Hub : Genes

GID8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.191 0.0710 0.0079 0.000 NA 0.019 NA 0.019 0.33000 NA 0.03500 NA 3.6e-02
2 GTEx Breast Mammary Tissue (Female) 0.213 0.1052 0.0630 -0.010 NA -0.001 NA -0.006 0.97000 NA 0.34000 NA 5.5e-01
3 GTEx Cells Transformed fibroblasts 0.151 0.0510 0.0023 -0.004 NA -0.002 NA -0.002 0.91000 NA 0.48000 NA 5.5e-01
4 GTEx Esophagus Muscularis 0.184 0.0640 0.0028 0.023 NA 0.055 NA 0.057 0.01500 NA 0.00029 NA 2.4e-04
5 GTEx Nerve Tibial 0.128 0.0461 0.0040 0.041 NA 0.036 NA 0.059 0.00063 NA 0.00140 NA 5.6e-05
6 GTEx Skin Sun Exposed Lower leg 0.115 0.0400 0.0017 0.000 NA -0.002 NA 0.000 0.33000 NA 0.56000 NA 3.3e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.9 1.4 4.6 0.3 0.0 -2.1 -1.5 -1.0 -0.5
Bipolar Disorder or Schizophrenia 0.8 1.9 4.7 -1.5 0.0 -1.2 -2.2 -1.3 -1.2
Depressed Affect (Nagel 2018) 1.1 2.4 4.8 -2.2 0.0 -1.6 -1.6 -0.7 -1.9
Depression (Nagel 2018) 2.0 3.0 5.5 -2.4 0.0 -1.6 -2.2 -2.0 -0.9
Intelligence (Savage-Jansen 2018) 0.7 2.2 6.7 -0.9 0.0 -0.8 -1.3 -1.9 2.6
Neuroticism (Nagel 2018) 0.9 2.0 6.8 -2.6 0.0 -0.6 -1.7 -1.2 -0.8
Schizophrenia (2018) 0.7 1.4 3.9 -2.0 0.0 0.1 -1.6 -0.8 -1.1
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.4 0.9 3.7 -1.9 0.0 0.7 0.5 -0.5 -0.9
Alzheimer’s Disease (in mother) 0.7 0.8 2.0 1.0 0.0 -1.4 -0.6 -1.2 -0.3
Alzheimer’s Disease (in father) 0.8 0.9 1.8 0.8 0.0 1.3 0.7 0.8 1.2
Alzheimer’s Disease (including proxy) 0.3 0.5 2.0 1.4 0.0 -0.6 0.2 -0.6 0.1
Crohns Disease (2017) 0.8 1.8 4.1 2.0 0.0 2.0 1.5 0.8 -0.1
Irritable Bowel Disease (IBD) 1.0 2.3 6.3 2.5 0.0 1.1 1.3 1.6 -1.5
Ulcerative Colitis (UC) 1.0 1.8 7.5 1.0 0.0 -0.2 0.1 1.6 -2.7
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.9 1.6 4.5 -1.6 0.0 -1.2 -2.1 -1.0 -0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 4.2 0.9 0.0 0.1 -1.0 -1.2 2.0
Breast Cancer 0.8 1.8 5.1 -1.8 0.0 -1.3 -1.0 0.2 -2.3
Ovarian Cancer 0.2 0.2 0.8 -0.4 0.0 -0.9 -0.2 0.4 -0.3
Prostate Cancer 0.7 0.9 2.1 -1.0 0.0 -1.4 -0.2 -1.1 1.1
Age at First Birth 1.0 1.4 3.8 1.4 0.0 -0.9 -0.3 -1.9 -1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.1 2.8 6.7 -1.7 0.0 -1.9 -2.6 -1.9 0.2
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.6 0.9 4.2 0.3 0.0 1.0 2.1 0.3 -0.1
Mean Putamen Volume 0.9 1.1 2.1 0.3 0.0 -0.8 -1.5 -1.2 1.5
Fasting Glucose 1.7 2.1 8.8 0.2 0.0 0.9 -0.5 1.6 -3.0
HbA1C 0.8 0.8 1.3 0.9 0.0 1.1 1.1 0.7 -1.1
HDL Cholesterol 0.3 0.5 1.5 0.7 0.0 -0.2 1.2 0.6 -0.8
LDL Cholesterol 0.2 0.3 1.2 -0.4 0.0 -0.4 0.7 -0.1 1.1
Lupus 0.2 0.3 0.8 0.2 0.0 -0.4 -0.0 0.9 -0.8
Neuroticism (2016) 0.2 0.3 1.3 -1.1 0.0 -0.1 0.0 -0.2 0.8
Primary Biliary Cirrhosis 0.4 0.5 2.4 0.8 0.0 0.4 1.5 -0.2 0.1
Rheumatoid Arthritis 0.4 0.5 1.0 0.8 0.0 0.7 0.7 1.0 0.7
Schizophrenia (2014) 0.8 1.8 3.9 -2.0 0.0 -0.9 -1.5 -0.5 -1.9
Triglycerides 0.1 0.2 0.6 -0.1 0.0 -0.3 -0.7 -0.3 0.8
Type 2 Diabetes (T2D) (2012) 1.2 1.3 4.8 2.2 0.0 0.6 1.7 0.0 0.0
Ulcerative Colitis 0.6 0.9 4.0 0.1 0.0 -1.2 -0.3 0.1 -2.0
