TWAS hub - GID8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.191	0.0710	0.0079	0.000	NA	0.019	NA	0.019	0.33000	NA	0.03500	NA	3.6e-02
2	GTEx	Breast Mammary Tissue (Female)	0.213	0.1052	0.0630	-0.010	NA	-0.001	NA	-0.006	0.97000	NA	0.34000	NA	5.5e-01
3	GTEx	Cells Transformed fibroblasts	0.151	0.0510	0.0023	-0.004	NA	-0.002	NA	-0.002	0.91000	NA	0.48000	NA	5.5e-01
4	GTEx	Esophagus Muscularis	0.184	0.0640	0.0028	0.023	NA	0.055	NA	0.057	0.01500	NA	0.00029	NA	2.4e-04
5	GTEx	Nerve Tibial	0.128	0.0461	0.0040	0.041	NA	0.036	NA	0.059	0.00063	NA	0.00140	NA	5.6e-05
6	GTEx	Skin Sun Exposed Lower leg	0.115	0.0400	0.0017	0.000	NA	-0.002	NA	0.000	0.33000	NA	0.56000	NA	3.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
Ever used hormone-replacement therapy (HRT)	3.9	4.9	19.6	-1.5	-2.6	0.0	0.8	-4.4
Loneliness, isolation	3.4	4.7	12.2	-3.5	-2.1	-2.7	-1.1	-1.8
Guilty feelings	3.0	4.6	11.3	-3.3	-0.5	-3.4	-1.9	1.1
Had menopause	2.8	3.5	10.3	-2.1	-2.3	-0.4	-0.9	-3.2
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	6.4	-1.3	-2.5	-2.5	-0.6	-0.9
Medication: Atorvastatin	2.3	2.8	7.4	-1.6	-2.7	-1.8	-0.8	-1.8
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	9.4	-3.1	-1.8	-0.7	-0.5	-2.0
Body Mass Index (BMI) (2010)	2.1	2.8	6.7	-1.7	-1.9	-2.6	-1.9	0.2
Severe depression (siblings)	2.1	2.3	3.8	-1.5	-1.8	-1.9	-1.9	1.1
Medication: Ibuprofen	2.1	2.5	5.2	-1.0	-2.1	-2.0	-2.3	-0.4
Friendships satisfaction	2.1	2.7	4.6	-1.5	-1.6	-2.1	-2.1	1.4
Depression (Nagel 2018)	2.0	3.0	5.5	-2.4	-1.6	-2.2	-2.0	-0.9
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.9	-2.0	-1.4	-2.0	-0.5	-1.6
Waist circumference	2.0	7.2	16.5	-2.8	-2.8	-4.1	-2.6	2.1
Hip circumference	2.0	8.4	20.9	-3.7	-3.3	-4.6	-2.1	0.6
Heart disease (siblings)	2.0	2.5	5.8	1.9	-0.2	2.2	-0.9	2.4
Father’s age at death	1.9	2.5	9.0	-0.8	1.7	0.7	1.4	-3.0
Headache pain in last month	1.9	3.3	9.7	-0.7	-3.1	-2.6	-1.4	0.9
Number of full brothers	1.9	2.4	8.5	-0.4	0.6	-1.9	-1.4	2.9
Arm fat-free mass (left)	1.9	9.6	29.1	-4.3	-2.5	-5.4	-0.7	-1.6
Pack years adult smoking proportion	1.8	2.7	4.1	1.9	1.7	2.0	-1.6	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.5	-1.1	-2.1	-2.0	-1.9	-0.1
Arm fat-free mass (right)	1.8	9.2	27.1	-4.3	-2.5	-5.2	-0.6	-1.8
Leg fat mass (left)	1.8	6.9	12.9	-3.2	-3.1	-3.6	-2.8	1.0
Arm predicted mass (left)	1.8	9.0	28.9	-4.0	-2.4	-5.4	-0.9	-1.4
Fasting Glucose	1.7	2.1	8.8	0.2	0.9	-0.5	1.6	-3.0
Frequency of depressed mood in last 2 weeks	1.7	2.4	7.1	-1.6	-0.9	-1.7	-2.7	0.9
Weight	1.7	8.5	22.7	-3.9	-3.2	-4.8	-1.7	-0.1
Noisy workplace	1.7	2.1	4.0	-0.8	1.4	1.7	1.8	-2.0
Leg fat mass (right)	1.7	6.6	11.2	-3.2	-3.1	-3.4	-2.8	1.1
Arm predicted mass (right)	1.7	8.9	26.9	-4.2	-2.2	-5.2	-0.7	-1.8
Whole body water mass	1.7	9.4	28.4	-4.4	-2.4	-5.3	-0.6	-1.7
Leg fat-free mass (left)	1.6	8.3	23.6	-4.1	-2.6	-4.9	-0.9	-1.0
