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chr1:92,924,057-94,534,354

Best TWAS P=1.74e-17 · Best GWAS P=5.67e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	GTEx	Testis	TMED5	0.27	0.31	lasso	5	0.30	6.9e-14	-8.6	8.5	1.7e-17	-0.99	0.01	0.99	TRUE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMED5	0.08	0.06	enet	12	0.07	3.5e-08	-8.6	8.5	2.2e-17	-0.86	0.01	0.99	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMED5	0.06	0.07	enet	20	0.09	6.7e-11	-7.2	8.4	6.0e-17	-0.93	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	DR1	0.16	0.18	blup	29	0.19	4.1e-18	-8.6	-8.3	6.6e-17	0.96	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DR1	0.05	0.05	blup	29	0.06	4.1e-07	-8.6	-8.3	9.8e-17	0.97	0.00	1.00	FALSE
75	The Cancer Genome Atlas	Glioblastoma Multiforme	TMED5	0.08	0.05	blup	39	0.03	4.7e-02	-8.6	8.3	1.1e-16	-0.99	0.01	0.73	FALSE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DR1	0.03	0.02	blup	29	0.02	3.2e-03	-8.6	-8.3	1.1e-16	0.98	0.00	0.96	FALSE
54	GTEx	Spleen	CCDC18	0.29	0.07	lasso	10	0.15	9.2e-05	-8.6	8.2	2.1e-16	-0.91	0.03	0.93	FALSE
69	YFS	Blood	DR1	0.11	0.17	lasso	17	0.19	2.0e-58	-7.7	-8.2	2.1e-16	0.94	0.03	0.97	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	DR1	0.10	0.09	blup	29	0.08	3.9e-09	-7.6	-8.2	3.0e-16	0.96	0.01	0.99	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	DR1	0.05	0.03	blup	29	0.03	1.3e-04	-7.2	-8.2	3.5e-16	0.89	0.01	0.92	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	DR1	0.03	0.03	blup	29	0.03	1.1e-04	-7.6	-7.9	2.0e-15	0.97	0.01	0.98	FALSE
28	GTEx	Cells Transformed fibroblasts	TMED5	0.10	0.11	lasso	3	0.09	4.6e-07	-8.6	7.9	2.5e-15	-0.96	0.02	0.98	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	DR1	0.04	0.04	lasso	3	0.04	1.5e-08	-7.7	-7.9	3.3e-15	0.96	0.02	0.98	FALSE
87	The Cancer Genome Atlas	Stomach Adenocarcinoma	DR1	0.07	0.05	enet	9	0.07	6.2e-06	-8.6	-7.7	1.7e-14	0.93	0.01	0.99	FALSE
84	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DR1	0.09	0.09	lasso	2	0.07	4.7e-04	-7.7	-7.7	1.8e-14	0.96	0.01	0.76	FALSE
11	GTEx	Artery Tibial	DR1	0.17	0.11	lasso	8	0.18	5.9e-14	-8.6	-7.5	8.5e-14	0.90	0.03	0.97	FALSE
86	The Cancer Genome Atlas	Soft Tissue Sarcoma	DR1	0.10	0.03	lasso	4	0.06	3.2e-04	-5.3	-7.4	1.5e-13	0.88	0.01	0.97	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	TMED5	0.11	0.10	enet	17	0.13	2.7e-16	-7.2	7.4	1.6e-13	-0.86	0.02	0.98	FALSE
