Best TWAS P=1.87e-13 · Best GWAS P=2.9e-13 conditioned to 0.22
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM76B | 0.06 | 0.02 | lasso | 3 | 0.01 | 8.1e-03 | -6.0 | 6.4 | 1.9e-10 | -0.90 | 0.05 | 0.94 | FALSE |
2 | GTEx | Adipose Subcutaneous | CEP57 | 0.17 | 0.12 | enet | 26 | 0.14 | 3.1e-11 | -7.0 | -7.2 | 8.0e-13 | 0.91 | 0.02 | 0.98 | FALSE |
3 | GTEx | Adipose Subcutaneous | AP001877.1 | 0.16 | 0.04 | enet | 35 | 0.05 | 1.0e-04 | -6.0 | -6.2 | 5.9e-10 | 0.59 | 0.06 | 0.93 | FALSE |
4 | GTEx | Adipose Visceral Omentum | CEP57 | 0.10 | 0.16 | lasso | 1 | 0.13 | 3.3e-07 | -6.9 | -6.9 | 6.5e-12 | 0.99 | 0.02 | 0.98 | FALSE |
5 | GTEx | Artery Tibial | MTMR2 | 0.17 | 0.09 | enet | 23 | 0.11 | 1.2e-08 | -7.1 | 5.7 | 9.2e-09 | -0.75 | 0.02 | 0.98 | FALSE |
6 | GTEx | Brain Caudate basal ganglia | AP001877.1 | 0.21 | 0.03 | lasso | 15 | 0.01 | 1.4e-01 | -7.0 | -6.4 | 1.2e-10 | 0.89 | 0.03 | 0.84 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | AP001877.1 | 0.29 | 0.24 | lasso | 7 | 0.25 | 5.0e-07 | -7.1 | -6.9 | 6.8e-12 | 0.96 | 0.04 | 0.96 | FALSE |
8 | GTEx | Brain Putamen basal ganglia | AP001877.1 | 0.39 | 0.05 | lasso | 15 | 0.08 | 6.5e-03 | -7.0 | -5.6 | 1.9e-08 | 0.78 | 0.04 | 0.79 | FALSE |
9 | GTEx | Breast Mammary Tissue | CEP57 | 0.11 | 0.06 | lasso | 3 | 0.06 | 4.5e-04 | -7.1 | -7.0 | 2.0e-12 | 0.93 | 0.02 | 0.96 | FALSE |
10 | GTEx | Breast Mammary Tissue (Male) | CEP57 | 0.08 | 0.06 | lasso | 2 | 0.03 | 5.8e-02 | -6.2 | -6.2 | 4.3e-10 | 0.82 | 0.05 | 0.47 | FALSE |
11 | GTEx | Breast Mammary Tissue (Female) | CEP57 | 0.01 | 0.01 | lasso | 2 | -0.01 | 7.0e-01 | -5.9 | -6.6 | 3.9e-11 | 0.87 | 0.04 | 0.46 | FALSE |
12 | GTEx | Colon Transverse | CEP57 | 0.12 | 0.11 | lasso | 3 | 0.11 | 6.8e-06 | -6.0 | -6.8 | 1.4e-11 | 0.96 | 0.02 | 0.98 | FALSE |
13 | GTEx | Esophagus Mucosa | CEP57 | 0.14 | 0.14 | lasso | 3 | 0.10 | 6.0e-07 | -6.1 | -6.5 | 7.7e-11 | 0.89 | 0.06 | 0.94 | FALSE |
14 | GTEx | Esophagus Mucosa | AP001877.1 | 0.09 | 0.00 | lasso | 3 | 0.00 | 5.4e-01 | -7.3 | -7.4 | 1.9e-13 | 0.93 | 0.02 | 0.82 | TRUE |
15 | GTEx | Esophagus Muscularis | CEP57 | 0.15 | 0.05 | enet | 21 | 0.06 | 9.0e-05 | -6.1 | -6.7 | 3.0e-11 | 0.85 | 0.05 | 0.95 | FALSE |
16 | GTEx | Esophagus Muscularis | AP001877.1 | 0.17 | 0.09 | lasso | 6 | 0.10 | 6.2e-07 | -6.0 | -6.2 | 4.7e-10 | 0.87 | 0.14 | 0.85 | FALSE |
