TWAS hub - IL12RB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0270	8.0e-03	0.034	0.000	0.030	0.014	0.027	5.2e-05	3.5e-01	1.4e-04	7.1e-03	2.8e-04
2	METSIM	Adipose	0.0466	0.0162	1.8e-04	0.050	0.032	0.041	0.036	0.044	4.5e-08	1.2e-05	7.0e-07	3.9e-06	2.7e-07
3	TCGA	Bladder Urothelial Carcinoma	0.0670	0.0340	4.4e-03	0.017	0.002	0.006	NA	0.008	1.2e-02	2.3e-01	8.4e-02	NA	6.4e-02
4	TCGA	Breast Invasive Carcinoma	0.0612	0.0218	2.4e-09	0.032	0.047	0.042	NA	0.048	3.5e-07	6.7e-10	4.7e-09	NA	3.9e-10
5	TCGA	Colon Adenocarcinoma	0.1140	0.0560	2.2e-03	0.033	0.030	0.011	NA	0.028	5.1e-03	7.3e-03	7.0e-02	NA	9.3e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0526	0.0202	1.1e-05	0.026	0.047	0.050	NA	0.044	6.4e-04	5.0e-06	2.2e-06	NA	1.0e-05
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0974	0.0329	8.6e-09	0.084	0.086	0.062	NA	0.077	9.9e-10	6.9e-10	1.6e-07	NA	5.4e-09
8	TCGA	Brain Lower Grade Glioma	0.0464	0.0198	4.8e-04	0.029	0.030	0.031	NA	0.032	2.5e-04	2.1e-04	1.6e-04	NA	1.3e-04
9	TCGA	Lung Adenocarcinoma	0.1048	0.0363	2.5e-08	0.082	0.061	0.066	NA	0.063	7.8e-10	1.0e-07	3.9e-08	NA	6.8e-08
10	TCGA	Lung Squamous Cell Carcinoma	0.0746	0.0287	7.3e-07	0.040	0.057	0.054	NA	0.052	2.4e-05	4.9e-07	9.5e-07	NA	1.6e-06
11	TCGA	Prostate Adenocarcinoma	0.0950	0.0379	2.2e-06	0.006	0.047	0.032	NA	0.030	7.0e-02	1.1e-05	2.4e-04	NA	3.7e-04
12	TCGA	Testicular Germ Cell Tumors	0.1040	0.0530	7.9e-03	0.008	0.060	0.065	NA	0.027	1.6e-01	3.8e-03	2.6e-03	NA	3.9e-02
13	TCGA	Thyroid Carcinoma	0.0800	0.0350	2.8e-04	0.039	0.048	0.050	NA	0.051	1.1e-04	1.8e-05	1.2e-05	NA	8.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Mouth/teeth dental problems: Mouth ulcers	22.7	36.0	47.8	4.0	6.4	6.3	6.8	4.6	6.7	5.9	6.9	6.3	5.7	5.7	5.9	6.1
Gout (self-reported)	10.8	14.7	22.9	-4.2	-3.6	-3.3	-3.8	-3.7	-4.8	-3.5	-3.4	-2.7	-3.9	-4.3	-4.8	-3.3
Leg fat percentage (right)	8.1	29.2	47.2	-4.9	-5.3	-5.6	-4.3	-4.8	-5.1	-5.7	-4.8	-5.4	-6.8	-4.5	-6.9	-5.5
Friendships satisfaction	7.9	9.7	12.4	2.9	2.9	2.8	3.2	3.1	3.5	3.2	2.9	3.0	3.4	3.1	3.4	3.1
Body fat percentage	7.8	30.8	49.7	-5.1	-5.5	-5.9	-4.2	-5.1	-5.3	-5.6	-4.9	-5.4	-7.0	-4.5	-7.0	-5.8
Leg fat percentage (left)	7.7	27.8	47.6	-5.1	-5.0	-5.4	-4.3	-4.8	-5.1	-5.5	-4.6	-5.1	-6.7	-4.4	-6.9	-5.1
Risk taking	7.7	11.2	16.3	2.5	3.9	3.7	3.8	2.0	3.3	3.5	4.0	3.7	2.7	3.4	3.5	2.8
Lupus	7.5	11.3	14.2	3.1	3.7	3.5	3.6	3.6	3.4	3.4	3.8	3.3	3.4	3.1	2.8	3.0
Trunk fat percentage	7.3	29.1	46.5	-4.9	-5.4	-5.8	-4.0	-5.1	-5.0	-5.3	-4.8	-5.3	-6.8	-4.2	-6.8	-5.8
Leg fat mass (right)	6.9	26.6	48.4	-5.0	-5.0	-5.4	-4.0	-5.0	-5.3	-4.9	-4.4	-4.5	-6.0	-4.3	-7.0	-5.6
Waist Hip Ratio (WHR)	6.8	30.4	52.9	-4.0	-6.1	-6.3	-4.8	-4.9	-4.2	-6.3	-6.0	-7.3	-6.9	-3.5	-4.0	-5.8
Mouth/teeth dental problems	6.7	10.2	15.9	-1.7	-3.3	-3.2	-4.0	-1.8	-3.4	-3.6	-4.0	-3.8	-3.2	-2.7	-3.2	-2.6
Leg fat mass (left)	6.6	25.9	49.3	-5.1	-4.8	-5.2	-4.1	-5.0	-5.3	-4.7	-4.3	-4.3	-6.1	-4.2	-7.0	-5.3
Whole body fat mass	6.5	27.2	50.3	-5.0	-5.0	-5.3	-4.0	-5.3	-5.3	-4.8	-4.4	-4.6	-6.3	-4.2	-7.1	-5.5
Trunk fat mass	6.4	27.5	49.8	-4.9	-5.2	-5.5	-4.0	-5.3	-5.2	-4.8	-4.5	-4.8	-6.3	-4.1	-7.1	-5.8
Waist circumference	6.2	22.8	40.1	-4.3	-4.5	-4.8	-3.9	-4.5	-4.8	-4.3	-4.1	-4.9	-5.8	-3.8	-6.3	-5.2
Suffer from ‘nerves’	6.1	9.6	16.8	3.3	3.1	2.8	3.2	4.1	3.7	2.4	3.1	2.1	3.2	2.8	3.5	2.5
Blood clot in the leg (DVT)	5.9	7.6	11.8	-2.3	-3.2	-3.4	-2.6	-2.4	-2.5	-3.0	-3.2	-2.7	-2.6	-2.6	-2.4	-2.7
Primary Biliary Cirrhosis	5.8	8.3	12.4	1.2	3.2	3.5	3.0	2.2	2.9	2.8	3.5	2.8	2.5	3.1	2.6	3.3
Deep venous thrombosis (DVT) (self-reported)	5.8	7.4	12.6	-2.3	-3.3	-3.5	-2.4	-2.5	-2.3	-3.0	-3.2	-2.5	-2.5	-2.5	-2.2	-2.8
Hearing difficulty/problems with background noise	5.5	8.8	13.4	2.8	2.8	2.9	3.1	2.9	3.6	2.5	2.8	1.4	3.7	3.0	3.5	2.9
Prostate Cancer	5.1	7.2	15.1	-3.9	-2.7	-2.3	-2.3	-3.5	-3.0	-2.4	-2.0	-1.9	-3.2	-2.5	-2.2	-2.2
Qualifications: College or University degree	5.0	15.8	26.4	3.7	4.3	4.6	3.7	3.4	3.7	4.0	4.0	3.3	5.1	3.1	4.8	3.4
Arm fat percentage (right)	4.9	19.3	38.4	-4.3	-4.0	-4.3	-3.2	-4.2	-4.3	-4.1	-3.5	-4.1	-6.0	-3.4	-6.2	-4.4
Severe depression (siblings)	4.8	5.4	9.1	1.9	2.6	2.6	2.2	1.7	2.0	3.0	2.5	2.4	2.6	2.3	2.0	2.0
Vitamin and mineral supplements	4.7	6.4	9.4	-2.6	-2.6	-2.5	-2.1	-2.8	-2.9	-2.0	-2.3	-1.6	-2.9	-2.2	-2.8	-3.1
Myopia	4.7	6.8	14.8	2.4	2.6	3.0	1.9	3.0	2.7	2.1	2.2	2.0	2.7	2.4	2.5	3.9
Nervous feelings	4.6	8.5	13.1	2.9	3.0	2.5	3.5	3.6	3.3	2.4	3.1	3.0	3.3	1.9	3.0	2.0