Blood Eosinophil Count 0.5 3.8 9.2 -2.6 0.0 -0.8 -1.5 -3.0 2.0
Blood Platelet Count 0.1 1.5 4.8 -1.9 0.0 -0.2 -0.7 -0.6 -2.2
Blood Red Count 0.2 2.3 7.0 -1.1 0.0 -0.4 1.6 2.6 -1.6
Blood White Count 0.2 1.2 2.4 -0.9 0.0 1.5 1.5 -0.2 1.3
Heel T-Score 0.4 3.2 16.6 0.6 0.0 -0.6 -1.1 -0.9 4.1
BMI 0.8 4.8 15.1 -1.6 0.0 -1.7 -3.9 -2.0 2.1
Height 1.0 18.8 61.3 -7.8 0.0 -2.4 -3.7 2.7 -5.0
Waist Hip Ratio (WHR) 0.2 0.8 2.0 0.5 0.0 0.8 1.2 -0.6 1.4
Systolic Blood Pressure 0.4 2.2 5.7 1.2 0.0 1.8 2.4 1.3 -1.2
Smoking Status 0.1 0.1 0.5 -0.1 0.0 -0.0 -0.7 -0.0 -0.5
Allergy or Eczema 0.4 1.0 2.2 -0.1 0.0 -0.3 -1.4 -1.5 1.4
Cardiovascular Disease 0.1 0.4 0.9 -0.9 0.0 0.2 0.5 -0.8 -0.8
Hypothyroidism (self reported) 0.8 1.8 4.8 -2.2 0.0 -1.2 -0.7 -0.2 -2.1
Respiratory disease 0.1 0.2 0.9 -0.3 0.0 0.5 0.3 -0.9 -0.1
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.7 1.2 0.0 0.5 0.7 -0.9 1.9
Lung FEV1/FVC ratio 0.3 1.5 6.2 -0.7 0.0 -0.2 1.0 -1.0 2.5
Lung FVC 1.2 6.3 20.6 4.5 0.0 0.2 2.5 3.1 -1.2
Neuroticism 1.1 2.7 8.5 -2.9 0.0 -1.5 -1.6 -1.4 -0.7
Chronotype (morning person) 1.2 2.7 7.6 -2.5 0.0 -1.0 -0.7 -0.9 2.8
Hair Pigment 0.1 1.9 6.7 -1.1 0.0 1.6 0.8 -0.5 2.6
Tanning 0.1 1.8 5.4 0.5 0.0 0.1 1.3 1.8 -2.3
Hand grip strength (left) 0.7 1.8 5.7 0.9 0.0 -0.9 -2.4 0.5 -1.7
Number of treatments/medications taken 0.9 1.6 4.3 -0.6 0.0 -2.1 -0.1 -1.7 -1.4
Average weekly spirits intake 0.2 0.3 0.7 -0.0 0.0 -0.9 -0.5 -0.5 0.6
Sensitivity / hurt feelings 0.6 1.0 2.3 -1.5 0.0 -1.3 -1.0 -0.3 1.1
Frequency of depressed mood in last 2 weeks 1.7 2.4 7.1 -1.6 0.0 -0.9 -1.7 -2.7 0.9
Hearing difficulty/problems: Yes 0.8 1.3 5.7 -2.4 0.0 -1.0 -0.8 -0.6 -0.3
Relative age of first facial hair 0.6 1.3 5.0 2.2 0.0 1.2 0.9 0.6 -0.3
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 9.4 -3.1 0.0 -1.8 -0.7 -0.5 -2.0
Ever used hormone-replacement therapy (HRT) 3.9 4.9 19.6 -1.5 0.0 -2.6 0.0 0.8 -4.4
Ever had hysterectomy (womb removed) 0.7 0.8 4.2 -2.1 0.0 -0.5 0.7 0.2 0.0
Systolic blood pressure, automated reading 0.2 0.5 2.8 0.1 0.0 0.6 1.7 0.1 0.4
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.0 -0.9 0.0 -0.6 0.8 0.1 1.4
Angina 0.3 0.4 1.2 -1.0 0.0 -0.5 0.1 -0.2 -1.1
Medication for hormone replacement therapy 1.0 1.1 4.2 -0.4 0.0 -0.2 0.8 1.4 -2.0
Vitamin and mineral supplements 0.6 0.8 3.3 0.2 0.0 -1.8 -0.7 -0.1 -0.9
Supplements: Zinc 0.6 0.6 2.9 -1.7 0.0 0.3 -0.5 0.6 -0.3
Medication: Co-codamol 0.5 0.5 1.3 0.4 0.0 -1.1 -0.8 -1.0 -0.4
Medication: Metformin 0.7 1.0 3.1 -0.0 0.0 -1.8 -0.1 -0.4 1.7
Diabetes (father) 0.5 0.6 2.0 0.2 0.0 -1.1 0.3 0.5 -1.4
Diabetes (mother) 0.7 0.8 3.1 -1.3 0.0 -0.0 -1.8 -0.1 0.3
Severe depression (siblings) 2.1 2.3 3.8 -1.5 0.0 -1.8 -1.9 -1.9 1.1
Pack years adult smoking proportion 1.8 2.7 4.1 1.9 0.0 1.7 2.0 -1.6 1.8
Impedance of leg (right) 1.0 5.0 21.9 0.9 0.0 2.0 4.7 1.9 -0.3
Leg fat-free mass (left) 1.6 8.3 23.6 -4.1 0.0 -2.6 -4.9 -0.9 -1.0
Trunk fat percentage 0.9 3.7 8.8 -3.0 0.0 -2.3 -1.9 -2.0 0.1