Medication: Levothyroxine sodium	1.6	2.8	12.2	-1.6	-0.5	0.1	1.3	-3.5
Leg predicted mass (left)	1.6	8.3	23.5	-4.1	-2.6	-4.8	-0.9	-1.1
Trunk fat-free mass	1.6	9.0	26.4	-4.4	-2.1	-5.1	-0.4	-1.9
Mean time to correctly identify matches	1.6	3.1	6.5	-2.5	-1.8	-2.0	-1.8	-1.3
Whole body fat mass	1.6	6.8	14.0	-3.7	-3.2	-3.3	-2.4	0.1
Whole body fat-free mass	1.6	9.3	27.6	-4.4	-2.5	-5.2	-0.7	-1.6
Leg fat-free mass (right)	1.6	8.3	25.2	-4.0	-2.6	-5.0	-0.8	-1.2
Leg predicted mass (right)	1.6	8.3	25.3	-3.9	-2.7	-5.0	-0.8	-1.2
Basal metabolic rate	1.6	8.9	25.9	-4.3	-2.5	-5.1	-0.9	-1.3
Trunk predicted mass	1.5	8.5	25.4	-4.2	-2.0	-5.0	-0.3	-1.9
Pain experienced in last month	1.5	2.5	7.5	0.4	2.7	1.4	2.2	-0.4
Body mass index (BMI)	1.4	6.1	13.8	-1.8	-2.9	-3.7	-2.8	1.8
Trunk fat mass	1.4	6.1	14.5	-3.8	-2.7	-3.2	-2.1	-0.2
Lung cancer (father)	1.4	1.6	6.8	-0.3	0.5	1.4	0.7	2.6
Medication for pain relief, constipation, heartburn	1.4	2.4	6.4	1.2	2.5	0.4	2.3	0.9
Eye problems/disorders: Glaucoma	1.4	1.6	4.5	-1.1	1.0	-2.1	-0.6	1.6
Leg fat percentage (left)	1.4	4.9	9.2	-2.1	-2.4	-2.2	-3.0	2.2
Pack years of smoking	1.4	2.1	3.8	1.3	1.4	1.7	-2.0	1.4
Arm fat mass (right)	1.3	5.2	10.3	-2.9	-3.0	-3.2	-2.0	0.5
Breastfed as a baby	1.3	1.6	4.4	-2.1	0.1	-1.6	-0.7	-1.6
Medication for cholesterol	1.3	2.0	3.9	1.8	1.6	1.3	0.9	2.0
Arm fat mass (left)	1.3	5.3	9.9	-3.0	-2.9	-3.2	-2.1	0.4
Commuting to job workplace: Cycle	1.3	1.5	4.2	0.1	-2.0	-1.7	0.9	-1.1
Type 2 Diabetes (T2D) (2012)	1.2	1.3	4.8	2.2	0.6	1.7	0.0	0.0
Lung FVC	1.2	6.3	20.6	4.5	0.2	2.5	3.1	-1.2
Chronotype (morning person)	1.2	2.7	7.6	-2.5	-1.0	-0.7	-0.9	2.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	4.2	-2.0	-0.9	-2.0	-0.3	-0.0
Leg fat percentage (right)	1.2	4.4	8.2	-2.1	-2.4	-1.8	-2.9	2.2
Had major operations	1.2	1.4	4.2	0.5	0.6	1.8	-0.5	2.0
Myopia	1.2	1.8	6.1	-1.4	-0.4	-2.5	0.0	-1.6
Depressed Affect (Nagel 2018)	1.1	2.4	4.8	-2.2	-1.6	-1.6	-0.7	-1.9
Neuroticism	1.1	2.7	8.5	-2.9	-1.5	-1.6	-1.4	-0.7
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	-1.3	-1.1	-1.6	-1.3	1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	6.2	-0.1	-2.5	-1.3	-1.4	-0.6
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.2	-1.6	-0.3	-2.0	-1.2	-0.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.7	-0.2	-0.9	-0.6	-2.4	1.1
Leg pain on walking	1.1	1.3	3.5	0.9	1.6	0.8	1.9	0.6
Medication: Lisinopril	1.1	1.4	5.5	0.8	-0.4	0.9	-2.3	1.3
Irritable Bowel Disease (IBD)	1.0	2.3	6.3	2.5	1.1	1.3	1.6	-1.5
Ulcerative Colitis (UC)	1.0	1.8	7.5	1.0	-0.2	0.1	1.6	-2.7
Age at First Birth	1.0	1.4	3.8	1.4	-0.9	-0.3	-1.9	-1.2
Height	1.0	18.8	61.3	-7.8	-2.4	-3.7	2.7	-5.0
Medication for hormone replacement therapy	1.0	1.1	4.2	-0.4	-0.2	0.8	1.4	-2.0
Impedance of leg (right)	1.0	5.0	21.9	0.9	2.0	4.7	1.9	-0.3