Arm fat percentage (left)	4.6	18.4	37.1	-4.4	-3.9	-4.2	-3.1	-4.2	-4.2	-4.0	-3.3	-4.0	-5.9	-3.1	-6.1	-4.3
Heel T-Score	4.2	33.5	64.0	3.5	5.2	4.1	7.3	2.6	6.4	8.0	6.2	6.6	7.3	6.3	5.4	3.1
Number of full sisters	4.2	5.1	8.7	2.9	2.1	1.8	1.9	2.2	2.4	2.4	1.8	1.4	3.0	2.7	2.7	1.3
Arm fat mass (left)	4.2	17.4	39.3	-4.5	-3.7	-3.8	-3.0	-4.5	-4.5	-3.5	-3.0	-3.3	-5.4	-3.1	-6.3	-4.2
Bilateral oophorectomy (both ovaries removed)	3.9	4.5	11.8	-2.4	-1.6	-1.1	-2.1	-1.9	-2.5	-2.4	-1.6	-1.3	-3.4	-1.5	-3.1	-0.9
Arm fat mass (right)	3.9	16.1	38.0	-4.3	-3.5	-3.7	-2.9	-4.3	-4.3	-3.4	-2.9	-3.1	-5.2	-3.0	-6.2	-4.1
Birth weight of first child	3.9	7.2	8.5	-2.6	-2.9	-2.8	-2.8	-2.5	-2.7	-2.9	-2.9	-2.4	-2.8	-2.4	-2.5	-2.5
Crohns Disease (2017)	3.8	8.3	14.0	1.9	2.8	2.3	3.7	3.0	3.7	2.6	3.3	3.0	2.6	3.0	2.1	2.6
Qualifications: NVQ or HND or HNC or equivalent	3.8	4.5	7.6	-1.7	-2.3	-2.2	-2.7	-1.2	-2.0	-2.4	-2.5	-2.2	-2.8	-2.0	-2.1	-0.8
Qualifications: A levels/AS levels or equivalent	3.7	8.1	11.7	2.3	3.0	3.4	2.0	2.7	2.5	3.1	2.6	2.5	3.4	2.7	2.9	3.4
Lung FEV1/FVC ratio	3.4	17.2	21.1	-3.9	-4.4	-4.3	-4.0	-3.7	-4.1	-4.6	-4.0	-4.0	-4.5	-4.4	-4.2	-3.6
Comparative height size at age 10	3.4	18.7	31.7	-3.4	-5.1	-5.6	-4.1	-4.1	-4.4	-3.5	-4.9	-3.4	-3.2	-3.4	-4.8	-5.3
Illnesses of mother	3.2	3.9	6.1	1.5	2.3	2.5	1.5	1.5	1.8	2.1	2.0	1.6	2.3	2.2	1.7	2.5
Happiness	3.0	3.6	5.2	1.2	2.0	1.7	2.0	1.8	1.8	2.3	2.0	2.0	2.0	2.1	2.0	1.7
Family relationship satisfaction	3.0	3.7	6.0	1.1	1.9	1.8	2.0	1.9	2.1	2.1	1.9	1.5	2.0	2.0	1.9	2.4
BMI	2.9	16.6	38.3	-4.6	-3.5	-3.7	-2.6	-4.0	-4.4	-3.6	-2.6	-2.9	-5.1	-3.8	-6.2	-4.3
Heart attack	2.9	3.7	5.0	1.3	2.2	2.1	1.9	1.4	2.1	2.2	2.2	1.6	2.0	2.1	1.5	2.0
Heart attack/myocardial infarction (self-reported)	2.9	3.8	5.0	1.4	2.2	2.1	2.0	1.4	2.1	2.2	2.2	1.6	2.0	2.0	1.6	1.9
Average weekly spirits intake	2.8	3.5	7.2	-1.9	-1.7	-1.9	-0.8	-2.1	-1.9	-1.7	-1.3	-1.2	-2.4	-1.7	-2.1	-2.7
Relative age voice broke	2.8	4.3	5.7	1.8	2.1	2.2	1.9	2.3	2.2	1.8	2.1	2.0	2.4	1.9	1.9	2.2
Medication: Levothyroxine sodium	2.8	4.8	7.9	1.3	2.3	2.3	1.8	1.7	2.0	2.6	2.3	2.2	2.8	2.0	2.4	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.3	10.2	2.3	1.9	1.8	1.8	3.2	2.4	1.6	1.7	1.1	1.9	2.0	1.9	2.4
Tinnitus: Yes, now most or all of the time	2.8	3.3	6.1	1.4	2.2	2.2	1.6	1.1	1.4	2.1	2.1	2.5	1.5	1.6	1.7	1.7
Weight	2.7	13.2	33.5	-3.7	-3.2	-3.5	-2.7	-4.0	-4.1	-2.6	-2.7	-2.4	-3.9	-2.9	-5.8	-4.1
Worry too long after embarrassment	2.7	4.5	7.4	2.2	2.1	2.0	2.3	2.5	2.1	1.9	2.1	1.4	2.7	2.0	2.1	1.7
Illnesses of father: Heart disease	2.7	3.7	6.7	1.8	2.2	1.8	2.2	1.8	2.0	1.6	2.2	2.6	1.7	1.4	1.8	1.5
Crohns Disease (2012)	2.5	4.0	8.2	1.5	0.0	0.7	2.9	2.1	2.9	2.2	2.1	2.2	1.6	2.5	1.8	1.1
Body mass index (BMI)	2.5	10.6	26.8	-3.7	-2.6	-2.7	-2.1	-3.5	-3.5	-2.7	-1.9	-2.5	-4.4	-2.6	-5.2	-3.3
Average weekly champagne plus white wine intake	2.5	3.5	7.6	2.2	1.7	1.7	1.2	2.0	1.7	2.2	1.3	1.7	1.6	2.8	1.8	1.7
Had other major operations	2.3	2.8	4.5	-1.1	-1.8	-2.1	-1.5	-1.0	-1.5	-1.9	-2.0	-1.3	-2.0	-1.9	-1.8	-1.4
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	5.7	1.2	1.8	1.9	1.7	1.9	1.8	1.6	1.8	1.5	1.2	1.6	1.1	2.4
Neuroticism score	2.3	4.9	8.9	2.1	2.1	1.8	3.0	2.8	2.6	1.9	2.4	1.5	2.4	1.8	2.3	1.1
Comparative body size at age 10	2.3	6.2	13.3	-2.9	-1.5	-1.3	-2.1	-3.0	-3.6	-1.9	-1.5	-1.1	-3.1	-2.9	-3.2	-2.5
Medication: Allopurinol	2.3	3.1	5.5	-2.0	-1.6	-1.2	-2.0	-2.1	-2.3	-1.5	-1.7	-1.3	-1.8	-1.5	-2.0	-1.3
Alcohol drinker status: Previous	2.3	2.6	4.6	1.1	1.9	2.0	1.7	1.0	1.2	2.1	1.8	1.8	1.7	1.6	1.0	1.5
Long-standing illness, disability or infirmity	2.2	3.3	6.5	2.5	1.6	1.1	2.0	2.5	2.4	1.7	1.4	0.6	2.0	1.6	1.9	1.0
Father’s age at death	2.1	2.8	6.8	-1.6	-1.4	-1.7	-1.4	-1.3	-1.9	-1.8	-1.4	-0.9	-2.6	-1.1	-2.3	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.8	5.1	1.2	2.0	2.3	1.8	1.5	1.5	1.4	1.9	1.4	1.2	1.7	1.3	1.9
Multivitamins +/- minerals	2.0	2.6	3.6	1.7	1.7	1.7	1.3	1.5	1.7	1.6	1.5	1.4	1.9	1.3	1.8	1.8
Worrier / anxious feelings	2.0	3.7	9.9	2.2	1.9	1.4	1.9	3.2	2.3	1.4	1.7	0.9	2.2	1.6	1.9	1.5
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.6	-1.1	-1.5	-1.6	-1.8	-0.7	-1.5	-1.4	-1.6	-1.3	-1.3	-1.9	-2.1	-1.1
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	8.2	1.2	2.2	2.4	1.4	1.3	2.1	2.0	2.0	1.6	2.1	1.9	2.2	2.9
Illnesses of father: None of the above (group 1)	2.0	2.4	4.2	-1.5	-2.0	-1.9	-1.2	-1.9	-1.3	-1.3	-1.6	-1.9	-0.7	-1.5	-0.3	-2.1
Worry (Nagel 2018)	1.9	4.0	9.9	2.4	1.8	1.1	2.6	3.1	2.6	1.3	1.9	1.1	2.1	1.3	2.3	0.7