Hand grip strength (right) 0.4 1.0 4.5 0.1 0.0 -0.4 -2.1 -0.3 -1.1
Townsend deprivation index at recruitment 0.5 0.7 3.2 -1.8 0.0 0.8 -0.1 0.6 -0.0
Current tobacco smoking 0.2 0.4 1.8 -0.1 0.0 -1.3 -0.3 -0.5 -0.0
Average weekly fortified wine intake 0.3 0.4 1.7 -0.2 0.0 0.6 -1.3 0.6 0.2
Maternal smoking around birth 0.7 1.1 3.4 1.3 0.0 0.3 1.9 0.5 -0.9
Fed-up feelings 0.8 1.5 2.7 -1.5 0.0 -1.6 -0.6 -1.6 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.8 -0.8 0.0 -2.0 -0.8 -0.9 -0.9
Relative age voice broke 0.9 1.3 4.9 0.4 0.0 -0.3 0.3 2.2 -1.7
Taking other prescription medications 1.0 1.5 4.7 -2.2 0.0 0.2 -0.8 -1.5 -1.2
Age when periods started (menarche) 0.7 1.8 4.8 -1.8 0.0 1.0 1.0 0.7 -2.2
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 3.9 0.1 0.0 1.1 2.0 1.2 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 5.9 -1.0 0.0 -0.2 -0.2 -2.4 2.2
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 3.9 -2.0 0.0 -1.4 -2.0 -0.5 -1.6
Qualifications: CSEs or equivalent 0.2 0.3 0.7 -0.5 0.0 -0.4 -0.3 0.8 0.6
Serious illness, injury or assault to yourself 0.4 0.4 1.4 0.6 0.0 0.8 0.5 -0.1 1.2
High blood pressure 0.6 1.8 4.6 -1.8 0.0 -2.1 -0.2 -1.4 -0.8
Hayfever, allergic rhinitis or eczema 0.5 1.2 3.8 -0.3 0.0 -0.4 -2.0 -0.9 1.5
Multivitamins +/- minerals 0.5 0.6 3.1 0.1 0.0 1.8 -0.1 -0.2 0.6
Stomach or abdominal pain in last month 0.6 0.8 2.0 1.4 0.0 -1.3 0.5 0.7 -0.4
Supplements: Glucosamine 0.1 0.2 0.5 -0.4 0.0 -0.7 -0.5 0.0 0.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.8 -0.2 0.0 0.4 0.9 0.2 -0.7
Medication: Atenolol 0.5 0.7 2.1 -1.3 0.0 0.2 -1.5 -0.3 0.3
Medication: Levothyroxine sodium 1.6 2.8 12.2 -1.6 0.0 -0.5 0.1 1.3 -3.5
Sitting height 1.0 7.5 17.6 -4.2 0.0 -0.9 -2.0 2.3 -4.1
Chronic bronchitis/emphysema (father) 0.6 0.7 1.8 1.4 0.0 1.0 -0.8 -0.3 -0.7
High blood pressure (mother) 0.5 0.7 1.7 -1.3 0.0 -1.1 -0.1 -0.3 -1.0
Body mass index (BMI) 1.4 6.1 13.8 -1.8 0.0 -2.9 -3.7 -2.8 1.8
Impedance of leg (left) 0.9 4.4 18.6 1.0 0.0 2.0 4.3 1.6 -0.3
Leg predicted mass (left) 1.6 8.3 23.5 -4.1 0.0 -2.6 -4.8 -0.9 -1.1
Trunk fat mass 1.4 6.1 14.5 -3.8 0.0 -2.7 -3.2 -2.1 -0.2
Waist circumference 2.0 7.2 16.5 -2.8 0.0 -2.8 -4.1 -2.6 2.1
Number of incorrect matches in round 0.3 0.5 1.3 -1.2 0.0 0.3 -0.5 -1.0 0.1
Past tobacco smoking 0.5 0.9 3.3 0.9 0.0 0.4 1.8 1.1 0.4
Alcohol usually taken with meals 0.2 0.3 0.8 -0.2 0.0 0.3 -0.8 -0.4 0.9
Nervous feelings 0.5 1.0 2.7 -1.6 0.0 -0.2 1.4 0.2 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.4 -0.3 0.0 -0.8 -1.0 -1.2 0.1
Hearing difficulty/problems with background noise 0.8 1.2 6.4 -2.5 0.0 -0.5 -0.4 -0.3 -0.8
Hair/balding pattern: Pattern 2 1.1 1.4 2.7 -1.3 0.0 -1.1 -1.6 -1.3 1.1
Had menopause 2.8 3.5 10.3 -2.1 0.0 -2.3 -0.4 -0.9 -3.2
Had other major operations 0.6 0.7 2.1 -0.9 0.0 -0.2 -1.1 -1.5 0.5
Forced vital capacity (FVC) 0.8 3.2 12.8 0.1 0.0 0.6 0.0 3.6 -2.5
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.9 -0.9 0.0 -0.1 0.0 -1.7 1.7
