Hub : Genes

SLC35A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0406 0.0206 5.1e-03 -0.001 0.010 0.010 0.012 0.000 5.3e-01 1.1e-02 9.6e-03 5.2e-03 2.8e-01
2 NTR Blood 0.0203 0.0088 8.0e-04 0.002 0.006 0.005 0.007 0.002 4.7e-02 4.3e-03 7.4e-03 1.4e-03 6.8e-02
3 ROSMAP Brain Pre-frontal Cortex 0.3048 0.0425 0.0e+00 0.481 0.469 0.495 0.492 0.493 4.1e-70 8.9e-68 5.7e-73 2.1e-72 1.4e-72
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0191 0.0107 5.2e-03 0.009 0.005 0.001 NA 0.002 2.9e-02 8.7e-02 2.2e-01 NA 1.9e-01
5 TCGA Brain Lower Grade Glioma 0.0553 0.0270 1.8e-04 0.044 0.019 0.032 NA 0.032 8.6e-06 2.7e-03 1.4e-04 NA 1.3e-04
6 TCGA Lung Squamous Cell Carcinoma 0.0583 0.0244 4.2e-06 0.070 0.055 0.064 NA 0.065 2.2e-08 6.5e-07 8.8e-08 NA 7.8e-08
7 TCGA Ovarian Serous Cystadenocarcinoma 0.0450 0.0270 7.1e-03 0.035 0.017 0.018 NA 0.021 2.1e-03 2.4e-02 2.1e-02 NA 1.4e-02
8 TCGA Prostate Adenocarcinoma 0.0503 0.0218 3.5e-06 0.029 0.049 0.041 NA 0.040 4.8e-04 6.8e-06 3.8e-05 NA 4.4e-05
9 TCGA Testicular Germ Cell Tumors 0.1360 0.0760 3.2e-03 0.036 0.074 0.048 NA 0.038 1.9e-02 1.4e-03 8.8e-03 NA 1.7e-02
10 TCGA Thyroid Carcinoma 0.0820 0.0310 1.6e-07 0.074 0.061 0.066 NA 0.065 1.1e-07 1.4e-06 5.0e-07 NA 6.9e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.5 0.8 4.7 -0.8 -2.2 0.5 -0.0 -1.2 -1.1 -0.3 -0.1 0.0 -0.4
Bipolar Disorder or Schizophrenia 0.8 2.0 11.4 -0.1 -3.4 -1.1 1.1 -0.0 0.1 1.3 0.5 0.8 -1.8
Depressed Affect (Nagel 2018) 0.3 0.7 1.8 0.5 1.4 -0.7 0.4 1.3 1.3 0.4 0.4 0.6 -0.2
Depression (Nagel 2018) 0.8 1.2 5.7 -0.1 2.4 1.1 0.2 -0.6 -0.6 -0.6 1.7 -0.0 1.2
Intelligence (Savage-Jansen 2018) 0.2 0.7 3.5 -0.0 -1.9 0.2 -0.5 -0.8 -0.8 -0.3 -0.8 -1.0 0.4
Neuroticism (Nagel 2018) 0.3 0.7 2.0 0.5 0.5 -1.2 0.5 1.4 1.3 0.9 0.0 0.5 -0.5
Schizophrenia (2018) 1.1 2.3 6.7 0.5 -2.6 -1.8 1.4 0.9 1.0 1.9 0.7 1.1 -2.0
Schizophrenia vs Biploar Disorder 0.2 0.3 1.4 1.2 0.3 0.1 -0.3 -0.1 -0.1 -0.2 -0.4 -1.0 0.4
Worry (Nagel 2018) 1.4 2.9 4.8 1.4 -0.3 -2.2 1.6 2.2 2.1 2.0 1.0 1.6 -1.8
Alzheimer’s Disease (in mother) 0.7 0.8 1.3 1.2 0.1 -1.0 0.8 1.1 1.1 0.9 0.4 1.1 -0.9
Alzheimer’s Disease (in father) 0.1 0.1 0.3 -0.2 -0.5 -0.3 0.0 0.2 0.2 0.4 -0.4 0.6 -0.2
Alzheimer’s Disease (including proxy) 1.0 1.4 3.2 0.6 -0.9 -1.5 1.3 0.7 0.7 1.6 0.5 1.8 -1.5
Crohns Disease (2017) 1.8 4.0 7.3 1.3 -0.7 -2.0 2.7 1.4 1.6 2.2 2.4 2.7 -2.1
Irritable Bowel Disease (IBD) 0.5 1.3 3.8 0.7 -0.6 -0.6 1.8 0.0 0.2 1.1 2.0 1.5 -1.0
Ulcerative Colitis (UC) 0.3 0.5 1.6 -0.2 -0.7 0.8 0.0 -1.3 -1.1 -0.4 0.4 -0.4 0.5
Major Depression (MDD) 0.6 0.7 2.7 -1.0 1.6 0.1 -0.8 0.4 0.3 -0.2 -1.0 -0.5 1.0
Reaction Time 0.6 1.2 5.0 0.5 1.8 -0.1 1.3 0.5 0.5 0.2 2.2 1.0 -0.7
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.5 0.2 -1.0 0.6 -0.9 -0.8 -0.8 -0.6 -1.1 -1.2 0.6
Breast Cancer 0.5 1.2 5.4 2.3 -0.6 -0.2 -0.9 1.2 1.1 0.0 -1.6 0.1 -0.2
Ovarian Cancer 0.0 0.0 0.1 0.1 0.3 0.2 0.0 0.1 0.0 -0.1 0.3 -0.0 0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.0 1.4 7.2 -1.2 -2.7 -1.2 0.2 -0.4 -0.7 1.0 -1.0 -0.2 -1.0
Bipolar Disorder (2011) 3.4 3.3 6.9 1.4 -1.5 -1.5 2.4 0.6 0.9 1.9 2.4 2.6 -1.9
Body Mass Index (BMI) (2010) 2.8 3.8 5.7 -2.4 0.9 2.3 -1.8 -2.2 -2.3 -2.2 -0.9 -1.8 2.0
Coronary Artery Disease (CAD) 2.2 2.6 6.9 1.4 -2.6 -2.1 1.2 1.1 1.2 2.2 -0.2 1.4 -1.4
Crohns Disease (2012) 2.8 4.4 6.2 2.4 -1.0 -2.3 2.1 2.1 2.2 2.3 1.3 2.5 -2.2
Mean Putamen Volume 0.5 0.6 1.5 0.2 0.2 -0.9 -0.2 1.2 1.2 0.8 -1.2 -0.3 -0.1
Fasting Glucose 0.2 0.3 0.9 0.2 -0.4 0.3 0.5 -0.4 -0.5 -0.2 0.9 0.9 -0.4
HbA1C 0.3 0.3 1.2 -0.9 -1.1 0.1 -0.0 -0.6 -0.5 0.1 -0.3 0.0 -0.5
HDL Cholesterol 0.5 0.8 1.5 0.9 -1.2 -1.2 0.5 0.9 0.7 1.1 -0.4 0.7 -0.9
LDL Cholesterol 0.3 0.4 1.5 -1.2 0.2 0.5 -0.8 -0.4 -0.4 -0.4 -0.9 -0.4 0.5
Lupus 0.5 0.8 2.3 -1.0 0.7 0.8 -0.2 -1.5 -1.5 -0.5 0.4 0.0 0.8
Neuroticism (2016) 0.7 1.1 4.9 -0.5 2.2 0.7 -1.1 -0.0 -0.0 -0.9 -1.0 -0.6 1.3
