Hub : Genes

TARS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.5520	0.1190	2.9e-03	-0.009	NA	-0.011	NA	-0.011	6.5e-01	NA	8.8e-01	NA	8.2e-01
2	GTEx	Cells Transformed fibroblasts	0.2210	0.0490	3.7e-08	0.134	NA	0.178	NA	0.163	3.2e-10	NA	2.3e-13	NA	3.0e-12
3	ROSMAP	Brain Pre-frontal Cortex	0.0956	0.0270	5.6e-07	0.054	0.066	0.072	0.075	0.077	1.7e-07	6.3e-09	1.3e-09	6.3e-10	3.7e-10
4	YFS	Blood	0.0300	0.0109	1.2e-03	0.002	0.007	0.001	0.008	0.001	6.8e-02	1.5e-03	1.1e-01	1.0e-03	1.6e-01
5	TCGA	Prostate Adenocarcinoma	0.0302	0.0190	5.9e-03	0.030	0.023	0.024	NA	0.030	3.6e-04	1.6e-03	1.3e-03	NA	3.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	0.9	0.4	0.7	-0.8	-0.9	0.5
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	0.2	-0.5	-0.5	-0.2	-0.2
Depressed Affect (Nagel 2018)	1.1	2.4	10.0	0.8	-0.4	3.2	0.8	0.8
Depression (Nagel 2018)	0.8	1.3	5.3	0.3	-0.2	2.3	-0.1	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.5	1.2	-0.8	0.3	-1.1	0.4	0.4
Neuroticism (Nagel 2018)	0.7	1.6	6.2	0.5	0.0	2.5	0.4	1.2
Schizophrenia (2018)	0.2	0.4	1.5	-0.0	-1.2	0.1	0.5	-0.7
Schizophrenia vs Biploar Disorder	0.5	0.7	2.4	0.7	-0.4	-1.5	-0.1	-0.7
Worry (Nagel 2018)	0.7	1.6	4.8	0.0	0.5	1.6	-0.1	2.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.6	-0.5	0.6	-0.1	1.3	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.1	0.0	0.3	0.4	0.0
Alzheimer’s Disease (including proxy)	0.3	0.5	1.6	-0.3	0.6	-0.2	1.3	0.3
Crohns Disease (2017)	0.8	1.8	2.8	0.8	-1.7	0.8	1.6	-1.5
Irritable Bowel Disease (IBD)	0.7	1.8	4.4	-0.4	-2.1	0.7	0.9	-1.7
Ulcerative Colitis (UC)	0.5	1.0	1.6	-1.2	-1.3	0.2	-0.8	-1.1
Major Depression (MDD)	0.9	1.1	2.7	-0.4	-0.6	1.6	1.4	0.1
Reaction Time	0.1	0.1	0.4	-0.6	-0.2	0.2	-0.5	0.0
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.7	-2.4	0.6	-0.3	1.1	0.7
Breast Cancer	0.0	0.0	0.1	0.3	-0.3	-0.0	-0.0	-0.1
Ovarian Cancer	0.4	0.6	1.5	-1.2	0.7	-0.1	0.5	0.7
Prostate Cancer	1.5	2.1	7.0	-1.4	-0.1	2.6	-0.3	1.1
Age at First Birth	0.4	0.6	2.9	-0.3	-0.1	-1.7	-0.3	-0.2
Bipolar Disorder (2011)	2.0	1.9	5.2	-0.1	2.3	-0.4	-0.7	1.9
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	-0.9	0.2	0.9	-0.5	-0.2
Coronary Artery Disease (CAD)	0.4	0.5	2.3	0.0	0.3	-1.5	0.2	0.5
Crohns Disease (2012)	0.4	0.6	1.4	0.5	-1.2	0.8	-0.2	-0.8
Mean Putamen Volume	1.4	1.7	6.1	-2.5	-1.0	-0.1	0.5	-1.0
Fasting Glucose	0.4	0.5	1.4	-0.5	0.3	0.9	-1.2	-0.4
HbA1C	2.4	2.6	5.8	-2.4	-0.3	0.7	2.2	1.3
HDL Cholesterol	0.4	0.7	2.2	0.7	-0.1	0.9	1.5	0.3
LDL Cholesterol	0.4	0.6	1.7	-0.7	-0.7	1.3	0.3	-0.4
Lupus	0.9	1.4	2.6	0.3	-1.5	-0.8	1.2	-1.6
Neuroticism (2016)	0.4	0.5	1.2	0.9	-0.1	0.5	1.1	0.7
Primary Biliary Cirrhosis	0.6	0.8	2.1	-1.4	0.9	-0.6	0.5	0.8
Rheumatoid Arthritis	0.2	0.3	0.7	0.6	0.4	0.2	-0.3	0.9
Schizophrenia (2014)	0.1	0.2	0.4	0.7	-0.4	-0.6	-0.4	0.0
