Hub : Genes

MTMR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.061	0.0250	8.6e-03	0.064	0.001	0.037	0.05	0.062	3.3e-08	2.6e-01	2.4e-05	1e-06	4.6e-08
2	GTEx	Artery Aorta	0.494	0.0730	7.8e-13	0.129	NA	0.268	NA	0.264	1.4e-07	NA	4.7e-15	NA	8.3e-15
3	GTEx	Artery Tibial	0.175	0.0441	3.8e-07	0.094	NA	0.106	NA	0.101	8.3e-08	NA	1.2e-08	NA	2.5e-08
4	GTEx	Nerve Tibial	0.141	0.0412	2.7e-05	0.096	NA	0.082	NA	0.072	2.7e-07	NA	2.0e-06	NA	8.0e-06
5	GTEx	Testis	0.225	0.0600	1.1e-05	0.182	NA	0.144	NA	0.177	1.7e-08	NA	6.4e-07	NA	2.8e-08
6	TCGA	Colon Adenocarcinoma	0.128	0.0820	7.3e-03	0.049	0.024	0.063	NA	0.043	7.8e-04	1.4e-02	1.6e-04	NA	1.6e-03
7	TCGA	Prostate Adenocarcinoma	0.132	0.0466	9.6e-14	0.118	0.138	0.082	NA	0.142	2.5e-12	2.7e-14	6.1e-09	NA	1.3e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.2	0.4	-0.1	0.5	0.4	0.3	0.6	-0.2	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	1.9	0.0	-0.7	-1.4	-1.4	-1.1	1.1	-0.3
Depressed Affect (Nagel 2018)	0.4	0.9	2.0	-1.4	1.0	0.9	0.8	0.8	0.0	-1.1
Depression (Nagel 2018)	1.2	1.8	3.0	-1.3	1.7	1.6	1.3	1.5	0.1	-1.4
Intelligence (Savage-Jansen 2018)	4.6	14.2	33.2	0.7	-3.8	-4.2	-5.8	-5.0	2.7	1.6
Neuroticism (Nagel 2018)	1.2	2.8	4.0	-1.9	2.0	1.6	1.9	1.9	0.1	-1.5
Schizophrenia (2018)	1.1	2.4	4.5	0.1	-1.3	-2.1	-2.0	-2.0	1.6	-0.0
Schizophrenia vs Biploar Disorder	0.8	1.1	2.7	-1.0	-0.2	-0.6	-1.6	-1.0	1.2	-0.9
Worry (Nagel 2018)	5.3	11.2	16.6	-3.2	4.0	4.1	3.7	3.8	-0.3	-2.8
Alzheimer’s Disease (in mother)	2.0	2.4	4.6	0.6	-2.0	-2.0	-1.6	-2.1	0.3	1.1
Alzheimer’s Disease (in father)	0.4	0.5	2.3	0.4	0.2	-0.4	0.7	0.3	-1.5	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.1	-0.5	-0.8	0.3	-0.3	-0.9	0.7
Crohns Disease (2017)	0.3	0.6	1.1	-0.1	0.8	1.1	0.9	0.8	-0.5	-0.8
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.1	-0.2	0.1	-0.4	-0.8	0.6	-0.2
Ulcerative Colitis (UC)	0.3	0.5	1.7	-0.1	-0.5	-0.2	-0.7	-1.3	1.1	0.0
Major Depression (MDD)	2.0	2.4	2.9	-1.7	1.7	1.7	1.5	1.6	-0.9	-1.7
Reaction Time	0.5	0.9	2.1	0.4	-0.1	0.6	1.4	1.5	-0.5	1.3
Verbal and Numeric Reasoning (VNR)	3.8	9.2	20.8	0.5	-3.0	-3.6	-4.6	-4.2	1.6	1.2
Breast Cancer	1.8	4.4	10.6	-0.4	-1.4	-1.7	-3.3	-2.9	2.7	0.3
Ovarian Cancer	0.9	1.2	4.7	-0.3	2.2	0.7	0.2	0.1	-0.2	-1.8
Prostate Cancer	0.4	0.6	1.9	-0.7	0.6	0.2	1.0	1.4	-0.7	-0.1
Age at First Birth	1.6	2.3	3.2	1.4	-1.8	-1.7	-1.8	-1.8	-0.1	1.5
Bipolar Disorder (2011)	1.4	1.4	4.2	2.0	-0.8	-1.4	-0.9	-1.2	-0.4	0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	0.0	-0.5	-0.8	0.4	0.0	-0.6	0.4