Taking other prescription medications	1.0	1.5	4.7	-2.2	0.2	-0.8	-1.5	-1.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.9	0.1	1.1	2.0	1.2	-0.1
Sitting height	1.0	7.5	17.6	-4.2	-0.9	-2.0	2.3	-4.1
Impedance of arm (left)	1.0	4.7	19.9	0.8	1.8	4.5	1.9	-1.0
Standing height	1.0	10.0	26.7	-5.2	-1.1	-2.7	2.4	-4.4
Exposure to tobacco smoke at home	1.0	1.1	2.6	-1.3	-0.6	-1.6	-1.4	0.6
Body fat percentage	1.0	3.9	6.9	-2.6	-2.4	-2.0	-2.5	0.9
Age at first live birth	1.0	1.7	6.5	2.6	0.5	1.4	0.7	-1.1
Eye problems/disorders: None of the above	1.0	1.1	5.0	2.2	0.3	1.2	-0.1	-0.3
Number of full sisters	1.0	1.3	3.6	-0.8	-1.9	-1.8	-0.3	-0.0
Mother’s age at death	1.0	1.3	2.7	-0.6	-1.7	-1.5	-1.6	-0.2
Risk taking	1.0	1.4	5.4	-0.1	-1.5	-2.3	-0.7	-0.3
Impedance of whole body	1.0	5.2	21.3	0.9	2.0	4.6	2.0	-0.9
Bipolar Disorder (2018)	0.9	1.4	4.6	0.3	-2.1	-1.5	-1.0	-0.5
Neuroticism (Nagel 2018)	0.9	2.0	6.8	-2.6	-0.6	-1.7	-1.2	-0.8
Reaction Time	0.9	1.6	4.5	-1.6	-1.2	-2.1	-1.0	-0.6
Mean Putamen Volume	0.9	1.1	2.1	0.3	-0.8	-1.5	-1.2	1.5
Number of treatments/medications taken	0.9	1.6	4.3	-0.6	-2.1	-0.1	-1.7	-1.4
Trunk fat percentage	0.9	3.7	8.8	-3.0	-2.3	-1.9	-2.0	0.1
Relative age voice broke	0.9	1.3	4.9	0.4	-0.3	0.3	2.2	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.9	-1.0	-0.2	-0.2	-2.4	2.2
Impedance of leg (left)	0.9	4.4	18.6	1.0	2.0	4.3	1.6	-0.3
Neuroticism score	0.9	1.9	6.9	-2.6	-1.1	-1.4	-0.7	-1.1
Impedance of arm (right)	0.9	4.4	18.3	1.1	1.4	4.3	2.0	-0.8
Medication: Lansoprazole	0.9	1.1	3.5	1.6	0.4	1.9	-0.2	0.6
Loud music exposure frequency	0.9	1.0	3.1	0.8	-0.4	0.8	1.8	-1.2
Glaucoma (self-reported)	0.9	1.0	2.9	-0.8	1.1	-1.2	-0.3	1.7
Worry too long after embarrassment	0.9	1.5	3.8	-1.9	-0.6	-1.9	-1.0	0.1
Pulse rate, automated reading	0.9	2.8	11.5	-3.4	0.1	-0.9	-1.5	-1.4
Illnesses of father: Heart disease	0.9	1.2	6.3	0.1	-2.5	-0.6	-0.5	0.2
Bipolar Disorder or Schizophrenia	0.8	1.9	4.7	-1.5	-1.2	-2.2	-1.3	-1.2
Alzheimer’s Disease (in father)	0.8	0.9	1.8	0.8	1.3	0.7	0.8	1.2
Crohns Disease (2017)	0.8	1.8	4.1	2.0	2.0	1.5	0.8	-0.1
Breast Cancer	0.8	1.8	5.1	-1.8	-1.3	-1.0	0.2	-2.3
HbA1C	0.8	0.8	1.3	0.9	1.1	1.1	0.7	-1.1
Schizophrenia (2014)	0.8	1.8	3.9	-2.0	-0.9	-1.5	-0.5	-1.9
BMI	0.8	4.8	15.1	-1.6	-1.7	-3.9	-2.0	2.1
Hypothyroidism (self reported)	0.8	1.8	4.8	-2.2	-1.2	-0.7	-0.2	-2.1
Hearing difficulty/problems: Yes	0.8	1.3	5.7	-2.4	-1.0	-0.8	-0.6	-0.3
Fed-up feelings	0.8	1.5	2.7	-1.5	-1.6	-0.6	-1.6	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.8	-0.8	-2.0	-0.8	-0.9	-0.9
Hearing difficulty/problems with background noise	0.8	1.2	6.4	-2.5	-0.5	-0.4	-0.3	-0.8
Forced vital capacity (FVC)	0.8	3.2	12.8	0.1	0.6	0.0	3.6	-2.5
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.9	0.6	0.7	-0.6	1.7	-1.3
Qualifications: None of the above	0.8	1.7	4.8	1.2	0.9	2.2	1.3	-1.2
Arm fat percentage (right)	0.8	3.3	6.2	-1.8	-2.5	-2.0	-2.1	1.2