Triglycerides	0.1	0.1	0.3	-0.1	-0.6	0.1	0.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	0.4	0.5	-1.0	-0.7	0.5
Ulcerative Colitis	0.9	1.3	1.9	-1.0	-1.3	1.4	-0.8	-1.2
Blood Eosinophil Count	0.3	2.0	5.4	0.3	2.3	0.2	-1.3	1.7
Blood Platelet Count	0.1	1.2	3.9	-0.1	-1.0	0.7	2.0	-0.8
Blood Red Count	0.0	0.3	1.0	-0.4	1.0	0.0	0.2	0.5
Blood White Count	0.3	2.4	4.5	0.9	1.7	-2.1	-1.5	1.1
Heel T-Score	0.3	2.0	3.8	-1.2	-2.0	0.2	1.3	-1.7
BMI	0.1	0.4	1.2	0.0	1.1	-0.5	0.0	0.8
Height	1.3	24.6	102.6	-0.8	-3.5	10.1	2.4	1.2
Waist Hip Ratio (WHR)	0.7	3.0	6.4	-1.3	-2.3	0.2	1.2	-2.5
Systolic Blood Pressure	0.3	1.5	6.4	-0.2	-0.1	-2.5	-0.2	-1.0
Smoking Status	0.1	0.3	0.9	-1.0	-0.7	0.2	-0.4	-0.2
Allergy or Eczema	0.6	1.5	4.5	0.9	1.1	-2.1	-0.9	0.4
Cardiovascular Disease	0.2	0.6	1.8	0.5	0.0	-1.3	0.6	-0.6
Hypothyroidism (self reported)	0.6	1.4	3.3	1.8	-0.4	1.6	0.2	0.8
Respiratory disease	0.3	0.6	2.9	0.3	-0.2	0.1	-1.7	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	-0.1	0.2	0.2	0.6
Lung FEV1/FVC ratio	0.3	1.4	3.1	-0.8	0.9	1.3	-1.8	0.7
Lung FVC	0.6	2.9	7.1	1.6	-1.0	-2.7	-0.4	-2.0
Neuroticism	0.3	0.8	2.4	0.2	-0.0	1.5	-0.4	1.2
Chronotype (morning person)	0.4	0.9	1.6	0.9	1.0	-1.3	0.0	0.9
Hair Pigment	0.4	11.3	54.8	0.7	-0.1	-0.8	-7.4	-0.7
Tanning	0.4	5.1	19.3	0.9	-0.8	1.8	4.4	-1.1
Hand grip strength (left)	0.6	1.6	3.3	-1.5	-1.0	1.8	-0.6	-0.9
Number of treatments/medications taken	0.2	0.4	1.8	0.3	-0.3	-1.3	-0.3	0.1
Average weekly spirits intake	0.6	0.7	2.0	0.4	-0.5	-0.1	-1.4	-1.1
Sensitivity / hurt feelings	0.5	0.9	1.9	1.4	-1.2	0.2	0.1	-1.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.4	-0.6	-0.5	1.8	-0.4	0.2
Hearing difficulty/problems: Yes	0.0	0.1	0.2	0.4	-0.0	0.1	0.2	-0.3
Relative age of first facial hair	0.5	1.0	3.1	0.6	0.9	-0.0	1.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	1.4	0.4	0.4	0.0	1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.2	-0.5	0.8	0.6	0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	-0.3	0.7	-0.2	-0.9	1.3
Systolic blood pressure, automated reading	0.5	1.4	4.1	-0.2	-1.6	-0.3	0.3	-2.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	-0.7	-1.0	0.1	0.2	-1.1
Angina	0.7	0.9	1.8	-1.3	0.7	-1.4	-0.5	0.1
Medication for hormone replacement therapy	0.2	0.2	0.5	0.4	-0.3	-0.7	-0.2	0.3
Vitamin and mineral supplements	0.3	0.4	1.9	0.0	0.5	-1.4	0.0	0.2
Supplements: Zinc	1.8	1.9	4.9	0.2	1.4	2.2	-0.0	1.7
Medication: Co-codamol	0.2	0.2	0.7	-0.6	0.3	-0.8	-0.2	-0.2
Medication: Metformin	0.2	0.3	1.1	0.2	-0.4	0.2	1.1	0.1
Diabetes (father)	0.7	0.9	1.7	0.5	1.1	-0.5	-0.9	1.3
Diabetes (mother)	1.0	1.3	2.7	-1.6	1.2	0.6	-0.8	1.1
Severe depression (siblings)	0.9	1.0	4.6	0.1	0.6	-2.1	-0.3	-0.1
Pack years adult smoking proportion	2.3	3.5	5.8	1.9	1.8	-1.6	-2.4	1.4
Impedance of leg (right)	0.2	1.2	2.9	0.4	-1.7	-0.9	0.7	-1.3
