Best TWAS P=2.43e-10 · Best GWAS P=3.36e-10 conditioned to 0.0786
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KIAA1683 | 0.09 | 0.06 | enet | 14 | 0.10 | 6.6e-12 | 3.7 | -5.3 | 1.0e-07 | 0.61 | 0.74 | 0.26 | FALSE |
2 | GTEx | Colon Transverse | SSBP4 | 0.18 | 0.01 | enet | 21 | 0.00 | 3.6e-01 | -4.3 | 5.3 | 1.2e-07 | -0.59 | 0.05 | 0.39 | FALSE |
3 | GTEx | Pancreas | AC007192.6 | 0.19 | 0.00 | enet | 28 | 0.01 | 1.3e-01 | -5.4 | 5.8 | 5.9e-09 | -0.55 | 0.03 | 0.58 | FALSE |
4 | GTEx | Thyroid | KIAA1683 | 0.11 | 0.07 | enet | 14 | 0.12 | 2.1e-09 | -4.1 | -5.3 | 1.3e-07 | 0.63 | 0.66 | 0.33 | FALSE |
5 | GTEx | Vagina | LRRC25 | 0.63 | 0.02 | enet | 2 | 0.04 | 5.3e-02 | -5.2 | 5.2 | 2.2e-07 | -0.59 | 0.04 | 0.17 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | JUND | 0.17 | 0.17 | lasso | 5 | 0.20 | 2.7e-25 | -5.2 | -5.2 | 1.8e-07 | 0.60 | 0.54 | 0.46 | FALSE |
7 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | -5.2 | -6.3 | 2.4e-10 | 0.62 | 0.01 | 0.58 | TRUE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JUND | 0.05 | 0.04 | lasso | 1 | 0.04 | 4.3e-05 | -5.2 | -5.2 | 2.3e-07 | 0.58 | 0.12 | 0.26 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JUND | 0.11 | 0.03 | blup | 58 | 0.04 | 1.4e-03 | 2.3 | -5.4 | 5.5e-08 | 0.40 | 0.04 | 0.08 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JUND | 0.04 | 0.03 | lasso | 2 | 0.02 | 7.9e-04 | -5.2 | -5.2 | 2.5e-07 | 0.59 | 0.16 | 0.20 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | -3.7 | 5.1 | 2.7e-07 | -0.46 | 0.58 | 0.35 | TRUE |