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.9 0.6 0.0 0.7 -0.6 1.7 -1.3
Qualifications: None of the above 0.8 1.7 4.8 1.2 0.0 0.9 2.2 1.3 -1.2
Financial difficulties in last 2 years 0.6 0.8 2.4 -0.4 0.0 -1.6 -1.1 -0.3 0.8
Mouth/teeth dental problems 0.5 0.7 2.1 -0.8 0.0 1.5 -0.7 -1.0 0.1
Heart attack 0.1 0.1 0.4 0.6 0.0 -0.0 0.4 0.5 -0.1
Allergy 0.1 0.2 0.6 -0.2 0.0 -0.6 0.8 0.7 -0.1
Pain all over the body in last month 0.4 0.5 1.2 0.3 0.0 0.4 1.0 1.1 0.5
Diabetes (self-reported) 0.2 0.4 1.1 -0.6 0.0 -0.7 0.3 -0.3 1.1
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.5 -0.3 0.0 -0.0 -0.7 -0.5 0.0
Medication: Ramipril 0.6 0.8 2.7 -0.8 0.0 -1.3 0.1 -0.1 -1.7
Medication: Simvastatin 0.7 1.0 3.9 -2.0 0.0 0.2 -0.2 -1.1 -1.0
Fluid intelligence score 0.5 1.0 2.1 1.1 0.0 1.5 0.3 -0.6 1.4
Illnesses of siblings 0.2 0.3 1.1 -0.6 0.0 1.0 -0.6 0.4 -0.2
Neuroticism score 0.9 1.9 6.9 -2.6 0.0 -1.1 -1.4 -0.7 -1.1
Weight 1.7 8.5 22.7 -3.9 0.0 -3.2 -4.8 -1.7 -0.1
Impedance of arm (right) 0.9 4.4 18.3 1.1 0.0 1.4 4.3 2.0 -0.8
Arm fat percentage (right) 0.8 3.3 6.2 -1.8 0.0 -2.5 -2.0 -2.1 1.2
Trunk fat-free mass 1.6 9.0 26.4 -4.4 0.0 -2.1 -5.1 -0.4 -1.9
Hip circumference 2.0 8.4 20.9 -3.7 0.0 -3.3 -4.6 -2.1 0.6
Time employed in main current job 0.5 0.5 1.1 0.7 0.0 -1.1 0.7 -0.8 -0.7
Alcohol intake versus 10 years previously 0.5 0.7 2.7 -1.2 0.0 -1.6 0.1 0.0 -0.0
Father’s age at death 1.9 2.5 9.0 -0.8 0.0 1.7 0.7 1.4 -3.0
Worrier / anxious feelings 0.4 0.7 4.0 -2.0 0.0 0.0 -0.0 -0.4 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.7 -1.1 0.0 -0.6 -0.3 -1.3 0.4
Falls in the last year 0.5 0.7 1.5 -0.3 0.0 1.0 0.4 1.2 1.2
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 -0.2 0.0 0.8 0.3 0.9 -0.6
Number of live births 0.6 0.9 2.7 -0.3 0.0 0.2 -1.4 -0.8 1.6
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 8.6 -0.1 0.0 -0.1 -0.2 2.9 -1.7
Pulse rate 0.8 1.3 3.8 -1.5 0.0 -0.1 -1.2 -0.4 -1.9
Happiness 0.4 0.4 1.0 -1.0 0.0 -0.2 -0.5 -1.0 0.7
Noisy workplace 1.7 2.1 4.0 -0.8 0.0 1.4 1.7 1.8 -2.0
Qualifications: A levels/AS levels or equivalent 0.2 0.4 2.0 -0.3 0.0 -0.2 -1.4 0.3 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 -0.3 0.0 -0.0 -0.8 0.2 -0.6
Mouth/teeth dental problems: Dentures 0.6 0.9 3.4 0.9 0.0 -1.8 0.9 0.7 -0.2
Asthma 0.2 0.4 1.2 -0.3 0.0 1.1 -0.1 -0.9 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 4.5 -1.1 0.0 -2.1 -2.0 -1.9 -0.1
Medication: Cholesterol lowering 0.5 0.7 1.6 -1.1 0.0 0.3 1.3 -1.2 -0.4
Depression (self-reported) 0.2 0.3 1.3 0.4 0.0 -0.0 0.2 0.5 -1.2
Medication: Lansoprazole 0.9 1.1 3.5 1.6 0.0 0.4 1.9 -0.2 0.6
Prospective memory result 0.3 0.4 0.8 -0.1 0.0 0.9 0.8 0.2 0.9
Lung cancer (father) 1.4 1.6 6.8 -0.3 0.0 0.5 1.4 0.7 2.6
Illnesses of mother 0.3 0.4 0.8 0.9 0.0 0.9 0.5 0.4 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 8.7 0.6 0.0 0.5 0.7 3.0 -0.8
Pulse wave Arterial Stiffness index 0.6 0.7 2.2 0.0 0.0 -1.1 1.5 0.7 -0.5
Impedance of arm (left) 1.0 4.7 19.9 0.8 0.0 1.8 4.5 1.9 -1.0