Leg fat-free mass (left)	0.7	3.5	14.1	0.7	0.1	3.8	0.5	1.6
Trunk fat percentage	0.1	0.3	0.6	-0.5	-0.6	0.7	-0.1	0.7
Hand grip strength (right)	0.6	1.6	3.4	-1.2	-1.4	1.8	-0.4	-0.8
Townsend deprivation index at recruitment	1.2	1.6	4.0	0.4	1.9	-0.5	0.5	2.0
Current tobacco smoking	0.8	1.3	3.6	0.2	-0.9	-1.2	0.6	-1.9
Average weekly fortified wine intake	0.5	0.6	1.1	-0.9	0.2	1.0	1.0	0.3
Maternal smoking around birth	0.3	0.5	0.8	0.6	0.9	-0.8	-0.3	0.7
Fed-up feelings	1.0	1.8	3.3	1.8	1.4	1.0	-0.4	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.3	1.2	0.1	1.5	-0.4	0.9
Relative age voice broke	0.4	0.6	1.8	0.1	0.7	-0.5	1.4	0.8
Taking other prescription medications	0.9	1.4	4.2	1.0	0.8	-2.1	-0.8	0.5
Age when periods started (menarche)	0.3	0.8	2.1	-0.9	-0.1	1.1	1.4	0.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	-1.1	-1.4	0.7	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.5	0.7	-1.2	0.5	1.2	-1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.9	0.8	0.9	0.6	0.9	0.5
Qualifications: CSEs or equivalent	1.2	1.6	3.2	1.0	1.8	-0.2	-1.4	1.4
Serious illness, injury or assault to yourself	2.0	2.4	5.6	2.4	0.4	-2.3	1.0	-0.0
High blood pressure	0.4	1.1	2.2	0.0	-0.8	-1.3	1.5	-1.0
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.0	0.8	0.8	-1.4	-0.4	1.2
Multivitamins +/- minerals	0.6	0.8	2.5	1.6	-0.3	1.0	0.1	0.5
Stomach or abdominal pain in last month	1.3	1.7	2.4	1.5	1.3	-1.5	0.3	1.4
Supplements: Glucosamine	0.8	1.0	2.6	-1.4	0.3	1.6	0.3	0.7
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	3.8	1.8	1.1	-1.9	0.6	0.5
Medication: Atenolol	0.6	0.7	3.1	-0.4	0.0	-0.3	1.8	-0.5
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.4	-0.6	0.5	-0.7	-0.0
Sitting height	0.4	2.5	8.4	-0.4	0.2	2.9	0.7	1.9
Chronic bronchitis/emphysema (father)	0.9	1.0	4.3	0.2	0.7	0.4	-2.1	0.5
High blood pressure (mother)	0.9	1.2	3.0	-1.4	0.0	-1.7	1.0	0.2
Body mass index (BMI)	0.1	0.4	1.1	0.1	0.9	0.1	-0.3	1.1
Impedance of leg (left)	0.3	1.6	4.2	-0.2	-2.1	-0.9	0.6	-1.6
Leg predicted mass (left)	0.7	3.5	14.2	0.7	0.1	3.8	0.5	1.6
Trunk fat mass	0.3	1.2	4.2	-0.0	-0.2	2.1	-0.0	1.2
Waist circumference	0.2	0.6	1.7	0.3	0.3	1.3	0.5	0.8
Number of incorrect matches in round	0.3	0.5	1.0	0.2	0.5	1.0	-1.0	0.3
Past tobacco smoking	0.7	1.3	3.8	0.5	1.3	-1.0	1.9	-0.1
Alcohol usually taken with meals	0.5	0.8	1.6	-1.3	0.9	0.6	0.8	0.9
Nervous feelings	0.9	1.7	3.6	-1.1	0.3	1.9	0.3	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	-1.3	-0.4	0.4	-0.8	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.8	0.9	0.2	0.6	0.7	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	-0.5	-0.6	-0.2	-1.0	-0.8
Had menopause	0.1	0.2	0.4	-0.6	-0.1	-0.4	0.5	-0.3
Had other major operations	0.1	0.1	0.2	-0.3	0.1	-0.5	-0.5	0.1