Pulse rate	0.8	1.3	3.8	-1.5	-0.1	-1.2	-0.4	-1.9
Gout (self-reported)	0.8	1.1	3.6	-1.1	0.1	-1.9	-1.3	0.5
Forced vital capacity (FVC), Best measure	0.8	2.8	12.1	0.9	0.7	0.9	3.5	-1.6
Comparative body size at age 10	0.8	2.2	4.1	0.6	-2.0	-1.8	-2.0	1.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.3	1.8	-0.9	-0.6	-0.3	-1.2
Neck or shoulder pain in last month	0.8	1.1	4.1	1.0	0.0	0.9	0.6	-2.0
Family relationship satisfaction	0.8	1.0	3.1	-0.7	-1.4	-1.8	-0.8	-0.0
Supplements: Vitamin C	0.8	1.0	2.3	1.5	1.1	0.7	0.3	1.4
Arm fat percentage (left)	0.8	3.2	5.1	-1.9	-2.3	-1.9	-2.2	1.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.3	0.4	0.1	-1.0	-1.8	1.2
Commuting to job workplace: Walk	0.8	0.9	2.1	-1.0	-1.2	-0.6	-1.4	0.6
Breast cancer (self-reported)	0.8	1.0	4.4	-0.3	0.1	0.4	-1.1	2.1
Medication: Bendroflumethiazide	0.8	1.3	4.3	-0.1	-2.1	0.1	-0.9	-1.6
Cholesterol lowering medication	0.8	1.1	3.3	-1.8	-0.8	-1.5	-0.7	-0.2
Basal cell carcinoma (self-reported)	0.8	1.0	4.2	0.1	1.0	0.4	2.0	-0.7
Alcohol drinker status: Previous	0.8	0.9	3.7	-0.2	-0.1	0.9	0.9	-1.9
Intelligence (Savage-Jansen 2018)	0.7	2.2	6.7	-0.9	-0.8	-1.3	-1.9	2.6
Schizophrenia (2018)	0.7	1.4	3.9	-2.0	0.1	-1.6	-0.8	-1.1
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	1.0	-1.4	-0.6	-1.2	-0.3
Prostate Cancer	0.7	0.9	2.1	-1.0	-1.4	-0.2	-1.1	1.1
Hand grip strength (left)	0.7	1.8	5.7	0.9	-0.9	-2.4	0.5	-1.7
Ever had hysterectomy (womb removed)	0.7	0.8	4.2	-2.1	-0.5	0.7	0.2	0.0
Medication: Metformin	0.7	1.0	3.1	-0.0	-1.8	-0.1	-0.4	1.7
Diabetes (mother)	0.7	0.8	3.1	-1.3	-0.0	-1.8	-0.1	0.3
Maternal smoking around birth	0.7	1.1	3.4	1.3	0.3	1.9	0.5	-0.9
Age when periods started (menarche)	0.7	1.8	4.8	-1.8	1.0	1.0	0.7	-2.2
Medication: Simvastatin	0.7	1.0	3.9	-2.0	0.2	-0.2	-1.1	-1.0
Length of working week for main job	0.7	0.8	2.2	-0.3	0.1	-1.2	-1.5	1.0
Hair/balding pattern: Pattern 4	0.7	1.6	8.6	-1.0	0.3	-0.3	0.2	-2.9
Medication: Blood pressure	0.7	1.2	3.2	-1.4	-1.2	0.4	-1.8	-0.8
Comparative height size at age 10	0.7	4.0	10.8	-3.3	-1.9	-2.5	-0.0	-1.8
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	-0.1	-0.8	-1.5	-1.5	-0.2
Wears glasses or contact lenses	0.7	0.8	4.0	-2.0	0.1	0.6	-0.7	-0.6
Financial situation satisfaction	0.7	0.8	3.2	1.0	-1.8	-0.7	-0.1	0.6
High cholesterol (Self-reported)	0.7	1.3	4.2	-2.0	1.6	0.5	-0.1	-0.7
Alcohol drinker status: Never	0.7	0.9	2.3	0.9	1.2	0.6	1.5	0.8
Irritability	0.7	1.2	3.2	-0.2	-1.6	-1.8	-1.3	-0.3
Crohns Disease (2012)	0.6	0.9	4.2	0.3	1.0	2.1	0.3	-0.1
Ulcerative Colitis	0.6	0.9	4.0	0.1	-1.2	-0.3	0.1	-2.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.7	1.2	0.5	0.7	-0.9	1.9
Sensitivity / hurt feelings	0.6	1.0	2.3	-1.5	-1.3	-1.0	-0.3	1.1
Relative age of first facial hair	0.6	1.3	5.0	2.2	1.2	0.9	0.6	-0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.0	-0.9	-0.6	0.8	0.1	1.4
