Hub : Genes

SLC35A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0406	0.0206	5.1e-03	-0.001	0.010	0.010	0.012	0.000	5.3e-01	1.1e-02	9.6e-03	5.2e-03	2.8e-01
2	NTR	Blood	0.0203	0.0088	8.0e-04	0.002	0.006	0.005	0.007	0.002	4.7e-02	4.3e-03	7.4e-03	1.4e-03	6.8e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.3048	0.0425	0.0e+00	0.481	0.469	0.495	0.492	0.493	4.1e-70	8.9e-68	5.7e-73	2.1e-72	1.4e-72
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0191	0.0107	5.2e-03	0.009	0.005	0.001	NA	0.002	2.9e-02	8.7e-02	2.2e-01	NA	1.9e-01
5	TCGA	Brain Lower Grade Glioma	0.0553	0.0270	1.8e-04	0.044	0.019	0.032	NA	0.032	8.6e-06	2.7e-03	1.4e-04	NA	1.3e-04
6	TCGA	Lung Squamous Cell Carcinoma	0.0583	0.0244	4.2e-06	0.070	0.055	0.064	NA	0.065	2.2e-08	6.5e-07	8.8e-08	NA	7.8e-08
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0450	0.0270	7.1e-03	0.035	0.017	0.018	NA	0.021	2.1e-03	2.4e-02	2.1e-02	NA	1.4e-02
8	TCGA	Prostate Adenocarcinoma	0.0503	0.0218	3.5e-06	0.029	0.049	0.041	NA	0.040	4.8e-04	6.8e-06	3.8e-05	NA	4.4e-05
9	TCGA	Testicular Germ Cell Tumors	0.1360	0.0760	3.2e-03	0.036	0.074	0.048	NA	0.038	1.9e-02	1.4e-03	8.8e-03	NA	1.7e-02
10	TCGA	Thyroid Carcinoma	0.0820	0.0310	1.6e-07	0.074	0.061	0.066	NA	0.065	1.1e-07	1.4e-06	5.0e-07	NA	6.9e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.8	4.7	-0.8	-2.2	0.5	-0.0	-1.2	-1.1	-0.3	-0.1	0.0	-0.4
Bipolar Disorder or Schizophrenia	0.8	2.0	11.4	-0.1	-3.4	-1.1	1.1	-0.0	0.1	1.3	0.5	0.8	-1.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	0.5	1.4	-0.7	0.4	1.3	1.3	0.4	0.4	0.6	-0.2
Depression (Nagel 2018)	0.8	1.2	5.7	-0.1	2.4	1.1	0.2	-0.6	-0.6	-0.6	1.7	-0.0	1.2
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.5	-0.0	-1.9	0.2	-0.5	-0.8	-0.8	-0.3	-0.8	-1.0	0.4
Neuroticism (Nagel 2018)	0.3	0.7	2.0	0.5	0.5	-1.2	0.5	1.4	1.3	0.9	0.0	0.5	-0.5
Schizophrenia (2018)	1.1	2.3	6.7	0.5	-2.6	-1.8	1.4	0.9	1.0	1.9	0.7	1.1	-2.0
Schizophrenia vs Biploar Disorder	0.2	0.3	1.4	1.2	0.3	0.1	-0.3	-0.1	-0.1	-0.2	-0.4	-1.0	0.4
Worry (Nagel 2018)	1.4	2.9	4.8	1.4	-0.3	-2.2	1.6	2.2	2.1	2.0	1.0	1.6	-1.8
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	1.2	0.1	-1.0	0.8	1.1	1.1	0.9	0.4	1.1	-0.9
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.0	0.2	0.2	0.4	-0.4	0.6	-0.2
Alzheimer’s Disease (including proxy)	1.0	1.4	3.2	0.6	-0.9	-1.5	1.3	0.7	0.7	1.6	0.5	1.8	-1.5
Crohns Disease (2017)	1.8	4.0	7.3	1.3	-0.7	-2.0	2.7	1.4	1.6	2.2	2.4	2.7	-2.1
Irritable Bowel Disease (IBD)	0.5	1.3	3.8	0.7	-0.6	-0.6	1.8	0.0	0.2	1.1	2.0	1.5	-1.0
Ulcerative Colitis (UC)	0.3	0.5	1.6	-0.2	-0.7	0.8	0.0	-1.3	-1.1	-0.4	0.4	-0.4	0.5
Major Depression (MDD)	0.6	0.7	2.7	-1.0	1.6	0.1	-0.8	0.4	0.3	-0.2	-1.0	-0.5	1.0
Reaction Time	0.6	1.2	5.0	0.5	1.8	-0.1	1.3	0.5	0.5	0.2	2.2	1.0	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	0.2	-1.0	0.6	-0.9	-0.8	-0.8	-0.6	-1.1	-1.2	0.6
Breast Cancer	0.5	1.2	5.4	2.3	-0.6	-0.2	-0.9	1.2	1.1	0.0	-1.6	0.1	-0.2
Ovarian Cancer	0.0	0.0	0.1	0.1	0.3	0.2	0.0	0.1	0.0	-0.1	0.3	-0.0	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.0	1.4	7.2	-1.2	-2.7	-1.2	0.2	-0.4	-0.7	1.0	-1.0	-0.2	-1.0
Bipolar Disorder (2011)	3.4	3.3	6.9	1.4	-1.5	-1.5	2.4	0.6	0.9	1.9	2.4	2.6	-1.9
Body Mass Index (BMI) (2010)	2.8	3.8	5.7	-2.4	0.9	2.3	-1.8	-2.2	-2.3	-2.2	-0.9	-1.8	2.0
Coronary Artery Disease (CAD)	2.2	2.6	6.9	1.4	-2.6	-2.1	1.2	1.1	1.2	2.2	-0.2	1.4	-1.4
Crohns Disease (2012)	2.8	4.4	6.2	2.4	-1.0	-2.3	2.1	2.1	2.2	2.3	1.3	2.5	-2.2
Mean Putamen Volume	0.5	0.6	1.5	0.2	0.2	-0.9	-0.2	1.2	1.2	0.8	-1.2	-0.3	-0.1
Fasting Glucose	0.2	0.3	0.9	0.2	-0.4	0.3	0.5	-0.4	-0.5	-0.2	0.9	0.9	-0.4
HbA1C	0.3	0.3	1.2	-0.9	-1.1	0.1	-0.0	-0.6	-0.5	0.1	-0.3	0.0	-0.5
HDL Cholesterol	0.5	0.8	1.5	0.9	-1.2	-1.2	0.5	0.9	0.7	1.1	-0.4	0.7	-0.9
LDL Cholesterol	0.3	0.4	1.5	-1.2	0.2	0.5	-0.8	-0.4	-0.4	-0.4	-0.9	-0.4	0.5
Lupus	0.5	0.8	2.3	-1.0	0.7	0.8	-0.2	-1.5	-1.5	-0.5	0.4	0.0	0.8
