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chr5:59,028,853-61,156,570

Best TWAS P=6.84e-19 · Best GWAS P=5.48e-19 conditioned to 0.00441

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Skin Not Sun Exposed Suprapubic	ELOVL7	0.14	0.09	lasso	3	0.08	6.3e-05	-8.3	8.9	6.8e-19	-0.57	0.07	0.74	TRUE
17	GTEx	Thyroid	GNL3LP1	0.10	0.04	enet	16	0.02	1.0e-02	7.8	8.1	5.7e-16	-0.60	0.37	0.42	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PART1	0.18	0.12	lasso	9	0.15	2.6e-18	-4.3	-5.8	7.6e-09	0.10	1.00	0.00	TRUE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	ERCC8	0.04	0.01	blup	39	0.01	8.1e-03	-5.6	-8.7	3.8e-18	0.67	0.01	0.81	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	ERCC8	0.06	0.04	lasso	1	0.02	2.3e-03	-8.5	-8.5	1.4e-17	0.62	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERCC8	0.07	0.04	lasso	3	0.04	4.7e-05	-8.5	-8.5	2.2e-17	0.62	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ELOVL7	0.04	0.03	blup	355	0.03	1.4e-04	6.6	-8.5	2.7e-17	0.67	0.07	0.92	FALSE
10	GTEx	Esophagus Mucosa	ERCC8	0.16	0.06	enet	11	0.09	1.3e-06	-8.3	-8.3	8.3e-17	0.60	0.10	0.89	FALSE
5	GTEx	Brain Cerebellar Hemisphere	GNL3LP1	0.21	0.17	lasso	10	0.12	6.2e-04	7.8	8.1	5.4e-16	-0.71	0.22	0.60	FALSE
8	GTEx	Cells Transformed fibroblasts	ERCC8	0.08	0.04	lasso	6	0.05	1.7e-04	-8.5	-8.0	1.2e-15	0.59	0.10	0.89	FALSE
9	GTEx	Cells Transformed fibroblasts	GNL3LP1	0.05	0.10	lasso	2	0.09	1.4e-07	7.8	7.8	4.6e-15	-0.58	0.87	0.13	FALSE
11	GTEx	Esophagus Mucosa	GNL3LP1	0.05	0.07	lasso	3	0.05	3.2e-04	7.6	7.8	4.8e-15	-0.55	0.39	0.16	FALSE
7	GTEx	Brain Hippocampus	GNL3LP1	0.51	0.04	enet	2	0.14	4.1e-04	7.8	7.8	5.5e-15	-0.59	0.06	0.17	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERCC8	0.09	0.06	enet	7	0.06	8.5e-13	-8.5	-7.8	8.6e-15	0.59	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ERCC8	0.03	0.01	enet	9	0.02	9.2e-04	-8.5	-7.7	1.9e-14	0.63	0.00	0.97	FALSE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ERCC8	0.06	0.03	blup	39	0.03	2.8e-04	-5.6	-7.6	2.4e-14	0.60	0.09	0.70	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ELOVL7	0.06	0.07	blup	66	0.07	2.1e-08	-8.5	7.6	2.7e-14	-0.58	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DEPDC1B	0.04	0.00	blup	341	0.03	3.4e-04	7.1	7.4	1.5e-13	-0.43	0.08	0.70	FALSE
13	GTEx	Pancreas	SMIM15	0.10	0.03	enet	22	0.05	3.8e-03	-8.5	7.3	2.4e-13	-0.53	0.06	0.38	FALSE
31	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ERCC8	0.11	0.07	enet	6	0.09	2.0e-04	-5.7	-7.2	6.6e-13	0.54	0.02	0.90	FALSE
16	GTEx	Stomach	ELOVL7	0.15	0.14	enet	14	0.16	4.7e-08	-6.3	7.0	2.0e-12	-0.58	0.18	0.75	FALSE
18	METSIM	Adipose	ERCC8	0.07	0.08	blup	317	0.08	8.9e-12	8.6	-6.9	3.7e-12	0.76	0.00	1.00	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	RP11-546M4.1	0.35	0.20	bslmm	322	0.24	1.8e-30	-4.5	6.7	2.5e-11	-0.28	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ELOVL7	0.19	0.10	enet	17	0.17	1.7e-08	-1.9	6.3	2.4e-10	-0.48	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	ERCC8	0.11	0.03	blup	39	0.04	4.3e-05	-8.5	-6.1	1.4e-09	0.52	0.00	1.00	FALSE
4	GTEx	Artery Tibial	ERCC8	0.09	0.01	lasso	5	0.00	2.4e-01	1.9	-6.0	2.2e-09	0.46	0.05	0.28	FALSE
12	GTEx	Pancreas	ELOVL7	0.16	0.11	lasso	3	0.07	4.9e-04	-4.9	5.9	3.1e-09	-0.43	0.26	0.13	FALSE
6	GTEx	Brain Cerebellum	GNL3LP1	0.18	0.18	enet	9	0.11	3.2e-04	7.6	5.9	3.3e-09	-0.57	0.13	0.63	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	ERCC8	0.09	0.09	lasso	1	0.08	2.1e-05	-5.6	-5.6	2.5e-08	0.44	0.33	0.17	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	NDUFAF2	0.08	0.06	enet	15	0.07	1.9e-09	-4.3	-5.5	3.1e-08	0.40	1.00	0.00	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	DEPDC1B	0.05	0.01	lasso	9	0.01	4.8e-03	-4.0	5.5	4.6e-08	-0.36	0.24	0.04	FALSE
14	GTEx	Pancreas	GNL3LP1	0.08	0.05	lasso	5	0.04	6.7e-03	6.6	5.4	7.4e-08	-0.45	0.18	0.12	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NDUFAF2	0.10	0.09	lasso	6	0.09	1.1e-10	-4.2	-5.2	1.8e-07	0.37	0.99	0.01	FALSE