Vitamin and mineral supplements	0.6	0.8	3.3	0.2	-1.8	-0.7	-0.1	-0.9
Supplements: Zinc	0.6	0.6	2.9	-1.7	0.3	-0.5	0.6	-0.3
High blood pressure	0.6	1.8	4.6	-1.8	-2.1	-0.2	-1.4	-0.8
Stomach or abdominal pain in last month	0.6	0.8	2.0	1.4	-1.3	0.5	0.7	-0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	1.4	1.0	-0.8	-0.3	-0.7
Had other major operations	0.6	0.7	2.1	-0.9	-0.2	-1.1	-1.5	0.5
Financial difficulties in last 2 years	0.6	0.8	2.4	-0.4	-1.6	-1.1	-0.3	0.8
Medication: Ramipril	0.6	0.8	2.7	-0.8	-1.3	0.1	-0.1	-1.7
Number of live births	0.6	0.9	2.7	-0.3	0.2	-1.4	-0.8	1.6
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	8.6	-0.1	-0.1	-0.2	2.9	-1.7
Mouth/teeth dental problems: Dentures	0.6	0.9	3.4	0.9	-1.8	0.9	0.7	-0.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.2	0.0	-1.1	1.5	0.7	-0.5
Medication: Paracetamol	0.6	1.1	4.0	0.2	-2.0	-0.2	-1.5	0.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.6	-1.5	-0.8	-0.2	0.3	-1.9
High blood pressure (siblings)	0.6	0.9	2.6	1.6	-0.5	0.3	1.2	-1.0
Wheeze or whistling in the chest in last year	0.6	1.1	2.4	-1.1	-1.0	1.0	-0.9	-1.6
Pulse wave peak to peak time	0.6	0.7	2.3	-0.3	1.2	-1.5	-0.8	0.3
Emphysema/chronic bronchitis	0.6	0.7	1.0	1.0	0.6	0.9	-0.9	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.6	-0.7	-1.2	-0.6	-1.3
Knee pain experienced in last month	0.6	0.9	3.6	0.1	-0.5	-1.9	-1.2	-0.2
Hypertension (Self-reported)	0.6	1.7	4.9	-1.8	-2.2	-0.1	-1.1	-0.9
Medication: Aspirin	0.6	0.8	2.6	-1.6	-0.5	0.7	-1.0	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.8	-1.2	0.3	0.3	-1.0	1.4
Average weekly champagne plus white wine intake	0.6	0.8	2.2	-1.2	0.3	-1.5	-0.7	-0.7
Medication: Paracetamol	0.6	0.9	3.4	0.4	-1.9	0.5	-1.1	-0.5
Vascular/heart problems diagnosed by doctor	0.6	1.8	4.6	1.9	2.1	0.2	1.1	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.2	0.9	0.1	-1.0	-1.2	2.0
Blood Eosinophil Count	0.5	3.8	9.2	-2.6	-0.8	-1.5	-3.0	2.0
Medication: Co-codamol	0.5	0.5	1.3	0.4	-1.1	-0.8	-1.0	-0.4
Diabetes (father)	0.5	0.6	2.0	0.2	-1.1	0.3	0.5	-1.4
Townsend deprivation index at recruitment	0.5	0.7	3.2	-1.8	0.8	-0.1	0.6	-0.0
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.8	-0.3	-0.4	-2.0	-0.9	1.5
Multivitamins +/- minerals	0.5	0.6	3.1	0.1	1.8	-0.1	-0.2	0.6
Medication: Atenolol	0.5	0.7	2.1	-1.3	0.2	-1.5	-0.3	0.3
High blood pressure (mother)	0.5	0.7	1.7	-1.3	-1.1	-0.1	-0.3	-1.0
Past tobacco smoking	0.5	0.9	3.3	0.9	0.4	1.8	1.1	0.4
Nervous feelings	0.5	1.0	2.7	-1.6	-0.2	1.4	0.2	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.9	-0.9	-0.1	0.0	-1.7	1.7
Mouth/teeth dental problems	0.5	0.7	2.1	-0.8	1.5	-0.7	-1.0	0.1
Fluid intelligence score	0.5	1.0	2.1	1.1	1.5	0.3	-0.6	1.4
Time employed in main current job	0.5	0.5	1.1	0.7	-1.1	0.7	-0.8	-0.7