88	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMED5	0.05	0.06	lasso	2	0.05	1.4e-04	-7.2	7.2	4.3e-13	-0.95	0.02	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DR1	0.21	0.20	blup	305	0.23	1.8e-27	-8.6	-7.2	5.0e-13	0.85	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DR1	0.03	0.03	lasso	1	0.03	3.2e-04	-7.2	-7.2	6.2e-13	0.81	0.02	0.64	FALSE
83	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMED5	0.05	0.05	enet	11	0.04	9.7e-04	-6.6	7.1	1.2e-12	-0.86	0.02	0.84	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC18	0.03	0.03	blup	52	0.03	5.0e-04	-4.1	7.0	2.1e-12	-0.76	0.04	0.67	FALSE
65	NTR	Blood	TMED5	0.01	0.01	blup	277	0.01	5.2e-04	-7.2	7.0	2.3e-12	-0.83	0.02	0.97	FALSE
70	YFS	Blood	TMED5	0.14	0.19	lasso	16	0.22	1.1e-69	-5.3	7.0	2.3e-12	-0.88	1.00	0.00	FALSE
29	GTEx	Cells Transformed fibroblasts	DR1	0.18	0.21	enet	18	0.24	6.0e-18	-5.4	-7.0	2.4e-12	0.82	0.96	0.04	FALSE
6	GTEx	Adipose Visceral Omentum	DR1	0.10	0.05	lasso	5	0.06	5.0e-04	-6.7	-6.9	4.6e-12	0.84	0.11	0.87	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	DR1	0.09	0.12	enet	20	0.16	1.2e-20	-5.3	-6.8	8.8e-12	0.88	0.34	0.66	FALSE
17	GTEx	Brain Cerebellum	RP4-717I23.3	0.48	0.53	enet	32	0.57	2.9e-20	-5.3	6.8	1.0e-11	-0.83	0.68	0.32	FALSE
8	GTEx	Artery Aorta	DR1	0.15	0.10	lasso	5	0.14	3.1e-08	-5.3	-6.8	1.3e-11	0.85	0.18	0.82	FALSE
14	GTEx	Brain Cerebellar Hemisphere	TMED5	0.37	0.06	enet	21	0.11	1.1e-03	-7.7	6.8	1.4e-11	-0.87	0.02	0.93	FALSE
47	GTEx	Nerve Tibial	CCDC18	0.06	0.04	lasso	11	0.04	7.2e-04	-7.2	6.7	1.7e-11	-0.85	0.04	0.92	FALSE
61	METSIM	Adipose	CCDC18	0.08	0.06	lasso	4	0.07	4.9e-10	-5.2	6.7	2.3e-11	-0.77	0.98	0.02	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMED5	0.06	0.00	enet	7	0.01	2.5e-02	3.8	6.6	4.1e-11	-0.62	0.02	0.40	FALSE
48	GTEx	Nerve Tibial	RP4-717I23.3	0.43	0.46	enet	39	0.54	1.0e-44	-5.4	6.5	6.0e-11	-0.77	1.00	0.00	FALSE
35	GTEx	Esophagus Gastroesophageal Junction	RP4-717I23.3	0.31	0.26	lasso	17	0.30	1.4e-11	-5.3	6.5	6.4e-11	-0.84	0.16	0.84	FALSE
38	GTEx	Esophagus Muscularis	CCDC18	0.06	0.05	lasso	4	0.04	2.8e-03	-6.7	6.5	6.8e-11	-0.78	0.09	0.84	FALSE
39	GTEx	Esophagus Muscularis	RP4-717I23.3	0.31	0.38	lasso	5	0.42	2.0e-27	-5.3	6.4	1.4e-10	-0.78	1.00	0.00	FALSE
33	GTEx	Colon Transverse	CCDC18	0.10	0.04	enet	11	0.04	8.0e-03	-4.1	6.3	3.5e-10	-0.63	0.22	0.59	FALSE
31	GTEx	Colon Sigmoid	RP4-717I23.3	0.28	0.30	lasso	8	0.33	2.4e-12	-5.3	6.3	3.8e-10	-0.75	0.85	0.15	FALSE
4	GTEx	Adipose Subcutaneous	DR1	0.18	0.14	lasso	6	0.12	3.7e-10	-5.4	-6.2	6.6e-10	0.76	0.98	0.02	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RP4-717I23.3	0.44	0.40	lasso	6	0.48	5.8e-14	-5.0	6.2	6.7e-10	-0.79	0.39	0.61	FALSE