Coronary Artery Disease (CAD)	0.9	1.1	3.0	-0.7	0.6	1.2	1.7	1.7	-0.1	-0.0
Crohns Disease (2012)	0.3	0.4	1.5	-0.8	0.2	0.0	-0.0	-0.5	1.2	-0.8
Mean Putamen Volume	0.9	1.1	2.3	0.6	-0.9	-1.5	-1.2	-0.9	1.2	0.5
Fasting Glucose	0.7	0.8	2.4	-1.6	0.4	1.4	0.3	0.9	0.0	-0.3
HbA1C	0.3	0.3	0.8	-0.7	-0.2	0.2	0.1	0.9	0.4	0.7
HDL Cholesterol	0.0	0.1	0.2	0.1	0.2	-0.5	0.3	-0.1	0.4	0.0
LDL Cholesterol	1.5	2.3	4.7	0.6	1.3	1.5	2.1	2.2	-1.5	0.8
Lupus	0.6	0.8	3.9	-2.0	0.4	-0.4	-0.4	-0.2	0.7	-1.0
Neuroticism (2016)	2.3	3.3	6.8	-1.6	2.3	2.6	1.4	1.6	-0.2	-2.0
Primary Biliary Cirrhosis	0.3	0.4	1.2	-0.1	-1.1	-0.7	-0.1	-0.4	0.7	0.4
Rheumatoid Arthritis	3.7	5.1	9.2	-0.8	2.6	3.0	3.0	2.8	-0.9	-1.3
Schizophrenia (2014)	0.8	1.8	3.3	-1.0	-0.2	-0.9	-1.7	-1.7	1.8	-1.4
Triglycerides	1.6	2.6	4.1	-1.7	1.6	1.7	1.8	2.0	-1.2	-1.1
Type 2 Diabetes (T2D) (2012)	1.7	2.0	6.8	-2.6	1.3	1.1	0.5	1.4	0.9	-1.1
Ulcerative Colitis	0.2	0.3	0.8	0.3	-0.9	-0.4	-0.2	-0.9	0.1	0.6
Blood Eosinophil Count	0.2	1.2	4.4	-0.0	0.4	1.2	1.4	0.9	-2.1	-0.1
Blood Platelet Count	0.3	3.9	9.4	0.0	2.1	2.8	3.1	2.3	-0.3	-0.6
Blood Red Count	1.5	15.0	25.0	0.7	-4.6	-3.9	-5.0	-4.8	4.3	1.4
Blood White Count	0.4	3.1	7.4	-1.1	1.4	2.4	2.7	1.9	-0.9	-1.0
Heel T-Score	0.5	4.1	10.9	-0.8	-2.3	-1.6	-1.6	-1.3	3.3	2.3
BMI	0.1	0.5	1.0	-1.0	0.2	0.8	0.9	0.4	0.6	-0.4
Height	0.5	9.9	27.9	-0.9	-2.0	-1.9	-5.3	-4.6	3.3	-0.7
Waist Hip Ratio (WHR)	1.4	6.2	9.1	-2.6	3.0	2.8	2.4	2.5	-0.1	-2.7
Systolic Blood Pressure	0.4	2.2	4.9	1.4	-0.0	0.7	1.9	1.6	-2.2	1.2
Smoking Status	2.8	6.6	12.5	-1.1	2.6	2.8	3.5	3.4	-2.3	-1.3
Allergy or Eczema	0.4	1.1	5.5	2.3	-0.7	0.1	-0.8	-0.4	-0.9	0.6
Cardiovascular Disease	1.0	3.4	9.7	0.6	1.1	1.3	3.1	2.0	-2.5	-0.2
Hypothyroidism (self reported)	0.6	1.3	4.5	0.5	-0.1	-0.2	-2.1	-2.0	-0.4	-0.5
Respiratory disease	1.5	3.3	5.6	1.8	1.3	2.4	2.1	2.4	-1.5	0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.3	0.2	0.2	1.0	1.2	1.5	-0.7	0.1
Lung FEV1/FVC ratio	0.2	1.2	3.2	0.5	-1.2	-1.8	-0.9	-0.9	1.0	0.7
Lung FVC	0.0	0.2	0.6	-0.4	0.6	0.2	0.2	-0.0	0.4	-0.8
Neuroticism	1.3	3.2	5.2	-2.3	2.1	2.2	1.2	1.4	0.7	-2.0
Chronotype (morning person)	0.6	1.4	2.9	0.7	-0.2	0.1	1.7	1.7	-1.7	0.9
Hair Pigment	0.1	1.7	4.7	-0.3	-1.1	-1.0	-2.2	-1.2	1.8	0.6
Tanning	0.3	3.2	7.2	-1.0	1.5	2.0	2.7	2.3	-1.4	-1.0
Hand grip strength (left)	0.6	1.5	4.2	0.7	-0.7	0.2	-2.1	-1.9	1.0	0.2
Number of treatments/medications taken	2.8	5.0	8.5	-0.3	2.5	2.1	2.9	2.8	-2.3	-1.5