Alcohol intake versus 10 years previously	0.5	0.7	2.7	-1.2	-1.6	0.1	0.0	-0.0
Falls in the last year	0.5	0.7	1.5	-0.3	1.0	0.4	1.2	1.2
Medication: Cholesterol lowering	0.5	0.7	1.6	-1.1	0.3	1.3	-1.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	8.7	0.6	0.5	0.7	3.0	-0.8
Blood clot in the leg (DVT)	0.5	0.6	2.3	0.6	1.5	0.3	-0.8	0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	1.2	0.7	-0.5	1.2	1.1
Medication: Aspirin	0.5	0.7	1.8	-1.3	-0.6	0.9	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.8	-0.0	-0.5	-0.2	1.5	-1.9
Long-standing illness, disability or infirmity	0.5	0.7	3.1	-1.8	-0.9	-0.4	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.0	-0.8	0.7	-0.5	0.0	-1.4
Ever depressed for a whole week	0.5	0.6	2.4	0.6	0.7	-0.2	1.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.7	0.5	1.6	0.2	-0.7	0.2
Worry (Nagel 2018)	0.4	0.9	3.7	-1.9	0.7	0.5	-0.5	-0.9
Primary Biliary Cirrhosis	0.4	0.5	2.4	0.8	0.4	1.5	-0.2	0.1
Rheumatoid Arthritis	0.4	0.5	1.0	0.8	0.7	0.7	1.0	0.7
Heel T-Score	0.4	3.2	16.6	0.6	-0.6	-1.1	-0.9	4.1
Systolic Blood Pressure	0.4	2.2	5.7	1.2	1.8	2.4	1.3	-1.2
Allergy or Eczema	0.4	1.0	2.2	-0.1	-0.3	-1.4	-1.5	1.4
Hand grip strength (right)	0.4	1.0	4.5	0.1	-0.4	-2.1	-0.3	-1.1
Serious illness, injury or assault to yourself	0.4	0.4	1.4	0.6	0.8	0.5	-0.1	1.2
Pain all over the body in last month	0.4	0.5	1.2	0.3	0.4	1.0	1.1	0.5
Worrier / anxious feelings	0.4	0.7	4.0	-2.0	0.0	-0.0	-0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	-1.1	-0.6	-0.3	-1.3	0.4
Happiness	0.4	0.4	1.0	-1.0	-0.2	-0.5	-1.0	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	0.8	1.0	1.0	-0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	0.7	0.9	-0.0	0.8	-1.0
Number of children fathered	0.4	0.4	1.1	0.2	-0.9	-0.8	-1.0	0.4
Health satisfaction	0.4	0.5	2.1	-1.5	-0.4	-0.8	-0.2	0.4
Shortness of breath walking on level ground	0.4	0.5	2.2	0.6	-1.5	-0.4	0.4	-0.1
Angina (self-reported)	0.4	0.5	1.6	-1.1	-0.4	0.2	0.0	-1.3
Medication: Seretide 50 evohaler	0.4	0.4	1.0	0.9	0.8	-0.2	0.4	-1.0
Overall health rating	0.4	0.8	1.3	-0.8	-1.1	-0.7	-0.9	1.1
Qualifications: nursing, teaching	0.4	0.6	2.5	0.5	-0.9	0.3	-0.2	1.6
Eye problems/disorders: Cataract	0.4	0.4	1.0	-1.0	-0.5	-1.0	0.5	-0.3
Medication: Gliclazide	0.4	0.5	2.5	0.3	0.5	0.3	-0.2	1.6
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	-1.6	-0.2	0.3	-0.9	-0.8
Miserableness	0.4	0.6	1.5	-0.7	-0.8	-0.7	1.2	-0.8
Ever taken oral contraceptive pill	0.4	0.5	2.0	-0.5	1.4	-0.4	0.5	0.4
Hearing aid user	0.4	0.4	1.4	-1.2	-0.9	-0.2	0.2	-0.2
Medication: Blood pressure	0.4	0.8	3.5	-0.1	-1.9	-0.5	-0.6	-0.7
Illnesses of father: High blood pressure	0.4	0.5	1.4	-0.1	0.8	-0.5	0.9	-1.2
Ever smoked	0.4	0.6	1.5	-0.9	-0.8	-1.2	-0.5	-0.9
Number of operations (self-reported)	0.4	0.6	1.8	-0.3	0.8	-0.2	-0.9	1.3