Primary Biliary Cirrhosis 0.4 0.6 1.0 -0.6 0.6 1.0 -0.7 -0.9 -0.9 -0.9 -0.4 -0.8 0.8
Rheumatoid Arthritis 0.7 0.9 2.3 -1.4 1.5 0.8 0.3 -1.0 -0.9 -0.6 1.3 0.1 0.1
Schizophrenia (2014) 1.1 2.5 12.4 -0.4 -3.5 -1.9 0.9 0.4 0.5 1.8 -0.4 0.4 -2.0
Triglycerides 1.1 1.8 4.4 0.1 0.2 -1.1 1.6 1.1 1.1 1.4 1.9 2.1 -1.4
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.0 0.7 -0.2 -0.4 1.1 0.9 1.0 0.3 1.4 1.0 -0.8
Ulcerative Colitis 0.3 0.5 2.9 1.0 -1.7 -0.0 0.2 -0.6 -0.6 0.1 0.1 -0.3 -0.3
Blood Eosinophil Count 3.3 25.7 38.2 3.2 -4.6 -6.0 5.8 4.5 4.7 5.9 3.8 5.1 -6.2
Blood Platelet Count 0.2 2.6 7.7 2.8 -0.4 -1.5 0.9 2.5 2.4 1.3 0.2 0.9 -0.6
Blood Red Count 0.3 3.2 4.8 2.0 0.0 -1.4 2.0 1.9 2.0 1.6 2.2 2.1 -1.6
Blood White Count 4.3 32.2 50.0 -2.8 6.7 6.9 -6.1 -4.7 -4.9 -7.1 -3.1 -5.8 6.7
Heel T-Score 0.7 5.7 9.1 1.3 -2.9 -2.8 2.9 0.9 1.0 3.0 1.9 2.7 -3.0
BMI 0.8 4.4 7.4 -1.9 2.7 2.7 -2.1 -1.6 -1.6 -2.5 -0.9 -1.8 2.5
Height 0.1 2.0 7.5 0.8 -1.7 0.4 -1.9 -0.4 -0.5 -0.8 -2.7 -2.1 0.7
Waist Hip Ratio (WHR) 1.3 5.8 9.1 1.8 -2.1 -2.2 3.0 1.9 2.0 2.5 2.7 3.0 -2.4
Systolic Blood Pressure 0.2 1.2 2.8 0.9 0.7 -1.1 1.0 1.0 1.0 1.1 0.7 1.7 -1.3
Smoking Status 1.6 3.9 6.1 1.3 0.8 -1.7 2.2 2.3 2.4 1.7 2.4 2.5 -1.5
Allergy or Eczema 2.4 6.4 22.4 0.8 -4.7 -3.1 1.8 1.9 2.0 3.1 -0.3 1.6 -2.8
Cardiovascular Disease 0.0 0.2 0.9 -1.0 0.6 -0.1 0.2 0.1 0.1 0.1 0.2 0.3 -0.4
Hypothyroidism (self reported) 4.0 9.2 13.7 2.3 -0.9 -3.0 3.7 3.0 3.1 3.1 3.3 3.5 -3.4
Respiratory disease 3.6 8.1 11.0 2.9 -2.3 -3.1 2.8 2.9 3.0 3.3 1.7 3.3 -2.7
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.6 -0.8 -0.1 0.7 -0.5 -1.2 -1.2 -0.8 -0.1 -1.3 0.6
Lung FEV1/FVC ratio 0.3 1.7 3.0 0.6 0.3 1.6 -1.7 -1.0 -1.1 -1.6 -1.6 -1.3 1.2
Lung FVC 1.7 8.8 14.2 -1.5 1.0 3.5 -3.8 -2.9 -3.0 -3.5 -3.1 -2.5 3.5
Neuroticism 0.2 0.5 1.9 0.1 1.4 -0.5 0.0 1.1 1.1 0.3 0.1 0.2 0.1
Chronotype (morning person) 0.7 1.6 4.3 1.1 -0.2 1.1 -1.7 -0.2 -0.3 -1.3 -2.1 -1.4 1.7
Hair Pigment 0.0 0.4 1.1 -0.4 0.8 0.9 0.2 -0.6 -0.6 -0.7 1.1 0.2 0.3
Tanning 0.0 0.3 0.6 0.6 0.5 0.1 -0.5 0.4 0.4 -0.6 -0.4 -0.5 0.8
Hand grip strength (left) 0.8 2.1 4.2 -0.8 2.0 2.1 -1.5 -1.2 -1.2 -1.8 -0.7 -0.4 1.7
Number of treatments/medications taken 0.3 0.5 2.6 0.9 0.1 0.0 0.9 -0.1 -0.0 -0.1 1.6 0.3 -0.6
Average weekly spirits intake 0.6 0.7 1.9 0.6 -0.1 -0.9 1.0 0.7 0.7 0.7 1.0 0.5 -1.4
Sensitivity / hurt feelings 0.1 0.3 0.7 0.5 -0.0 -0.2 -0.2 0.9 0.8 0.1 -0.4 -0.0 0.8
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.4 0.8 1.3 -0.1 0.8 0.7 0.7 0.3 1.5 0.7 0.2
Hearing difficulty/problems: Yes 0.2 0.2 1.0 1.0 0.4 0.0 0.4 0.1 0.1 0.2 0.7 0.6 -0.2
Relative age of first facial hair 0.7 1.4 2.7 -0.0 -1.6 -1.4 1.2 1.3 1.3 1.5 0.4 1.2 -0.8
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.5 -0.1 1.1 1.1 -1.2 -0.4 -0.4 -1.1 -1.0 -1.1 1.2
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.0 0.3 0.2 -0.1 -0.2 1.0 1.0 -0.1 -0.0 -0.4 0.2
Ever had hysterectomy (womb removed) 0.5 0.6 1.6 -1.0 1.3 0.7 -0.3 -0.7 -0.7 -0.6 0.3 -0.8 0.8
Systolic blood pressure, automated reading 0.1 0.3 2.1 0.8 1.5 0.3 0.1 0.1 0.1 -0.2 0.4 0.3 0.1
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.1 -0.3 0.1 1.4 -1.1 -1.2 -1.2 -1.5 -0.3 -1.4 1.3
Angina 0.6 0.8 3.7 -1.9 0.8 -0.1 0.4 -0.5 -0.5 0.4 0.8 1.3 -0.7
Medication for hormone replacement therapy 0.2 0.2 0.5 0.7 0.1 -0.3 0.3 0.6 0.5 0.1 0.4 0.6 -0.7
Vitamin and mineral supplements 1.0 1.3 4.0 0.7 -0.3 -1.0 1.9 0.1 0.2 1.2 2.0 0.9 -1.3
Supplements: Zinc 1.7 1.8 4.3 0.7 -0.9 -1.0 1.8 0.4 0.5 1.4 2.1 2.1 -1.3
Medication: Co-codamol 0.3 0.4 0.8 0.7 -0.6 0.6 0.2 -0.8 -0.8 -0.6 0.9 -0.5 0.0
Medication: Metformin 0.2 0.2 0.4 0.4 -0.7 -0.5 0.6 -0.4 -0.4 0.4 0.5 -0.5 -0.4
Diabetes (father) 1.4 1.7 3.4 -0.7 -0.8 -1.6 1.5 0.8 0.8 1.8 1.0 1.6 -1.6
Diabetes (mother) 0.5 0.6 2.2 1.3 0.6 -0.2 1.0 0.3 0.4 0.3 1.5 0.7 -0.3