Forced vital capacity (FVC)	0.4	1.7	3.4	1.4	-1.8	0.5	0.7	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.8	1.0	-1.2	1.0	1.7	-1.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.4	1.2	-0.3	-0.4	-0.7	-0.1
Qualifications: None of the above	0.3	0.6	1.8	-0.2	-1.4	0.6	0.2	-0.8
Financial difficulties in last 2 years	2.6	3.4	5.1	1.9	1.9	-2.2	-1.0	1.9
Mouth/teeth dental problems	0.4	0.6	2.6	-0.6	-0.1	0.4	1.6	-0.2
Heart attack	0.9	1.2	5.5	-0.5	0.4	-2.3	-0.4	-0.0
Allergy	0.1	0.3	0.7	-0.4	-0.0	0.8	0.6	-0.4
Pain all over the body in last month	0.3	0.3	0.5	0.6	-0.4	-0.7	-0.6	-0.1
Diabetes (self-reported)	0.3	0.5	1.1	-0.3	-1.1	0.7	0.6	-0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	2.1	-0.4	-1.0	0.2	-1.0	-1.4
Medication: Ramipril	0.5	0.6	1.2	-0.9	0.2	-1.1	-0.8	-0.6
Medication: Simvastatin	0.9	1.3	4.2	-0.4	-0.3	-2.1	-1.1	-0.8
Fluid intelligence score	0.4	0.8	2.0	-1.4	0.4	-0.0	1.4	-0.0
Illnesses of siblings	1.3	1.8	3.3	0.3	-1.3	1.8	1.7	-0.9
Neuroticism score	0.4	0.8	2.2	0.8	-0.2	1.5	-0.1	0.9
Weight	0.6	2.9	12.1	0.3	-0.1	3.5	0.6	1.5
Impedance of arm (right)	0.3	1.5	3.2	-1.7	-1.8	-0.3	0.5	-1.0
Arm fat percentage (right)	0.1	0.4	0.7	-0.7	0.7	-0.5	-0.3	0.8
Trunk fat-free mass	0.9	5.4	21.1	1.8	-0.1	4.6	0.8	1.4
Hip circumference	0.4	1.6	3.3	1.1	0.6	1.8	0.4	1.7
Time employed in main current job	0.3	0.3	0.7	-0.4	0.3	0.2	0.8	0.8
Alcohol intake versus 10 years previously	0.5	0.8	1.2	0.1	0.9	-1.1	0.8	1.1
Father’s age at death	0.1	0.1	0.2	0.0	-0.3	0.2	0.4	0.4
Worrier / anxious feelings	0.9	1.7	4.6	-0.7	0.6	1.6	0.4	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.4	0.8	0.7	0.1	-0.8	1.5
Falls in the last year	1.2	1.7	4.3	-0.1	1.9	-0.2	-0.6	2.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.9	0.0	-0.9	0.4	-0.0	-1.4
Number of live births	1.1	1.5	5.0	0.8	0.8	-2.2	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.1	0.7	-0.6	1.1	0.0	-0.8
Pulse rate	1.8	3.0	8.0	0.1	2.2	-1.1	-0.9	2.8
Happiness	0.6	0.8	1.7	1.2	-0.7	1.3	-0.7	-0.0
Noisy workplace	1.4	1.8	4.4	1.5	2.1	-0.2	-0.2	1.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.8	-0.2	-0.3	-0.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	5.8	-0.5	1.8	0.1	-0.4	2.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.5	-0.0	0.4	-0.8	-1.2	0.2
Asthma	0.3	0.6	1.3	1.2	-1.1	0.1	-0.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.8	0.7	1.7	-1.0	0.2	1.3
Medication: Cholesterol lowering	0.6	1.0	3.6	0.1	-0.5	-1.9	-0.6	-0.8
Depression (self-reported)	0.4	0.5	1.0	-0.6	0.8	-1.0	-0.4	0.7
Medication: Lansoprazole	0.1	0.1	0.2	0.1	-0.4	0.0	0.2	0.5
Prospective memory result	0.7	0.8	2.3	-0.3	1.3	-0.2	-0.1	1.5
Lung cancer (father)	0.1	0.1	0.3	-0.1	-0.4	-0.6	0.0	0.3
Illnesses of mother	0.4	0.5	1.6	0.5	0.0	0.3	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.1	1.1	-0.4	0.9	0.5	-0.3
Pulse wave Arterial Stiffness index	1.0	1.1	2.6	-0.9	-1.2	-0.2	-0.9	-1.6