Average weekly beer plus cider intake	0.4	0.6	2.1	-0.5	-1.5	-0.7	-0.8	-0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.2	0.3	0.3	0.1	-0.7	-1.5
Fractured/broken bones in last 5 years	0.4	0.5	0.9	-0.3	0.9	0.9	0.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.2	0.6	-0.5	-0.3	0.4	-1.5
Alzheimer’s Disease (including proxy)	0.3	0.5	2.0	1.4	-0.6	0.2	-0.6	0.1
HDL Cholesterol	0.3	0.5	1.5	0.7	-0.2	1.2	0.6	-0.8
Lung FEV1/FVC ratio	0.3	1.5	6.2	-0.7	-0.2	1.0	-1.0	2.5
Angina	0.3	0.4	1.2	-1.0	-0.5	0.1	-0.2	-1.1
Average weekly fortified wine intake	0.3	0.4	1.7	-0.2	0.6	-1.3	0.6	0.2
Number of incorrect matches in round	0.3	0.5	1.3	-1.2	0.3	-0.5	-1.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.4	-0.3	-0.8	-1.0	-1.2	0.1
Prospective memory result	0.3	0.4	0.8	-0.1	0.9	0.8	0.2	0.9
Illnesses of mother	0.3	0.4	0.8	0.9	0.9	0.5	0.4	0.3
Peak expiratory flow (PEF)	0.3	0.8	3.4	-0.8	-0.8	-1.8	0.4	0.1
Birth weight	0.3	0.7	2.8	-0.3	-0.2	-1.7	0.0	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	-0.9	0.4	-0.9	-0.4	-0.8
Migraine (self-reported)	0.3	0.4	1.4	-1.2	-0.6	-0.6	-0.4	-0.1
Medication: Allopurinol	0.3	0.3	1.0	-1.0	0.1	-1.0	0.2	-0.4
Medication: Omeprazole	0.3	0.4	1.2	0.8	-0.4	0.1	-0.3	-1.1
Suffer from ‘nerves’	0.3	0.5	1.0	-0.2	1.0	0.5	1.0	-0.9
Age at last live birth	0.3	0.5	1.4	1.2	0.2	-0.6	0.3	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.3	1.1	-0.2	0.7	0.0	-0.0
Smoking status: Previous	0.3	0.4	1.3	-0.3	0.2	-1.1	-1.0	-0.5
Ever had bowel cancer screening	0.3	0.4	0.9	-1.0	-0.6	-0.6	0.2	-0.7
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.9	-1.0	0.2	-0.8	0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.9	0.5	-0.4	1.4	0.8	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	-1.1	0.0	-1.0	-0.2	0.4
Osteoporosis (self-reported)	0.3	0.4	1.9	0.2	0.3	0.5	-0.4	-1.4
Osteoarthritis (self-reported)	0.3	0.4	0.9	-0.1	0.3	-0.9	-1.0	0.6
Smoking status: Current	0.3	0.4	1.8	-0.3	-1.3	-0.8	-0.2	-0.1
Commuting to job workplace: Public transport	0.3	0.4	2.0	-0.5	-1.4	-0.4	-0.3	-0.2
Ovarian Cancer	0.2	0.2	0.8	-0.4	-0.9	-0.2	0.4	-0.3
LDL Cholesterol	0.2	0.3	1.2	-0.4	-0.4	0.7	-0.1	1.1
Lupus	0.2	0.3	0.8	0.2	-0.4	-0.0	0.9	-0.8
Neuroticism (2016)	0.2	0.3	1.3	-1.1	-0.1	0.0	-0.2	0.8
Blood Red Count	0.2	2.3	7.0	-1.1	-0.4	1.6	2.6	-1.6
Blood White Count	0.2	1.2	2.4	-0.9	1.5	1.5	-0.2	1.3
Waist Hip Ratio (WHR)	0.2	0.8	2.0	0.5	0.8	1.2	-0.6	1.4
Average weekly spirits intake	0.2	0.3	0.7	-0.0	-0.9	-0.5	-0.5	0.6
Systolic blood pressure, automated reading	0.2	0.5	2.8	0.1	0.6	1.7	0.1	0.4
Current tobacco smoking	0.2	0.4	1.8	-0.1	-1.3	-0.3	-0.5	-0.0
Qualifications: CSEs or equivalent	0.2	0.3	0.7	-0.5	-0.4	-0.3	0.8	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	-0.2	0.4	0.9	0.2	-0.7
Alcohol usually taken with meals	0.2	0.3	0.8	-0.2	0.3	-0.8	-0.4	0.9
Diabetes (self-reported)	0.2	0.4	1.1	-0.6	-0.7	0.3	-0.3	1.1
