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chr1:73,798,439-75,701,824

Best TWAS P=2.1e-11 · Best GWAS P=5.04e-10 conditioned to 0.000342

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Colon Sigmoid	FPGT	0.26	0.13	enet	29	0.15	4.6e-06	5.5	-6.7	2.1e-11	-0.17	0.05	0.94	TRUE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TNNI3K	0.11	0.06	blup	159	0.07	4.8e-05	2.9	-6.1	1.4e-09	-0.59	0.04	0.75	TRUE
6	GTEx	Cells EBV-transformed lymphocytes	FPGT	0.31	0.22	lasso	3	0.25	1.3e-08	5.8	-6.1	8.6e-10	-0.16	0.03	0.96	FALSE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	FPGT	0.15	0.01	lasso	10	0.00	4.0e-01	5.8	-6.1	1.1e-09	-0.26	0.01	0.64	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	FPGT	0.10	0.07	enet	13	0.05	1.7e-03	5.8	-6.0	2.2e-09	-0.17	0.04	0.96	FALSE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	LRRIQ3	0.17	0.31	lasso	2	0.30	4.0e-18	5.9	-6.0	2.5e-09	-0.15	0.01	0.99	FALSE
5	GTEx	Artery Aorta	FPGT	0.18	0.20	lasso	4	0.17	8.5e-10	5.8	-6.0	2.6e-09	-0.17	0.03	0.97	FALSE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	LRRIQ3	0.29	0.23	enet	21	0.14	4.1e-05	5.8	-6.0	2.6e-09	-0.19	0.01	0.99	FALSE
12	GTEx	Lung	FPGT	0.08	0.05	enet	12	0.04	9.1e-04	5.8	-5.9	3.4e-09	-0.16	0.04	0.95	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRIQ3	0.24	0.36	enet	20	0.36	1.7e-21	5.8	-5.9	3.8e-09	-0.17	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRIQ3	0.29	0.40	lasso	5	0.40	4.1e-48	5.9	-5.9	4.3e-09	-0.17	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRIQ3	0.24	0.33	lasso	9	0.32	3.3e-37	5.9	-5.9	4.4e-09	-0.17	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LRRIQ3	0.20	0.26	lasso	8	0.24	1.9e-16	5.8	-5.9	4.5e-09	-0.16	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LRRIQ3	0.17	0.17	enet	8	0.16	2.6e-06	5.8	-5.9	4.6e-09	-0.17	0.01	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LRRIQ3	0.23	0.33	lasso	2	0.32	7.5e-40	5.9	-5.9	4.7e-09	-0.17	0.03	0.97	FALSE
22	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LRRIQ3	0.28	0.29	lasso	8	0.28	2.2e-14	5.8	-5.8	4.8e-09	-0.16	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	LRRIQ3	0.20	0.32	enet	19	0.31	1.4e-22	5.8	-5.9	4.8e-09	-0.16	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Soft Tissue Sarcoma	TNNI3K	0.15	0.08	lasso	3	0.07	5.0e-05	-5.3	-5.8	4.9e-09	-0.22	0.16	0.80	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LRRIQ3	0.24	0.30	enet	11	0.31	1.2e-35	5.9	-5.8	6.0e-09	-0.16	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	LRRIQ3	0.19	0.28	lasso	8	0.27	5.6e-56	5.8	-5.8	6.1e-09	-0.16	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRIQ3	0.29	0.44	enet	15	0.43	1.9e-49	5.9	-5.8	7.3e-09	-0.16	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRRIQ3	0.20	0.36	enet	15	0.35	1.9e-41	5.8	-5.7	9.4e-09	-0.16	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FPGT	0.35	0.50	enet	22	0.50	2.8e-70	5.9	-5.7	1.0e-08	-0.18	0.03	0.97	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	FPGT	0.19	0.18	enet	9	0.18	5.9e-07	5.5	-5.7	1.0e-08	-0.16	0.04	0.95	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRRIQ3	0.40	0.37	lasso	9	0.38	5.7e-23	5.8	-5.7	1.0e-08	-0.17	0.01	0.99	FALSE
10	GTEx	Esophagus Mucosa	FPGT	0.13	0.14	lasso	4	0.11	9.1e-08	5.8	-5.7	1.1e-08	-0.15	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Rectum Adenocarcinoma	LRRIQ3	0.27	0.24	blup	75	0.22	8.5e-06	5.9	-5.7	1.1e-08	-0.15	0.01	0.98	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	TNNI3K	0.18	0.17	enet	24	0.19	1.0e-23	-5.2	-5.7	1.4e-08	-0.20	0.47	0.53	FALSE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LRRIQ3	0.34	0.39	enet	32	0.39	1.1e-17	5.9	-5.7	1.4e-08	-0.15	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	LRRIQ3	0.13	0.20	lasso	8	0.20	4.3e-23	5.8	-5.6	1.9e-08	-0.15	0.01	0.99	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	LRRIQ3	0.22	0.29	enet	15	0.29	5.8e-37	5.8	-5.6	2.2e-08	-0.14	0.03	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	FPGT	0.19	0.18	enet	14	0.17	2.3e-09	5.5	-5.6	2.6e-08	-0.14	0.04	0.96	FALSE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LRRIQ3	0.11	0.09	blup	75	0.10	2.3e-05	5.9	-5.6	2.7e-08	-0.16	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	LRRIQ3	0.26	0.43	lasso	4	0.42	4.2e-44	5.9	-5.5	2.8e-08	-0.14	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FPGT	0.20	0.25	lasso	5	0.26	1.5e-11	5.8	-5.5	2.9e-08	-0.12	0.01	0.99	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	RP4-650F12.2	0.08	0.04	lasso	3	0.03	1.6e-04	-5.3	-5.5	3.1e-08	-0.18	0.11	0.88	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRIQ3	0.23	0.28	lasso	5	0.28	1.1e-23	5.8	-5.5	3.2e-08	-0.14	0.01	0.99	FALSE
11	GTEx	Heart Atrial Appendage	FPGT	0.10	0.09	lasso	13	0.08	1.5e-04	5.8	-5.5	3.6e-08	-0.14	0.05	0.91	FALSE
24	The Cancer Genome Atlas	Esophageal Carcinoma	LRRIQ3	0.22	0.16	blup	75	0.21	2.4e-07	5.8	-5.5	4.0e-08	-0.15	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	FPGT	0.16	0.16	lasso	7	0.16	1.6e-15	5.9	-5.5	4.1e-08	-0.14	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	FPGT	0.12	0.15	enet	10	0.15	2.6e-15	5.9	-5.5	4.4e-08	-0.16	0.01	0.99	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	FPGT-TNNI3K	0.09	0.05	enet	17	0.08	1.5e-10	-5.3	-5.4	5.2e-08	-0.11	0.21	0.79	FALSE
15	METSIM	Adipose	FPGT	0.06	0.06	lasso	6	0.07	1.0e-10	5.9	-5.4	7.4e-08	-0.13	0.03	0.97	FALSE
14	GTEx	Skin Sun Exposed Lower leg	FPGT	0.08	0.02	enet	12	0.04	2.5e-04	5.8	-5.3	1.2e-07	-0.20	0.04	0.92	FALSE
3	GTEx	Adipose Subcutaneous	FPGT	0.20	0.14	lasso	7	0.14	2.8e-11	5.8	-5.3	1.5e-07	-0.16	0.04	0.96	FALSE
7	GTEx	Cells Transformed fibroblasts	FPGT	0.19	0.06	lasso	6	0.13	9.6e-10	5.8	-5.2	1.8e-07	-0.12	0.03	0.97	FALSE