Average weekly spirits intake	0.6	0.7	1.7	1.3	-0.7	-0.6	0.1	-0.4	-1.2	0.8
Sensitivity / hurt feelings	1.8	3.1	5.2	-2.1	2.0	2.3	1.4	1.4	0.7	-1.9
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.2	-1.3	1.8	1.4	0.5	0.7	0.4	-2.0
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.9	0.2	-0.7	-0.9	-0.3	0.0	-0.2
Relative age of first facial hair	0.6	1.3	3.0	-0.6	-1.0	-0.8	-1.7	-1.3	1.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	-0.3	0.2	0.0	-1.3	-0.8	1.0	-1.2
Ever used hormone-replacement therapy (HRT)	4.5	5.7	10.9	-0.0	2.8	2.4	3.3	3.2	-1.7	-1.7
Ever had hysterectomy (womb removed)	3.7	4.1	8.1	-0.6	2.5	2.9	2.1	2.3	-0.8	-1.9
Systolic blood pressure, automated reading	0.7	1.9	4.0	0.9	0.5	1.4	2.0	1.9	-1.6	0.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	0.6	-0.4	-0.6	-1.2	-1.1	1.5	-0.5
Angina	0.2	0.3	1.2	-1.1	-0.2	-0.8	-0.0	-0.7	0.2	0.0
Medication for hormone replacement therapy	1.0	1.1	3.6	1.9	-0.9	-0.1	0.5	0.4	-0.6	1.7
Vitamin and mineral supplements	0.3	0.4	1.2	-0.5	-0.1	0.5	1.1	1.0	0.2	0.4
Supplements: Zinc	1.5	1.6	2.8	0.6	-1.7	-1.6	-1.3	-1.3	-0.2	1.5
Medication: Co-codamol	9.1	10.6	17.9	-1.6	4.2	4.2	3.8	4.0	-0.7	-2.2
Medication: Metformin	0.1	0.2	0.5	-0.4	-0.6	0.0	-0.1	0.2	0.7	0.1
Diabetes (father)	1.0	1.2	3.0	0.3	0.8	1.1	1.5	1.7	-1.1	0.5
Diabetes (mother)	0.6	0.7	2.8	-0.5	-0.0	-0.8	-0.7	-0.5	1.7	-0.9
Severe depression (siblings)	0.5	0.5	1.4	-0.2	-0.7	0.1	-1.0	-0.9	1.2	0.1
Pack years adult smoking proportion	4.2	6.4	9.4	-3.0	2.9	2.9	2.3	2.1	0.0	-3.1
Impedance of leg (right)	2.3	11.3	22.5	0.0	2.8	3.4	4.7	4.7	-4.0	-0.1
Leg fat-free mass (left)	0.7	3.8	9.0	-0.5	-0.7	-0.7	-2.8	-2.7	3.0	-1.0
Trunk fat percentage	1.0	4.0	9.2	-0.7	1.8	2.2	3.0	2.7	-1.6	-0.8
Hand grip strength (right)	0.8	2.0	6.2	0.8	-0.8	-0.3	-2.5	-2.4	1.0	0.2
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.5	-0.3	-0.1	-0.4	-0.2	0.2	0.0
Current tobacco smoking	2.2	3.6	5.8	-1.1	2.3	2.4	2.4	2.0	-0.8	-1.7
Average weekly fortified wine intake	0.2	0.3	0.8	0.2	-0.1	-0.6	-0.6	-0.5	-0.9	-0.2
Maternal smoking around birth	3.1	4.4	10.0	-1.0	2.5	3.2	2.4	2.3	-0.6	-1.6
Fed-up feelings	1.2	2.2	4.0	-2.0	1.6	1.6	1.1	1.0	0.6	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	4.9	6.6	12.6	-1.3	2.9	3.0	3.2	3.6	-1.2	-1.6
Relative age voice broke	0.3	0.4	1.1	-0.1	-1.0	-0.7	-0.6	0.0	-0.2	1.1
Taking other prescription medications	1.8	2.8	5.7	0.1	1.9	2.4	1.8	2.0	-1.0	-1.4
Age when periods started (menarche)	0.2	0.4	1.2	-0.7	0.4	-0.5	-0.2	-0.7	0.6	-1.1