Arm fat mass (right) 1.3 5.2 10.3 -2.9 0.0 -3.0 -3.2 -2.0 0.5
Trunk predicted mass 1.5 8.5 25.4 -4.2 0.0 -2.0 -5.0 -0.3 -1.9
Standing height 1.0 10.0 26.7 -5.2 0.0 -1.1 -2.7 2.4 -4.4
Length of working week for main job 0.7 0.8 2.2 -0.3 0.0 0.1 -1.2 -1.5 1.0
Exposure to tobacco smoke at home 1.0 1.1 2.6 -1.3 0.0 -0.6 -1.6 -1.4 0.6
Breastfed as a baby 1.3 1.6 4.4 -2.1 0.0 0.1 -1.6 -0.7 -1.6
Tense / ‘highly strung’ 0.2 0.3 1.1 -0.5 0.0 -0.2 -0.1 -1.0 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.9 -0.1 0.0 0.9 0.2 -0.9 0.7
Hair/balding pattern: Pattern 4 0.7 1.6 8.6 -1.0 0.0 0.3 -0.3 0.2 -2.9
Birth weight of first child 0.2 0.5 1.4 -0.3 0.0 0.6 -1.2 0.6 0.7
Peak expiratory flow (PEF) 0.3 0.8 3.4 -0.8 0.0 -0.8 -1.8 0.4 0.1
Pulse wave reflection index 0.2 0.2 1.0 0.4 0.0 -0.1 1.0 0.1 0.5
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.1 0.8 0.0 1.0 1.0 -0.3 0.6
Loud music exposure frequency 0.9 1.0 3.1 0.8 0.0 -0.4 0.8 1.8 -1.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 6.2 -0.1 0.0 -2.5 -1.3 -1.4 -0.6
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 4.2 -2.0 0.0 -0.9 -2.0 -0.3 -0.0
Blood clot in the leg (DVT) 0.5 0.6 2.3 0.6 0.0 1.5 0.3 -0.8 0.4
Medication: Paracetamol 0.6 1.1 4.0 0.2 0.0 -2.0 -0.2 -1.5 0.0
Headache pain in last month 1.9 3.3 9.7 -0.7 0.0 -3.1 -2.6 -1.4 0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.5 1.2 0.0 0.7 -0.5 1.2 1.1
Glaucoma (self-reported) 0.9 1.0 2.9 -0.8 0.0 1.1 -1.2 -0.3 1.7
Gout (self-reported) 0.8 1.1 3.6 -1.1 0.0 0.1 -1.9 -1.3 0.5
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 3.6 -1.5 0.0 -0.8 -0.2 0.3 -1.9
Medication: Amlodipine 0.2 0.3 0.9 -0.2 0.0 -0.3 0.9 0.7 -0.7
Medication: Ventolin 100micrograms inhaler 1.1 1.4 4.2 -1.6 0.0 -0.3 -2.0 -1.2 -0.4
Birth weight 0.3 0.7 2.8 -0.3 0.0 -0.2 -1.7 0.0 -1.1
Chronic bronchitis/emphysema (mother) 1.1 1.3 5.7 -0.2 0.0 -0.9 -0.6 -2.4 1.1
High blood pressure (siblings) 0.6 0.9 2.6 1.6 0.0 -0.5 0.3 1.2 -1.0
Forced vital capacity (FVC), Best measure 0.8 2.8 12.1 0.9 0.0 0.7 0.9 3.5 -1.6
Body fat percentage 1.0 3.9 6.9 -2.6 0.0 -2.4 -2.0 -2.5 0.9
Leg fat percentage (right) 1.2 4.4 8.2 -2.1 0.0 -2.4 -1.8 -2.9 2.2
Arm fat-free mass (right) 1.8 9.2 27.1 -4.3 0.0 -2.5 -5.2 -0.6 -1.8
Exposure to tobacco smoke outside home 0.2 0.3 1.5 -0.2 0.0 -0.2 0.0 0.4 -1.2
Comparative body size at age 10 0.8 2.2 4.1 0.6 0.0 -2.0 -1.8 -2.0 1.3
Number of full brothers 1.9 2.4 8.5 -0.4 0.0 0.6 -1.9 -1.4 2.9
Worry too long after embarrassment 0.9 1.5 3.8 -1.9 0.0 -0.6 -1.9 -1.0 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 0.7 0.0 0.9 -0.0 0.8 -1.0
Wheeze or whistling in the chest in last year 0.6 1.1 2.4 -1.1 0.0 -1.0 1.0 -0.9 -1.6
Number of children fathered 0.4 0.4 1.1 0.2 0.0 -0.9 -0.8 -1.0 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.8 -0.9 0.0 0.4 -0.9 -0.4 -0.8
Age at first live birth 1.0 1.7 6.5 2.6 0.0 0.5 1.4 0.7 -1.1
Pulse wave peak to peak time 0.6 0.7 2.3 -0.3 0.0 1.2 -1.5 -0.8 0.3