Impedance of arm (left)	0.3	1.2	3.2	-1.8	-1.5	0.0	0.1	-0.7
Arm fat mass (right)	0.1	0.5	1.2	-0.1	0.5	0.9	-0.1	1.1
Trunk predicted mass	0.9	5.3	20.1	1.8	-0.0	4.5	0.8	1.5
Standing height	1.4	14.0	59.9	0.4	-2.4	7.7	1.9	0.9
Length of working week for main job	0.8	0.9	2.2	1.5	0.4	1.1	-0.7	0.8
Exposure to tobacco smoke at home	0.5	0.6	1.6	0.8	-0.2	1.3	0.7	-0.1
Breastfed as a baby	1.5	1.9	5.6	1.0	2.4	-0.9	-0.4	1.4
Tense / ‘highly strung’	0.3	0.5	0.8	-0.9	-0.8	0.8	0.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	7.4	0.8	2.0	-2.7	-1.1	2.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.4	0.2	0.0	0.1	-0.2	0.6
Birth weight of first child	0.8	1.5	5.2	-1.1	-2.3	0.4	-0.3	-1.1
Peak expiratory flow (PEF)	0.7	1.6	5.6	-1.4	-0.5	2.4	-0.3	-0.5
Pulse wave reflection index	1.7	2.1	5.6	-0.1	-1.5	0.3	-1.7	-2.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.5	0.4	0.7	-0.8	0.7
Loud music exposure frequency	0.7	0.8	2.5	-1.1	-0.4	-0.2	1.6	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	0.9	0.9	0.2	-0.4	1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.6	0.9	0.1	1.6	0.2	1.0
Blood clot in the leg (DVT)	1.0	1.3	2.4	-1.6	1.2	0.1	-1.3	0.8
Medication: Paracetamol	1.4	2.3	4.4	0.6	2.1	-1.8	0.5	1.8
Headache pain in last month	0.5	0.9	2.5	-1.1	0.3	-1.0	-1.6	0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.9	0.2	-0.6	2.0	1.0	-0.3
Glaucoma (self-reported)	0.3	0.4	1.3	0.3	0.6	0.4	1.1	0.3
Gout (self-reported)	0.3	0.4	0.6	0.3	0.6	-0.4	-0.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.8	1.3	-0.7	1.2	-0.2	0.1
Medication: Amlodipine	1.3	1.9	5.1	1.0	-2.3	0.9	0.0	-1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.6	-0.2	0.6	0.1	1.0
Birth weight	1.3	2.9	4.9	-1.7	-2.2	1.6	-0.1	-2.0
Chronic bronchitis/emphysema (mother)	2.7	3.2	7.5	1.8	2.7	0.1	-0.9	2.1
High blood pressure (siblings)	3.9	5.7	8.9	1.2	3.0	-2.4	-1.9	2.9
Forced vital capacity (FVC), Best measure	0.4	1.5	2.4	1.4	-1.6	0.8	1.2	-1.1
Body fat percentage	0.0	0.1	0.3	-0.3	-0.2	0.2	-0.1	0.5
Leg fat percentage (right)	0.0	0.2	0.4	0.4	0.3	-0.7	-0.0	0.3
Arm fat-free mass (right)	0.9	4.8	19.0	1.5	-0.4	4.4	1.1	1.2
Exposure to tobacco smoke outside home	0.3	0.3	0.9	-0.5	-0.1	1.0	0.5	0.4
Comparative body size at age 10	0.8	2.3	4.0	1.6	0.2	-2.0	-2.0	-0.9
Number of full brothers	0.5	0.6	1.2	-0.6	0.2	1.1	0.3	1.1
Worry too long after embarrassment	0.3	0.5	1.5	-0.4	-0.1	1.2	0.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.9	2.0	-0.1	-0.3	-0.7	-0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.4	-0.3	0.3	-0.8	0.3
Number of children fathered	0.9	1.0	3.0	0.1	-1.3	-0.2	-0.5	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.5	0.6	1.0	1.6	0.8	1.2
Age at first live birth	0.4	0.7	1.9	-0.2	1.4	-1.0	0.7	0.3
Pulse wave peak to peak time	1.2	1.4	3.0	1.1	1.1	0.6	1.1	1.7