7	GTEx	Adipose Visceral Omentum	RP4-717I23.3	0.28	0.32	enet	19	0.34	1.4e-18	-5.3	6.1	1.0e-09	-0.74	1.00	0.00	FALSE
16	GTEx	Brain Cerebellum	DR1	0.17	0.10	enet	23	0.12	2.2e-04	-5.3	-6.1	1.3e-09	0.67	0.17	0.37	FALSE
51	GTEx	Pituitary	RP4-717I23.3	0.53	0.44	lasso	11	0.47	1.8e-13	-5.3	6.0	1.9e-09	-0.74	0.87	0.13	FALSE
12	GTEx	Artery Tibial	RP4-717I23.3	0.22	0.32	lasso	11	0.36	9.0e-30	-5.3	5.9	3.5e-09	-0.75	1.00	0.00	FALSE
40	GTEx	Heart Atrial Appendage	DR1	0.10	0.06	lasso	4	0.05	2.8e-03	-7.2	-5.9	4.6e-09	0.74	0.20	0.60	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC100131564	0.39	0.53	bslmm	315	0.54	9.6e-78	-5.3	5.8	5.7e-09	-0.74	1.00	0.00	FALSE
32	GTEx	Colon Transverse	DR1	0.14	0.14	lasso	5	0.10	1.7e-05	-5.3	-5.8	5.8e-09	0.73	0.23	0.75	FALSE
37	GTEx	Esophagus Muscularis	DR1	0.12	0.06	lasso	7	0.07	6.6e-05	-5.3	-5.8	6.1e-09	0.74	0.36	0.40	FALSE
56	GTEx	Stomach	RP4-717I23.3	0.33	0.35	lasso	8	0.38	2.5e-19	-5.3	5.8	6.4e-09	-0.75	0.99	0.01	FALSE
46	GTEx	Nerve Tibial	DR1	0.10	0.08	lasso	4	0.07	8.8e-06	-5.4	-5.8	7.4e-09	0.69	0.71	0.27	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	RP4-717I23.3	0.33	0.57	lasso	9	0.58	2.6e-92	-5.3	5.7	9.7e-09	-0.71	1.00	0.00	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	RP4-717I23.3	0.32	0.36	lasso	10	0.36	9.8e-13	-5.3	5.7	1.3e-08	-0.71	0.97	0.03	FALSE
44	GTEx	Lung	DR1	0.07	0.07	lasso	4	0.06	2.4e-05	-5.2	-5.7	1.4e-08	0.72	0.81	0.16	FALSE
60	GTEx	Vagina	RP4-717I23.3	0.26	0.13	lasso	7	0.09	3.8e-03	-5.3	5.6	1.9e-08	-0.67	0.12	0.53	FALSE
23	GTEx	Brain Putamen basal ganglia	RP4-717I23.3	0.38	0.34	enet	37	0.34	9.1e-09	-5.3	5.6	2.6e-08	-0.72	0.52	0.44	FALSE
58	GTEx	Thyroid	RP4-717I23.3	0.41	0.44	lasso	10	0.49	1.8e-42	-5.3	5.6	2.6e-08	-0.69	1.00	0.00	FALSE
19	GTEx	Brain Frontal Cortex BA9	RP4-717I23.3	0.48	0.53	lasso	12	0.53	1.6e-16	-5.3	5.5	2.9e-08	-0.70	0.74	0.26	FALSE
59	GTEx	Uterus	RP4-717I23.3	0.23	0.16	enet	14	0.17	2.7e-04	-5.3	5.5	2.9e-08	-0.65	0.23	0.32	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	RP4-717I23.3	0.50	0.42	lasso	5	0.47	3.0e-14	-5.3	5.5	3.5e-08	-0.69	0.96	0.04	FALSE
24	GTEx	Breast Mammary Tissue	RP4-717I23.3	0.30	0.32	enet	17	0.33	1.4e-17	-5.3	5.5	4.3e-08	-0.66	1.00	0.00	FALSE
21	GTEx	Brain Hypothalamus	RP4-717I23.3	0.33	0.35	enet	25	0.37	1.1e-09	-5.2	5.5	4.4e-08	-0.69	0.55	0.44	FALSE
18	GTEx	Brain Cortex	RP4-717I23.3	0.39	0.37	enet	19	0.42	1.0e-12	-5.2	5.5	4.6e-08	-0.69	0.91	0.09	FALSE
13	GTEx	Brain Caudate basal ganglia	RP4-717I23.3	0.43	0.46	enet	24	0.48	9.2e-16	-5.3	5.4	6.2e-08	-0.68	0.99	0.01	FALSE
