Best TWAS P=1.46e-21 · Best GWAS P=1.3e-46 conditioned to 2.35e-30
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NPR3 | 0.07 | 0.02 | bslmm | 470 | 0.02 | 2.2e-03 | -10.2 | 9.5 | 1.5e-21 | 0.36 | 0.07 | 0.57 | TRUE |
| 2 | GTEx | Artery Aorta | DROSHA | 0.35 | 0.06 | lasso | 8 | 0.10 | 6.2e-06 | 5.7 | -5.7 | 1.1e-08 | 0.05 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | DROSHA | 0.20 | 0.11 | lasso | 4 | 0.09 | 1.7e-07 | 5.7 | -5.8 | 7.2e-09 | 0.03 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Heart Atrial Appendage | CTD-2203K17.1 | 0.25 | 0.17 | enet | 47 | 0.20 | 1.4e-09 | 2.2 | -5.5 | 4.0e-08 | -0.06 | 0.73 | 0.21 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TARS | 0.10 | 0.05 | lasso | 6 | 0.08 | 3.7e-10 | -5.7 | 7.7 | 9.9e-15 | 0.03 | 0.83 | 0.16 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | GOLPH3 | 0.05 | 0.03 | blup | 44 | 0.02 | 3.3e-03 | -5.3 | -5.8 | 6.2e-09 | -0.03 | 0.00 | 0.96 | TRUE |