Health satisfaction 0.4 0.5 2.1 -1.5 0.0 -0.4 -0.8 -0.2 0.4
Shortness of breath walking on level ground 0.4 0.5 2.2 0.6 0.0 -1.5 -0.4 0.4 -0.1
Qualifications: College or University degree 0.2 0.5 1.4 0.1 0.0 -0.0 -1.2 -0.8 1.1
Eye problems/disorders: None of the above 1.0 1.1 5.0 2.2 0.0 0.3 1.2 -0.1 -0.3
Mouth/teeth dental problems: Loose teeth 0.8 1.0 3.3 1.8 0.0 -0.9 -0.6 -0.3 -1.2
Emphysema/chronic bronchitis 0.6 0.7 1.0 1.0 0.0 0.6 0.9 -0.9 -1.0
Medication for pain relief, constipation, heartburn 1.4 2.4 6.4 1.2 0.0 2.5 0.4 2.3 0.9
Neck or shoulder pain in last month 0.8 1.1 4.1 1.0 0.0 0.0 0.9 0.6 -2.0
Medication: Blood pressure 0.7 1.2 3.2 -1.4 0.0 -1.2 0.4 -1.8 -0.8
Angina (self-reported) 0.4 0.5 1.6 -1.1 0.0 -0.4 0.2 0.0 -1.3
Migraine (self-reported) 0.3 0.4 1.4 -1.2 0.0 -0.6 -0.6 -0.4 -0.1
Medication: Ibuprofen 2.1 2.5 5.2 -1.0 0.0 -2.1 -2.0 -2.3 -0.4
Medication: Allopurinol 0.3 0.3 1.0 -1.0 0.0 0.1 -1.0 0.2 -0.4
Medication: Omeprazole 0.3 0.4 1.2 0.8 0.0 -0.4 0.1 -0.3 -1.1
Medication: Seretide 50 evohaler 0.4 0.4 1.0 0.9 0.0 0.8 -0.2 0.4 -1.0
Mean time to correctly identify matches 1.6 3.1 6.5 -2.5 0.0 -1.8 -2.0 -1.8 -1.3
Heart disease (mother) 0.2 0.3 1.1 -0.1 0.0 1.0 0.8 0.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.8 -0.6 0.0 -0.7 -1.2 -0.6 -1.3
Whole body fat mass 1.6 6.8 14.0 -3.7 0.0 -3.2 -3.3 -2.4 0.1
Leg fat mass (right) 1.7 6.6 11.2 -3.2 0.0 -3.1 -3.4 -2.8 1.1
Arm predicted mass (right) 1.7 8.9 26.9 -4.2 0.0 -2.2 -5.2 -0.7 -1.8
Pulse rate, automated reading 0.9 2.8 11.5 -3.4 0.0 0.1 -0.9 -1.5 -1.4
Alcohol intake frequency. 0.2 0.5 2.3 -0.6 0.0 -1.5 0.1 0.0 -0.3
Comparative height size at age 10 0.7 4.0 10.8 -3.3 0.0 -1.9 -2.5 -0.0 -1.8
Number of full sisters 1.0 1.3 3.6 -0.8 0.0 -1.9 -1.8 -0.3 -0.0
Suffer from ‘nerves’ 0.3 0.5 1.0 -0.2 0.0 1.0 0.5 1.0 -0.9
Overall health rating 0.4 0.8 1.3 -0.8 0.0 -1.1 -0.7 -0.9 1.1
Chest pain or discomfort 0.2 0.3 0.7 0.8 0.0 -0.6 -0.1 0.4 -0.8
Had major operations 1.2 1.4 4.2 0.5 0.0 0.6 1.8 -0.5 2.0
Age at last live birth 0.3 0.5 1.4 1.2 0.0 0.2 -0.6 0.3 -0.9
Family relationship satisfaction 0.8 1.0 3.1 -0.7 0.0 -1.4 -1.8 -0.8 -0.0
Leg pain on walking 1.1 1.3 3.5 0.9 0.0 1.6 0.8 1.9 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.7 0.2 0.0 0.8 -0.9 0.2 0.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.2 -0.1 0.0 -0.8 -1.5 -1.5 -0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.2 0.0 -0.2 0.5 0.4 0.1
Medication: Aspirin 0.5 0.7 1.8 -1.3 0.0 -0.6 0.9 -0.5 -1.1
Supplements: Vitamin C 0.8 1.0 2.3 1.5 0.0 1.1 0.7 0.3 1.4
Knee pain experienced in last month 0.6 0.9 3.6 0.1 0.0 -0.5 -1.9 -1.2 -0.2
Hypertension (Self-reported) 0.6 1.7 4.9 -1.8 0.0 -2.2 -0.1 -1.1 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 1.1 0.0 -0.2 0.7 0.0 -0.0
Illnesses of father: Heart disease 0.9 1.2 6.3 0.1 0.0 -2.5 -0.6 -0.5 0.2
Illnesses of siblings: Diabetes 0.2 0.2 0.7 0.0 0.0 -0.5 0.8 0.7 0.3
Smoking status: Previous 0.3 0.4 1.3 -0.3 0.0 0.2 -1.1 -1.0 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.8 -0.0 0.0 -0.5 -0.2 1.5 -1.9