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	6.9	0.1	1.5	2.0	2.6	2.0	-1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	0.5	-0.6	0.4	0.4	0.5	-0.2	0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.0	0.2	-0.3	-0.7	-0.7	-1.0	1.0	-0.4
Qualifications: CSEs or equivalent	0.3	0.4	2.1	0.2	-0.5	0.0	0.5	-0.0	0.5	1.4
Serious illness, injury or assault to yourself	0.4	0.5	1.1	-0.6	-0.5	1.0	-0.0	0.6	1.0	0.8
High blood pressure	1.3	3.8	9.7	0.9	0.7	1.3	3.1	2.6	-2.6	0.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.9	2.2	-0.4	0.6	-1.0	-0.5	-1.3	0.1
Multivitamins +/- minerals	0.1	0.2	0.6	-0.2	-0.1	-0.3	-0.8	-0.8	0.1	-0.1
Stomach or abdominal pain in last month	0.4	0.4	1.6	-0.2	1.3	0.8	0.2	0.8	-0.1	-0.4
Supplements: Glucosamine	0.4	0.6	1.9	1.2	0.6	0.2	0.3	0.0	-1.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	0.9	-0.1	0.4	1.2	0.5	-0.4	0.4
Medication: Atenolol	0.2	0.3	0.6	-0.4	-0.7	-0.8	-0.1	-0.1	0.4	0.8
Medication: Levothyroxine sodium	0.8	1.3	4.4	-0.9	1.4	1.0	-0.7	-0.6	-0.1	-2.1
Sitting height	0.4	2.7	8.4	-0.0	-0.7	-0.1	-2.5	-2.9	1.8	-0.9
Chronic bronchitis/emphysema (father)	1.0	1.2	2.2	-0.3	1.3	1.4	1.5	1.4	-0.5	-0.1
High blood pressure (mother)	0.2	0.3	1.1	0.1	0.3	-0.4	0.9	1.0	0.2	0.3
Body mass index (BMI)	0.2	0.7	1.6	-0.6	0.8	1.2	0.9	0.8	0.0	-1.0
Impedance of leg (left)	1.6	7.8	15.8	-0.2	2.2	2.6	4.0	3.9	-3.4	-0.1
Leg predicted mass (left)	0.7	3.8	9.3	-0.4	-0.8	-0.7	-2.8	-2.7	3.0	-1.0
Trunk fat mass	0.4	1.9	3.4	-0.8	1.4	1.8	1.8	1.5	-0.5	-1.1
Waist circumference	1.0	3.6	6.6	-1.8	2.3	2.5	1.5	1.4	0.2	-2.6
Number of incorrect matches in round	5.2	8.7	15.4	-1.5	3.4	3.4	3.6	3.9	-1.6	-2.2
Past tobacco smoking	1.0	1.9	3.4	1.3	-1.6	-1.1	-1.8	-1.5	0.5	1.3
Alcohol usually taken with meals	2.7	4.3	7.3	1.8	-1.7	-2.7	-2.6	-2.6	0.9	1.6
Nervous feelings	3.7	7.0	10.8	-2.6	3.3	3.3	2.8	2.7	-0.0	-2.3
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	8.7	-3.0	1.6	1.5	1.4	1.6	1.2	-1.3
Hearing difficulty/problems with background noise	0.4	0.6	1.6	1.0	-0.5	-1.3	-0.4	-0.1	-0.7	1.0
Hair/balding pattern: Pattern 2	1.5	1.9	3.8	-0.5	-1.6	-1.8	-1.6	-1.9	0.5	1.0
Had menopause	3.0	3.7	6.7	0.2	2.3	2.6	2.1	2.6	-1.2	-1.2
Had other major operations	1.2	1.5	2.5	1.0	-1.3	-1.5	-1.4	-1.6	-0.1	1.0
Forced vital capacity (FVC)	0.5	1.9	3.0	1.7	-1.0	-0.9	-1.7	-1.7	1.0	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.5	1.4	-1.2	-0.4	0.0	0.3	-0.6	1.9
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	4.2	-0.7	0.3	-0.1	-1.0	-0.5	2.0	-1.7