Ulcerative Colitis (UC)	1.9	3.5	7.2	-2.2	-2.0	-2.1	-1.8	-1.4	-1.6	-2.2	-1.6	-2.0	-1.8	-2.7	-1.1	-1.4
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	5.0	-1.0	-1.6	-1.5	-1.6	-1.1	-1.3	-1.9	-1.8	-2.2	-0.8	-2.2	-0.6	-1.1
Age started oral contraceptive pill	1.9	2.4	4.1	1.4	1.8	1.9	1.6	1.4	1.4	1.4	1.7	1.7	2.0	1.3	0.7	1.5
Neuroticism (2016)	1.8	2.6	5.3	1.5	1.6	0.9	2.3	2.0	1.9	1.7	1.8	1.7	1.2	2.0	1.0	0.5
Supplements: Vitamin C	1.8	2.1	4.8	1.8	1.5	1.4	1.6	1.3	1.6	1.4	1.3	0.5	1.8	0.9	2.2	0.8
Breast cancer (self-reported)	1.8	2.2	3.7	-1.0	-1.8	-1.9	-1.4	-1.2	-1.3	-1.4	-1.7	-1.3	-1.5	-1.4	-1.4	-1.7
Triglycerides	1.7	2.8	6.0	0.9	1.4	0.8	1.8	0.5	2.0	2.2	1.6	1.5	1.9	2.4	2.4	0.7
Hypothyroidism (self reported)	1.7	4.0	9.9	0.8	2.3	2.7	1.2	1.3	1.8	1.9	2.1	1.6	1.6	1.9	2.4	3.1
Age when periods started (menarche)	1.7	4.1	13.7	2.6	1.8	1.6	1.4	1.5	2.4	1.1	1.2	1.6	2.5	1.6	3.7	2.0
Breastfed as a baby	1.7	2.1	5.3	1.7	1.7	2.3	0.8	0.9	0.9	1.9	1.2	1.0	1.4	1.3	1.5	1.7
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.7	1.0	1.2	1.3	1.0	1.2	1.5	1.7	1.2	1.1	2.2	1.1	1.8	1.5
Medication: Ibuprofen	1.7	2.0	4.2	-0.3	-1.4	-1.6	-1.4	-0.5	-1.1	-1.9	-1.7	-2.0	-0.5	-2.0	-0.9	-1.3
Depression (self-reported)	1.6	1.9	3.0	1.7	1.3	1.1	1.3	1.7	1.5	1.5	1.1	1.2	1.6	1.2	1.5	1.0
Loud music exposure frequency	1.6	1.7	3.0	-0.4	1.2	1.2	1.6	0.2	1.4	1.7	1.7	1.5	1.1	1.2	1.2	1.5
Number of children fathered	1.6	1.8	4.9	-1.8	-1.2	-1.3	-0.6	-2.2	-0.8	-1.4	-0.7	-1.3	-1.1	-1.2	-1.3	-1.5
Eye problems/disorders: None of the above	1.6	1.8	4.3	0.8	1.6	2.1	1.0	0.8	0.9	1.3	1.6	1.5	0.9	1.6	0.4	1.9
Osteoarthritis (self-reported)	1.5	1.9	3.2	-0.5	-1.4	-1.2	-1.3	-0.7	-1.3	-1.6	-1.6	-1.8	-1.7	-1.5	-1.5	-1.2
Mean Putamen Volume	1.4	1.7	3.7	-1.0	-1.2	-0.9	-1.7	-0.2	-1.3	-1.4	-1.5	-1.0	-1.6	-1.5	-1.9	-0.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	6.3	1.3	1.2	1.6	0.5	2.0	1.4	-0.2	0.7	0.6	0.9	0.9	1.6	2.5
Birth weight	1.4	2.9	4.8	-1.0	-1.5	-1.7	-1.9	-1.5	-2.1	-1.5	-1.8	-1.2	-1.7	-1.9	-1.7	-2.2
Commuting to job workplace: Walk	1.4	1.5	3.5	0.3	1.5	1.9	1.0	0.6	1.0	1.0	1.4	1.2	1.2	1.0	1.0	1.8
Pack years of smoking	1.4	2.0	5.6	-2.1	-1.2	-0.9	-0.9	-2.4	-1.6	-0.4	-0.8	-0.8	-1.8	-1.0	-1.8	-1.3
Blood Red Count	1.3	12.6	21.8	-2.3	-3.6	-3.8	-3.2	-3.0	-3.6	-3.8	-3.7	-4.0	-2.7	-4.3	-2.5	-4.7
Pack years adult smoking proportion	1.3	2.0	5.7	-2.2	-1.2	-0.9	-0.9	-2.4	-1.6	-0.2	-0.7	-0.8	-1.7	-1.0	-1.7	-1.3
Hip circumference	1.3	5.7	22.3	-2.5	-1.9	-2.0	-1.5	-2.4	-2.8	-1.3	-1.4	-1.2	-2.6	-1.9	-4.7	-2.6
Medication: Gliclazide	1.3	1.4	2.4	0.7	1.3	1.1	1.4	1.0	1.5	1.5	1.4	0.8	1.5	0.6	1.0	1.1
Guilty feelings	1.3	1.9	5.9	1.1	1.7	2.4	1.1	1.3	1.0	1.0	1.6	0.3	0.8	1.4	1.0	2.0
Ovarian Cancer	1.2	1.6	3.2	-0.2	-1.5	-1.8	-1.1	-0.6	-1.2	-1.2	-1.7	-1.0	-1.0	-1.1	-1.5	-1.7
Fasting Glucose	1.2	1.4	2.6	1.6	1.4	1.1	1.1	1.3	0.6	1.5	1.1	1.3	1.0	1.6	1.1	0.0
Supplements: Glucosamine	1.2	1.6	3.7	-1.2	-1.1	-0.9	-1.4	-1.6	-1.6	-1.1	-1.1	-0.9	-0.8	-1.9	-0.5	-1.3
Tense / ‘highly strung’	1.2	2.0	5.0	1.8	1.3	1.1	1.9	1.7	1.3	1.4	1.4	0.4	2.2	0.6	1.6	-0.2
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	4.6	0.9	1.3	1.2	0.6	1.9	1.4	1.4	1.0	1.3	2.0	1.0	0.8	2.1
Mean time to correctly identify matches	1.2	2.3	6.9	2.1	1.5	1.4	1.0	1.8	1.3	1.5	1.0	1.4	2.6	0.3	1.4	1.4
Qualifications: nursing, teaching	1.2	1.9	3.1	1.5	1.4	1.4	0.9	1.0	1.6	1.2	1.1	1.1	1.8	1.5	1.6	1.7
Qualifications: None of the above	1.1	2.3	5.5	-0.5	-1.5	-1.5	-1.2	-1.5	-1.5	-1.1	-1.6	-2.1	-1.4	-1.3	-1.5	-2.3
Exposure to tobacco smoke at home	1.1	1.2	2.2	1.4	0.8	0.4	1.3	1.2	1.2	1.3	0.8	1.4	1.1	0.9	1.5	0.3
Back pain experienced in last month	1.1	1.7	4.2	-0.9	-1.4	-1.1	-0.8	-1.2	-1.0	-1.3	-1.2	-1.2	-1.4	-2.0	-1.5	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.3	1.3	1.1	0.9	1.8	0.9	1.0	1.0	1.3	1.1	1.0	1.5	1.1	-0.2
LDL Cholesterol	1.0	1.5	4.7	-0.9	-1.7	-2.2	-0.5	-1.3	-0.8	-0.8	-1.4	-0.8	-0.6	-1.0	-0.7	-2.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.1	1.4	0.9	0.5	1.2	1.3	1.6	1.1	0.8	0.3	1.8	0.9	1.2	0.5
Headache pain in last month	1.0	1.6	3.0	0.5	1.2	1.0	1.7	0.5	1.6	1.7	1.6	1.4	1.3	1.2	1.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.2	1.5	1.1	1.2	1.3	1.4	1.2	1.0	1.0	0.5	0.9	0.7	1.0	0.8
Medication: Omeprazole	1.0	1.1	3.1	1.2	1.0	0.7	1.8	0.8	0.9	0.9	1.1	1.0	1.0	1.3	1.2	-0.5
Had major operations	1.0	1.1	3.2	0.8	0.4	-0.1	1.5	0.4	1.4	1.5	0.8	1.5	1.0	1.8	0.4	0.3
Loneliness, isolation	1.0	1.4	2.5	1.3	1.0	1.2	1.5	1.1	1.3	1.1	1.1	0.6	1.6	1.3	1.3	0.7
Ever taken oral contraceptive pill	1.0	1.1	2.4	1.3	0.9	0.7	0.9	1.2	0.9	1.3	0.8	1.3	1.5	0.7	0.8	0.6