Neuroticism (2016)	0.7	1.1	4.9	-0.5	2.2	0.7	-1.1	-0.0	-0.0	-0.9	-1.0	-0.6	1.3
Primary Biliary Cirrhosis	0.4	0.6	1.0	-0.6	0.6	1.0	-0.7	-0.9	-0.9	-0.9	-0.4	-0.8	0.8
Rheumatoid Arthritis	0.7	0.9	2.3	-1.4	1.5	0.8	0.3	-1.0	-0.9	-0.6	1.3	0.1	0.1
Schizophrenia (2014)	1.1	2.5	12.4	-0.4	-3.5	-1.9	0.9	0.4	0.5	1.8	-0.4	0.4	-2.0
Triglycerides	1.1	1.8	4.4	0.1	0.2	-1.1	1.6	1.1	1.1	1.4	1.9	2.1	-1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	0.7	-0.2	-0.4	1.1	0.9	1.0	0.3	1.4	1.0	-0.8
Ulcerative Colitis	0.3	0.5	2.9	1.0	-1.7	-0.0	0.2	-0.6	-0.6	0.1	0.1	-0.3	-0.3
Blood Eosinophil Count	3.3	25.7	38.2	3.2	-4.6	-6.0	5.8	4.5	4.7	5.9	3.8	5.1	-6.2
Blood Platelet Count	0.2	2.6	7.7	2.8	-0.4	-1.5	0.9	2.5	2.4	1.3	0.2	0.9	-0.6
Blood Red Count	0.3	3.2	4.8	2.0	0.0	-1.4	2.0	1.9	2.0	1.6	2.2	2.1	-1.6
Blood White Count	4.3	32.2	50.0	-2.8	6.7	6.9	-6.1	-4.7	-4.9	-7.1	-3.1	-5.8	6.7
Heel T-Score	0.7	5.7	9.1	1.3	-2.9	-2.8	2.9	0.9	1.0	3.0	1.9	2.7	-3.0
BMI	0.8	4.4	7.4	-1.9	2.7	2.7	-2.1	-1.6	-1.6	-2.5	-0.9	-1.8	2.5
Height	0.1	2.0	7.5	0.8	-1.7	0.4	-1.9	-0.4	-0.5	-0.8	-2.7	-2.1	0.7
Waist Hip Ratio (WHR)	1.3	5.8	9.1	1.8	-2.1	-2.2	3.0	1.9	2.0	2.5	2.7	3.0	-2.4
Systolic Blood Pressure	0.2	1.2	2.8	0.9	0.7	-1.1	1.0	1.0	1.0	1.1	0.7	1.7	-1.3
Smoking Status	1.6	3.9	6.1	1.3	0.8	-1.7	2.2	2.3	2.4	1.7	2.4	2.5	-1.5
Allergy or Eczema	2.4	6.4	22.4	0.8	-4.7	-3.1	1.8	1.9	2.0	3.1	-0.3	1.6	-2.8
Cardiovascular Disease	0.0	0.2	0.9	-1.0	0.6	-0.1	0.2	0.1	0.1	0.1	0.2	0.3	-0.4
Hypothyroidism (self reported)	4.0	9.2	13.7	2.3	-0.9	-3.0	3.7	3.0	3.1	3.1	3.3	3.5	-3.4
Respiratory disease	3.6	8.1	11.0	2.9	-2.3	-3.1	2.8	2.9	3.0	3.3	1.7	3.3	-2.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-0.8	-0.1	0.7	-0.5	-1.2	-1.2	-0.8	-0.1	-1.3	0.6
Lung FEV1/FVC ratio	0.3	1.7	3.0	0.6	0.3	1.6	-1.7	-1.0	-1.1	-1.6	-1.6	-1.3	1.2
Lung FVC	1.7	8.8	14.2	-1.5	1.0	3.5	-3.8	-2.9	-3.0	-3.5	-3.1	-2.5	3.5
Neuroticism	0.2	0.5	1.9	0.1	1.4	-0.5	0.0	1.1	1.1	0.3	0.1	0.2	0.1
Chronotype (morning person)	0.7	1.6	4.3	1.1	-0.2	1.1	-1.7	-0.2	-0.3	-1.3	-2.1	-1.4	1.7
Hair Pigment	0.0	0.4	1.1	-0.4	0.8	0.9	0.2	-0.6	-0.6	-0.7	1.1	0.2	0.3
Tanning	0.0	0.3	0.6	0.6	0.5	0.1	-0.5	0.4	0.4	-0.6	-0.4	-0.5	0.8
Hand grip strength (left)	0.8	2.1	4.2	-0.8	2.0	2.1	-1.5	-1.2	-1.2	-1.8	-0.7	-0.4	1.7
Number of treatments/medications taken	0.3	0.5	2.6	0.9	0.1	0.0	0.9	-0.1	-0.0	-0.1	1.6	0.3	-0.6
Average weekly spirits intake	0.6	0.7	1.9	0.6	-0.1	-0.9	1.0	0.7	0.7	0.7	1.0	0.5	-1.4
Sensitivity / hurt feelings	0.1	0.3	0.7	0.5	-0.0	-0.2	-0.2	0.9	0.8	0.1	-0.4	-0.0	0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	0.8	1.3	-0.1	0.8	0.7	0.7	0.3	1.5	0.7	0.2
Hearing difficulty/problems: Yes	0.2	0.2	1.0	1.0	0.4	0.0	0.4	0.1	0.1	0.2	0.7	0.6	-0.2
Relative age of first facial hair	0.7	1.4	2.7	-0.0	-1.6	-1.4	1.2	1.3	1.3	1.5	0.4	1.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.5	-0.1	1.1	1.1	-1.2	-0.4	-0.4	-1.1	-1.0	-1.1	1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.0	0.3	0.2	-0.1	-0.2	1.0	1.0	-0.1	-0.0	-0.4	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	-1.0	1.3	0.7	-0.3	-0.7	-0.7	-0.6	0.3	-0.8	0.8
Systolic blood pressure, automated reading	0.1	0.3	2.1	0.8	1.5	0.3	0.1	0.1	0.1	-0.2	0.4	0.3	0.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.1	-0.3	0.1	1.4	-1.1	-1.2	-1.2	-1.5	-0.3	-1.4	1.3
Angina	0.6	0.8	3.7	-1.9	0.8	-0.1	0.4	-0.5	-0.5	0.4	0.8	1.3	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.5	0.7	0.1	-0.3	0.3	0.6	0.5	0.1	0.4	0.6	-0.7
Vitamin and mineral supplements	1.0	1.3	4.0	0.7	-0.3	-1.0	1.9	0.1	0.2	1.2	2.0	0.9	-1.3
Supplements: Zinc	1.7	1.8	4.3	0.7	-0.9	-1.0	1.8	0.4	0.5	1.4	2.1	2.1	-1.3
Medication: Co-codamol	0.3	0.4	0.8	0.7	-0.6	0.6	0.2	-0.8	-0.8	-0.6	0.9	-0.5	0.0
Medication: Metformin	0.2	0.2	0.4	0.4	-0.7	-0.5	0.6	-0.4	-0.4	0.4	0.5	-0.5	-0.4
Diabetes (father)	1.4	1.7	3.4	-0.7	-0.8	-1.6	1.5	0.8	0.8	1.8	1.0	1.6	-1.6
Diabetes (mother)	0.5	0.6	2.2	1.3	0.6	-0.2	1.0	0.3	0.4	0.3	1.5	0.7	-0.3