Health satisfaction	1.0	1.3	3.5	1.9	-0.3	1.5	0.6	0.7
Shortness of breath walking on level ground	1.1	1.3	3.1	-0.1	0.8	-1.8	-1.6	0.4
Qualifications: College or University degree	0.4	1.3	3.6	-1.4	0.5	-1.9	-0.4	-0.8
Eye problems/disorders: None of the above	1.7	2.0	5.4	-1.2	1.2	-0.7	-2.3	1.1
Mouth/teeth dental problems: Loose teeth	2.4	2.8	6.1	2.5	1.4	0.4	-2.2	1.0
Emphysema/chronic bronchitis	0.6	0.7	1.8	-0.1	-1.0	1.3	-0.7	-0.3
Medication for pain relief, constipation, heartburn	1.1	1.9	6.0	-0.6	-1.5	2.5	0.5	-0.8
Neck or shoulder pain in last month	0.2	0.2	0.5	-0.1	-0.7	0.4	-0.6	-0.3
Medication: Blood pressure	0.3	0.6	1.6	-1.2	-0.2	-1.1	-0.1	-0.1
Angina (self-reported)	0.9	1.2	3.1	-1.3	0.7	-1.8	-0.7	0.1
Migraine (self-reported)	0.4	0.5	1.3	-0.5	-0.6	0.1	-1.1	-0.6
Medication: Ibuprofen	0.5	0.6	0.9	0.4	0.9	-0.9	-0.7	0.8
Medication: Allopurinol	0.2	0.2	0.5	-0.7	-0.3	0.4	-0.6	-0.1
Medication: Omeprazole	0.5	0.6	1.0	-0.3	-1.0	-1.0	0.4	-0.9
Medication: Seretide 50 evohaler	0.8	0.9	4.0	0.2	-0.5	2.0	-0.6	0.4
Mean time to correctly identify matches	0.1	0.2	0.4	-0.1	-0.5	0.7	-0.6	-0.1
Heart disease (mother)	0.6	0.7	2.3	-0.5	-0.7	-0.2	-1.5	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	-1.1	-0.2	-0.7	0.5	-0.1
Whole body fat mass	0.2	0.8	2.9	-0.1	-0.1	1.7	0.2	1.1
Leg fat mass (right)	0.1	0.4	1.0	0.6	0.4	0.8	0.0	1.0
Arm predicted mass (right)	0.9	4.7	17.9	1.4	-0.1	4.2	1.2	1.4
Pulse rate, automated reading	0.8	2.6	4.5	0.7	2.1	-1.9	-0.9	1.9
Alcohol intake frequency.	0.1	0.2	0.5	-0.1	0.3	-0.7	-0.1	0.6
Comparative height size at age 10	1.8	10.0	38.1	1.8	-1.9	6.2	1.9	1.0
Number of full sisters	0.8	0.9	3.2	1.8	0.5	0.4	0.9	0.6
Suffer from ‘nerves’	0.3	0.5	0.8	-0.8	-0.2	0.9	-0.6	0.9
Overall health rating	0.3	0.6	2.1	1.4	0.2	-0.1	0.0	0.9
Chest pain or discomfort	0.5	0.8	2.0	-0.6	0.4	0.3	-1.4	1.1
Had major operations	1.3	1.6	4.3	1.6	-0.2	-0.9	2.1	-0.4
Age at last live birth	0.7	1.1	3.2	0.6	1.8	-1.1	-0.3	0.6
Family relationship satisfaction	0.6	0.8	1.8	1.3	-0.5	-0.2	1.0	-0.9
Leg pain on walking	1.2	1.5	5.7	-0.6	0.9	0.2	-2.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	0.9	0.9	0.0	-1.3	0.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.7	1.1	1.6	-0.9	-1.3	1.2
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	5.5	-2.1	-1.4	2.3	0.2	-1.0
Medication: Aspirin	0.6	0.8	1.9	0.9	-0.0	-1.4	-1.1	-0.5
Supplements: Vitamin C	0.4	0.5	1.6	-0.8	1.3	0.1	-0.1	0.1
Knee pain experienced in last month	0.3	0.5	1.7	-0.6	-0.4	0.5	-1.3	-0.2
Hypertension (Self-reported)	0.5	1.3	3.1	0.3	-1.0	-1.0	1.8	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.4	-0.8	-1.4	0.6	1.6	-0.9
Illnesses of father: Heart disease	1.1	1.6	3.5	-1.5	-0.7	-1.9	1.2	-0.4
Illnesses of siblings: Diabetes	1.2	1.4	5.1	-2.3	0.1	-0.7	-1.3	0.1