Reaction Time	0.9	1.6	6.0	1.7	1.1	1.0	0.7	1.7	1.1	1.3	0.6	0.9	2.5	-0.0	1.4	1.0
Ulcerative Colitis	0.9	1.3	3.0	-1.7	-1.3	-1.5	-0.9	-1.2	-0.6	-1.2	-0.9	-1.1	-1.1	-1.3	-0.5	-0.6
Impedance of leg (right)	0.9	4.2	10.4	0.2	-2.7	-2.8	-1.8	0.0	-0.5	-3.2	-3.0	-2.9	-1.7	-1.5	-0.2	-1.6
High blood pressure (mother)	0.9	1.3	2.9	-0.9	-1.4	-1.7	-0.7	-0.5	-1.0	-0.9	-1.2	-0.6	-1.2	-1.2	-1.1	-1.6
Shortness of breath walking on level ground	0.9	1.1	2.1	-0.6	-0.9	-0.5	-0.6	-1.2	-1.4	-0.7	-0.8	-1.4	-1.1	-0.9	-1.0	-1.4
Neck or shoulder pain in last month	0.9	1.3	4.8	0.6	0.4	0.1	0.9	0.4	2.0	1.5	0.6	0.5	1.3	0.9	2.2	1.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.7	-0.7	-1.1	-0.7	-1.0	-0.9	-1.0	-1.3	-1.1	-1.6	-1.2	-1.0	-0.8	-0.7
Diastolic blood pressure, automated reading	0.9	2.7	6.8	-2.4	-0.7	-1.2	-0.2	-2.2	-1.8	-0.7	-0.0	0.2	-2.6	-1.1	-2.3	-2.2
Commuting to job workplace: Cycle	0.9	1.1	2.9	0.7	0.8	1.3	0.7	1.2	1.3	1.0	0.8	0.1	1.4	0.6	1.4	1.7
Rheumatoid Arthritis	0.8	1.2	3.0	1.2	1.4	1.7	1.1	0.6	1.0	0.3	1.3	1.0	0.6	0.7	1.3	0.9
Blood Eosinophil Count	0.8	5.8	21.6	3.7	2.3	2.4	0.8	3.1	1.7	1.7	1.1	0.4	4.7	0.5	3.0	1.3
Lung FVC	0.8	3.9	8.5	1.5	2.3	2.8	1.4	1.6	1.8	2.0	2.1	1.6	1.6	1.6	1.7	2.9
Neuroticism	0.8	1.9	5.7	1.3	1.2	0.7	2.4	1.8	1.8	0.9	1.6	1.3	1.2	0.8	1.3	0.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.7	1.6	0.9	1.1	0.9	1.6	1.0	0.8	0.8	-0.1	1.4	0.5	1.3	0.4
Average weekly fortified wine intake	0.8	0.9	2.7	0.9	0.5	0.6	0.7	1.1	1.6	0.6	0.6	0.1	0.5	1.6	0.8	1.4
Financial difficulties in last 2 years	0.8	1.1	2.6	0.9	1.0	1.0	1.0	0.6	1.3	1.2	1.0	0.6	0.9	0.9	1.6	1.1
Pulse wave reflection index	0.8	1.0	1.9	-1.4	-1.0	-0.9	-0.9	-1.2	-1.1	-0.7	-0.8	-0.9	-1.1	-1.1	-1.3	-0.5
Pulse rate, automated reading	0.8	2.6	8.2	-0.5	-2.0	-2.6	-0.8	-1.2	-1.1	-1.5	-1.8	-1.1	-1.4	-1.2	-0.8	-2.9
Age at last live birth	0.8	1.2	2.8	1.0	1.2	1.2	0.8	0.9	1.1	1.2	1.0	0.5	1.4	0.6	1.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.8	1.4	0.4	0.2	1.2	0.4	1.3	0.9	0.5	0.0	1.1	0.0	1.7	-0.2
Leg fat-free mass (left)	0.7	3.9	13.4	-2.3	-1.5	-1.8	-1.2	-2.7	-2.6	-0.5	-1.0	-0.4	-1.5	-1.4	-3.7	-2.5
Current tobacco smoking	0.7	1.2	3.0	-0.2	-1.2	-1.2	-0.8	-0.9	-1.3	-1.0	-1.3	-0.9	-0.7	-1.3	-0.9	-1.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.0	1.6	1.1	1.3	0.2	2.2	1.0	-0.1	0.5	-0.4	0.9	0.1	2.1	1.6
Impedance of leg (left)	0.7	3.5	8.3	-0.0	-2.5	-2.6	-1.8	-0.1	-0.5	-2.9	-2.8	-2.6	-1.5	-1.3	-0.1	-1.4
Leg predicted mass (left)	0.7	3.8	13.0	-2.3	-1.4	-1.7	-1.1	-2.7	-2.5	-0.5	-1.0	-0.4	-1.5	-1.3	-3.6	-2.5
Pulse rate	0.7	1.2	4.0	-0.5	-1.2	-1.1	-0.8	-0.5	-0.9	-1.2	-1.1	-1.1	-2.0	-0.8	-1.1	-1.2
Wheeze or whistling in the chest in last year	0.7	1.2	3.3	-0.4	-1.0	-1.0	-1.3	-0.2	-0.7	-1.8	-1.3	-1.6	-1.6	-0.6	-1.1	-0.2
Leg pain on walking	0.7	0.9	3.1	0.7	1.1	1.8	-0.0	1.1	-0.4	1.0	0.7	0.8	0.2	-0.2	-0.6	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	3.0	0.2	-0.8	-1.2	-0.4	0.4	-0.8	-1.1	-0.8	-0.8	-0.1	-1.0	-0.8	-1.7
Medication: Paracetamol	0.7	1.0	2.2	-1.0	-0.8	-0.8	-0.4	-1.3	-1.4	-0.5	-0.5	-0.7	-1.3	-1.1	-1.2	-1.5
Fractured/broken bones in last 5 years	0.7	0.8	2.7	-0.2	-0.6	-0.3	-1.3	-0.1	-0.8	-1.5	-1.0	-0.8	-1.0	-1.6	-0.3	0.5
Impedance of whole body	0.7	3.3	8.2	0.1	-2.5	-2.5	-1.7	-0.2	-0.2	-2.7	-2.8	-2.9	-1.6	-0.8	0.3	-1.3
Neuroticism (Nagel 2018)	0.6	1.4	4.2	1.2	0.9	0.5	1.9	2.0	1.6	0.4	1.2	0.6	0.7	1.1	1.2	0.4
Blood White Count	0.6	4.1	14.2	-1.9	-2.2	-2.9	-0.5	-2.8	-1.4	-1.3	-1.5	-1.8	-0.9	-2.0	-0.2	-3.8
Medication: Metformin	0.6	0.9	2.3	-1.0	-0.8	-0.8	-0.9	-0.7	-1.0	-0.7	-0.7	-1.1	-0.5	-1.5	-1.1	-1.1
Diabetes (father)	0.6	0.8	1.6	-0.7	-1.0	-1.3	-0.9	-0.5	-0.9	-0.8	-1.0	-0.8	-0.9	-0.4	-0.2	-1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	1.1	0.7	0.6	0.6	1.2	1.1	0.5	0.4	-0.8	0.8	1.0	0.7	0.4
Pain all over the body in last month	0.6	0.7	3.6	0.2	-0.8	-0.6	-0.8	0.0	-0.6	-0.9	-1.0	-1.9	-0.0	-0.3	-0.7	-0.8
Medication: Simvastatin	0.6	0.9	3.7	-0.7	-0.5	-0.3	-0.4	-1.6	-1.1	-0.1	-0.3	-1.5	-0.8	-0.7	-0.4	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.4	1.1	0.6	0.4	1.4	1.0	1.5	0.9	0.9	0.3	1.2	0.7	1.1	0.2
Medication: Amlodipine	0.6	0.8	3.7	-1.0	-0.3	0.2	-0.6	-1.2	-1.2	-0.7	-0.3	-0.5	-0.4	-1.9	-1.2	-0.6
Arm fat-free mass (right)	0.6	3.3	14.9	-2.2	-1.0	-1.2	-1.0	-2.4	-2.5	-0.2	-0.6	0.3	-0.9	-1.3	-3.9	-2.1
Arm predicted mass (right)	0.6	3.1	13.6	-2.0	-1.0	-1.2	-0.9	-2.3	-2.5	-0.2	-0.6	0.3	-0.8	-1.2	-3.7	-2.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	-1.3	-0.9	-1.4	-0.3	-0.9	-0.4	-0.3	-0.4	0.0	-1.2	-0.4	-1.2	-0.8