Severe depression (siblings) 0.6 0.7 3.8 0.4 0.1 0.1 -1.2 0.4 0.3 -0.4 -1.9 -0.6 0.7
Pack years adult smoking proportion 0.4 0.6 1.3 0.9 1.1 0.4 -0.5 1.1 1.1 -0.4 -0.4 -0.1 0.8
Impedance of leg (right) 7.6 36.8 52.5 4.4 -5.1 -7.0 7.2 4.8 5.1 7.2 5.3 6.5 -7.0
Leg fat-free mass (left) 3.2 16.7 25.9 -2.2 3.1 4.8 -5.1 -3.2 -3.3 -4.9 -4.1 -4.6 4.6
Trunk fat percentage 0.3 1.1 2.8 0.7 0.0 -0.9 1.6 0.5 0.6 1.1 1.7 0.9 -1.3
Hand grip strength (right) 0.5 1.3 2.2 -0.9 1.3 1.5 -1.2 -1.1 -1.2 -1.2 -0.8 -0.7 1.3
Townsend deprivation index at recruitment 0.4 0.6 2.4 0.9 -0.0 -0.0 1.0 0.0 0.1 0.1 1.6 1.1 -0.1
Current tobacco smoking 0.5 0.8 1.6 1.3 0.5 -0.7 0.9 1.1 1.2 0.7 1.0 1.0 -0.5
Average weekly fortified wine intake 2.9 3.3 5.8 0.3 0.6 2.4 -2.2 -2.0 -2.0 -2.3 -1.6 -1.3 2.2
Maternal smoking around birth 0.8 1.1 4.1 -0.2 1.3 -0.4 1.3 0.1 0.1 0.6 2.0 1.6 -0.5
Fed-up feelings 0.3 0.5 2.7 -1.1 1.6 -0.5 0.5 0.3 0.2 0.4 0.6 0.3 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 5.0 1.2 0.7 -0.5 1.5 0.9 0.9 0.9 2.2 1.1 -0.6
Relative age voice broke 3.5 5.3 10.1 1.7 -3.2 -2.6 2.9 1.7 1.8 2.8 2.0 2.0 -1.7
Taking other prescription medications 1.6 2.4 9.6 0.7 -0.5 -0.9 2.4 0.6 0.7 1.2 3.1 1.5 -1.6
Age when periods started (menarche) 1.2 2.9 7.9 2.1 -2.8 -1.7 1.6 1.0 1.1 1.6 0.8 1.2 -2.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 4.9 -2.2 0.4 -0.1 -0.2 -0.4 -0.4 0.1 -0.3 -0.4 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.4 1.0 0.4 -1.6 1.5 1.0 1.0 1.5 1.2 0.8 -1.2
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.4 1.5 0.7 -0.2 0.8 1.2 1.3 0.2 1.5 1.8 -0.5
Qualifications: CSEs or equivalent 3.8 5.0 7.8 0.6 -0.1 -2.8 2.5 2.4 2.4 2.8 1.9 2.6 -2.4
Serious illness, injury or assault to yourself 0.5 0.6 1.1 0.2 -0.4 0.8 -0.0 -1.0 -1.0 -0.7 0.8 -0.9 0.7
High blood pressure 0.3 1.0 2.5 -1.5 1.6 1.1 -0.3 -1.0 -1.0 -0.9 0.5 -0.0 0.4
Hayfever, allergic rhinitis or eczema 2.4 5.3 16.4 1.1 -4.1 -2.6 1.9 1.9 2.0 2.7 0.6 1.9 -2.6
Multivitamins +/- minerals 0.8 1.1 2.2 -0.6 0.1 1.4 -1.5 -0.7 -0.7 -1.4 -1.2 -0.5 1.3
Stomach or abdominal pain in last month 0.5 0.7 1.4 -0.0 0.2 -0.8 0.9 0.8 0.8 0.8 0.9 1.2 -1.1
Supplements: Glucosamine 1.6 2.1 3.8 -1.3 -1.2 1.0 -1.4 -2.0 -2.0 -1.2 -1.6 -1.4 0.9
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 4.0 -2.0 -0.6 1.1 -1.1 -1.9 -1.9 -0.9 -0.9 -1.7 1.1
Medication: Atenolol 0.3 0.4 1.1 0.9 1.1 0.7 0.0 -0.3 -0.3 -0.6 0.9 -0.3 0.5
Medication: Levothyroxine sodium 1.5 2.5 4.5 1.8 0.7 -1.0 1.8 1.8 1.8 1.1 2.1 1.7 -1.4
Sitting height 1.2 8.6 18.7 -0.1 0.5 2.9 -4.2 -1.6 -1.9 -3.2 -4.3 -3.9 3.1
Chronic bronchitis/emphysema (father) 2.7 3.2 4.9 1.3 -1.1 -2.1 2.2 1.6 1.6 2.1 1.7 1.9 -2.0
High blood pressure (mother) 0.5 0.8 3.0 -1.7 0.1 0.7 -0.9 -1.0 -1.1 -0.6 -0.7 0.1 0.5
Body mass index (BMI) 0.6 2.8 7.9 -1.3 2.8 2.1 -1.2 -1.4 -1.3 -2.0 -0.1 -1.2 1.7
Impedance of leg (left) 6.9 33.7 49.5 4.1 -4.6 -6.8 7.0 4.7 4.9 7.0 5.2 6.2 -6.6
Leg predicted mass (left) 3.1 16.5 25.7 -2.2 3.1 4.7 -5.1 -3.1 -3.3 -4.9 -4.1 -4.6 4.5
Trunk fat mass 0.0 0.1 0.7 0.4 0.8 0.3 0.3 -0.1 -0.0 -0.1 0.6 -0.2 -0.2
Waist circumference 0.2 0.9 2.1 -0.4 1.2 1.4 -0.5 -1.1 -1.0 -1.2 0.4 -0.7 0.9
Number of incorrect matches in round 0.4 0.6 2.0 -0.9 1.4 0.3 -0.8 -0.4 -0.5 -0.6 -0.8 -1.1 0.3
Past tobacco smoking 1.4 2.7 6.1 -1.5 -0.1 1.2 -1.8 -1.6 -1.7 -1.2 -2.1 -2.5 1.4
Alcohol usually taken with meals 0.7 1.2 4.7 -1.6 -2.2 -0.6 -0.7 -0.3 -0.4 0.4 -1.6 -0.9 0.2
Nervous feelings 1.1 2.0 3.6 1.6 -0.6 -1.9 1.4 1.3 1.3 1.9 0.7 1.1 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.6 0.3 0.6 -0.2 -0.4 0.8 0.6 -0.0 -0.6 0.1 0.4
Hearing difficulty/problems with background noise 0.8 1.3 2.2 0.6 -0.7 -1.5 0.5 1.5 1.5 1.4 -0.6 1.2 -1.4
Hair/balding pattern: Pattern 2 0.6 0.8 1.5 1.0 0.2 1.2 -0.6 -1.1 -1.1 -1.2 0.0 -0.2 0.7