17 | GTEx | Liver | FAM76B | 0.43 | 0.08 | enet | 32 | 0.13 | 1.4e-04 | -7.0 | -5.5 | 4.2e-08 | 0.73 | 0.04 | 0.92 | FALSE |
18 | GTEx | Liver | CEP57 | 0.24 | 0.10 | enet | 23 | 0.01 | 2.1e-01 | -7.0 | -7.2 | 4.8e-13 | 0.92 | 0.03 | 0.86 | FALSE |
19 | GTEx | Lung | CEP57 | 0.12 | 0.05 | enet | 16 | 0.04 | 4.4e-04 | -7.1 | -6.7 | 1.7e-11 | 0.92 | 0.04 | 0.96 | FALSE |
20 | GTEx | Muscle Skeletal | CEP57 | 0.15 | 0.18 | lasso | 9 | 0.18 | 1.8e-17 | -7.0 | -6.8 | 1.4e-11 | 0.93 | 0.04 | 0.96 | FALSE |
21 | GTEx | Nerve Tibial | MTMR2 | 0.14 | 0.10 | enet | 16 | 0.08 | 2.0e-06 | -7.1 | 7.2 | 4.8e-13 | -0.95 | 0.03 | 0.97 | FALSE |
22 | GTEx | Nerve Tibial | CEP57 | 0.15 | 0.08 | lasso | 6 | 0.07 | 1.9e-05 | -6.0 | -6.5 | 7.2e-11 | 0.92 | 0.04 | 0.96 | FALSE |
23 | GTEx | Nerve Tibial | AP001877.1 | 0.15 | 0.05 | lasso | 3 | 0.05 | 1.6e-04 | -7.0 | -7.3 | 3.5e-13 | 0.92 | 0.04 | 0.96 | FALSE |
24 | GTEx | Pancreas | CEP57 | 0.19 | 0.10 | lasso | 13 | 0.08 | 3.6e-04 | -6.1 | -6.5 | 6.1e-11 | 0.91 | 0.05 | 0.95 | FALSE |
25 | GTEx | Skin Not Sun Exposed Suprapubic | CEP57 | 0.14 | 0.06 | enet | 10 | 0.05 | 9.6e-04 | -5.4 | -6.6 | 5.1e-11 | 0.84 | 0.04 | 0.96 | FALSE |
26 | GTEx | Skin Sun Exposed Lower leg | CEP57 | 0.19 | 0.14 | enet | 24 | 0.16 | 4.1e-13 | -6.1 | -6.8 | 8.1e-12 | 0.92 | 0.05 | 0.95 | FALSE |
27 | GTEx | Small Intestine Terminal Ileum | AP001877.1 | 0.34 | 0.14 | lasso | 22 | 0.11 | 1.8e-03 | -6.2 | -6.8 | 1.1e-11 | 0.88 | 0.04 | 0.87 | FALSE |
28 | GTEx | Testis | MTMR2 | 0.22 | 0.18 | lasso | 3 | 0.18 | 2.8e-08 | -7.1 | 7.2 | 5.7e-13 | -0.97 | 0.02 | 0.98 | FALSE |
29 | GTEx | Thyroid | CEP57 | 0.11 | 0.01 | enet | 15 | 0.03 | 1.8e-03 | -6.1 | -6.1 | 1.2e-09 | 0.73 | 0.07 | 0.87 | FALSE |
30 | METSIM | Adipose | CEP57 | 0.06 | 0.07 | lasso | 1 | 0.06 | 1.8e-09 | -6.2 | -6.2 | 4.7e-10 | 0.85 | 0.04 | 0.96 | FALSE |
31 | ROSMAP | Brain Pre-frontal Cortex | AP001877.1 | 0.17 | 0.27 | lasso | 12 | 0.27 | 3.6e-35 | -7.0 | -7.0 | 2.5e-12 | 0.95 | 0.04 | 0.96 | FALSE |
32 | YFS | Blood | CEP57 | 0.04 | 0.03 | lasso | 5 | 0.03 | 3.4e-11 | -6.9 | -6.0 | 2.2e-09 | 0.85 | 0.04 | 0.96 | FALSE |
33 | YFS | Blood | FAM76B | 0.14 | 0.25 | lasso | 10 | 0.26 | 8.1e-83 | -6.9 | 7.0 | 2.7e-12 | -0.94 | 0.04 | 0.96 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CEP57 | 0.02 | 0.00 | blup | 53 | 0.01 | 6.0e-02 | -6.0 | -6.5 | 6.4e-11 | 0.90 | 0.02 | 0.59 | FALSE |