Qualifications: None of the above	12.4	26.6	52.3	-2.2	5.1	5.7	7.2	7.2	-3.5	-2.4
Financial difficulties in last 2 years	2.3	3.0	5.8	0.7	-2.0	-1.1	-2.1	-2.4	2.2	0.7
Mouth/teeth dental problems	0.4	0.6	1.5	1.2	-0.1	0.1	0.3	0.3	-1.2	1.2
Heart attack	1.1	1.4	4.6	2.1	-1.0	-0.7	-0.8	-0.6	-1.0	1.2
Allergy	1.4	3.2	7.7	-2.6	0.0	-1.9	-0.6	-1.4	2.8	-1.1
Pain all over the body in last month	0.3	0.3	1.2	-0.7	0.5	0.4	0.1	-0.0	0.5	-1.1
Diabetes (self-reported)	0.3	0.4	1.3	-0.5	0.2	0.7	0.9	1.1	-0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.1	0.7	0.7	0.8	1.0	1.0	-0.9	-0.2
Medication: Ramipril	0.9	1.1	3.9	0.3	1.0	0.6	0.9	1.3	-2.0	0.1
Medication: Simvastatin	0.2	0.4	1.2	0.4	-0.2	-0.1	1.1	0.6	-0.3	0.8
Fluid intelligence score	2.5	5.2	11.7	0.5	-2.3	-2.6	-3.4	-3.1	1.2	1.0
Illnesses of siblings	0.8	1.2	3.3	-1.0	-0.7	-0.3	-1.8	-1.6	0.6	-0.5
Neuroticism score	2.8	5.9	8.9	-3.0	2.8	3.0	1.7	2.1	0.9	-2.7
Weight	0.2	0.8	1.7	-0.7	0.4	0.9	-0.6	-0.7	1.2	-1.3
Impedance of arm (right)	0.4	1.8	3.7	0.4	0.8	0.3	1.9	1.8	-1.9	0.9
Arm fat percentage (right)	0.5	1.9	5.2	-0.5	1.1	1.4	2.3	1.8	-1.0	-0.4
Trunk fat-free mass	0.9	5.2	11.8	-0.8	-1.0	-0.6	-3.4	-3.4	3.1	-1.3
Hip circumference	0.1	0.3	0.9	-0.2	0.1	0.4	-0.4	-0.5	0.9	-0.8
Time employed in main current job	0.5	0.6	1.5	-0.3	1.2	0.7	0.4	0.1	0.6	-1.2
Alcohol intake versus 10 years previously	3.9	5.9	10.7	-1.2	3.3	2.6	2.7	3.0	-0.9	-2.3
Father’s age at death	1.6	2.2	4.2	0.5	-1.3	-2.0	-1.8	-2.0	1.2	0.6
Worrier / anxious feelings	5.7	10.7	20.3	-2.5	3.6	3.5	4.1	4.5	-1.2	-2.3
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	12.4	-1.2	3.0	3.5	2.8	3.2	-0.2	-1.6
Falls in the last year	1.5	2.1	4.8	0.7	2.2	1.3	1.7	1.5	-0.7	-1.3
Hair/balding pattern: Pattern 3	0.9	1.3	2.6	-1.3	1.3	-0.0	1.6	1.4	0.4	-1.1
Number of live births	1.3	1.8	4.6	1.0	0.9	1.5	1.5	1.3	-2.2	-0.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.5	1.8	-1.2	-1.5	-2.2	-2.4	0.9	1.2
Pulse rate	0.6	0.9	3.4	-0.4	1.1	1.8	0.6	0.8	-0.2	-0.9
Happiness	4.7	5.7	10.5	0.5	-3.1	-2.4	-3.2	-2.5	1.7	2.0
Noisy workplace	1.0	1.3	4.3	0.2	1.4	0.6	1.2	0.7	-0.6	-2.1
Qualifications: A levels/AS levels or equivalent	11.1	24.5	52.7	0.9	-3.8	-6.2	-7.3	-6.9	4.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	6.1	2.1	-1.1	-1.9	-2.0	-2.5	-0.6	0.8
Mouth/teeth dental problems: Dentures	3.7	6.3	12.3	-0.1	2.4	2.7	3.5	3.4	-2.1	-1.6
Asthma	1.7	3.3	5.0	1.8	1.7	2.1	2.2	2.2	-1.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-0.7	0.6	-0.2	-0.4	-0.5	0.3	-1.1