Had menopause 0.7 0.8 2.0 0.1 1.1 1.0 -0.9 -0.4 -0.4 -1.2 -0.3 -1.4 1.2
Had other major operations 0.2 0.3 1.3 -0.1 0.0 -0.2 0.8 0.3 0.3 0.3 1.1 0.8 -0.4
Forced vital capacity (FVC) 0.6 2.3 6.7 -1.5 -0.7 1.1 -2.1 -1.3 -1.4 -1.2 -2.6 -1.3 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 1.7 1.1 0.2 -1.0 1.3 0.4 0.5 1.0 1.1 0.7 -0.9
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.0 1.4 0.5 -0.5 0.0 1.2 1.2 0.4 -0.4 0.5 0.2
Qualifications: None of the above 2.0 4.2 20.6 2.0 2.2 -0.3 2.6 0.7 0.8 0.4 4.5 1.8 -1.2
Financial difficulties in last 2 years 0.8 1.1 6.5 0.5 0.7 -0.2 1.5 -0.1 -0.0 0.5 2.6 1.1 -0.4
Mouth/teeth dental problems 0.4 0.7 2.7 0.3 -1.2 -0.0 -1.0 -0.1 -0.1 -0.3 -1.7 -1.2 0.2
Heart attack 0.8 1.1 1.7 -0.7 1.3 1.2 -1.3 -0.6 -0.7 -1.3 -0.8 -0.9 1.2
Allergy 4.0 9.2 13.5 -1.8 3.7 3.5 -3.0 -3.0 -3.1 -3.6 -1.6 -3.0 3.3
Pain all over the body in last month 1.5 1.6 4.1 1.4 -1.6 -0.7 1.6 0.3 0.5 0.9 2.0 1.3 -1.2
Diabetes (self-reported) 1.2 1.8 4.5 -1.8 0.1 1.1 -0.7 -1.8 -1.8 -1.2 -0.1 -2.1 0.7
Hayfever/allergic rhinitis (self-reported) 2.0 2.7 6.2 1.4 -2.5 -2.0 1.3 1.7 1.7 2.0 0.3 1.1 -1.5
Medication: Ramipril 1.2 1.5 2.6 -1.6 1.5 1.4 -0.9 -1.4 -1.4 -1.4 -0.0 -0.4 1.0
Medication: Simvastatin 0.8 1.2 3.4 -1.5 -0.4 0.8 -0.6 -1.8 -1.8 -0.7 -0.5 -0.8 0.3
Fluid intelligence score 0.5 1.1 6.0 0.4 -2.4 -1.1 0.0 0.5 0.5 1.1 -1.3 -0.1 -0.8
Illnesses of siblings 0.3 0.4 1.9 1.4 -0.7 0.5 -0.5 -0.2 -0.2 -0.7 -0.4 -0.8 -0.0
Neuroticism score 0.2 0.4 0.7 0.8 0.2 -0.6 0.6 0.8 0.7 0.6 0.7 0.9 -0.1
Weight 0.9 4.3 6.5 -1.1 2.3 2.5 -2.3 -1.6 -1.6 -2.5 -1.5 -2.4 2.2
Impedance of arm (right) 4.0 18.5 29.3 2.5 -4.5 -5.4 4.8 3.6 3.7 5.4 2.7 3.9 -5.3
Arm fat percentage (right) 0.1 0.6 2.0 -0.1 0.7 -0.5 1.2 0.2 0.4 0.6 1.4 0.3 -0.9
Trunk fat-free mass 2.2 12.5 21.7 -1.3 2.6 4.1 -4.7 -2.3 -2.5 -4.3 -3.8 -4.0 4.0
Hip circumference 0.6 2.7 4.0 -1.4 1.2 2.0 -1.6 -2.0 -2.0 -1.8 -0.9 -1.8 1.5
Time employed in main current job 0.6 0.7 1.4 -0.3 -0.4 -1.1 0.5 1.1 1.1 1.2 0.0 1.0 -0.7
Alcohol intake versus 10 years previously 1.3 1.9 5.0 2.2 -1.0 -1.1 1.4 1.4 1.5 1.1 1.3 1.2 -1.1
Father’s age at death 2.3 3.1 6.1 1.0 0.0 2.2 -2.0 -1.3 -1.4 -2.5 -1.0 -2.3 2.3
Worrier / anxious feelings 0.2 0.4 1.5 1.2 0.1 -0.8 0.3 0.8 0.8 0.6 -0.1 0.1 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 3.0 0.8 -0.5 -1.7 1.4 1.4 1.4 1.6 0.8 1.0 -1.6
Falls in the last year 2.1 2.9 7.7 -1.5 0.5 1.8 -0.9 -2.8 -2.7 -1.7 -0.0 -1.9 1.0
Hair/balding pattern: Pattern 3 0.3 0.4 1.3 -1.1 0.0 -0.8 0.4 -0.3 -0.2 0.8 -0.0 -0.5 -0.7
Number of live births 0.4 0.5 2.2 -0.7 -0.1 -0.2 1.0 -0.5 -0.4 0.5 1.5 0.5 -0.7
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 6.8 -1.4 -0.3 1.5 -2.2 -1.4 -1.5 -1.5 -2.6 -1.4 1.6
Pulse rate 0.7 1.2 3.3 -1.8 0.1 1.3 -0.9 -1.2 -1.2 -1.1 -0.4 -0.9 1.0
Happiness 0.3 0.3 1.2 1.1 -0.2 -0.0 -0.6 0.6 0.6 -0.0 -1.0 0.1 0.0
Noisy workplace 1.6 2.0 4.0 2.0 0.9 -1.1 1.6 1.4 1.5 0.9 1.6 1.3 -1.6
Qualifications: A levels/AS levels or equivalent 2.0 4.5 8.9 -3.0 -1.0 1.9 -2.3 -2.4 -2.4 -1.7 -2.5 -1.4 1.9
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 4.9 -0.7 -0.5 -1.2 1.9 0.2 0.3 1.6 2.2 2.1 -1.7
Mouth/teeth dental problems: Dentures 1.8 3.0 6.9 0.3 0.8 -1.4 2.1 1.7 1.8 1.6 2.3 2.6 -1.5
Asthma 4.6 9.0 14.3 2.5 -2.0 -3.2 3.0 3.3 3.4 3.4 2.0 3.8 -2.9
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.1 0.2 0.2 0.2 0.1 -0.0 -0.4 -0.4 -0.1 0.0 -0.2 -0.0
Medication: Cholesterol lowering 0.4 0.6 2.0 -0.9 -0.8 0.2 -0.3 -1.4 -1.4 -0.2 -0.4 -0.0 -0.3
Depression (self-reported) 0.2 0.2 0.8 -0.9 0.2 0.2 -0.1 -0.9 -0.8 -0.2 -0.0 -0.4 -0.0
Medication: Lansoprazole 0.8 0.9 3.3 0.8 1.8 0.8 0.4 -0.3 -0.3 -0.8 1.8 -0.2 0.2
Prospective memory result 0.2 0.3 0.8 -0.1 0.4 -0.3 0.7 -0.3 -0.3 0.2 0.9 0.8 -0.6
Lung cancer (father) 0.1 0.1 0.4 0.6 0.3 0.1 0.2 -0.1 -0.1 -0.2 0.7 -0.3 0.3