Smoking status: Previous	0.6	0.9	3.3	-0.3	-0.3	0.7	-1.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted	3.8	8.0	19.6	-0.6	-3.3	4.4	2.6	-1.7
Whole body fat-free mass	0.8	4.8	19.3	1.4	-0.1	4.4	0.8	1.5
Leg fat-free mass (right)	0.7	3.6	15.4	0.3	-0.1	3.9	0.5	1.5
Arm fat percentage (left)	0.1	0.4	0.8	-0.7	0.7	-0.2	-0.2	0.9
Average weekly red wine intake	0.2	0.2	0.8	0.1	-0.1	-0.2	-0.9	-0.5
Handedness (chirality/laterality): Left-handed	1.1	1.3	4.0	-0.1	-0.2	-0.1	-2.0	-1.5
Mood swings	0.7	1.3	3.2	0.6	1.4	0.9	-0.0	1.8
Loneliness, isolation	0.5	0.7	1.7	1.3	-1.2	0.4	0.2	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.8	0.8	0.1	-0.9	-0.5	-0.0
Ever had bowel cancer screening	0.5	0.5	2.0	1.4	0.1	0.8	-0.4	0.2
Diabetes diagnosed by doctor	0.4	0.7	1.1	-0.8	-1.1	0.9	0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.7	-0.6	0.1	0.0	1.3	0.5
Friendships satisfaction	0.7	0.9	1.8	-0.7	-1.3	-0.4	0.7	-1.3
Qualifications: nursing, teaching	0.3	0.5	1.2	-0.1	1.0	-1.1	0.5	0.1
Commuting to job workplace: Walk	1.0	1.1	3.0	0.3	-0.2	-1.4	0.8	-1.7
Eye problems/disorders: Cataract	1.4	1.7	3.9	0.3	-1.7	0.5	2.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.1	-1.1	-1.3	-0.2	-1.3	-1.5
Medication for cholesterol	0.7	1.1	2.7	-0.6	1.6	-0.6	-1.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.7	0.9	0.8	-1.4	-1.6	0.9
Back pain experienced in last month	0.9	1.4	4.6	0.7	0.8	-2.2	0.8	0.6
Mineral and other dietary supplements	0.6	0.8	2.1	-0.6	0.3	-1.5	-0.7	-1.1
Breast cancer (self-reported)	0.6	0.8	1.8	0.7	1.3	-1.1	-0.1	0.4
Asthma (self-reported)	0.3	0.6	1.3	1.1	-1.2	0.1	-0.4	0.1
Osteoporosis (self-reported)	0.7	0.9	2.1	1.5	-0.9	1.0	0.8	0.1
Osteoarthritis (self-reported)	0.5	0.6	2.0	-0.7	-0.2	0.7	1.4	0.4
Medication: Aspirin	0.9	1.1	4.0	0.6	0.4	-2.0	-0.9	-0.4
Medication: Gliclazide	0.8	1.0	3.2	1.8	0.4	-0.8	0.1	0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	1.0	0.6	0.9	-0.2	0.7
Smoking status: Current	0.8	1.2	3.6	-0.1	-1.1	-0.9	0.5	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.3	1.2	0.7	-1.5	0.7	-0.1
Whole body water mass	0.8	4.8	19.5	1.3	-0.1	4.4	0.7	1.5
Leg predicted mass (right)	0.6	3.4	14.8	0.3	-0.2	3.9	0.6	1.3
Arm fat mass (left)	0.1	0.5	1.3	-0.1	0.4	1.2	0.0	1.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	-0.3	-1.0	-1.3	0.4	-0.8
Average weekly champagne plus white wine intake	1.4	1.9	7.2	-0.3	2.7	-0.7	-0.4	1.3
Miserableness	2.3	4.0	14.8	0.3	0.4	3.9	1.1	1.9
Guilty feelings	0.3	0.5	1.3	1.1	0.6	-0.4	-0.4	0.7
Wears glasses or contact lenses	0.4	0.4	1.8	0.3	0.0	-1.3	-0.2	-0.3
Ever taken oral contraceptive pill	0.3	0.4	1.1	1.0	-0.1	-0.6	0.7	-0.0
Hearing aid user	0.6	0.7	1.1	1.0	-0.6	0.8	-0.8	-0.7
Mother’s age at death	1.1	1.3	4.4	-1.2	-0.3	0.8	2.1	-0.0
Financial situation satisfaction	1.8	2.3	3.2	1.5	1.7	0.1	-1.8	1.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	1.4	-0.2	0.5	-0.9	-0.3