Severe depression (siblings)	0.6	0.7	3.8	0.4	0.1	0.1	-1.2	0.4	0.3	-0.4	-1.9	-0.6	0.7
Pack years adult smoking proportion	0.4	0.6	1.3	0.9	1.1	0.4	-0.5	1.1	1.1	-0.4	-0.4	-0.1	0.8
Impedance of leg (right)	7.6	36.8	52.5	4.4	-5.1	-7.0	7.2	4.8	5.1	7.2	5.3	6.5	-7.0
Leg fat-free mass (left)	3.2	16.7	25.9	-2.2	3.1	4.8	-5.1	-3.2	-3.3	-4.9	-4.1	-4.6	4.6
Trunk fat percentage	0.3	1.1	2.8	0.7	0.0	-0.9	1.6	0.5	0.6	1.1	1.7	0.9	-1.3
Hand grip strength (right)	0.5	1.3	2.2	-0.9	1.3	1.5	-1.2	-1.1	-1.2	-1.2	-0.8	-0.7	1.3
Townsend deprivation index at recruitment	0.4	0.6	2.4	0.9	-0.0	-0.0	1.0	0.0	0.1	0.1	1.6	1.1	-0.1
Current tobacco smoking	0.5	0.8	1.6	1.3	0.5	-0.7	0.9	1.1	1.2	0.7	1.0	1.0	-0.5
Average weekly fortified wine intake	2.9	3.3	5.8	0.3	0.6	2.4	-2.2	-2.0	-2.0	-2.3	-1.6	-1.3	2.2
Maternal smoking around birth	0.8	1.1	4.1	-0.2	1.3	-0.4	1.3	0.1	0.1	0.6	2.0	1.6	-0.5
Fed-up feelings	0.3	0.5	2.7	-1.1	1.6	-0.5	0.5	0.3	0.2	0.4	0.6	0.3	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	5.0	1.2	0.7	-0.5	1.5	0.9	0.9	0.9	2.2	1.1	-0.6
Relative age voice broke	3.5	5.3	10.1	1.7	-3.2	-2.6	2.9	1.7	1.8	2.8	2.0	2.0	-1.7
Taking other prescription medications	1.6	2.4	9.6	0.7	-0.5	-0.9	2.4	0.6	0.7	1.2	3.1	1.5	-1.6
Age when periods started (menarche)	1.2	2.9	7.9	2.1	-2.8	-1.7	1.6	1.0	1.1	1.6	0.8	1.2	-2.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	4.9	-2.2	0.4	-0.1	-0.2	-0.4	-0.4	0.1	-0.3	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.4	1.0	0.4	-1.6	1.5	1.0	1.0	1.5	1.2	0.8	-1.2
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.4	1.5	0.7	-0.2	0.8	1.2	1.3	0.2	1.5	1.8	-0.5
Qualifications: CSEs or equivalent	3.8	5.0	7.8	0.6	-0.1	-2.8	2.5	2.4	2.4	2.8	1.9	2.6	-2.4
Serious illness, injury or assault to yourself	0.5	0.6	1.1	0.2	-0.4	0.8	-0.0	-1.0	-1.0	-0.7	0.8	-0.9	0.7
High blood pressure	0.3	1.0	2.5	-1.5	1.6	1.1	-0.3	-1.0	-1.0	-0.9	0.5	-0.0	0.4
Hayfever, allergic rhinitis or eczema	2.4	5.3	16.4	1.1	-4.1	-2.6	1.9	1.9	2.0	2.7	0.6	1.9	-2.6
Multivitamins +/- minerals	0.8	1.1	2.2	-0.6	0.1	1.4	-1.5	-0.7	-0.7	-1.4	-1.2	-0.5	1.3
Stomach or abdominal pain in last month	0.5	0.7	1.4	-0.0	0.2	-0.8	0.9	0.8	0.8	0.8	0.9	1.2	-1.1
Supplements: Glucosamine	1.6	2.1	3.8	-1.3	-1.2	1.0	-1.4	-2.0	-2.0	-1.2	-1.6	-1.4	0.9
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.0	-2.0	-0.6	1.1	-1.1	-1.9	-1.9	-0.9	-0.9	-1.7	1.1
Medication: Atenolol	0.3	0.4	1.1	0.9	1.1	0.7	0.0	-0.3	-0.3	-0.6	0.9	-0.3	0.5
Medication: Levothyroxine sodium	1.5	2.5	4.5	1.8	0.7	-1.0	1.8	1.8	1.8	1.1	2.1	1.7	-1.4
Sitting height	1.2	8.6	18.7	-0.1	0.5	2.9	-4.2	-1.6	-1.9	-3.2	-4.3	-3.9	3.1
Chronic bronchitis/emphysema (father)	2.7	3.2	4.9	1.3	-1.1	-2.1	2.2	1.6	1.6	2.1	1.7	1.9	-2.0
High blood pressure (mother)	0.5	0.8	3.0	-1.7	0.1	0.7	-0.9	-1.0	-1.1	-0.6	-0.7	0.1	0.5
Body mass index (BMI)	0.6	2.8	7.9	-1.3	2.8	2.1	-1.2	-1.4	-1.3	-2.0	-0.1	-1.2	1.7
Impedance of leg (left)	6.9	33.7	49.5	4.1	-4.6	-6.8	7.0	4.7	4.9	7.0	5.2	6.2	-6.6
Leg predicted mass (left)	3.1	16.5	25.7	-2.2	3.1	4.7	-5.1	-3.1	-3.3	-4.9	-4.1	-4.6	4.5
Trunk fat mass	0.0	0.1	0.7	0.4	0.8	0.3	0.3	-0.1	-0.0	-0.1	0.6	-0.2	-0.2
Waist circumference	0.2	0.9	2.1	-0.4	1.2	1.4	-0.5	-1.1	-1.0	-1.2	0.4	-0.7	0.9
Number of incorrect matches in round	0.4	0.6	2.0	-0.9	1.4	0.3	-0.8	-0.4	-0.5	-0.6	-0.8	-1.1	0.3
Past tobacco smoking	1.4	2.7	6.1	-1.5	-0.1	1.2	-1.8	-1.6	-1.7	-1.2	-2.1	-2.5	1.4
Alcohol usually taken with meals	0.7	1.2	4.7	-1.6	-2.2	-0.6	-0.7	-0.3	-0.4	0.4	-1.6	-0.9	0.2
Nervous feelings	1.1	2.0	3.6	1.6	-0.6	-1.9	1.4	1.3	1.3	1.9	0.7	1.1	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	0.3	0.6	-0.2	-0.4	0.8	0.6	-0.0	-0.6	0.1	0.4
Hearing difficulty/problems with background noise	0.8	1.3	2.2	0.6	-0.7	-1.5	0.5	1.5	1.5	1.4	-0.6	1.2	-1.4
Hair/balding pattern: Pattern 2	0.6	0.8	1.5	1.0	0.2	1.2	-0.6	-1.1	-1.1	-1.2	0.0	-0.2	0.7