Illnesses of mother 0.5 0.6 2.1 1.4 0.0 0.2 -0.8 0.6 0.5 -0.4 -1.1 -0.8 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.4 9.1 -2.3 0.4 2.8 -3.0 -2.7 -2.8 -2.6 -2.8 -2.3 2.6
Pulse wave Arterial Stiffness index 0.6 0.6 1.7 -0.1 1.3 1.3 -0.5 -0.7 -0.6 -1.1 0.2 -0.5 0.8
Impedance of arm (left) 3.0 13.7 22.0 1.8 -3.8 -4.7 4.2 3.0 3.1 4.7 2.4 3.6 -4.6
Arm fat mass (right) 0.2 0.9 3.2 -0.6 1.8 1.1 -0.5 -0.7 -0.7 -1.0 0.2 -1.0 0.7
Trunk predicted mass 2.2 12.5 21.5 -1.2 2.6 4.2 -4.6 -2.4 -2.6 -4.3 -3.8 -4.1 4.0
Standing height 0.3 3.1 10.0 0.5 -0.8 1.3 -2.5 -0.9 -1.0 -1.5 -3.2 -2.5 1.3
Length of working week for main job 0.1 0.1 0.5 0.2 -0.4 -0.3 -0.1 -0.0 -0.0 0.2 -0.7 0.1 -0.7
Exposure to tobacco smoke at home 0.9 1.0 2.7 -0.3 -0.9 -0.7 1.3 -0.1 -0.0 1.2 1.3 1.6 -0.9
Breastfed as a baby 0.3 0.3 0.8 0.5 0.2 0.9 -0.6 -0.6 -0.6 -0.8 0.0 0.2 0.7
Tense / ‘highly strung’ 2.7 4.4 7.7 0.4 -1.9 -2.8 2.4 1.8 1.9 2.6 1.6 2.3 -2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.3 0.7 0.1 -0.9 0.4 1.1 1.1 0.9 -0.2 1.5 -0.7
Hair/balding pattern: Pattern 4 0.1 0.3 0.8 0.9 -0.3 -0.4 0.2 0.9 0.9 0.3 0.1 0.1 0.2
Birth weight of first child 0.8 1.4 8.4 0.1 -0.2 0.2 -1.7 0.1 -0.0 -0.4 -2.9 -1.4 0.7
Peak expiratory flow (PEF) 0.3 0.6 1.5 -0.0 0.4 1.2 -1.1 -0.5 -0.6 -1.1 -0.8 -0.4 0.9
Pulse wave reflection index 1.2 1.5 2.9 -1.1 1.2 1.5 -1.3 -1.0 -1.0 -1.5 -0.6 -0.6 1.7
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.8 0.9 0.3 -0.4 -0.3 0.4 0.4 0.2 -0.9 0.2 -0.2
Loud music exposure frequency 0.4 0.4 3.1 -1.8 0.5 -0.4 0.5 -0.2 -0.2 0.3 0.6 -0.2 -0.0
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 6.3 -1.6 -1.0 0.8 -1.8 -0.9 -1.0 -0.8 -2.5 -1.4 1.2
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 -0.2 -0.0 -0.4 0.1 0.1 0.1 0.2 -0.1 -0.3 -0.2
Blood clot in the leg (DVT) 1.7 2.2 4.4 -0.3 -0.1 -1.2 1.9 1.3 1.3 1.5 2.1 1.8 -1.8
Medication: Paracetamol 0.3 0.6 1.9 -0.2 1.3 0.8 0.3 -0.6 -0.6 -0.6 1.4 -0.0 0.5
Headache pain in last month 0.8 1.4 3.2 -0.1 -0.1 -1.8 1.2 1.3 1.3 1.7 0.3 1.0 -1.5
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.3 1.2 0.2 -0.8 0.9 1.5 1.5 1.0 0.9 0.6 -0.3
Glaucoma (self-reported) 0.4 0.4 1.1 1.1 1.0 -0.1 -0.3 0.7 0.7 -0.2 -0.4 -0.9 0.4
Gout (self-reported) 0.3 0.5 1.7 1.2 1.3 0.2 -0.3 0.8 0.8 -0.4 0.0 -0.2 0.2
Hypothyroidism/myxoedema (self-reported) 3.6 7.0 12.5 1.7 0.2 -2.2 3.3 2.6 2.8 2.5 3.5 3.1 -2.8
Medication: Amlodipine 0.2 0.2 0.5 -0.0 0.7 0.0 -0.3 0.7 0.6 -0.1 -0.3 -0.4 0.6
Medication: Ventolin 100micrograms inhaler 2.5 3.3 6.8 1.8 -0.4 -1.3 2.0 2.0 2.1 1.5 2.1 2.6 -1.3
Birth weight 6.1 13.2 20.7 -2.4 -0.1 3.7 -4.5 -3.6 -3.8 -3.9 -4.5 -4.1 3.4
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.3 -0.1 0.2 0.6 -0.3 -1.0 -1.0 -0.5 0.1 -1.5 1.1
High blood pressure (siblings) 1.3 1.9 3.2 -1.6 1.4 1.2 -1.7 -0.8 -0.9 -1.2 -1.7 -1.1 1.8
Forced vital capacity (FVC), Best measure 1.3 4.7 7.1 -1.9 -0.4 2.1 -2.6 -2.4 -2.5 -2.1 -2.7 -2.1 2.0
Body fat percentage 0.3 1.3 4.5 0.5 0.3 -0.8 1.9 0.4 0.5 1.1 2.1 1.1 -1.3
Leg fat percentage (right) 0.9 3.2 11.7 0.9 0.9 -1.0 2.7 0.7 0.8 1.4 3.4 2.0 -1.7
Arm fat-free mass (right) 2.1 10.7 16.6 -1.2 3.0 4.0 -4.0 -2.3 -2.4 -4.1 -2.9 -3.7 3.9
Exposure to tobacco smoke outside home 0.4 0.6 1.7 0.6 0.5 0.2 -1.0 0.6 0.5 -0.4 -1.3 -0.8 0.9
Comparative body size at age 10 0.8 2.3 4.3 -1.1 1.6 2.1 -1.7 -0.8 -0.8 -2.1 -0.8 -1.1 2.1
Number of full brothers 2.8 3.5 6.7 0.5 0.6 -1.9 1.8 2.4 2.4 1.9 1.4 2.6 -1.9
Worry too long after embarrassment 0.1 0.1 0.2 -0.3 -0.3 -0.4 0.3 -0.2 -0.2 0.5 0.4 -0.1 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.8 0.3 -1.0 -1.1 0.3 0.5 0.5 1.0 -0.4 0.9 -1.4
Wheeze or whistling in the chest in last year 2.3 4.2 11.1 2.7 0.6 -1.9 1.0 3.3 3.3 1.5 0.2 1.4 -1.8
Number of children fathered 0.6 0.7 2.5 -1.6 1.0 0.2 -0.5 -0.7 -0.7 -0.5 -0.4 -1.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 2.0 1.2 -0.3 -0.4 -0.4 0.8 0.8 0.4 -1.4 0.1 -0.1
