Best TWAS P=2.4e-13 · Best GWAS P=1.56e-15 conditioned to 3.57e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -6.9 | -7.3 | 2.4e-13 | -0.57 | 0.32 | 0.17 | TRUE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -6.1 | -7.1 | 1.0e-12 | -0.48 | 0.50 | 0.16 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -7.5 | -7.0 | 2.9e-12 | -0.44 | 0.01 | 0.97 | FALSE |
| 3 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -6.9 | -6.9 | 7.1e-12 | -0.48 | 0.12 | 0.14 | FALSE |
| 7 | GTEx | Muscle Skeletal | PPA2 | 0.19 | 0.06 | enet | 28 | 0.11 | 8.7e-11 | -7.5 | -6.7 | 2.5e-11 | -0.47 | 0.23 | 0.77 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPA2 | 0.11 | 0.03 | blup | 84 | 0.03 | 4.7e-04 | -7.2 | -6.4 | 2.0e-10 | -0.45 | 0.02 | 0.96 | FALSE |
| 8 | GTEx | Nerve Tibial | PPA2 | 0.13 | 0.07 | enet | 23 | 0.07 | 2.1e-05 | -7.2 | -6.0 | 2.7e-09 | -0.30 | 0.48 | 0.29 | FALSE |
| 2 | GTEx | Artery Aorta | PPA2 | 0.11 | -0.01 | enet | 24 | 0.01 | 1.6e-01 | -6.1 | -5.8 | 5.3e-09 | -0.33 | 0.09 | 0.13 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -7.1 | -5.6 | 1.8e-08 | -0.48 | 0.46 | 0.36 | FALSE |
| 6 | GTEx | Lung | PPA2 | 0.09 | 0.02 | enet | 16 | 0.03 | 1.4e-03 | 2.2 | -5.5 | 3.6e-08 | -0.42 | 0.24 | 0.14 | FALSE |