Medication: Cholesterol lowering	0.2	0.3	0.8	0.1	-0.5	-0.2	0.9	-0.0	-0.4	0.9
Depression (self-reported)	1.4	1.7	3.8	-1.1	2.0	1.8	-0.3	0.2	0.3	-1.9
Medication: Lansoprazole	1.5	1.7	3.8	1.4	1.1	0.5	1.7	1.4	-2.0	-0.1
Prospective memory result	0.9	1.1	2.9	0.1	1.7	1.2	0.9	1.0	0.6	-1.2
Lung cancer (father)	1.2	1.4	3.0	0.8	-0.6	1.0	1.4	1.5	-0.9	1.7
Illnesses of mother	1.9	2.3	4.1	-0.1	1.9	2.0	1.6	1.2	-1.7	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.6	1.3	-1.5	-1.9	-2.3	-2.6	1.1	1.0
Pulse wave Arterial Stiffness index	3.2	3.7	8.3	-0.8	1.8	2.9	1.9	1.9	-1.0	-2.4
Impedance of arm (left)	0.5	2.3	5.0	0.9	0.9	0.2	2.2	1.9	-2.2	0.9
Arm fat mass (right)	0.2	0.7	1.7	-0.6	0.7	1.3	1.1	0.8	0.1	-0.9
Trunk predicted mass	1.0	5.4	12.3	-0.8	-1.0	-0.6	-3.5	-3.5	3.1	-1.3
Standing height	0.3	2.7	7.4	-0.2	-0.5	-0.3	-2.7	-2.6	2.1	-0.7
Length of working week for main job	0.4	0.4	0.9	0.2	0.7	0.6	-0.4	-0.1	0.9	-1.0
Exposure to tobacco smoke at home	1.7	2.0	3.9	2.0	0.4	1.2	1.4	1.7	-1.8	0.4
Breastfed as a baby	5.3	6.6	12.4	1.0	-3.5	-2.7	-3.0	-3.3	0.6	2.3
Tense / ‘highly strung’	3.9	6.5	14.7	-1.8	3.8	3.2	1.8	2.4	0.4	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.2	-2.3	0.8	0.4	-1.2	-0.6	1.9	-1.6
Hair/balding pattern: Pattern 4	0.6	1.3	2.6	0.6	1.1	1.5	1.2	1.6	-1.0	0.4
Birth weight of first child	0.8	1.4	2.6	1.2	0.9	1.6	1.3	1.3	-1.2	0.0
Peak expiratory flow (PEF)	0.1	0.3	0.8	0.6	0.1	-0.5	-0.6	-0.9	0.2	-0.4
Pulse wave reflection index	0.6	0.7	3.5	-0.8	0.6	0.7	0.0	-0.3	0.3	-1.9
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.3	0.1	1.3	1.8	1.5	1.3	-0.8	-1.8
Loud music exposure frequency	1.6	1.7	3.5	1.9	-1.3	-1.7	-0.9	-0.8	-1.0	1.1
Qualifications: O levels/GCSEs or equivalent	6.3	10.0	18.2	0.7	-3.4	-3.2	-4.3	-4.1	2.8	2.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.9	-0.4	-0.3	-0.9	-0.6	-0.7	1.4	-0.3
Blood clot in the leg (DVT)	2.2	2.8	7.1	2.7	-0.8	0.1	0.7	1.0	-2.3	2.3
Medication: Paracetamol	2.5	4.1	10.2	-1.0	2.1	1.7	3.2	2.8	-1.5	-0.7
Headache pain in last month	0.2	0.4	0.9	0.8	0.9	-0.0	0.9	0.4	-0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.8	-0.0	-0.3	-0.5	-2.2	-1.4	1.7	-0.3
Glaucoma (self-reported)	0.4	0.5	1.7	-1.3	0.1	0.8	-0.2	0.1	1.2	-0.1
Gout (self-reported)	0.6	0.9	2.0	0.3	-1.4	-0.2	-1.3	-0.4	-0.9	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	3.0	0.2	0.3	0.3	-1.7	-1.6	-0.1	-1.3
Medication: Amlodipine	1.3	1.8	5.4	2.0	-0.2	-0.1	1.2	1.2	-2.3	0.6