Age at first live birth 1.7 3.0 5.6 -1.2 -0.3 1.7 -1.9 -2.3 -2.4 -1.8 -1.6 -1.7 1.6
Pulse wave peak to peak time 0.4 0.5 1.5 0.2 -1.2 -1.1 0.3 0.6 0.6 1.0 -0.4 0.3 -0.7
Health satisfaction 4.4 5.7 8.8 1.5 0.2 -2.6 2.6 2.6 2.7 2.4 2.3 2.6 -3.0
Shortness of breath walking on level ground 1.3 1.5 9.0 -0.5 3.0 1.2 -0.4 -0.6 -0.6 -1.4 1.0 -0.5 0.9
Qualifications: College or University degree 5.3 16.8 39.9 -2.5 -0.8 3.4 -5.6 -3.1 -3.4 -3.8 -6.3 -5.1 4.1
Eye problems/disorders: None of the above 0.8 0.9 3.1 0.7 0.7 -0.9 0.2 1.8 1.7 0.7 -0.3 0.8 -0.6
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.3 0.5 -0.0 -0.8 0.8 1.1 1.1 0.7 0.8 1.1 -0.7
Emphysema/chronic bronchitis 0.3 0.3 1.3 0.6 0.7 0.3 -0.6 -0.1 -0.1 -0.6 -0.5 -1.2 0.6
Medication for pain relief, constipation, heartburn 0.6 1.1 2.6 1.1 -0.6 -1.2 0.2 1.6 1.6 1.0 -0.6 0.6 -0.7
Neck or shoulder pain in last month 4.2 5.9 8.9 1.8 -2.0 -2.6 2.3 2.6 2.6 2.9 1.2 3.0 -2.8
Medication: Blood pressure 1.2 2.1 4.5 -0.4 1.3 2.0 -1.7 -1.3 -1.3 -2.1 -0.8 -1.1 1.5
Angina (self-reported) 0.8 1.0 4.5 -2.1 0.8 -0.1 0.5 -0.7 -0.7 0.5 0.9 1.4 -0.8
Migraine (self-reported) 0.6 0.7 2.0 0.5 0.0 -1.1 0.8 1.4 1.4 0.8 0.4 0.8 -0.2
Medication: Ibuprofen 0.1 0.1 0.6 0.8 -0.5 0.2 0.1 -0.5 -0.5 -0.0 0.0 0.1 -0.1
Medication: Allopurinol 0.2 0.3 1.2 0.3 0.5 0.5 -0.5 -0.4 -0.5 -0.7 -0.2 -1.1 0.4
Medication: Omeprazole 0.2 0.2 1.3 -0.0 0.4 0.4 0.6 0.1 0.1 -0.1 1.2 0.6 0.3
Medication: Seretide 50 evohaler 5.0 5.8 9.3 1.8 -0.6 -2.5 2.5 3.0 3.0 2.5 1.9 2.8 -2.5
Mean time to correctly identify matches 0.3 0.5 2.0 0.9 1.3 0.3 0.6 0.1 0.2 -0.3 1.4 0.2 -0.3
Heart disease (mother) 0.4 0.5 2.1 -0.1 1.0 -0.1 0.9 -0.3 -0.2 0.4 1.5 0.7 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 2.5 1.0 -1.6 -1.3 1.3 0.9 1.0 1.2 0.8 1.2 -1.5
Whole body fat mass 0.1 0.5 2.2 0.1 1.5 0.9 -0.1 -0.6 -0.6 -0.8 0.6 -0.6 0.3
Leg fat mass (right) 0.1 0.5 2.6 0.2 1.6 0.7 0.4 -0.3 -0.3 -0.5 1.3 -0.0 0.2
Arm predicted mass (right) 2.2 11.1 18.1 -1.3 2.8 3.9 -4.3 -2.2 -2.4 -4.1 -3.3 -3.7 4.0
Pulse rate, automated reading 0.1 0.4 1.3 -0.7 -1.1 0.1 0.5 -0.8 -0.8 0.2 0.7 0.4 -0.1
Alcohol intake frequency. 3.0 6.9 12.3 0.2 -1.6 -3.5 3.3 2.4 2.5 3.5 2.4 2.4 -2.9
Comparative height size at age 10 0.4 2.1 5.0 -0.0 1.4 1.2 -2.2 0.1 -0.1 -1.4 -2.2 -2.2 1.1
Number of full sisters 1.2 1.5 8.2 -1.0 1.0 0.9 1.1 -0.8 -0.7 -0.4 2.9 1.1 0.1
Suffer from ‘nerves’ 0.1 0.1 0.4 0.0 -0.3 -0.1 0.2 0.0 0.0 0.2 0.3 0.6 -0.5
Overall health rating 1.0 2.2 5.1 1.5 0.8 -1.1 1.9 1.4 1.5 1.2 2.2 1.1 -1.4
Chest pain or discomfort 0.4 0.5 1.4 1.1 0.1 -0.4 0.4 0.8 0.8 0.3 0.4 1.0 -1.2
Had major operations 0.3 0.3 2.0 -1.4 -1.0 -0.2 0.1 -0.2 -0.1 0.5 -0.0 0.4 0.0
Age at last live birth 1.0 1.5 2.4 -1.1 -0.1 1.1 -1.5 -1.5 -1.6 -1.2 -1.4 -0.9 1.0
Family relationship satisfaction 0.3 0.4 1.0 0.9 -0.0 -0.7 0.1 1.0 0.9 0.5 -0.5 0.4 -0.2
Leg pain on walking 0.2 0.2 1.0 -0.3 0.3 -0.1 -0.6 0.5 0.4 -0.0 -1.0 0.0 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.0 4.4 0.4 -0.4 -1.0 1.8 1.5 1.6 1.3 1.8 2.1 -1.3
Commuting to job workplace: Car/motor vehicle 2.3 2.6 4.9 -0.2 0.4 -1.8 1.7 1.8 1.8 2.2 1.2 2.2 -1.5
Illness, injury, bereavement, stress in last 2 years 2.7 3.3 11.4 -1.4 0.4 1.4 -2.7 -0.8 -0.9 -1.7 -3.4 -1.8 1.8
Medication: Aspirin 3.4 4.5 9.3 -2.1 0.7 2.6 -1.7 -3.0 -3.0 -2.3 -0.7 -1.6 2.0
Supplements: Vitamin C 0.7 0.8 2.3 -0.3 0.2 0.8 -1.5 -0.2 -0.3 -0.9 -1.5 -0.8 1.0
Knee pain experienced in last month 0.5 0.8 6.6 -0.2 2.6 0.6 -0.1 -0.3 -0.3 -0.7 0.6 -0.4 0.4
Hypertension (Self-reported) 0.5 1.3 2.7 -1.6 1.5 1.4 -0.7 -1.2 -1.3 -1.2 0.1 -0.6 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.8 1.2 0.6 0.3 0.6 -0.1 0.0 -0.1 1.4 0.6 -0.0
Illnesses of father: Heart disease 0.3 0.4 1.8 -0.6 -1.3 -0.4 0.4 -0.6 -0.6 0.6 0.0 0.1 -0.6