Had menopause	0.7	0.8	2.0	0.1	1.1	1.0	-0.9	-0.4	-0.4	-1.2	-0.3	-1.4	1.2
Had other major operations	0.2	0.3	1.3	-0.1	0.0	-0.2	0.8	0.3	0.3	0.3	1.1	0.8	-0.4
Forced vital capacity (FVC)	0.6	2.3	6.7	-1.5	-0.7	1.1	-2.1	-1.3	-1.4	-1.2	-2.6	-1.3	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.7	1.1	0.2	-1.0	1.3	0.4	0.5	1.0	1.1	0.7	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	1.4	0.5	-0.5	0.0	1.2	1.2	0.4	-0.4	0.5	0.2
Qualifications: None of the above	2.0	4.2	20.6	2.0	2.2	-0.3	2.6	0.7	0.8	0.4	4.5	1.8	-1.2
Financial difficulties in last 2 years	0.8	1.1	6.5	0.5	0.7	-0.2	1.5	-0.1	-0.0	0.5	2.6	1.1	-0.4
Mouth/teeth dental problems	0.4	0.7	2.7	0.3	-1.2	-0.0	-1.0	-0.1	-0.1	-0.3	-1.7	-1.2	0.2
Heart attack	0.8	1.1	1.7	-0.7	1.3	1.2	-1.3	-0.6	-0.7	-1.3	-0.8	-0.9	1.2
Allergy	4.0	9.2	13.5	-1.8	3.7	3.5	-3.0	-3.0	-3.1	-3.6	-1.6	-3.0	3.3
Pain all over the body in last month	1.5	1.6	4.1	1.4	-1.6	-0.7	1.6	0.3	0.5	0.9	2.0	1.3	-1.2
Diabetes (self-reported)	1.2	1.8	4.5	-1.8	0.1	1.1	-0.7	-1.8	-1.8	-1.2	-0.1	-2.1	0.7
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	6.2	1.4	-2.5	-2.0	1.3	1.7	1.7	2.0	0.3	1.1	-1.5
Medication: Ramipril	1.2	1.5	2.6	-1.6	1.5	1.4	-0.9	-1.4	-1.4	-1.4	-0.0	-0.4	1.0
Medication: Simvastatin	0.8	1.2	3.4	-1.5	-0.4	0.8	-0.6	-1.8	-1.8	-0.7	-0.5	-0.8	0.3
Fluid intelligence score	0.5	1.1	6.0	0.4	-2.4	-1.1	0.0	0.5	0.5	1.1	-1.3	-0.1	-0.8
Illnesses of siblings	0.3	0.4	1.9	1.4	-0.7	0.5	-0.5	-0.2	-0.2	-0.7	-0.4	-0.8	-0.0
Neuroticism score	0.2	0.4	0.7	0.8	0.2	-0.6	0.6	0.8	0.7	0.6	0.7	0.9	-0.1
Weight	0.9	4.3	6.5	-1.1	2.3	2.5	-2.3	-1.6	-1.6	-2.5	-1.5	-2.4	2.2
Impedance of arm (right)	4.0	18.5	29.3	2.5	-4.5	-5.4	4.8	3.6	3.7	5.4	2.7	3.9	-5.3
Arm fat percentage (right)	0.1	0.6	2.0	-0.1	0.7	-0.5	1.2	0.2	0.4	0.6	1.4	0.3	-0.9
Trunk fat-free mass	2.2	12.5	21.7	-1.3	2.6	4.1	-4.7	-2.3	-2.5	-4.3	-3.8	-4.0	4.0
Hip circumference	0.6	2.7	4.0	-1.4	1.2	2.0	-1.6	-2.0	-2.0	-1.8	-0.9	-1.8	1.5
Time employed in main current job	0.6	0.7	1.4	-0.3	-0.4	-1.1	0.5	1.1	1.1	1.2	0.0	1.0	-0.7
Alcohol intake versus 10 years previously	1.3	1.9	5.0	2.2	-1.0	-1.1	1.4	1.4	1.5	1.1	1.3	1.2	-1.1
Father’s age at death	2.3	3.1	6.1	1.0	0.0	2.2	-2.0	-1.3	-1.4	-2.5	-1.0	-2.3	2.3
Worrier / anxious feelings	0.2	0.4	1.5	1.2	0.1	-0.8	0.3	0.8	0.8	0.6	-0.1	0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.0	0.8	-0.5	-1.7	1.4	1.4	1.4	1.6	0.8	1.0	-1.6
Falls in the last year	2.1	2.9	7.7	-1.5	0.5	1.8	-0.9	-2.8	-2.7	-1.7	-0.0	-1.9	1.0
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-1.1	0.0	-0.8	0.4	-0.3	-0.2	0.8	-0.0	-0.5	-0.7
Number of live births	0.4	0.5	2.2	-0.7	-0.1	-0.2	1.0	-0.5	-0.4	0.5	1.5	0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	6.8	-1.4	-0.3	1.5	-2.2	-1.4	-1.5	-1.5	-2.6	-1.4	1.6
Pulse rate	0.7	1.2	3.3	-1.8	0.1	1.3	-0.9	-1.2	-1.2	-1.1	-0.4	-0.9	1.0
Happiness	0.3	0.3	1.2	1.1	-0.2	-0.0	-0.6	0.6	0.6	-0.0	-1.0	0.1	0.0
Noisy workplace	1.6	2.0	4.0	2.0	0.9	-1.1	1.6	1.4	1.5	0.9	1.6	1.3	-1.6
Qualifications: A levels/AS levels or equivalent	2.0	4.5	8.9	-3.0	-1.0	1.9	-2.3	-2.4	-2.4	-1.7	-2.5	-1.4	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	4.9	-0.7	-0.5	-1.2	1.9	0.2	0.3	1.6	2.2	2.1	-1.7
Mouth/teeth dental problems: Dentures	1.8	3.0	6.9	0.3	0.8	-1.4	2.1	1.7	1.8	1.6	2.3	2.6	-1.5
Asthma	4.6	9.0	14.3	2.5	-2.0	-3.2	3.0	3.3	3.4	3.4	2.0	3.8	-2.9
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.2	0.2	0.2	0.1	-0.0	-0.4	-0.4	-0.1	0.0	-0.2	-0.0
Medication: Cholesterol lowering	0.4	0.6	2.0	-0.9	-0.8	0.2	-0.3	-1.4	-1.4	-0.2	-0.4	-0.0	-0.3
Depression (self-reported)	0.2	0.2	0.8	-0.9	0.2	0.2	-0.1	-0.9	-0.8	-0.2	-0.0	-0.4	-0.0
Medication: Lansoprazole	0.8	0.9	3.3	0.8	1.8	0.8	0.4	-0.3	-0.3	-0.8	1.8	-0.2	0.2
Prospective memory result	0.2	0.3	0.8	-0.1	0.4	-0.3	0.7	-0.3	-0.3	0.2	0.9	0.8	-0.6
Lung cancer (father)	0.1	0.1	0.4	0.6	0.3	0.1	0.2	-0.1	-0.1	-0.2	0.7	-0.3	0.3
