Best TWAS P=9.7e-11 · Best GWAS P=3.3e-10 conditioned to 0.00034
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | CABLES2 | 0.21 | 0.18 | enet | 16 | 0.20 | 8.3e-16 | -5.6 | -6.5 | 9.7e-11 | 0.01 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Nerve Tibial | DIDO1 | 0.11 | 0.06 | lasso | 3 | 0.07 | 6.2e-06 | 5.2 | -5.6 | 2.0e-08 | -0.65 | 0.07 | 0.92 | TRUE |
| 5 | GTEx | Esophagus Muscularis | CABLES2 | 0.28 | 0.23 | lasso | 6 | 0.35 | 5.4e-22 | -5.1 | -6.3 | 4.1e-10 | 0.02 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | CABLES2 | 0.25 | 0.10 | lasso | 4 | 0.15 | 4.8e-06 | -5.1 | -6.1 | 9.3e-10 | 0.01 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CABLES2 | 0.28 | 0.00 | enet | 8 | 0.00 | 2.5e-01 | 5.4 | -6.1 | 9.5e-10 | 0.02 | 0.04 | 0.49 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | CABLES2 | 0.17 | 0.02 | lasso | 6 | 0.05 | 3.7e-03 | -5.6 | -6.0 | 1.6e-09 | 0.01 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Heart Left Ventricle | CABLES2 | 0.19 | 0.20 | lasso | 5 | 0.18 | 3.8e-10 | 5.4 | -6.0 | 2.1e-09 | 0.02 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | CABLES2 | 0.16 | 0.07 | lasso | 7 | 0.10 | 2.5e-06 | 5.4 | -5.6 | 1.6e-08 | 0.03 | 0.03 | 0.96 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | CABLES2 | 0.18 | 0.17 | enet | 13 | 0.16 | 3.4e-13 | 4.8 | -5.6 | 1.9e-08 | 0.03 | 0.08 | 0.91 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | GID8 | 0.19 | 0.00 | enet | 14 | 0.02 | 3.5e-02 | 5.1 | -5.2 | 2.3e-07 | -0.32 | 0.07 | 0.24 | FALSE |