Illnesses of siblings: Diabetes 0.8 1.0 2.5 -0.6 -0.6 -1.5 1.1 0.8 0.9 1.6 0.4 0.8 -1.2
Smoking status: Previous 0.7 1.1 3.1 0.5 0.3 -0.7 1.3 0.7 0.8 0.8 1.8 1.5 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 1.9 -1.0 0.3 0.7 -1.1 -1.0 -1.0 -0.8 -1.2 -1.4 0.8
Whole body fat-free mass 2.7 15.5 25.2 -1.7 3.1 4.6 -5.0 -2.8 -3.0 -4.8 -4.0 -4.5 4.5
Leg fat-free mass (right) 3.8 20.4 31.2 -2.7 3.4 5.2 -5.6 -3.5 -3.7 -5.3 -4.5 -5.2 5.1
Arm fat percentage (left) 0.1 0.5 1.8 -0.6 1.1 -0.1 0.9 -0.1 0.0 0.2 1.4 0.2 -0.5
Average weekly red wine intake 0.7 1.0 3.8 -1.9 -0.8 0.6 -1.1 -0.8 -0.8 -0.4 -1.4 -0.0 0.7
Handedness (chirality/laterality): Left-handed 1.1 1.4 8.1 2.8 -0.6 -0.4 -0.4 1.3 1.2 0.0 -1.3 -0.4 -0.3
Mood swings 0.4 0.8 1.7 0.0 1.3 0.6 -1.2 0.4 0.3 -0.9 -1.3 -0.5 1.2
Loneliness, isolation 0.1 0.2 1.1 -0.1 -1.0 -0.2 0.3 -0.4 -0.4 0.2 0.3 0.1 -0.2
Long-standing illness, disability or infirmity 0.6 0.9 1.6 1.2 0.1 -0.7 1.1 1.0 1.1 0.7 1.3 0.9 -0.8
Ever had bowel cancer screening 2.1 2.4 5.1 -0.9 -0.3 1.7 -2.2 -1.1 -1.1 -1.9 -2.3 -1.7 1.2
Diabetes diagnosed by doctor 0.5 0.8 2.1 -1.4 -1.1 -0.2 0.3 -1.3 -1.3 0.1 0.4 -0.8 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.5 -0.3 1.1 1.2 -0.5 -0.9 -0.8 -1.0 0.3 0.3 1.1
Friendships satisfaction 0.4 0.5 0.7 0.8 -0.8 -0.7 0.5 0.8 0.8 0.7 0.5 0.7 -0.3
Qualifications: nursing, teaching 0.9 1.3 4.9 -1.5 -1.8 -0.0 -1.0 -0.8 -0.8 0.1 -2.2 -0.8 -0.2
Commuting to job workplace: Walk 0.5 0.5 1.6 0.1 -1.3 0.8 -0.2 -1.1 -1.0 -0.7 0.2 -0.3 0.5
Eye problems/disorders: Cataract 0.8 0.9 2.9 -1.7 -1.1 0.5 -0.2 -1.5 -1.4 -0.3 0.0 -0.0 0.1
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.7 -2.0 1.4 1.6 -0.6 -2.2 -2.1 -1.4 0.5 -0.7 0.9
Medication for cholesterol 0.2 0.3 0.7 0.4 -0.8 -0.7 0.1 0.6 0.6 0.6 -0.5 0.2 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 3.3 -1.5 -1.8 -0.6 1.2 -0.8 -0.8 0.7 1.5 1.0 -1.5
Back pain experienced in last month 0.7 1.1 1.8 1.0 -0.2 -0.7 1.2 1.0 1.1 0.7 1.3 1.2 -1.3
Mineral and other dietary supplements 2.2 3.0 6.2 0.5 0.3 -1.9 2.5 1.3 1.4 2.0 2.2 1.5 -2.2
Breast cancer (self-reported) 0.3 0.4 1.3 -1.1 -0.8 -0.1 0.5 -0.7 -0.6 0.2 0.5 -0.4 -0.3
Asthma (self-reported) 5.1 10.2 15.2 2.9 -2.0 -3.3 3.2 3.6 3.7 3.5 2.2 3.9 -3.0
Osteoporosis (self-reported) 0.1 0.1 0.7 0.4 -0.9 0.1 0.2 -0.1 -0.1 0.0 0.2 0.1 0.0
Osteoarthritis (self-reported) 0.4 0.5 1.5 0.2 -1.2 -0.8 0.8 0.4 0.5 0.7 0.3 0.5 -1.1
Medication: Aspirin 4.5 5.9 10.8 -1.7 0.6 3.1 -2.3 -3.3 -3.3 -2.9 -1.2 -1.9 2.4
Medication: Gliclazide 0.3 0.3 1.4 -1.2 -0.6 0.3 -0.3 -0.6 -0.6 -0.5 -0.4 -0.3 -0.1
Illnesses of father: None of the above (group 1) 0.6 0.7 3.3 1.4 0.7 0.5 0.6 -0.2 -0.2 -0.5 1.8 -0.3 0.5
Smoking status: Current 0.8 1.3 2.4 1.4 0.5 -0.9 1.0 1.5 1.6 0.8 1.1 1.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.2 -0.1 0.5 1.5 -1.5 -0.6 -0.7 -1.4 -1.0 -0.4 1.3
Whole body water mass 2.6 15.0 24.4 -1.7 3.1 4.5 -4.9 -2.7 -2.9 -4.7 -4.0 -4.5 4.4
Leg predicted mass (right) 3.8 20.2 31.0 -2.6 3.4 5.1 -5.6 -3.5 -3.7 -5.2 -4.5 -5.1 5.1
Arm fat mass (left) 0.3 1.1 3.6 -0.9 1.9 1.3 -0.6 -0.9 -0.8 -1.2 0.1 -1.1 0.9
Number of self-reported non-cancer illnesses 2.7 4.7 8.9 1.0 -0.5 -2.0 2.7 1.8 1.9 2.1 2.8 3.0 -2.5
Average weekly champagne plus white wine intake 0.3 0.4 0.9 -0.9 -0.9 0.0 -0.5 -0.7 -0.7 -0.1 -0.7 -1.0 0.2
Miserableness 0.4 0.7 3.2 1.5 1.8 0.1 -0.2 0.6 0.6 -0.4 0.1 -0.1 0.5
Guilty feelings 2.3 3.5 7.2 -1.0 1.4 2.0 -2.5 -1.0 -1.2 -2.0 -2.1 -2.0 2.7
Wears glasses or contact lenses 2.1 2.4 4.5 -0.3 1.4 1.6 -1.9 -0.9 -0.9 -1.9 -1.6 -2.1 2.0
Ever taken oral contraceptive pill 6.0 6.7 10.9 0.4 0.7 3.1 -3.3 -2.3 -2.4 -3.3 -2.5 -2.8 3.1
Hearing aid user 0.9 1.0 2.1 0.0 0.5 1.5 -1.3 -0.8 -0.8 -1.5 -1.0 -0.5 1.3
Mother’s age at death 0.9 1.1 1.7 -0.0 -0.9 1.2 -1.2 -1.1 -1.2 -1.1 -0.9 -1.3 1.1
Financial situation satisfaction 0.2 0.2 0.5 0.5 0.7 0.3 -0.7 0.4 0.3 -0.3 -0.6 0.2 0.5