Illnesses of mother	0.5	0.6	2.1	1.4	0.0	0.2	-0.8	0.6	0.5	-0.4	-1.1	-0.8	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	9.1	-2.3	0.4	2.8	-3.0	-2.7	-2.8	-2.6	-2.8	-2.3	2.6
Pulse wave Arterial Stiffness index	0.6	0.6	1.7	-0.1	1.3	1.3	-0.5	-0.7	-0.6	-1.1	0.2	-0.5	0.8
Impedance of arm (left)	3.0	13.7	22.0	1.8	-3.8	-4.7	4.2	3.0	3.1	4.7	2.4	3.6	-4.6
Arm fat mass (right)	0.2	0.9	3.2	-0.6	1.8	1.1	-0.5	-0.7	-0.7	-1.0	0.2	-1.0	0.7
Trunk predicted mass	2.2	12.5	21.5	-1.2	2.6	4.2	-4.6	-2.4	-2.6	-4.3	-3.8	-4.1	4.0
Standing height	0.3	3.1	10.0	0.5	-0.8	1.3	-2.5	-0.9	-1.0	-1.5	-3.2	-2.5	1.3
Length of working week for main job	0.1	0.1	0.5	0.2	-0.4	-0.3	-0.1	-0.0	-0.0	0.2	-0.7	0.1	-0.7
Exposure to tobacco smoke at home	0.9	1.0	2.7	-0.3	-0.9	-0.7	1.3	-0.1	-0.0	1.2	1.3	1.6	-0.9
Breastfed as a baby	0.3	0.3	0.8	0.5	0.2	0.9	-0.6	-0.6	-0.6	-0.8	0.0	0.2	0.7
Tense / ‘highly strung’	2.7	4.4	7.7	0.4	-1.9	-2.8	2.4	1.8	1.9	2.6	1.6	2.3	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.3	0.7	0.1	-0.9	0.4	1.1	1.1	0.9	-0.2	1.5	-0.7
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	0.9	-0.3	-0.4	0.2	0.9	0.9	0.3	0.1	0.1	0.2
Birth weight of first child	0.8	1.4	8.4	0.1	-0.2	0.2	-1.7	0.1	-0.0	-0.4	-2.9	-1.4	0.7
Peak expiratory flow (PEF)	0.3	0.6	1.5	-0.0	0.4	1.2	-1.1	-0.5	-0.6	-1.1	-0.8	-0.4	0.9
Pulse wave reflection index	1.2	1.5	2.9	-1.1	1.2	1.5	-1.3	-1.0	-1.0	-1.5	-0.6	-0.6	1.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	0.9	0.3	-0.4	-0.3	0.4	0.4	0.2	-0.9	0.2	-0.2
Loud music exposure frequency	0.4	0.4	3.1	-1.8	0.5	-0.4	0.5	-0.2	-0.2	0.3	0.6	-0.2	-0.0
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	6.3	-1.6	-1.0	0.8	-1.8	-0.9	-1.0	-0.8	-2.5	-1.4	1.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	-0.2	-0.0	-0.4	0.1	0.1	0.1	0.2	-0.1	-0.3	-0.2
Blood clot in the leg (DVT)	1.7	2.2	4.4	-0.3	-0.1	-1.2	1.9	1.3	1.3	1.5	2.1	1.8	-1.8
Medication: Paracetamol	0.3	0.6	1.9	-0.2	1.3	0.8	0.3	-0.6	-0.6	-0.6	1.4	-0.0	0.5
Headache pain in last month	0.8	1.4	3.2	-0.1	-0.1	-1.8	1.2	1.3	1.3	1.7	0.3	1.0	-1.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.3	1.2	0.2	-0.8	0.9	1.5	1.5	1.0	0.9	0.6	-0.3
Glaucoma (self-reported)	0.4	0.4	1.1	1.1	1.0	-0.1	-0.3	0.7	0.7	-0.2	-0.4	-0.9	0.4
Gout (self-reported)	0.3	0.5	1.7	1.2	1.3	0.2	-0.3	0.8	0.8	-0.4	0.0	-0.2	0.2
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	12.5	1.7	0.2	-2.2	3.3	2.6	2.8	2.5	3.5	3.1	-2.8
Medication: Amlodipine	0.2	0.2	0.5	-0.0	0.7	0.0	-0.3	0.7	0.6	-0.1	-0.3	-0.4	0.6
Medication: Ventolin 100micrograms inhaler	2.5	3.3	6.8	1.8	-0.4	-1.3	2.0	2.0	2.1	1.5	2.1	2.6	-1.3
Birth weight	6.1	13.2	20.7	-2.4	-0.1	3.7	-4.5	-3.6	-3.8	-3.9	-4.5	-4.1	3.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.3	-0.1	0.2	0.6	-0.3	-1.0	-1.0	-0.5	0.1	-1.5	1.1
High blood pressure (siblings)	1.3	1.9	3.2	-1.6	1.4	1.2	-1.7	-0.8	-0.9	-1.2	-1.7	-1.1	1.8
Forced vital capacity (FVC), Best measure	1.3	4.7	7.1	-1.9	-0.4	2.1	-2.6	-2.4	-2.5	-2.1	-2.7	-2.1	2.0
Body fat percentage	0.3	1.3	4.5	0.5	0.3	-0.8	1.9	0.4	0.5	1.1	2.1	1.1	-1.3
Leg fat percentage (right)	0.9	3.2	11.7	0.9	0.9	-1.0	2.7	0.7	0.8	1.4	3.4	2.0	-1.7
Arm fat-free mass (right)	2.1	10.7	16.6	-1.2	3.0	4.0	-4.0	-2.3	-2.4	-4.1	-2.9	-3.7	3.9
Exposure to tobacco smoke outside home	0.4	0.6	1.7	0.6	0.5	0.2	-1.0	0.6	0.5	-0.4	-1.3	-0.8	0.9
Comparative body size at age 10	0.8	2.3	4.3	-1.1	1.6	2.1	-1.7	-0.8	-0.8	-2.1	-0.8	-1.1	2.1
Number of full brothers	2.8	3.5	6.7	0.5	0.6	-1.9	1.8	2.4	2.4	1.9	1.4	2.6	-1.9
Worry too long after embarrassment	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.3	-0.2	-0.2	0.5	0.4	-0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.8	0.3	-1.0	-1.1	0.3	0.5	0.5	1.0	-0.4	0.9	-1.4
Wheeze or whistling in the chest in last year	2.3	4.2	11.1	2.7	0.6	-1.9	1.0	3.3	3.3	1.5	0.2	1.4	-1.8
Number of children fathered	0.6	0.7	2.5	-1.6	1.0	0.2	-0.5	-0.7	-0.7	-0.5	-0.4	-1.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.0	1.2	-0.3	-0.4	-0.4	0.8	0.8	0.4	-1.4	0.1	-0.1