Medication: Aspirin	0.6	0.8	1.7	1.1	1.2	1.3	0.6	1.0	0.9	1.0	0.7	0.0	1.1	0.1	0.7	1.0
Knee pain experienced in last month	0.6	0.9	1.5	-1.2	-0.9	-0.7	-0.9	-1.2	-0.8	-0.9	-0.7	-1.0	-1.2	-1.1	-0.9	-0.4
Mood swings	0.6	1.0	3.3	0.4	0.9	0.3	1.8	0.9	1.1	1.2	1.3	1.1	1.0	0.9	0.8	-0.0
Eye problems/disorders: Cataract	0.6	0.7	1.8	-0.7	-1.1	-1.3	-0.6	-0.6	-0.2	-1.1	-0.9	-1.1	-0.6	-0.8	-0.1	-0.9
Mother’s age at death	0.6	0.7	2.2	-0.5	-0.9	-1.0	-0.2	-1.0	-0.3	-0.8	-0.6	-1.1	0.1	-1.0	0.6	-1.5
Commuting to job workplace: Public transport	0.6	0.7	3.1	-1.0	-0.4	0.3	-0.7	-1.8	-1.3	-0.4	-0.3	-0.9	-0.7	-1.0	0.3	-0.8
High cholesterol (Self-reported)	0.6	1.1	3.1	-0.8	-0.9	-0.9	-0.6	-1.1	-0.7	-0.8	-0.8	-1.8	-1.0	-1.0	-0.9	-1.5
Illnesses of father: High blood pressure	0.6	0.8	2.3	-1.4	-0.1	-0.1	-0.6	-1.1	-1.2	-0.6	-0.2	0.4	-1.2	-0.8	-1.5	0.0
Basal metabolic rate	0.6	3.1	13.5	-2.0	-1.1	-1.4	-0.9	-2.4	-2.4	-0.1	-0.7	0.1	-1.0	-1.1	-3.7	-2.2
Arm fat-free mass (left)	0.6	3.2	14.3	-2.1	-1.0	-1.2	-1.1	-2.5	-2.5	-0.3	-0.6	0.3	-1.0	-1.3	-3.8	-2.0
Intelligence (Savage-Jansen 2018)	0.5	1.6	4.2	1.7	0.7	1.1	-0.6	1.8	0.8	0.1	-0.2	-0.5	2.0	0.2	2.0	1.9
HbA1C	0.5	0.6	2.5	-0.5	-0.6	-0.4	-1.2	0.2	-0.7	-0.4	-1.0	-1.6	-0.1	-0.2	-1.1	0.1
HDL Cholesterol	0.5	0.8	2.0	-0.4	-0.6	-0.2	-1.1	-0.0	-1.2	-1.2	-0.8	-0.7	-0.7	-1.4	-1.2	-0.2
Chronotype (morning person)	0.5	1.2	3.5	0.4	1.6	1.9	0.8	0.5	0.4	1.2	1.5	1.0	1.6	0.6	0.1	1.0
Diabetes (self-reported)	0.5	0.8	3.0	-0.8	-0.8	-1.2	-0.8	-0.6	-0.4	-0.6	-0.7	-1.1	-0.2	-1.7	0.1	-1.2
Impedance of arm (right)	0.5	2.5	6.5	0.1	-2.2	-2.2	-1.4	-0.2	-0.0	-2.1	-2.5	-2.6	-1.4	-0.5	0.6	-1.0
Time employed in main current job	0.5	0.6	3.4	-1.1	-0.5	-0.4	0.1	-1.9	-0.2	-0.2	-0.1	-0.4	-1.1	0.5	0.5	-0.6
Hair/balding pattern: Pattern 4	0.5	1.2	3.0	-1.7	-0.6	-0.3	-0.7	-1.3	-1.6	-1.2	-0.3	0.5	-1.1	-1.5	-1.6	-0.6
Peak expiratory flow (PEF)	0.5	1.1	2.6	-0.8	-1.0	-1.0	-1.6	-0.2	-0.9	-0.7	-1.2	-1.3	-1.3	-0.3	-1.6	-0.1
Medication: Paracetamol	0.5	0.8	2.0	-1.3	-0.7	-0.5	-0.1	-1.4	-0.9	-0.4	-0.3	-0.8	-1.3	-0.7	-1.0	-0.8
Number of full brothers	0.5	0.6	2.3	-0.1	0.6	0.4	0.6	-0.2	0.9	0.7	0.7	-0.0	1.5	0.6	1.5	0.5
Angina (self-reported)	0.5	0.7	1.8	0.7	0.6	0.4	1.0	0.8	1.4	0.5	0.8	0.6	0.6	1.1	1.0	0.8
Migraine (self-reported)	0.5	0.7	2.0	-0.4	-0.6	-0.6	-0.9	-0.6	-0.9	-1.3	-0.9	-0.6	-0.8	-1.4	-0.7	-0.5
Chest pain or discomfort	0.5	0.7	2.0	1.1	0.9	1.0	0.9	0.9	0.7	0.8	0.8	0.0	0.8	1.4	-0.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.7	-1.0	-1.3	-1.6	-0.7	-1.3	-0.8	-0.5	-1.1	-0.7	-0.2	-0.2	-0.4	-1.5
Leg fat-free mass (right)	0.5	2.6	10.0	-2.1	-0.9	-1.1	-0.8	-2.5	-2.2	0.1	-0.5	0.2	-1.0	-0.8	-3.2	-1.9
Leg predicted mass (right)	0.5	2.5	10.0	-2.0	-0.9	-1.1	-0.8	-2.4	-2.2	0.1	-0.5	0.2	-0.9	-0.8	-3.2	-1.8
Financial situation satisfaction	0.5	0.6	1.8	-0.4	0.7	1.0	0.4	-0.8	0.3	1.4	0.8	0.1	0.9	0.8	0.7	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.3	1.1	0.8	0.7	0.7	0.4	0.5	1.1	0.6	1.1	1.0	-0.3	0.9	-0.1
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	0.6	0.9	1.1	0.3	0.1	0.4	0.8	0.7	0.5	0.3	0.5	0.8	0.7
Breast Cancer	0.4	0.9	2.1	1.2	0.7	0.9	0.2	1.2	0.7	1.0	0.3	-0.9	1.3	0.8	1.4	0.5
Allergy or Eczema	0.4	1.0	4.2	1.2	0.5	0.7	-0.5	1.6	0.4	-0.7	-0.1	-1.4	0.5	-0.6	2.1	0.7
Hair Pigment	0.4	10.6	15.5	-2.4	-3.4	-3.0	-3.8	-2.3	-3.6	-3.8	-3.7	-3.9	-3.5	-3.2	-2.6	-2.2
Number of treatments/medications taken	0.4	0.6	1.5	1.2	0.9	0.6	0.9	1.2	0.6	1.0	0.7	0.0	1.1	-0.2	-0.1	-0.0
Systolic blood pressure, automated reading	0.4	1.2	2.9	-1.3	-0.2	-0.0	-0.7	-1.3	-1.7	-0.8	-0.2	-0.2	-1.7	-1.4	-1.4	-1.0
Angina	0.4	0.6	1.6	0.8	0.5	0.3	0.8	0.7	1.3	0.3	0.7	0.4	0.5	1.0	1.0	0.7
Medication: Co-codamol	0.4	0.5	1.5	0.5	1.1	1.2	0.5	0.4	-0.1	1.0	1.0	0.8	0.4	0.1	-0.4	0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.0	0.6	0.9	1.0	0.9	0.2	0.7	0.8	0.9	0.2	0.8	0.4	0.8	0.1
Allergy	0.4	0.8	3.3	-0.3	0.1	0.0	0.9	-1.2	0.1	1.8	0.7	1.4	0.6	1.1	-0.8	-0.7
Illnesses of siblings	0.4	0.5	1.9	-0.7	-0.9	-0.8	-0.4	-0.3	-0.1	-1.4	-0.8	-0.3	-1.2	-0.2	-0.3	0.5
Falls in the last year	0.4	0.5	3.1	0.8	-0.4	-0.2	-0.7	0.8	0.2	-0.4	-0.8	-1.8	-0.1	-0.5	0.0	0.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	0.6	0.7	0.4	1.4	0.2	0.8	1.1	1.0	1.4	0.5	0.7	0.2	-0.2
Impedance of arm (left)	0.4	1.9	5.5	0.2	-1.9	-1.8	-1.2	-0.1	0.0	-1.8	-2.1	-2.3	-1.3	-0.3	0.5	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	-0.8	-0.7	-0.3	-0.7	-0.7	-0.7	-0.7	-0.6	-1.3	-0.9	-0.7	-0.2	-0.1
