00	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	CRIPT	0.28	0.16	enet	10	0.23	5.4e-08	5.31	6.5	1.1e-10	0.47	0.74	0.13	FALSE
39	GTEx	Thyroid	CRIPT	0.08	0.10	lasso	2	0.11	5.1e-09	6.52	6.4	1.5e-10	0.35	0.98	0.01	FALSE
6	GTEx	Artery Tibial	CRIPT	0.22	0.17	lasso	5	0.22	7.5e-17	5.31	6.4	1.6e-10	0.38	1.00	0.00	FALSE
28	GTEx	Nerve Tibial	CRIPT	0.17	0.16	enet	9	0.20	2.3e-14	6.00	6.4	1.8e-10	0.36	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	PIGF	0.06	0.06	lasso	4	0.05	4.4e-06	6.00	6.4	1.8e-10	0.32	0.68	0.28	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRIPT	0.18	0.14	lasso	3	0.17	2.1e-18	6.52	6.3	2.7e-10	0.37	1.00	0.00	FALSE
12	GTEx	Breast Mammary Tissue (Female)	AC016722.4	0.20	0.05	lasso	3	0.05	1.3e-02	-3.80	-6.3	3.0e-10	-0.32	0.07	0.24	FALSE
16	GTEx	Cells Transformed fibroblasts	ATP6V1E2	0.23	0.23	lasso	3	0.25	4.8e-19	6.39	-6.3	3.3e-10	-0.36	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	CRIPT	0.11	0.10	lasso	4	0.11	1.6e-10	5.31	6.2	4.3e-10	0.36	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ATP6V1E2	0.06	0.03	lasso	5	0.04	3.3e-04	5.49	-6.2	4.8e-10	-0.39	0.20	0.15	FALSE
38	GTEx	Testis	SOCS5	0.17	0.01	lasso	3	0.03	1.2e-02	-3.44	-6.2	6.9e-10	-0.41	0.07	0.64	FALSE
68	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PIGF	0.14	0.02	blup	66	0.08	8.6e-06	7.08	6.2	7.4e-10	0.37	0.18	0.42	FALSE
69	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ATP6V1E2	0.10	0.08	lasso	2	0.07	8.8e-04	5.50	-6.2	7.5e-10	-0.37	0.12	0.28	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	PIGF	0.07	0.09	lasso	3	0.08	2.2e-08	6.00	6.1	8.2e-10	0.28	0.73	0.26	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PIGF	0.10	0.06	lasso	3	0.07	1.7e-08	6.72	6.1	8.6e-10	0.37	0.63	0.37	FALSE
24	GTEx	Esophagus Muscularis	ATP6V1E2	0.30	0.10	enet	42	0.17	1.9e-10	5.49	-6.1	1.1e-09	-0.34	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATP6V1E2	0.10	0.11	enet	9	0.12	1.4e-13	5.50	-6.0	1.9e-09	-0.38	1.00	0.00	FALSE
27	GTEx	Muscle Skeletal	ATP6V1E2	0.30	0.16	enet	27	0.21	2.5e-20	-0.41	-6.0	2.1e-09	-0.39	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	PIGF	0.08	0.09	enet	14	0.09	9.7e-11	6.00	6.0	2.1e-09	0.25	0.88	0.12	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	ATP6V1E2	0.31	-0.01	enet	28	0.05	2.1e-02	4.66	-6.0	2.3e-09	-0.28	0.12	0.08	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ATP6V1E2	0.09	0.07	lasso	3	0.07	5.6e-08	5.49	-6.0	2.7e-09	-0.36	0.90	0.10	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP6V1E2	0.12	0.08	blup	76	0.07	9.3e-09	5.50	-6.0	2.8e-09	-0.40	0.99	0.01	FALSE
44	METSIM	Adipose	ATP6V1E2	0.16	0.18	lasso	11	0.19	2.7e-27	5.50	-5.9	3.9e-09	-0.36	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Rectum Adenocarcinoma	CRIPT	0.25	0.10	enet	7	0.15	1.9e-04	5.31	5.9	4.4e-09	0.38	0.05	0.19	FALSE
40	GTEx	Thyroid	ATP6V1E2	0.13	0.03	enet	15	0.06	2.1e-05	5.50	-5.8	6.1e-09	-0.39	0.76	0.09	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PIGF	0.08	0.06	blup	71	0.07	7.3e-08	6.72	5.8	9.2e-09	0.38	0.31	0.69	FALSE
76	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ATP6V1E2	0.11	0.12	lasso	2	0.11	1.0e-04	5.49	-5.7	1.0e-08	-0.35	0.04	0.43	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	ATP6V1E2	0.20	0.14	lasso	6	0.13	5.4e-13	5.50	-5.7	1.0e-08	-0.35	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	ATP6V1E2	0.13	0.03	blup	76	0.04	3.8e-09	6.39	-5.7	1.3e-08	-0.42	0.96	0.03	FALSE
41	GTEx	Vagina	ATP6V1E2	0.31	0.00	lasso	7	-0.01	6.5e-01	5.50	-5.7	1.6e-08	-0.39	0.08	0.21	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ATP6V1E2	0.08	0.06	lasso	4	0.06	4.9e-07	5.50	-5.5	3.1e-08	-0.36	0.71	0.29	FALSE
7	GTEx	Brain Cerebellar Hemisphere	CRIPT	0.41	0.16	enet	29	0.23	1.1e-06	5.33	5.4	7.2e-08	0.35	0.24	0.06	FALSE
45	METSIM	Adipose	CRIPT	0.07	0.08	bslmm	667	0.07	2.0e-10	5.31	5.4	7.2e-08	0.40	1.00	0.00	FALSE
18	GTEx	Colon Transverse	ATP6V1E2	0.27	0.03	enet	34	0.12	2.2e-06	6.39	-5.3	9.6e-08	-0.35	0.26	0.07	FALSE
29	GTEx	Nerve Tibial	ATP6V1E2	0.22	0.06	enet	41	0.13	3.2e-09	6.39	-5.3	1.1e-07	-0.27	0.84	0.04	FALSE
3	GTEx	Adipose Visceral Omentum	ATP6V1E2	0.25	0.22	enet	11	0.28	1.1e-14	5.50	-5.2	1.7e-07	-0.35	1.00	0.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	ATP6V1E2	0.36	0.17	lasso	10	0.28	2.8e-23	5.50	-5.2	2.0e-07	-0.48	1.00	0.00	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	ATP6V1E2	0.32	0.13	lasso	5	0.14	1.2e-05	5.49	-5.2	2.1e-07	-0.33	0.48	0.03	FALSE
43	GTEx	Whole Blood	ATP6V1E2	0.07	0.06	enet	10	0.06	8.1e-06	6.39	-5.2	2.1e-07	-0.34	0.95	0.00	FALSE
8	GTEx	Brain Cortex	CRIPT	0.35	0.17	lasso	7	0.09	2.1e-03	5.33	5.2	2.5e-07	0.39	0.26	0.06	FALSE