Age at first live birth	1.7	3.0	5.6	-1.2	-0.3	1.7	-1.9	-2.3	-2.4	-1.8	-1.6	-1.7	1.6
Pulse wave peak to peak time	0.4	0.5	1.5	0.2	-1.2	-1.1	0.3	0.6	0.6	1.0	-0.4	0.3	-0.7
Health satisfaction	4.4	5.7	8.8	1.5	0.2	-2.6	2.6	2.6	2.7	2.4	2.3	2.6	-3.0
Shortness of breath walking on level ground	1.3	1.5	9.0	-0.5	3.0	1.2	-0.4	-0.6	-0.6	-1.4	1.0	-0.5	0.9
Qualifications: College or University degree	5.3	16.8	39.9	-2.5	-0.8	3.4	-5.6	-3.1	-3.4	-3.8	-6.3	-5.1	4.1
Eye problems/disorders: None of the above	0.8	0.9	3.1	0.7	0.7	-0.9	0.2	1.8	1.7	0.7	-0.3	0.8	-0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	0.5	-0.0	-0.8	0.8	1.1	1.1	0.7	0.8	1.1	-0.7
Emphysema/chronic bronchitis	0.3	0.3	1.3	0.6	0.7	0.3	-0.6	-0.1	-0.1	-0.6	-0.5	-1.2	0.6
Medication for pain relief, constipation, heartburn	0.6	1.1	2.6	1.1	-0.6	-1.2	0.2	1.6	1.6	1.0	-0.6	0.6	-0.7
Neck or shoulder pain in last month	4.2	5.9	8.9	1.8	-2.0	-2.6	2.3	2.6	2.6	2.9	1.2	3.0	-2.8
Medication: Blood pressure	1.2	2.1	4.5	-0.4	1.3	2.0	-1.7	-1.3	-1.3	-2.1	-0.8	-1.1	1.5
Angina (self-reported)	0.8	1.0	4.5	-2.1	0.8	-0.1	0.5	-0.7	-0.7	0.5	0.9	1.4	-0.8
Migraine (self-reported)	0.6	0.7	2.0	0.5	0.0	-1.1	0.8	1.4	1.4	0.8	0.4	0.8	-0.2
Medication: Ibuprofen	0.1	0.1	0.6	0.8	-0.5	0.2	0.1	-0.5	-0.5	-0.0	0.0	0.1	-0.1
Medication: Allopurinol	0.2	0.3	1.2	0.3	0.5	0.5	-0.5	-0.4	-0.5	-0.7	-0.2	-1.1	0.4
Medication: Omeprazole	0.2	0.2	1.3	-0.0	0.4	0.4	0.6	0.1	0.1	-0.1	1.2	0.6	0.3
Medication: Seretide 50 evohaler	5.0	5.8	9.3	1.8	-0.6	-2.5	2.5	3.0	3.0	2.5	1.9	2.8	-2.5
Mean time to correctly identify matches	0.3	0.5	2.0	0.9	1.3	0.3	0.6	0.1	0.2	-0.3	1.4	0.2	-0.3
Heart disease (mother)	0.4	0.5	2.1	-0.1	1.0	-0.1	0.9	-0.3	-0.2	0.4	1.5	0.7	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.5	1.0	-1.6	-1.3	1.3	0.9	1.0	1.2	0.8	1.2	-1.5
Whole body fat mass	0.1	0.5	2.2	0.1	1.5	0.9	-0.1	-0.6	-0.6	-0.8	0.6	-0.6	0.3
Leg fat mass (right)	0.1	0.5	2.6	0.2	1.6	0.7	0.4	-0.3	-0.3	-0.5	1.3	-0.0	0.2
Arm predicted mass (right)	2.2	11.1	18.1	-1.3	2.8	3.9	-4.3	-2.2	-2.4	-4.1	-3.3	-3.7	4.0
Pulse rate, automated reading	0.1	0.4	1.3	-0.7	-1.1	0.1	0.5	-0.8	-0.8	0.2	0.7	0.4	-0.1
Alcohol intake frequency.	3.0	6.9	12.3	0.2	-1.6	-3.5	3.3	2.4	2.5	3.5	2.4	2.4	-2.9
Comparative height size at age 10	0.4	2.1	5.0	-0.0	1.4	1.2	-2.2	0.1	-0.1	-1.4	-2.2	-2.2	1.1
Number of full sisters	1.2	1.5	8.2	-1.0	1.0	0.9	1.1	-0.8	-0.7	-0.4	2.9	1.1	0.1
Suffer from ‘nerves’	0.1	0.1	0.4	0.0	-0.3	-0.1	0.2	0.0	0.0	0.2	0.3	0.6	-0.5
Overall health rating	1.0	2.2	5.1	1.5	0.8	-1.1	1.9	1.4	1.5	1.2	2.2	1.1	-1.4
Chest pain or discomfort	0.4	0.5	1.4	1.1	0.1	-0.4	0.4	0.8	0.8	0.3	0.4	1.0	-1.2
Had major operations	0.3	0.3	2.0	-1.4	-1.0	-0.2	0.1	-0.2	-0.1	0.5	-0.0	0.4	0.0
Age at last live birth	1.0	1.5	2.4	-1.1	-0.1	1.1	-1.5	-1.5	-1.6	-1.2	-1.4	-0.9	1.0
Family relationship satisfaction	0.3	0.4	1.0	0.9	-0.0	-0.7	0.1	1.0	0.9	0.5	-0.5	0.4	-0.2
Leg pain on walking	0.2	0.2	1.0	-0.3	0.3	-0.1	-0.6	0.5	0.4	-0.0	-1.0	0.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	4.4	0.4	-0.4	-1.0	1.8	1.5	1.6	1.3	1.8	2.1	-1.3
Commuting to job workplace: Car/motor vehicle	2.3	2.6	4.9	-0.2	0.4	-1.8	1.7	1.8	1.8	2.2	1.2	2.2	-1.5
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	11.4	-1.4	0.4	1.4	-2.7	-0.8	-0.9	-1.7	-3.4	-1.8	1.8
Medication: Aspirin	3.4	4.5	9.3	-2.1	0.7	2.6	-1.7	-3.0	-3.0	-2.3	-0.7	-1.6	2.0
Supplements: Vitamin C	0.7	0.8	2.3	-0.3	0.2	0.8	-1.5	-0.2	-0.3	-0.9	-1.5	-0.8	1.0
Knee pain experienced in last month	0.5	0.8	6.6	-0.2	2.6	0.6	-0.1	-0.3	-0.3	-0.7	0.6	-0.4	0.4
Hypertension (Self-reported)	0.5	1.3	2.7	-1.6	1.5	1.4	-0.7	-1.2	-1.3	-1.2	0.1	-0.6	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.8	1.2	0.6	0.3	0.6	-0.1	0.0	-0.1	1.4	0.6	-0.0
Illnesses of father: Heart disease	0.3	0.4	1.8	-0.6	-1.3	-0.4	0.4	-0.6	-0.6	0.6	0.0	0.1	-0.6