Heart disease (mother)	0.4	0.5	1.7	0.9	0.1	-0.1	1.0	0.8	0.8	0.4	0.4	0.3	0.4	1.3	0.6	-0.4
Alcohol intake frequency.	0.4	0.9	1.8	0.1	1.1	1.3	1.0	-0.1	0.7	1.1	1.3	1.0	0.9	1.1	0.7	1.2
Whole body fat-free mass	0.4	2.0	9.7	-1.6	-0.6	-0.9	-0.6	-2.0	-2.0	0.4	-0.3	0.7	-0.4	-0.7	-3.1	-1.8
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.7	0.8	0.3	0.1	0.5	0.4	0.4	0.9	0.3	1.3	1.2	0.6	0.4	-0.0
Osteoporosis (self-reported)	0.4	0.4	1.4	0.4	0.7	0.6	0.7	1.1	0.7	0.3	0.6	0.4	0.1	1.2	-0.2	0.8
Smoking status: Current	0.4	0.6	1.2	0.1	-0.9	-0.9	-0.7	-0.5	-0.9	-0.8	-1.1	-0.7	-0.3	-1.1	-0.6	-1.1
Wears glasses or contact lenses	0.4	0.5	1.0	-0.2	-0.7	-0.5	-0.8	-0.0	-0.7	-1.0	-0.8	-0.8	-0.8	-0.7	-0.7	-0.5
Ever depressed for a whole week	0.4	0.5	1.4	-0.5	0.8	0.9	0.6	0.6	0.2	0.6	0.9	0.9	-0.1	0.5	-0.1	1.2
Cholesterol lowering medication	0.4	0.7	2.8	-0.9	-0.3	-0.3	-0.4	-0.6	-0.8	-0.7	-0.2	-0.6	-1.3	-0.9	-1.7	-0.5
Arm predicted mass (left)	0.4	2.0	10.6	-1.6	-0.6	-0.8	-0.7	-1.9	-2.0	0.1	-0.3	0.6	-0.5	-0.9	-3.3	-1.6
Schizophrenia (2018)	0.3	0.5	2.2	0.5	-0.4	-0.1	-0.8	0.2	-0.9	-1.0	-0.8	-0.6	-0.5	-1.5	-0.4	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.3	1.2	0.6	0.2	0.4	-0.4	0.6	0.4	-0.5	-0.1	-0.6	1.1	-0.9	0.7	0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.8	0.8	-0.5	-0.8	-0.2	0.1	0.3	-0.6	-0.7	-0.3	0.1	-0.1	0.9	-0.6
Age at First Birth	0.3	0.4	1.2	0.8	0.7	0.8	0.0	0.4	0.1	1.1	0.4	0.9	0.7	0.4	0.1	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	0.0	-0.8	-1.3	0.0	-0.4	0.5	-0.4	-0.6	-0.4	0.6	-1.4	1.1	-0.9
Relative age of first facial hair	0.3	0.7	3.4	0.8	0.5	0.7	0.4	0.4	0.7	0.3	0.5	0.5	1.8	-0.3	1.6	0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.3	2.4	0.2	0.4	0.4	-0.2	1.1	0.6	-0.3	0.1	0.2	0.1	-0.2	-0.1	1.5
Ever had hysterectomy (womb removed)	0.3	0.3	1.8	0.6	-0.2	-0.6	-0.0	1.3	0.6	-0.5	-0.5	-0.3	-0.3	0.6	-0.5	0.6
Medication for hormone replacement therapy	0.3	0.3	0.8	0.6	0.6	0.7	0.3	0.6	0.3	0.9	0.5	0.6	0.3	0.3	0.7	0.5
Diabetes (mother)	0.3	0.4	1.9	-0.0	-0.8	-1.1	-0.0	-0.2	0.0	-0.3	-0.7	-1.1	-0.3	-0.2	0.2	-1.4
Hand grip strength (right)	0.3	0.7	2.1	1.1	0.6	0.5	-0.2	1.4	0.6	0.7	0.1	1.0	1.0	1.0	-0.0	1.2
Townsend deprivation index at recruitment	0.3	0.5	1.1	0.0	0.6	1.0	0.1	-0.7	0.2	1.1	0.6	-0.5	1.0	0.7	0.9	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	0.9	0.6	1.1	0.3	0.4	0.3	0.5	0.4	-0.8	0.6	0.2	0.8	0.2
Taking other prescription medications	0.3	0.4	1.4	0.9	0.4	-0.2	1.2	1.0	0.6	0.9	0.5	0.4	0.6	0.4	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.3	-0.4	0.6	0.5	1.1	-0.6	0.8	1.5	1.0	1.0	0.6	1.3	0.5	0.5
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.7	0.3	0.2	0.7	0.6	0.9	0.4	0.4	0.7	0.5	0.7	0.9	0.6
High blood pressure	0.3	1.0	1.9	-1.3	-0.3	0.0	-0.6	-1.3	-1.3	-0.1	-0.3	-1.0	-1.2	-1.2	-1.4	-0.8
Sitting height	0.3	2.0	5.5	-1.2	-1.4	-1.7	-0.8	-2.0	-1.4	-0.4	-1.0	0.4	-0.1	-1.1	-2.2	-2.3
Number of incorrect matches in round	0.3	0.5	3.5	0.3	0.2	0.6	-0.1	-0.4	-0.9	-0.2	0.1	-0.1	0.7	-1.9	0.7	-0.9
Past tobacco smoking	0.3	0.5	1.7	-1.3	-0.4	-0.3	0.3	-0.9	-0.5	-0.3	0.2	0.2	-1.2	0.2	-1.2	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.0	-0.7	-0.8	-0.8	0.4	0.0	-0.6	-0.9	-0.9	-0.5	-0.3	-0.6	0.2
Had menopause	0.3	0.4	1.2	-0.6	-0.2	0.1	-0.6	-0.3	-0.4	-0.8	-0.3	-0.7	-1.0	-0.3	-1.1	0.2
Forced vital capacity (FVC)	0.3	1.3	3.7	0.9	0.9	0.9	0.3	1.1	1.3	1.0	0.7	0.9	1.3	1.6	0.9	1.9
Medication: Ramipril	0.3	0.4	1.7	-1.3	-0.1	0.3	-0.3	-1.1	-0.2	0.1	0.1	-1.1	-0.2	-0.2	-0.5	0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	0.6	0.5	0.4	0.7	0.3	0.3	0.7	0.4	0.5	1.1	0.8	0.9	-0.2
Medication: Cholesterol lowering	0.3	0.4	1.9	-0.0	-0.4	-0.5	0.1	-0.6	0.4	0.1	-0.3	-1.4	0.6	-0.4	1.0	-0.9
Medication: Lansoprazole	0.3	0.3	1.4	0.5	0.0	-0.4	0.7	1.2	1.1	-0.4	0.2	-0.4	-0.1	0.5	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.5	0.4	0.7	0.6	0.5	1.1	0.1	0.1	0.7	1.6	0.1	0.9	-0.1	0.8
Glaucoma (self-reported)	0.3	0.4	1.3	0.5	-0.8	-1.1	0.1	0.3	0.1	-0.5	-0.7	-0.4	-0.3	-0.3	0.0	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.5	0.4	-0.2	-0.2	-0.7	0.4	-0.7	-0.3	-0.6	-0.0	-0.8	0.1	-1.6	0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.9	-0.1	-0.2	-0.1	-0.9	0.1	-0.6	-0.7	-0.5	-0.1	-0.7	-0.7	-1.4	0.5
High blood pressure (siblings)	0.3	0.4	1.0	-0.3	0.8	1.0	0.1	0.1	0.2	1.0	0.8	0.4	0.5	0.5	0.1	0.8
Forced vital capacity (FVC), Best measure	0.3	1.1	2.5	1.1	0.9	1.1	0.4	1.2	1.0	1.1	0.7	0.9	1.4	1.4	0.4	1.6