9	GTEx	Artery Aorta	RP4-717I23.3	0.26	0.36	lasso	5	0.33	4.6e-19	-5.3	5.4	7.0e-08	-0.67	1.00	0.00	FALSE
63	METSIM	Adipose	RP4-717I23.3	0.21	0.34	enet	34	0.34	3.0e-52	-5.0	5.4	7.6e-08	-0.67	1.00	0.00	FALSE
50	GTEx	Pancreas	RP4-717I23.3	0.28	0.32	lasso	8	0.32	4.0e-14	-5.3	5.3	9.1e-08	-0.66	1.00	0.00	FALSE
41	GTEx	Heart Atrial Appendage	RP4-717I23.3	0.30	0.25	lasso	6	0.27	1.3e-12	-5.3	5.3	9.2e-08	-0.66	1.00	0.00	FALSE
64	METSIM	Adipose	TMED5	0.05	0.07	lasso	17	0.06	2.4e-09	-5.3	5.3	9.7e-08	-0.66	1.00	0.00	FALSE
25	GTEx	Breast Mammary Tissue (Male)	RP4-717I23.3	0.29	0.23	lasso	8	0.21	1.5e-05	-5.3	5.3	9.8e-08	-0.65	0.36	0.14	FALSE
20	GTEx	Brain Hippocampus	RP4-717I23.3	0.28	0.24	lasso	7	0.22	8.0e-06	-5.3	5.3	1.0e-07	-0.66	0.40	0.52	FALSE
10	GTEx	Artery Coronary	RP4-717I23.3	0.14	0.17	lasso	5	0.17	3.1e-06	-5.3	5.3	1.1e-07	-0.66	0.45	0.45	FALSE
34	GTEx	Colon Transverse	RP4-717I23.3	0.25	0.28	lasso	5	0.23	2.0e-11	-5.3	5.3	1.1e-07	-0.66	1.00	0.00	FALSE
45	GTEx	Lung	RP4-717I23.3	0.38	0.36	lasso	9	0.36	3.9e-29	-5.3	5.3	1.1e-07	-0.66	1.00	0.00	FALSE
49	GTEx	Ovary	RP4-717I23.3	0.44	0.43	lasso	7	0.42	1.5e-11	-5.3	5.3	1.1e-07	-0.65	0.96	0.03	FALSE
73	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC18	0.08	0.08	lasso	1	0.05	7.7e-04	-5.3	-5.3	1.1e-07	0.67	0.40	0.13	FALSE
74	The Cancer Genome Atlas	Colon Adenocarcinoma	DR1	0.36	0.06	enet	9	0.06	2.2e-04	-7.2	-5.3	1.1e-07	0.66	0.07	0.57	FALSE
42	GTEx	Heart Left Ventricle	RP4-717I23.3	0.20	0.25	lasso	5	0.26	3.1e-14	-5.3	5.3	1.2e-07	-0.66	1.00	0.00	FALSE
52	GTEx	Prostate	RP4-717I23.3	0.46	0.46	lasso	10	0.45	1.1e-12	-5.2	5.3	1.2e-07	-0.64	0.88	0.12	FALSE
5	GTEx	Adipose Subcutaneous	RP4-717I23.3	0.34	0.39	lasso	7	0.44	2.5e-39	-5.3	5.3	1.4e-07	-0.66	1.00	0.00	FALSE
26	GTEx	Breast Mammary Tissue (Female)	RP4-717I23.3	0.19	0.20	lasso	13	0.19	2.1e-06	-5.3	5.3	1.4e-07	-0.66	0.79	0.12	FALSE
36	GTEx	Esophagus Mucosa	RP4-717I23.3	0.23	0.27	lasso	2	0.29	1.5e-19	-5.2	5.3	1.4e-07	-0.64	1.00	0.00	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	RP4-717I23.3	0.40	0.41	lasso	9	0.38	3.7e-22	-5.3	5.3	1.4e-07	-0.65	1.00	0.00	FALSE
62	METSIM	Adipose	DR1	0.04	0.04	lasso	3	0.04	1.0e-06	-5.0	-5.2	1.5e-07	0.65	0.97	0.02	FALSE
30	GTEx	Cells Transformed fibroblasts	RP4-717I23.3	0.25	0.30	lasso	3	0.33	3.8e-25	-5.0	5.2	1.9e-07	-0.66	1.00	0.00	FALSE
55	GTEx	Spleen	RP4-717I23.3	0.39	0.46	enet	22	0.48	5.3e-14	-5.0	5.2	2.4e-07	-0.66	0.99	0.01	FALSE
43	GTEx	Liver	RP4-717I23.3	0.22	0.21	lasso	8	0.16	3.6e-05	-5.3	5.1	2.8e-07	-0.63	0.63	0.04	FALSE