Illnesses of siblings: Diabetes	0.8	1.0	2.5	-0.6	-0.6	-1.5	1.1	0.8	0.9	1.6	0.4	0.8	-1.2
Smoking status: Previous	0.7	1.1	3.1	0.5	0.3	-0.7	1.3	0.7	0.8	0.8	1.8	1.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	1.9	-1.0	0.3	0.7	-1.1	-1.0	-1.0	-0.8	-1.2	-1.4	0.8
Whole body fat-free mass	2.7	15.5	25.2	-1.7	3.1	4.6	-5.0	-2.8	-3.0	-4.8	-4.0	-4.5	4.5
Leg fat-free mass (right)	3.8	20.4	31.2	-2.7	3.4	5.2	-5.6	-3.5	-3.7	-5.3	-4.5	-5.2	5.1
Arm fat percentage (left)	0.1	0.5	1.8	-0.6	1.1	-0.1	0.9	-0.1	0.0	0.2	1.4	0.2	-0.5
Average weekly red wine intake	0.7	1.0	3.8	-1.9	-0.8	0.6	-1.1	-0.8	-0.8	-0.4	-1.4	-0.0	0.7
Handedness (chirality/laterality): Left-handed	1.1	1.4	8.1	2.8	-0.6	-0.4	-0.4	1.3	1.2	0.0	-1.3	-0.4	-0.3
Mood swings	0.4	0.8	1.7	0.0	1.3	0.6	-1.2	0.4	0.3	-0.9	-1.3	-0.5	1.2
Loneliness, isolation	0.1	0.2	1.1	-0.1	-1.0	-0.2	0.3	-0.4	-0.4	0.2	0.3	0.1	-0.2
Long-standing illness, disability or infirmity	0.6	0.9	1.6	1.2	0.1	-0.7	1.1	1.0	1.1	0.7	1.3	0.9	-0.8
Ever had bowel cancer screening	2.1	2.4	5.1	-0.9	-0.3	1.7	-2.2	-1.1	-1.1	-1.9	-2.3	-1.7	1.2
Diabetes diagnosed by doctor	0.5	0.8	2.1	-1.4	-1.1	-0.2	0.3	-1.3	-1.3	0.1	0.4	-0.8	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.5	-0.3	1.1	1.2	-0.5	-0.9	-0.8	-1.0	0.3	0.3	1.1
Friendships satisfaction	0.4	0.5	0.7	0.8	-0.8	-0.7	0.5	0.8	0.8	0.7	0.5	0.7	-0.3
Qualifications: nursing, teaching	0.9	1.3	4.9	-1.5	-1.8	-0.0	-1.0	-0.8	-0.8	0.1	-2.2	-0.8	-0.2
Commuting to job workplace: Walk	0.5	0.5	1.6	0.1	-1.3	0.8	-0.2	-1.1	-1.0	-0.7	0.2	-0.3	0.5
Eye problems/disorders: Cataract	0.8	0.9	2.9	-1.7	-1.1	0.5	-0.2	-1.5	-1.4	-0.3	0.0	-0.0	0.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.7	-2.0	1.4	1.6	-0.6	-2.2	-2.1	-1.4	0.5	-0.7	0.9
Medication for cholesterol	0.2	0.3	0.7	0.4	-0.8	-0.7	0.1	0.6	0.6	0.6	-0.5	0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	3.3	-1.5	-1.8	-0.6	1.2	-0.8	-0.8	0.7	1.5	1.0	-1.5
Back pain experienced in last month	0.7	1.1	1.8	1.0	-0.2	-0.7	1.2	1.0	1.1	0.7	1.3	1.2	-1.3
Mineral and other dietary supplements	2.2	3.0	6.2	0.5	0.3	-1.9	2.5	1.3	1.4	2.0	2.2	1.5	-2.2
Breast cancer (self-reported)	0.3	0.4	1.3	-1.1	-0.8	-0.1	0.5	-0.7	-0.6	0.2	0.5	-0.4	-0.3
Asthma (self-reported)	5.1	10.2	15.2	2.9	-2.0	-3.3	3.2	3.6	3.7	3.5	2.2	3.9	-3.0
Osteoporosis (self-reported)	0.1	0.1	0.7	0.4	-0.9	0.1	0.2	-0.1	-0.1	0.0	0.2	0.1	0.0
Osteoarthritis (self-reported)	0.4	0.5	1.5	0.2	-1.2	-0.8	0.8	0.4	0.5	0.7	0.3	0.5	-1.1
Medication: Aspirin	4.5	5.9	10.8	-1.7	0.6	3.1	-2.3	-3.3	-3.3	-2.9	-1.2	-1.9	2.4
Medication: Gliclazide	0.3	0.3	1.4	-1.2	-0.6	0.3	-0.3	-0.6	-0.6	-0.5	-0.4	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	3.3	1.4	0.7	0.5	0.6	-0.2	-0.2	-0.5	1.8	-0.3	0.5
Smoking status: Current	0.8	1.3	2.4	1.4	0.5	-0.9	1.0	1.5	1.6	0.8	1.1	1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	-0.1	0.5	1.5	-1.5	-0.6	-0.7	-1.4	-1.0	-0.4	1.3
Whole body water mass	2.6	15.0	24.4	-1.7	3.1	4.5	-4.9	-2.7	-2.9	-4.7	-4.0	-4.5	4.4
Leg predicted mass (right)	3.8	20.2	31.0	-2.6	3.4	5.1	-5.6	-3.5	-3.7	-5.2	-4.5	-5.1	5.1
Arm fat mass (left)	0.3	1.1	3.6	-0.9	1.9	1.3	-0.6	-0.9	-0.8	-1.2	0.1	-1.1	0.9
Number of self-reported non-cancer illnesses	2.7	4.7	8.9	1.0	-0.5	-2.0	2.7	1.8	1.9	2.1	2.8	3.0	-2.5
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.9	-0.9	0.0	-0.5	-0.7	-0.7	-0.1	-0.7	-1.0	0.2
Miserableness	0.4	0.7	3.2	1.5	1.8	0.1	-0.2	0.6	0.6	-0.4	0.1	-0.1	0.5
Guilty feelings	2.3	3.5	7.2	-1.0	1.4	2.0	-2.5	-1.0	-1.2	-2.0	-2.1	-2.0	2.7
Wears glasses or contact lenses	2.1	2.4	4.5	-0.3	1.4	1.6	-1.9	-0.9	-0.9	-1.9	-1.6	-2.1	2.0
Ever taken oral contraceptive pill	6.0	6.7	10.9	0.4	0.7	3.1	-3.3	-2.3	-2.4	-3.3	-2.5	-2.8	3.1
Hearing aid user	0.9	1.0	2.1	0.0	0.5	1.5	-1.3	-0.8	-0.8	-1.5	-1.0	-0.5	1.3
Mother’s age at death	0.9	1.1	1.7	-0.0	-0.9	1.2	-1.2	-1.1	-1.2	-1.1	-0.9	-1.3	1.1