Medication: Ventolin 100micrograms inhaler	2.6	3.3	7.5	0.2	2.0	2.0	2.7	2.3	-0.8	-1.2
Birth weight	0.4	0.9	2.0	1.4	-1.4	0.3	-0.7	-0.7	0.3	1.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.1	-0.1	-0.0	0.7	0.7	1.1	0.0	0.5
High blood pressure (siblings)	0.5	0.7	2.6	0.8	0.5	0.0	1.6	1.2	0.1	0.2
Forced vital capacity (FVC), Best measure	0.6	2.3	4.8	1.2	-1.4	-1.2	-2.2	-2.1	1.1	1.1
Body fat percentage	1.3	5.0	11.1	-1.1	2.0	2.4	3.3	3.0	-1.7	-1.1
Leg fat percentage (right)	2.2	8.0	16.4	-1.1	2.6	3.1	4.0	3.8	-2.4	-1.3
Arm fat-free mass (right)	0.5	2.8	6.5	-0.5	-0.5	-0.1	-2.5	-2.4	2.2	-1.3
Exposure to tobacco smoke outside home	0.9	1.2	3.0	1.0	0.4	1.3	1.3	1.7	-0.8	0.6
Comparative body size at age 10	0.1	0.4	1.1	0.3	-0.7	-1.0	0.2	0.0	0.0	1.1
Number of full brothers	0.9	1.1	3.6	-1.0	-1.0	-0.6	-0.5	-1.1	1.9	0.4
Worry too long after embarrassment	0.1	0.2	0.6	-0.2	0.6	0.3	0.4	0.8	-0.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	2.8	-1.3	1.1	1.3	-0.4	0.5	1.7	-1.3
Wheeze or whistling in the chest in last year	1.4	2.6	6.8	-0.7	1.9	2.6	1.5	1.7	-0.7	-1.2
Number of children fathered	2.6	2.9	5.1	-0.7	2.1	1.9	2.3	1.9	-1.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	4.2	4.9	10.4	-0.8	1.8	2.4	3.2	3.2	-1.9	-0.6
Age at first live birth	4.9	8.7	17.5	1.5	-2.8	-3.2	-4.1	-4.2	1.8	1.6
Pulse wave peak to peak time	3.1	3.7	7.8	0.9	-1.8	-2.8	-1.9	-1.9	1.0	2.4
Health satisfaction	0.9	1.2	3.0	-1.7	1.0	0.9	0.2	0.3	1.1	-1.6
Shortness of breath walking on level ground	0.4	0.5	1.3	-1.2	0.7	-0.0	-0.2	-0.2	0.8	-1.1
Qualifications: College or University degree	6.5	20.6	53.5	-1.1	-3.0	-4.8	-7.3	-6.2	4.4	0.1
Eye problems/disorders: None of the above	0.9	1.0	1.4	-0.9	1.2	0.9	1.0	1.0	-1.0	-1.0
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.0	-1.0	0.2	-0.9	-0.5	-1.4	1.2	-1.0
Emphysema/chronic bronchitis	3.8	4.3	8.0	-0.4	2.3	2.4	2.8	2.6	-1.8	-1.0
Medication for pain relief, constipation, heartburn	3.1	5.4	12.7	0.7	-2.5	-1.9	-3.6	-3.1	2.0	1.1
Neck or shoulder pain in last month	0.9	1.3	2.7	-0.8	1.4	-0.1	-0.8	-0.7	1.6	-1.6
Medication: Blood pressure	1.5	2.7	7.2	0.4	0.6	0.6	2.7	2.3	-2.3	0.6
Angina (self-reported)	0.3	0.3	1.2	-1.1	-0.2	-0.8	0.0	-0.7	0.1	-0.1
Migraine (self-reported)	0.7	0.8	2.7	0.8	-1.2	-0.9	-0.2	-0.2	-0.4	1.7
Medication: Ibuprofen	0.1	0.1	0.2	-0.1	-0.3	-0.4	-0.4	-0.3	0.2	0.2
Medication: Allopurinol	0.3	0.4	1.2	-0.9	-0.4	0.1	-1.1	-0.5	0.2	-0.4
Medication: Omeprazole	4.2	5.0	9.3	-2.7	2.4	1.8	3.1	2.5	-0.6	-1.7