Commuting to job workplace: Public transport	1.2	1.5	2.9	-0.4	-1.7	1.6	1.1	-0.8
Eye problems/disorders: Glaucoma	0.4	0.5	1.8	0.2	0.5	0.6	1.3	0.2
Medication: Blood pressure	0.8	1.6	2.3	-0.6	-1.5	1.0	1.5	-1.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.1	0.2	-0.0	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	0.5	-0.8	0.6	0.2	-0.2
High cholesterol (Self-reported)	0.3	0.6	1.4	1.2	-0.2	-1.1	0.2	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.5	0.2	-0.2	0.5	0.2
Medication: Paracetamol	0.9	1.4	3.4	0.6	1.4	-1.8	0.2	1.0
Medication: Lisinopril	1.3	1.6	7.5	0.4	-0.6	0.0	2.7	0.4
Medication: Atorvastatin	2.0	2.5	6.2	2.2	0.6	-2.5	-0.9	0.2
Illnesses of father: High blood pressure	0.6	0.7	1.9	-0.6	-0.9	0.1	-0.7	-1.4
Alcohol drinker status: Never	0.3	0.3	1.0	-0.1	1.0	-0.2	-0.1	0.7
Ever smoked	0.7	1.2	4.6	-0.2	-0.9	0.7	-2.1	-0.0
Basal metabolic rate	0.8	4.3	17.5	1.2	-0.2	4.2	0.8	1.4
Leg fat percentage (left)	0.0	0.1	0.3	-0.0	0.1	-0.5	0.1	0.2
Arm fat-free mass (left)	0.7	3.7	13.8	1.4	-0.1	3.7	1.0	1.2
Number of operations (self-reported)	0.4	0.6	1.4	1.0	0.1	-1.2	-0.9	0.2
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.3	-0.9	0.4	-0.1	-0.6
Irritability	0.2	0.4	0.7	0.8	0.6	0.2	-0.9	0.1
Risk taking	1.3	2.0	5.9	2.4	0.3	-1.8	-0.4	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.9	0.2	-1.1	0.9	0.1
Fractured/broken bones in last 5 years	0.6	0.8	1.6	0.7	-0.6	1.3	-0.8	-1.0
Age started oral contraceptive pill	0.5	0.6	2.0	-0.0	-0.6	0.5	1.4	0.6
Diastolic blood pressure, automated reading	0.3	1.0	2.6	0.7	-0.1	-1.6	-0.6	-1.1
Ever depressed for a whole week	0.1	0.1	0.2	-0.3	-0.1	-0.5	0.4	0.4
Unable to work because of sickness or disability	0.6	0.7	2.3	0.1	0.9	-1.5	-0.8	-0.0
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	0.3	0.5	0.5	-0.2
Myopia	0.2	0.3	0.7	-0.4	-0.6	0.4	-0.2	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.2	0.2	0.5	1.5	-1.2	1.0
Cholesterol lowering medication	0.6	0.8	2.2	-0.4	-0.9	-1.5	-0.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	-0.1	-1.1	-0.7	0.5	-0.7
Pain experienced in last month	0.3	0.5	1.4	0.9	-0.3	1.2	0.3	-0.4
Supplements: Calcium	0.6	0.6	1.1	-0.1	-1.0	0.7	0.8	-1.0
Basal cell carcinoma (self-reported)	1.0	1.2	3.0	1.2	-1.7	0.6	-0.2	-1.0
Heart attack/myocardial infarction (self-reported)	0.8	1.1	5.1	-0.3	0.4	-2.2	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.0	-1.2	1.0	0.2	-1.4	0.5
Heart disease (siblings)	0.5	0.6	2.0	-0.4	-1.4	-0.5	-0.0	-0.9
Alcohol drinker status: Previous	0.1	0.2	0.3	-0.5	-0.2	-0.4	-0.6	0.0
Pack years of smoking	2.3	3.4	5.9	1.6	1.9	-1.5	-2.4	1.6
Impedance of whole body	0.3	1.5	4.1	-1.4	-2.0	-0.4	0.3	-1.2
Leg fat mass (left)	0.1	0.3	0.8	0.3	0.3	0.8	0.1	0.9
Arm predicted mass (left)	0.7	3.6	13.2	1.5	-0.3	3.6	1.1	1.1