Medication for pain relief, constipation, heartburn	0.3	0.6	2.7	0.4	0.6	0.6	0.3	0.7	0.4	0.6	0.7	1.6	0.4	1.0	0.5	0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-0.2	0.3	0.1	0.8	-0.8	0.2	0.9	0.6	0.9	0.5	0.4	0.8	-0.6
Average weekly red wine intake	0.3	0.5	1.5	0.3	0.2	0.1	0.5	0.7	1.2	0.4	0.3	-0.6	0.6	1.1	1.2	0.6
Diabetes diagnosed by doctor	0.3	0.5	2.0	-0.1	-0.7	-1.1	-0.6	-0.2	-0.2	-0.3	-0.8	-1.0	0.2	-1.4	0.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.3	0.4	0.2	0.3	0.2	0.4	0.7	0.7	0.1	0.2	1.1	-0.3	0.6	0.7
Whole body water mass	0.3	1.9	9.3	-1.5	-0.4	-0.7	-0.4	-1.9	-1.9	0.5	-0.1	0.9	-0.2	-0.6	-3.0	-1.7
Miserableness	0.3	0.6	2.2	0.8	0.6	0.4	1.1	1.5	1.0	0.5	0.7	0.2	0.9	0.4	0.4	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	1.5	0.9	-0.2	-0.8	0.8	0.6	0.5	0.3	-0.1	0.2	0.5	0.3	0.8	-1.2
Medication: Blood pressure	0.3	0.5	1.8	-0.8	-0.4	-0.6	-0.4	-0.4	-0.5	-0.4	-0.3	-1.1	-0.9	-0.7	-1.3	-0.5
Ever smoked	0.3	0.5	2.2	1.2	0.5	0.4	-0.1	0.4	0.3	0.5	-0.1	0.0	1.4	-0.1	1.5	0.5
Irritability	0.3	0.6	1.5	-0.7	-0.9	-1.2	-0.1	-0.3	0.4	-1.2	-0.6	-0.7	-0.5	-0.5	1.1	-0.4
Unable to work because of sickness or disability	0.3	0.3	0.9	0.7	-0.3	0.0	-0.4	-0.2	-0.7	0.4	-0.5	-0.6	0.6	-0.9	-0.7	-0.7
Depression (Nagel 2018)	0.2	0.3	1.4	0.7	-0.1	0.2	0.1	0.2	-0.3	0.1	-0.1	-1.1	0.0	-0.2	0.1	-1.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.5	1.2	0.3	0.1	0.3	0.3	0.6	0.4	-0.0	0.2	0.5	0.5	1.2	-0.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.7	-0.3	0.4	-0.0	1.2	0.8	1.3	0.4	1.0	0.5	0.7	0.1	0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.4	0.1	-0.1	-0.2	-0.7	0.4	0.7	-0.4	-0.5	-0.0	0.9	0.3	1.4	1.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	0.8	-0.1	-0.5	1.0	0.8	0.9	0.3	0.1	0.0	0.5	0.5	0.0	-0.3
Schizophrenia (2014)	0.2	0.4	1.1	0.3	-0.3	0.0	-0.8	-0.0	-0.8	-0.7	-0.7	-0.6	-0.4	-1.1	-0.6	-0.3
Blood Platelet Count	0.2	1.8	11.0	1.4	1.1	1.4	0.5	1.4	1.3	0.5	0.7	0.3	0.3	0.9	3.3	1.5
Cardiovascular Disease	0.2	0.7	2.4	-1.5	-0.5	-0.5	0.1	-1.4	-0.6	0.3	-0.0	-0.4	-1.0	-1.1	-0.8	-1.2
Hand grip strength (left)	0.2	0.4	1.1	0.6	0.4	0.5	-0.0	0.6	0.4	0.7	0.1	1.1	1.0	0.5	0.2	0.9
Sensitivity / hurt feelings	0.2	0.4	1.1	0.1	0.5	0.1	1.1	0.9	0.8	0.9	0.9	0.0	0.5	0.7	0.2	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	1.4	0.5	-0.0	0.2	-0.3	1.1	0.3	-0.6	-0.2	-1.2	0.3	-0.5	0.0	0.6
Supplements: Zinc	0.2	0.2	0.9	1.0	0.4	0.5	0.1	0.4	-0.1	0.4	0.1	-0.1	0.6	0.2	0.5	-0.5
Maternal smoking around birth	0.2	0.3	1.2	0.5	-0.1	-0.1	-0.4	0.8	0.2	-0.6	-0.5	-0.2	0.0	0.1	-1.1	1.0
Stomach or abdominal pain in last month	0.2	0.2	1.2	0.5	0.1	0.1	0.4	-0.1	-0.2	0.4	0.4	-0.7	0.5	-0.2	0.3	-1.1
Alcohol usually taken with meals	0.2	0.3	1.6	0.1	0.4	0.7	0.6	-0.6	0.3	0.6	0.6	0.0	0.7	0.3	1.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.8	0.4	0.5	0.7	0.7	0.7	0.5	0.5	0.7	0.3	0.9	-0.1	0.9	0.4
Fluid intelligence score	0.2	0.4	1.3	-0.5	-0.0	-0.1	-0.0	-0.0	0.6	0.1	0.1	0.7	1.1	0.8	0.7	1.0
Trunk fat-free mass	0.2	1.2	6.7	-1.0	0.1	-0.1	-0.0	-1.3	-1.4	1.1	0.3	1.5	0.5	-0.1	-2.6	-1.1
Noisy workplace	0.2	0.3	1.3	-0.3	0.5	0.5	0.4	0.3	0.4	0.7	0.5	0.5	0.1	0.6	-0.2	1.1
Lung cancer (father)	0.2	0.2	1.1	-0.2	0.3	0.5	0.4	0.2	0.0	0.0	0.4	1.1	0.2	0.3	-0.1	0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	-0.4	-0.7	-0.9	-0.1	-0.5	-0.3	-0.1	-0.4	-0.1	-0.7	-0.4	-0.3	-0.7
Trunk predicted mass	0.2	1.2	6.7	-0.9	0.1	-0.2	-0.1	-1.2	-1.4	1.1	0.3	1.4	0.5	-0.2	-2.6	-1.1
Standing height	0.2	2.1	4.8	-0.5	-1.6	-2.0	-1.3	-1.6	-1.5	-0.0	-1.7	0.2	0.7	-0.7	-2.0	-2.2
Length of working week for main job	0.2	0.2	0.8	0.2	0.5	0.3	0.9	0.2	0.1	0.6	0.7	0.6	0.4	0.1	0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.0	-1.0	-0.2	0.1	-0.1	-0.9	-0.4	0.5	0.2	-0.2	-0.1	-0.1	-0.2	-0.3
Medication: Seretide 50 evohaler	0.2	0.3	1.0	0.2	0.7	0.8	0.3	0.8	0.5	0.1	0.6	-0.2	0.2	0.1	0.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.6	0.1	0.2	-0.9	0.4	-0.6	-0.3	-0.2	-0.4	-0.6	-0.3	-0.6	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.7	-0.3	0.1	-0.0	-0.5	-0.1	-0.5	0.0	0.4	-0.7	0.4	0.2	0.8
Hypertension (Self-reported)	0.2	0.6	1.2	-1.1	-0.1	0.2	-0.2	-1.1	-0.9	0.0	0.1	-0.9	-0.9	-1.1	-1.0	-0.8
Smoking status: Previous	0.2	0.3	1.0	0.9	0.4	0.2	-0.3	0.7	0.5	0.3	-0.1	-0.3	0.8	-0.2	1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	-0.6	-0.5	-0.2	-0.6	-1.2	-0.9	-0.3	-0.4	-0.0	-0.7	-0.6	-0.6	-0.8
Hearing aid user	0.2	0.2	0.6	0.8	-0.2	-0.2	-0.5	0.6	-0.0	-0.0	-0.6	-0.3	-0.1	-0.1	-0.4	0.6
Medication: Lisinopril	0.2	0.3	0.9	0.9	0.5	0.6	-0.1	0.9	0.2	0.5	0.1	-0.3	0.4	0.4	0.4	0.4