Illnesses of siblings	0.2	0.3	1.1	-0.6	1.0	-0.6	0.4	-0.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.2	0.8	0.3	0.9	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.0	-0.3	-0.2	-1.4	0.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.3	-0.0	-0.8	0.2	-0.6
Asthma	0.2	0.4	1.2	-0.3	1.1	-0.1	-0.9	-0.3
Depression (self-reported)	0.2	0.3	1.3	0.4	-0.0	0.2	0.5	-1.2
Tense / ‘highly strung’	0.2	0.3	1.1	-0.5	-0.2	-0.1	-1.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	-0.1	0.9	0.2	-0.9	0.7
Birth weight of first child	0.2	0.5	1.4	-0.3	0.6	-1.2	0.6	0.7
Pulse wave reflection index	0.2	0.2	1.0	0.4	-0.1	1.0	0.1	0.5
Medication: Amlodipine	0.2	0.3	0.9	-0.2	-0.3	0.9	0.7	-0.7
Exposure to tobacco smoke outside home	0.2	0.3	1.5	-0.2	-0.2	0.0	0.4	-1.2
Qualifications: College or University degree	0.2	0.5	1.4	0.1	-0.0	-1.2	-0.8	1.1
Heart disease (mother)	0.2	0.3	1.1	-0.1	1.0	0.8	0.2	-0.1
Alcohol intake frequency.	0.2	0.5	2.3	-0.6	-1.5	0.1	0.0	-0.3
Chest pain or discomfort	0.2	0.3	0.7	0.8	-0.6	-0.1	0.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.2	0.8	-0.9	0.2	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.0	-0.5	0.8	0.7	0.3
Average weekly red wine intake	0.2	0.3	1.0	0.0	1.0	-0.0	-0.6	-0.3
Back pain experienced in last month	0.2	0.3	1.1	-1.0	-0.1	0.2	-1.0	-0.1
Mineral and other dietary supplements	0.2	0.3	0.7	0.9	0.4	0.2	-0.7	-0.4
Asthma (self-reported)	0.2	0.4	1.5	-0.3	1.2	-0.0	-0.9	-0.2
Age started oral contraceptive pill	0.2	0.2	0.6	0.2	-0.7	0.2	0.8	-0.5
Diastolic blood pressure, automated reading	0.2	0.7	1.7	-0.7	-0.6	1.3	-1.0	0.8
Unable to work because of sickness or disability	0.2	0.3	0.8	0.2	-0.2	0.8	0.1	0.9
Triglycerides	0.1	0.2	0.6	-0.1	-0.3	-0.7	-0.3	0.8
Blood Platelet Count	0.1	1.5	4.8	-1.9	-0.2	-0.7	-0.6	-2.2
Smoking Status	0.1	0.1	0.5	-0.1	-0.0	-0.7	-0.0	-0.5
Cardiovascular Disease	0.1	0.4	0.9	-0.9	0.2	0.5	-0.8	-0.8
Respiratory disease	0.1	0.2	0.9	-0.3	0.5	0.3	-0.9	-0.1
Hair Pigment	0.1	1.9	6.7	-1.1	1.6	0.8	-0.5	2.6
Tanning	0.1	1.8	5.4	0.5	0.1	1.3	1.8	-2.3
Supplements: Glucosamine	0.1	0.2	0.5	-0.4	-0.7	-0.5	0.0	0.3
Heart attack	0.1	0.1	0.4	0.6	-0.0	0.4	0.5	-0.1
Allergy	0.1	0.2	0.6	-0.2	-0.6	0.8	0.7	-0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	-0.3	-0.0	-0.7	-0.5	0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	-0.2	0.5	0.4	0.1
Mood swings	0.1	0.2	0.4	-0.7	-0.6	0.0	0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.9	-0.5	-0.6	0.1	1.0	-0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.6	0.2	-0.8	-0.4	0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.6	0.5	0.0	0.4	0.4
Supplements: Calcium	0.1	0.1	0.4	0.1	-0.3	-0.3	0.6	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.5	0.1	0.4	0.4	-0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

GID8

Models

Trait associations