Whole body fat-free mass 1.6 9.3 27.6 -4.4 0.0 -2.5 -5.2 -0.7 -1.6
Leg fat-free mass (right) 1.6 8.3 25.2 -4.0 0.0 -2.6 -5.0 -0.8 -1.2
Arm fat percentage (left) 0.8 3.2 5.1 -1.9 0.0 -2.3 -1.9 -2.2 1.3
Average weekly red wine intake 0.2 0.3 1.0 0.0 0.0 1.0 -0.0 -0.6 -0.3
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.3 0.4 0.0 0.1 -1.0 -1.8 1.2
Mood swings 0.1 0.2 0.4 -0.7 0.0 -0.6 0.0 0.6 -0.3
Loneliness, isolation 3.4 4.7 12.2 -3.5 0.0 -2.1 -2.7 -1.1 -1.8
Long-standing illness, disability or infirmity 0.5 0.7 3.1 -1.8 0.0 -0.9 -0.4 -0.6 0.1
Ever had bowel cancer screening 0.3 0.4 0.9 -1.0 0.0 -0.6 -0.6 0.2 -0.7
Diabetes diagnosed by doctor 0.3 0.5 1.0 -0.9 0.0 -1.0 0.2 -0.8 0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.6 6.4 -1.3 0.0 -2.5 -2.5 -0.6 -0.9
Friendships satisfaction 2.1 2.7 4.6 -1.5 0.0 -1.6 -2.1 -2.1 1.4
Qualifications: nursing, teaching 0.4 0.6 2.5 0.5 0.0 -0.9 0.3 -0.2 1.6
Commuting to job workplace: Walk 0.8 0.9 2.1 -1.0 0.0 -1.2 -0.6 -1.4 0.6
Eye problems/disorders: Cataract 0.4 0.4 1.0 -1.0 0.0 -0.5 -1.0 0.5 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.9 0.5 0.0 -0.4 1.4 0.8 0.5
Medication for cholesterol 1.3 2.0 3.9 1.8 0.0 1.6 1.3 0.9 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.1 -1.1 0.0 0.0 -1.0 -0.2 0.4
Back pain experienced in last month 0.2 0.3 1.1 -1.0 0.0 -0.1 0.2 -1.0 -0.1
Mineral and other dietary supplements 0.2 0.3 0.7 0.9 0.0 0.4 0.2 -0.7 -0.4
Breast cancer (self-reported) 0.8 1.0 4.4 -0.3 0.0 0.1 0.4 -1.1 2.1
Asthma (self-reported) 0.2 0.4 1.5 -0.3 0.0 1.2 -0.0 -0.9 -0.2
Osteoporosis (self-reported) 0.3 0.4 1.9 0.2 0.0 0.3 0.5 -0.4 -1.4
Osteoarthritis (self-reported) 0.3 0.4 0.9 -0.1 0.0 0.3 -0.9 -1.0 0.6
Medication: Aspirin 0.6 0.8 2.6 -1.6 0.0 -0.5 0.7 -1.0 -0.8
Medication: Gliclazide 0.4 0.5 2.5 0.3 0.0 0.5 0.3 -0.2 1.6
Illnesses of father: None of the above (group 1) 0.6 0.7 1.8 -1.2 0.0 0.3 0.3 -1.0 1.4
Smoking status: Current 0.3 0.4 1.8 -0.3 0.0 -1.3 -0.8 -0.2 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.9 -0.5 0.0 -0.6 0.1 1.0 -0.5
Whole body water mass 1.7 9.4 28.4 -4.4 0.0 -2.4 -5.3 -0.6 -1.7
Leg predicted mass (right) 1.6 8.3 25.3 -3.9 0.0 -2.7 -5.0 -0.8 -1.2
Arm fat mass (left) 1.3 5.3 9.9 -3.0 0.0 -2.9 -3.2 -2.1 0.4
Number of self-reported non-cancer illnesses 0.4 0.7 2.6 -1.6 0.0 -0.2 0.3 -0.9 -0.8
Average weekly champagne plus white wine intake 0.6 0.8 2.2 -1.2 0.0 0.3 -1.5 -0.7 -0.7
Miserableness 0.4 0.6 1.5 -0.7 0.0 -0.8 -0.7 1.2 -0.8
Guilty feelings 3.0 4.6 11.3 -3.3 0.0 -0.5 -3.4 -1.9 1.1
Wears glasses or contact lenses 0.7 0.8 4.0 -2.0 0.0 0.1 0.6 -0.7 -0.6
Ever taken oral contraceptive pill 0.4 0.5 2.0 -0.5 0.0 1.4 -0.4 0.5 0.4
Hearing aid user 0.4 0.4 1.4 -1.2 0.0 -0.9 -0.2 0.2 -0.2
Mother’s age at death 1.0 1.3 2.7 -0.6 0.0 -1.7 -1.5 -1.6 -0.2
Financial situation satisfaction 0.7 0.8 3.2 1.0 0.0 -1.8 -0.7 -0.1 0.6
Tinnitus: Yes, now most or all of the time 0.5 0.5 2.0 -0.8 0.0 0.7 -0.5 0.0 -1.4
