Best TWAS P=2.22e-09 · Best GWAS P=2.85e-11 conditioned to 2.51e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM160A1 | 0.04 | 0.04 | blup | 436 | 0.06 | 1.8e-07 | -5.6 | 6.0 | 2.2e-09 | -0.39 | 0.44 | 0.56 | TRUE |
| 2 | GTEx | Brain Frontal Cortex BA9 | PET112 | 0.22 | 0.13 | enet | 14 | 0.05 | 1.6e-02 | -5.6 | 5.4 | 5.3e-08 | -0.26 | 0.19 | 0.22 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | PET112 | 0.26 | 0.20 | enet | 23 | 0.26 | 3.7e-09 | -5.7 | -5.5 | 3.8e-08 | 0.27 | 0.37 | 0.62 | FALSE |
| 4 | GTEx | Heart Left Ventricle | PET112 | 0.14 | 0.06 | lasso | 4 | 0.04 | 5.0e-03 | -5.6 | 5.3 | 9.0e-08 | -0.15 | 0.22 | 0.29 | FALSE |
| 5 | GTEx | Nerve Tibial | PET112 | 0.13 | 0.10 | enet | 13 | 0.10 | 9.7e-08 | -5.0 | 5.4 | 7.8e-08 | -0.20 | 0.51 | 0.49 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PET112 | 0.04 | 0.02 | bslmm | 410 | 0.04 | 5.2e-06 | -5.7 | 5.9 | 4.8e-09 | -0.35 | 0.36 | 0.56 | FALSE |