Best TWAS P=8.63e-10 · Best GWAS P=9.25e-09 conditioned to 0.0186
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | B3GALTL | 0.20 | 0.07 | enet | 39 | 0.12 | 5.1e-14 | 3.1 | 5.9 | 2.8e-09 | 0.62 | 0.54 | 0.45 | FALSE |
2 | GTEx | Artery Aorta | B3GALTL | 0.37 | 0.17 | enet | 29 | 0.30 | 4.3e-17 | 4.0 | 5.8 | 8.0e-09 | 0.63 | 0.24 | 0.75 | FALSE |
3 | GTEx | Artery Coronary | B3GALTL | 0.32 | 0.06 | enet | 12 | 0.20 | 2.5e-07 | 5.2 | 5.3 | 1.1e-07 | 0.77 | 0.01 | 0.98 | FALSE |
4 | GTEx | Artery Tibial | B3GALTL | 0.22 | 0.05 | lasso | 7 | 0.14 | 2.6e-11 | -4.7 | 6.1 | 8.6e-10 | 0.64 | 0.14 | 0.85 | TRUE |
5 | GTEx | Brain Cortex | B3GALTL | 0.25 | 0.13 | lasso | 8 | 0.15 | 5.4e-05 | 4.4 | 5.2 | 2.3e-07 | 0.70 | 0.14 | 0.79 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | B3GALTL | 0.32 | 0.29 | enet | 19 | 0.29 | 7.6e-22 | 4.1 | 5.3 | 1.4e-07 | 0.65 | 0.86 | 0.12 | FALSE |
7 | GTEx | Colon Sigmoid | B3GALTL | 0.34 | 0.12 | enet | 32 | 0.14 | 1.7e-05 | 4.0 | 5.6 | 1.9e-08 | 0.57 | 0.23 | 0.67 | FALSE |
8 | GTEx | Esophagus Mucosa | B3GALTL | 0.25 | 0.19 | lasso | 6 | 0.26 | 1.8e-17 | 4.9 | 5.3 | 1.3e-07 | 0.74 | 0.13 | 0.86 | FALSE |
9 | GTEx | Nerve Tibial | B3GALTL | 0.18 | 0.10 | lasso | 5 | 0.13 | 1.1e-09 | 4.9 | 5.4 | 5.0e-08 | 0.73 | 0.06 | 0.94 | FALSE |
10 | GTEx | Stomach | B3GALTL | 0.18 | 0.00 | lasso | 7 | 0.04 | 4.4e-03 | -4.7 | 5.7 | 1.1e-08 | 0.61 | 0.09 | 0.68 | FALSE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | B3GALTL | 0.02 | 0.00 | blup | 105 | 0.01 | 1.9e-03 | 5.3 | 6.0 | 2.3e-09 | 0.72 | 0.05 | 0.74 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | B3GALTL | 0.04 | 0.03 | lasso | 2 | 0.03 | 1.5e-04 | 4.9 | 5.2 | 2.5e-07 | 0.77 | 0.04 | 0.95 | FALSE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | B3GALTL | 0.03 | 0.02 | blup | 105 | 0.02 | 2.0e-03 | 4.0 | 5.5 | 4.9e-08 | 0.76 | 0.04 | 0.92 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | B3GALTL | 0.10 | 0.08 | blup | 104 | 0.12 | 3.3e-12 | 4.5 | 5.1 | 2.8e-07 | 0.61 | 0.56 | 0.42 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | B3GALTL | 0.14 | 0.17 | blup | 105 | 0.20 | 2.2e-19 | 4.6 | 5.2 | 2.2e-07 | 0.64 | 0.62 | 0.36 | FALSE |