Tinnitus: Yes, now most or all of the time 1.0 1.2 2.1 1.5 -0.4 -1.3 0.9 1.3 1.3 1.1 0.4 0.9 -1.1
Commuting to job workplace: Public transport 1.7 2.0 3.2 0.0 -0.2 1.4 -1.7 -1.8 -1.8 -1.7 -1.5 -1.3 1.4
Eye problems/disorders: Glaucoma 0.4 0.4 1.1 0.9 1.0 -0.4 0.7 0.5 0.6 0.3 1.0 -0.3 0.0
Medication: Blood pressure 0.5 1.0 3.3 -1.0 1.8 1.0 0.3 -0.8 -0.8 -0.7 1.7 0.1 0.6
Pain type(s) experienced in last month: Hip pain 1.3 1.6 5.0 -0.5 -0.0 -1.0 2.0 0.3 0.3 1.3 2.2 1.6 -1.2
Supplements: Fish oil (including cod liver oil) 3.9 5.2 12.4 -0.0 1.1 2.3 -3.5 -0.6 -0.7 -2.6 -3.5 -2.2 2.9
High cholesterol (Self-reported) 0.2 0.4 1.2 -0.0 -0.6 -0.8 0.8 0.0 0.1 0.9 0.4 0.6 -1.1
Medication: Bendroflumethiazide 0.5 0.7 1.4 -0.2 1.0 1.2 -1.0 -0.7 -0.7 -1.2 -0.3 -0.7 1.1
Medication: Paracetamol 0.2 0.3 0.9 -0.6 0.5 0.6 0.3 -0.7 -0.7 -0.4 0.9 0.1 0.3
Medication: Lisinopril 0.3 0.3 1.2 -0.8 -0.5 -0.1 0.8 -0.4 -0.3 0.2 1.1 0.0 -0.6
Medication: Atorvastatin 0.2 0.2 0.5 -0.2 0.5 0.5 -0.7 0.1 -0.0 -0.4 -0.7 -0.2 0.7
Illnesses of father: High blood pressure 0.6 0.7 3.4 -1.8 0.7 0.5 -0.8 -0.6 -0.7 -0.3 -1.1 0.2 0.3
Alcohol drinker status: Never 0.3 0.4 1.1 1.1 0.7 -0.2 0.3 0.9 0.9 0.1 0.5 -0.3 0.2
Ever smoked 1.7 3.0 5.7 2.1 -0.0 -1.5 1.5 2.2 2.3 1.3 1.4 2.4 -1.3
Basal metabolic rate 2.3 12.9 20.2 -1.7 3.0 4.2 -4.5 -2.6 -2.8 -4.4 -3.5 -4.1 4.1
Leg fat percentage (left) 0.7 2.6 10.2 0.7 1.3 -0.8 2.4 0.5 0.7 1.2 3.2 1.7 -1.3
Arm fat-free mass (left) 1.8 9.3 14.5 -0.9 2.7 3.7 -3.8 -2.1 -2.2 -3.8 -2.7 -3.5 3.6
Number of operations (self-reported) 0.8 1.1 3.2 -1.8 -1.2 -1.0 1.0 0.6 0.7 1.2 0.6 1.2 -0.8
Average weekly beer plus cider intake 0.6 0.8 3.4 0.6 1.8 1.0 0.2 -0.1 -0.1 -0.9 1.2 0.9 0.0
Irritability 0.3 0.5 1.1 -0.1 -0.1 0.6 -0.7 -0.7 -0.8 -0.9 -0.7 -1.0 0.7
Risk taking 1.5 2.2 3.5 -1.5 1.2 1.9 -1.7 -1.5 -1.6 -1.7 -1.2 -0.5 1.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 1.0 1.0 -0.9 -0.0 0.4 0.2 0.2 0.1 0.6 0.2 -0.2
Fractured/broken bones in last 5 years 1.6 2.0 3.9 0.8 -1.0 -1.4 2.0 0.8 0.9 1.4 1.8 1.6 -1.9
Age started oral contraceptive pill 1.2 1.5 4.7 -0.6 -0.4 0.8 -1.7 -0.3 -0.4 -0.9 -2.2 -1.8 1.3
Diastolic blood pressure, automated reading 1.8 5.5 9.0 -0.3 2.5 3.0 -2.3 -2.3 -2.3 -2.8 -1.1 -2.4 2.9
Ever depressed for a whole week 0.6 0.7 3.6 0.9 1.9 0.5 -0.3 0.7 0.7 -0.3 0.0 0.6 1.0
Unable to work because of sickness or disability 0.6 0.7 2.0 0.6 -0.0 -0.8 0.8 0.9 0.9 0.9 0.7 1.4 -0.9
Commuting to job workplace: Cycle 1.3 1.6 5.9 -1.6 -1.1 0.7 -1.7 -0.6 -0.7 -0.8 -2.4 -0.9 0.8
Myopia 0.2 0.3 0.6 0.7 0.5 0.1 -0.4 0.8 0.7 -0.1 -0.5 0.3 0.3
Vascular/heart problems diagnosed by doctor 0.7 1.8 4.8 2.2 -1.3 -1.6 0.8 1.7 1.8 1.3 0.0 0.2 -0.7
Cholesterol lowering medication 0.0 0.0 0.4 0.1 0.6 0.1 -0.0 0.1 0.1 0.1 0.0 -0.1 0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 1.5 0.1 0.0 0.5 0.5 -0.2 -0.2 -0.3 1.2 0.3 0.1
Pain experienced in last month 2.2 3.6 6.1 -0.9 0.9 2.1 -2.1 -1.9 -2.0 -2.2 -1.5 -2.2 2.5
Supplements: Calcium 0.1 0.1 0.5 0.3 -0.7 0.1 -0.2 -0.1 -0.1 0.1 -0.3 0.4 0.2
Basal cell carcinoma (self-reported) 0.4 0.5 1.8 1.4 0.8 0.0 -0.3 1.1 1.1 -0.2 -0.2 -0.0 0.3
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.0 -0.8 1.3 1.2 -1.4 -0.6 -0.7 -1.2 -1.2 -0.9 1.2
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 3.7 -0.6 -0.1 -0.9 1.6 1.0 1.0 1.2 1.9 1.6 -1.5
Heart disease (siblings) 1.4 1.8 3.6 -0.7 -1.9 -1.4 1.5 0.3 0.4 1.8 0.8 1.7 -1.6
Alcohol drinker status: Previous 1.5 1.7 5.3 -0.8 -0.3 -0.9 1.9 0.6 0.6 1.2 2.3 1.9 -1.0
Pack years of smoking 0.5 0.7 1.4 1.1 1.2 0.6 -0.7 1.0 1.0 -0.7 -0.4 -0.3 1.0
Impedance of whole body 4.9 24.9 37.8 3.1 -4.6 -6.0 6.0 3.9 4.1 6.2 4.0 5.0 -5.9
Leg fat mass (left) 0.1 0.5 2.9 0.1 1.7 0.6 0.4 -0.3 -0.3 -0.5 1.2 -0.1 0.2
Arm predicted mass (left) 1.6 8.2 12.7 -0.8 2.5 3.5 -3.6 -2.0 -2.1 -3.5 -2.7 -3.4 3.3