Best TWAS P=2.73e-10 · Best GWAS P=1.53e-08 conditioned to 0.107
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | RARS2 | 0.14 | 0.07 | lasso | 6 | 0.05 | 5.2e-06 | -5.5 | 5.4 | 6.6e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Nerve Tibial | RARS2 | 0.10 | 0.03 | enet | 8 | 0.04 | 1.4e-03 | -5.5 | 5.8 | 5.6e-09 | -0.73 | 0.04 | 0.88 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | C6orf163 | 0.07 | 0.03 | enet | 16 | 0.06 | 9.1e-09 | -4.7 | 5.3 | 8.8e-08 | -0.58 | 0.41 | 0.58 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C6orf163 | 0.10 | 0.04 | blup | 65 | 0.04 | 2.6e-09 | -4.7 | 5.8 | 7.9e-09 | -0.59 | 0.06 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC35A1 | 0.02 | 0.01 | blup | 72 | 0.00 | 8.7e-02 | 3.9 | -5.6 | 2.2e-08 | 0.51 | 0.08 | 0.39 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | RARS2 | 0.05 | 0.02 | lasso | 2 | 0.01 | 1.7e-02 | -5.5 | 5.5 | 3.2e-08 | -1.00 | 0.00 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC35A1 | 0.05 | 0.03 | blup | 72 | 0.05 | 6.8e-06 | -5.1 | -6.3 | 2.7e-10 | 0.72 | 0.03 | 0.96 | TRUE |