Financial situation satisfaction	0.2	0.2	0.5	0.5	0.7	0.3	-0.7	0.4	0.3	-0.3	-0.6	0.2	0.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.1	1.5	-0.4	-1.3	0.9	1.3	1.3	1.1	0.4	0.9	-1.1
Commuting to job workplace: Public transport	1.7	2.0	3.2	0.0	-0.2	1.4	-1.7	-1.8	-1.8	-1.7	-1.5	-1.3	1.4
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	0.9	1.0	-0.4	0.7	0.5	0.6	0.3	1.0	-0.3	0.0
Medication: Blood pressure	0.5	1.0	3.3	-1.0	1.8	1.0	0.3	-0.8	-0.8	-0.7	1.7	0.1	0.6
Pain type(s) experienced in last month: Hip pain	1.3	1.6	5.0	-0.5	-0.0	-1.0	2.0	0.3	0.3	1.3	2.2	1.6	-1.2
Supplements: Fish oil (including cod liver oil)	3.9	5.2	12.4	-0.0	1.1	2.3	-3.5	-0.6	-0.7	-2.6	-3.5	-2.2	2.9
High cholesterol (Self-reported)	0.2	0.4	1.2	-0.0	-0.6	-0.8	0.8	0.0	0.1	0.9	0.4	0.6	-1.1
Medication: Bendroflumethiazide	0.5	0.7	1.4	-0.2	1.0	1.2	-1.0	-0.7	-0.7	-1.2	-0.3	-0.7	1.1
Medication: Paracetamol	0.2	0.3	0.9	-0.6	0.5	0.6	0.3	-0.7	-0.7	-0.4	0.9	0.1	0.3
Medication: Lisinopril	0.3	0.3	1.2	-0.8	-0.5	-0.1	0.8	-0.4	-0.3	0.2	1.1	0.0	-0.6
Medication: Atorvastatin	0.2	0.2	0.5	-0.2	0.5	0.5	-0.7	0.1	-0.0	-0.4	-0.7	-0.2	0.7
Illnesses of father: High blood pressure	0.6	0.7	3.4	-1.8	0.7	0.5	-0.8	-0.6	-0.7	-0.3	-1.1	0.2	0.3
Alcohol drinker status: Never	0.3	0.4	1.1	1.1	0.7	-0.2	0.3	0.9	0.9	0.1	0.5	-0.3	0.2
Ever smoked	1.7	3.0	5.7	2.1	-0.0	-1.5	1.5	2.2	2.3	1.3	1.4	2.4	-1.3
Basal metabolic rate	2.3	12.9	20.2	-1.7	3.0	4.2	-4.5	-2.6	-2.8	-4.4	-3.5	-4.1	4.1
Leg fat percentage (left)	0.7	2.6	10.2	0.7	1.3	-0.8	2.4	0.5	0.7	1.2	3.2	1.7	-1.3
Arm fat-free mass (left)	1.8	9.3	14.5	-0.9	2.7	3.7	-3.8	-2.1	-2.2	-3.8	-2.7	-3.5	3.6
Number of operations (self-reported)	0.8	1.1	3.2	-1.8	-1.2	-1.0	1.0	0.6	0.7	1.2	0.6	1.2	-0.8
Average weekly beer plus cider intake	0.6	0.8	3.4	0.6	1.8	1.0	0.2	-0.1	-0.1	-0.9	1.2	0.9	0.0
Irritability	0.3	0.5	1.1	-0.1	-0.1	0.6	-0.7	-0.7	-0.8	-0.9	-0.7	-1.0	0.7
Risk taking	1.5	2.2	3.5	-1.5	1.2	1.9	-1.7	-1.5	-1.6	-1.7	-1.2	-0.5	1.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	1.0	-0.9	-0.0	0.4	0.2	0.2	0.1	0.6	0.2	-0.2
Fractured/broken bones in last 5 years	1.6	2.0	3.9	0.8	-1.0	-1.4	2.0	0.8	0.9	1.4	1.8	1.6	-1.9
Age started oral contraceptive pill	1.2	1.5	4.7	-0.6	-0.4	0.8	-1.7	-0.3	-0.4	-0.9	-2.2	-1.8	1.3
Diastolic blood pressure, automated reading	1.8	5.5	9.0	-0.3	2.5	3.0	-2.3	-2.3	-2.3	-2.8	-1.1	-2.4	2.9
Ever depressed for a whole week	0.6	0.7	3.6	0.9	1.9	0.5	-0.3	0.7	0.7	-0.3	0.0	0.6	1.0
Unable to work because of sickness or disability	0.6	0.7	2.0	0.6	-0.0	-0.8	0.8	0.9	0.9	0.9	0.7	1.4	-0.9
Commuting to job workplace: Cycle	1.3	1.6	5.9	-1.6	-1.1	0.7	-1.7	-0.6	-0.7	-0.8	-2.4	-0.9	0.8
Myopia	0.2	0.3	0.6	0.7	0.5	0.1	-0.4	0.8	0.7	-0.1	-0.5	0.3	0.3
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.8	2.2	-1.3	-1.6	0.8	1.7	1.8	1.3	0.0	0.2	-0.7
Cholesterol lowering medication	0.0	0.0	0.4	0.1	0.6	0.1	-0.0	0.1	0.1	0.1	0.0	-0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.5	0.1	0.0	0.5	0.5	-0.2	-0.2	-0.3	1.2	0.3	0.1
Pain experienced in last month	2.2	3.6	6.1	-0.9	0.9	2.1	-2.1	-1.9	-2.0	-2.2	-1.5	-2.2	2.5
Supplements: Calcium	0.1	0.1	0.5	0.3	-0.7	0.1	-0.2	-0.1	-0.1	0.1	-0.3	0.4	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.8	1.4	0.8	0.0	-0.3	1.1	1.1	-0.2	-0.2	-0.0	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.0	-0.8	1.3	1.2	-1.4	-0.6	-0.7	-1.2	-1.2	-0.9	1.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.7	-0.6	-0.1	-0.9	1.6	1.0	1.0	1.2	1.9	1.6	-1.5
Heart disease (siblings)	1.4	1.8	3.6	-0.7	-1.9	-1.4	1.5	0.3	0.4	1.8	0.8	1.7	-1.6
Alcohol drinker status: Previous	1.5	1.7	5.3	-0.8	-0.3	-0.9	1.9	0.6	0.6	1.2	2.3	1.9	-1.0
Pack years of smoking	0.5	0.7	1.4	1.1	1.2	0.6	-0.7	1.0	1.0	-0.7	-0.4	-0.3	1.0
Impedance of whole body	4.9	24.9	37.8	3.1	-4.6	-6.0	6.0	3.9	4.1	6.2	4.0	5.0	-5.9
Leg fat mass (left)	0.1	0.5	2.9	0.1	1.7	0.6	0.4	-0.3	-0.3	-0.5	1.2	-0.1	0.2
Arm predicted mass (left)	1.6	8.2	12.7	-0.8	2.5	3.5	-3.6	-2.0	-2.1	-3.5	-2.7	-3.4	3.3