Commuting to job workplace: Public transport 0.3 0.4 2.0 -0.5 0.0 -1.4 -0.4 -0.3 -0.2
Eye problems/disorders: Glaucoma 1.4 1.6 4.5 -1.1 0.0 1.0 -2.1 -0.6 1.6
Medication: Blood pressure 0.4 0.8 3.5 -0.1 0.0 -1.9 -0.5 -0.6 -0.7
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.6 0.2 0.0 -0.8 -0.4 0.2 0.5
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.3 -0.6 0.0 0.5 0.0 0.4 0.4
High cholesterol (Self-reported) 0.7 1.3 4.2 -2.0 0.0 1.6 0.5 -0.1 -0.7
Medication: Bendroflumethiazide 0.8 1.3 4.3 -0.1 0.0 -2.1 0.1 -0.9 -1.6
Medication: Paracetamol 0.6 0.9 3.4 0.4 0.0 -1.9 0.5 -1.1 -0.5
Medication: Lisinopril 1.1 1.4 5.5 0.8 0.0 -0.4 0.9 -2.3 1.3
Medication: Atorvastatin 2.3 2.8 7.4 -1.6 0.0 -2.7 -1.8 -0.8 -1.8
Illnesses of father: High blood pressure 0.4 0.5 1.4 -0.1 0.0 0.8 -0.5 0.9 -1.2
Alcohol drinker status: Never 0.7 0.9 2.3 0.9 0.0 1.2 0.6 1.5 0.8
Ever smoked 0.4 0.6 1.5 -0.9 0.0 -0.8 -1.2 -0.5 -0.9
Basal metabolic rate 1.6 8.9 25.9 -4.3 0.0 -2.5 -5.1 -0.9 -1.3
Leg fat percentage (left) 1.4 4.9 9.2 -2.1 0.0 -2.4 -2.2 -3.0 2.2
Arm fat-free mass (left) 1.9 9.6 29.1 -4.3 0.0 -2.5 -5.4 -0.7 -1.6
Number of operations (self-reported) 0.4 0.6 1.8 -0.3 0.0 0.8 -0.2 -0.9 1.3
Average weekly beer plus cider intake 0.4 0.6 2.1 -0.5 0.0 -1.5 -0.7 -0.8 -0.6
Irritability 0.7 1.2 3.2 -0.2 0.0 -1.6 -1.8 -1.3 -0.3
Risk taking 1.0 1.4 5.4 -0.1 0.0 -1.5 -2.3 -0.7 -0.3
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.2 0.3 0.0 0.3 0.1 -0.7 -1.5
Fractured/broken bones in last 5 years 0.4 0.5 0.9 -0.3 0.0 0.9 0.9 0.8 -0.7
Age started oral contraceptive pill 0.2 0.2 0.6 0.2 0.0 -0.7 0.2 0.8 -0.5
Diastolic blood pressure, automated reading 0.2 0.7 1.7 -0.7 0.0 -0.6 1.3 -1.0 0.8
Ever depressed for a whole week 0.5 0.6 2.4 0.6 0.0 0.7 -0.2 1.5 -0.5
Unable to work because of sickness or disability 0.2 0.3 0.8 0.2 0.0 -0.2 0.8 0.1 0.9
Commuting to job workplace: Cycle 1.3 1.5 4.2 0.1 0.0 -2.0 -1.7 0.9 -1.1
Myopia 1.2 1.8 6.1 -1.4 0.0 -0.4 -2.5 0.0 -1.6
Vascular/heart problems diagnosed by doctor 0.6 1.8 4.6 1.9 0.0 2.1 0.2 1.1 1.0
Cholesterol lowering medication 0.8 1.1 3.3 -1.8 0.0 -0.8 -1.5 -0.7 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.2 0.6 0.0 -0.5 -0.3 0.4 -1.5
Pain experienced in last month 1.5 2.5 7.5 0.4 0.0 2.7 1.4 2.2 -0.4
Supplements: Calcium 0.1 0.1 0.4 0.1 0.0 -0.3 -0.3 0.6 -0.2
Basal cell carcinoma (self-reported) 0.8 1.0 4.2 0.1 0.0 1.0 0.4 2.0 -0.7
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.5 0.0 0.1 0.4 0.4 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.7 0.5 0.0 1.6 0.2 -0.7 0.2
Heart disease (siblings) 2.0 2.5 5.8 1.9 0.0 -0.2 2.2 -0.9 2.4
Alcohol drinker status: Previous 0.8 0.9 3.7 -0.2 0.0 -0.1 0.9 0.9 -1.9
Pack years of smoking 1.4 2.1 3.8 1.3 0.0 1.4 1.7 -2.0 1.4
Impedance of whole body 1.0 5.2 21.3 0.9 0.0 2.0 4.6 2.0 -0.9
Leg fat mass (left) 1.8 6.9 12.9 -3.2 0.0 -3.1 -3.6 -2.8 1.0
Arm predicted mass (left) 1.8 9.0 28.9 -4.0 0.0 -2.4 -5.4 -0.9 -1.4