Number of operations (self-reported)	0.2	0.3	2.1	-0.2	0.0	-0.3	-0.2	-0.2	-0.4	0.2	-0.2	0.7	-0.3	-0.3	-1.4	0.2
Average weekly beer plus cider intake	0.2	0.3	1.5	-0.7	-0.1	0.0	-0.4	0.2	-0.1	-0.3	0.0	0.5	-0.7	0.0	-1.2	1.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	0.8	0.2	0.1	0.4	0.1	-0.3	0.3	0.1	0.8	-0.0	0.1	-0.4	-0.7
Pain experienced in last month	0.2	0.4	2.0	0.5	0.8	0.6	0.2	1.0	-0.1	0.1	0.6	1.4	-0.1	0.7	-0.4	0.3
Supplements: Calcium	0.2	0.2	2.0	0.5	0.2	0.2	0.4	-0.0	0.3	0.4	0.2	-0.0	0.5	-0.2	1.4	-0.4
Basal cell carcinoma (self-reported)	0.2	0.3	0.8	0.0	0.5	0.4	0.6	-0.0	-0.1	0.9	0.5	0.7	0.4	0.8	0.4	-0.3
Bipolar Disorder (2018)	0.1	0.1	0.4	0.2	-0.0	-0.0	-0.0	-0.0	-0.0	0.4	-0.1	0.5	-0.2	0.6	-0.4	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.5	-0.4	-0.1	-0.7	0.1	-0.7	-0.5	-0.7	-0.2	-0.5	-0.8	-0.6	-0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.8	-0.0	-0.1	-0.3	0.9	0.8	0.4	-0.3	0.3	0.1	-0.4	0.3	-0.4	-0.3
Height	0.1	2.4	6.2	-0.3	-1.6	-2.4	-1.2	-1.4	-1.1	0.5	-1.6	0.2	1.9	-0.6	-2.3	-2.5
Systolic Blood Pressure	0.1	0.5	1.9	0.1	1.1	1.4	0.7	0.2	0.1	0.5	1.1	1.0	-0.2	-0.3	0.5	0.8
Smoking Status	0.1	0.3	1.6	1.3	0.0	-0.3	-0.1	0.9	0.2	0.2	-0.5	0.1	0.7	0.0	0.3	0.1
Respiratory disease	0.1	0.2	0.7	0.4	0.4	0.4	-0.3	0.6	-0.4	-0.8	-0.1	0.0	-0.5	-0.6	-0.4	0.4
Tanning	0.1	1.4	3.6	1.4	0.4	-0.4	1.9	1.4	1.8	1.1	0.6	1.2	1.4	1.3	0.9	0.0
Fed-up feelings	0.1	0.2	0.7	-0.1	0.0	-0.3	0.8	0.4	0.1	0.1	0.5	0.2	0.1	-0.1	-0.6	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.1	-0.0	-0.1	-0.0	-0.3	-0.1	0.4	-0.1	-0.3	0.3	-0.3	-0.4	-0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	-0.8	0.1	-0.0	0.4	-0.2	-0.0	0.5	0.5	0.6	0.1	-0.0	-0.8	-0.2
Medication: Atenolol	0.1	0.1	0.3	0.3	0.4	0.3	0.5	0.1	0.3	0.5	0.4	-0.1	0.4	-0.2	-0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	-0.9	-0.0	-0.1	0.3	-0.9	0.3	0.8	0.3	0.4	0.0	0.8	0.3	0.2
Alcohol intake versus 10 years previously	0.1	0.2	1.0	0.3	0.2	0.1	0.3	-0.0	0.9	0.1	0.2	0.4	0.2	-0.0	1.0	0.8
Number of live births	0.1	0.1	0.4	0.1	0.0	-0.5	0.1	0.2	0.4	-0.2	-0.1	0.3	-0.5	0.4	-0.6	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	1.6	-0.1	0.0	0.1	-0.4	0.4	0.5	0.1	-0.0	-0.0	0.2	0.9	-0.1	1.3
Asthma	0.1	0.2	1.0	0.6	0.5	0.4	-0.1	1.0	-0.0	-0.5	-0.0	0.0	-0.4	0.1	-0.3	0.6
Prospective memory result	0.1	0.2	0.8	0.9	0.3	0.1	0.5	0.7	0.1	0.1	0.2	0.6	-0.3	0.3	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.8	0.1	0.2	0.2	-0.2	0.5	0.3	0.5	0.1	0.3	0.4	0.6	-0.5	0.9
Exposure to tobacco smoke outside home	0.1	0.2	0.8	0.3	0.5	0.8	-0.2	0.4	0.2	-0.2	0.3	-0.2	-0.1	0.0	0.1	0.9
Age at first live birth	0.1	0.1	0.4	-0.0	0.0	0.2	-0.1	-0.1	0.1	0.6	0.1	-0.4	0.6	0.3	0.6	-0.1
Pulse wave peak to peak time	0.1	0.1	0.6	0.4	0.4	0.5	-0.1	0.4	0.2	-0.0	0.1	0.0	0.8	0.2	0.0	0.5
Health satisfaction	0.1	0.2	0.8	-0.2	0.5	0.9	0.3	-0.2	-0.4	0.2	0.6	0.0	0.1	-0.1	-0.3	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.6	0.2	-0.2	-0.2	-0.0	0.0	0.6	-0.1	-0.2	-0.6	0.0	0.2	0.7	0.3
Medication: Blood pressure	0.1	0.2	0.7	0.1	0.3	0.8	0.0	-0.4	0.0	0.8	0.1	-0.6	0.1	-0.4	0.1	0.1
Overall health rating	0.1	0.2	0.6	0.5	0.2	-0.0	0.8	0.1	0.6	0.4	0.4	-0.3	0.2	0.2	0.4	-0.4
Ever had bowel cancer screening	0.1	0.2	0.7	0.1	-0.1	0.1	0.4	-0.5	0.6	0.2	0.1	-0.3	0.6	-0.1	0.8	0.0
Medication for cholesterol	0.1	0.2	1.3	0.1	-0.3	-0.1	-0.2	-0.4	0.0	-0.2	-0.3	0.2	0.6	0.5	1.1	0.0
Mineral and other dietary supplements	0.1	0.1	1.0	-0.3	-0.1	-0.3	0.3	0.1	0.3	-0.2	0.1	-0.0	-0.4	1.0	-0.2	0.1
Asthma (self-reported)	0.1	0.2	1.0	0.6	0.4	0.3	-0.2	1.0	-0.1	-0.6	-0.1	-0.0	-0.3	0.0	-0.2	0.6
Medication: Aspirin	0.1	0.1	0.5	0.5	0.5	0.6	-0.2	0.3	0.1	0.4	-0.0	-0.7	0.2	-0.4	-0.0	0.3
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.4	0.4	0.1	0.5	-0.2	0.3	0.3	0.4	0.1	-0.2	0.3	0.3	0.0
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.3	0.1	0.0	0.1	0.5	0.4	-0.0	0.0	-0.5	-0.3	0.1	-0.3	0.2
Medication: Atorvastatin	0.1	0.2	0.8	-0.0	0.1	-0.2	0.1	0.5	0.9	-0.2	0.1	-0.2	0.7	-0.2	0.3	0.6
Alcohol drinker status: Never	0.1	0.1	0.4	-0.5	-0.0	0.2	0.3	-0.4	0.4	-0.1	0.4	-0.3	-0.1	0.6	0.3	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	0.7	-0.4	-0.8	0.0	0.8	0.6	-0.7	-0.4	0.5	0.5	0.5	0.6	0.2
Heart disease (siblings)	0.1	0.1	0.6	0.1	0.1	-0.0	-0.1	-0.1	-0.0	0.2	0.0	-0.5	0.8	-0.5	0.3	-0.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.1	-0.2	-0.4	0.1	0.1	0.1	0.0	-0.1	0.0	0.2	-0.1	0.4	-0.3

Hub : Genes

IL12RB1

Models

Trait associations