Medication: Seretide 50 evohaler	0.2	0.3	0.6	0.2	-0.6	-0.3	-0.8	-0.7	0.2	-0.3
Mean time to correctly identify matches	0.9	1.7	3.5	1.0	-0.5	0.0	1.5	1.7	-1.5	1.9
Heart disease (mother)	0.3	0.3	0.8	0.9	0.2	-0.7	-0.6	-0.8	0.0	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.8	-0.5	-0.8	-0.4	-0.7	-0.4	1.3	-0.4
Whole body fat mass	0.4	1.8	3.2	-0.9	1.4	1.8	1.7	1.4	-0.5	-1.3
Leg fat mass (right)	0.7	2.7	4.8	-1.0	1.7	2.2	2.1	1.8	-0.8	-1.4
Arm predicted mass (right)	0.6	3.2	7.1	-0.8	-0.6	-0.1	-2.7	-2.5	2.4	-1.4
Pulse rate, automated reading	3.3	10.5	24.4	-1.9	4.0	4.9	2.9	3.0	-1.0	-3.4
Alcohol intake frequency.	0.2	0.4	1.0	0.2	0.7	0.7	0.4	1.0	0.7	0.0
Comparative height size at age 10	0.1	0.5	1.3	0.1	-0.6	0.1	-1.0	-0.4	1.1	0.6
Number of full sisters	0.3	0.4	2.1	1.5	-0.4	-0.4	0.1	-0.4	-0.4	0.4
Suffer from ‘nerves’	2.5	3.9	5.6	-2.2	2.3	2.4	1.7	1.6	0.3	-2.4
Overall health rating	1.3	2.8	5.6	-0.8	1.8	1.8	2.4	2.4	-0.2	-1.1
Chest pain or discomfort	0.4	0.5	1.7	-0.7	0.9	0.5	0.3	0.2	0.4	-1.3
Had major operations	1.4	1.6	2.8	0.8	-1.4	-1.1	-1.7	-1.4	0.8	1.5
Age at last live birth	5.3	7.6	16.1	2.5	-2.4	-2.8	-4.0	-4.0	-0.1	1.2
Family relationship satisfaction	5.5	6.8	14.1	0.0	-2.6	-2.9	-3.8	-3.5	2.5	0.2
Leg pain on walking	0.8	1.0	2.2	0.7	0.8	0.8	1.5	1.4	-0.8	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.1	1.8	-0.4	0.1	0.2	0.4	-1.1	1.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.0	-0.6	0.1	0.4	1.0	0.4	0.6	0.0
Illness, injury, bereavement, stress in last 2 years	3.5	4.2	6.2	-1.9	2.5	1.5	1.9	2.3	-1.6	-2.4
Medication: Aspirin	0.9	1.2	1.8	0.5	1.4	1.3	1.4	1.4	-0.9	-0.4
Supplements: Vitamin C	0.7	0.8	1.7	0.9	-0.6	-1.1	-1.3	-1.2	0.6	0.4
Knee pain experienced in last month	1.1	1.7	3.2	0.6	1.8	1.3	1.4	1.1	-1.5	-1.3
Hypertension (Self-reported)	1.5	4.1	9.1	1.1	0.9	1.4	3.0	2.6	-2.9	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.0	-1.3	1.7	1.0	1.5	1.1	-0.8	-1.4
Illnesses of father: Heart disease	0.4	0.6	2.1	-0.6	0.7	-0.2	-0.5	-0.5	0.7	-1.4
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.6	0.2	0.2	0.0	0.3	0.9	-0.3
Smoking status: Previous	1.2	1.9	4.2	-0.5	1.4	1.1	2.0	2.0	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.7	-0.1	-1.0	-1.4	-1.8	-1.9	1.2	0.2
Whole body fat-free mass	0.9	5.0	11.0	-0.6	-0.9	-0.6	-3.3	-3.3	3.2	-1.3
Leg fat-free mass (right)	1.1	5.8	12.3	-0.4	-1.4	-1.4	-3.5	-3.5	3.5	-0.6
Arm fat percentage (left)	0.5	1.9	5.1	-0.5	1.2	1.4	2.2	1.9	-1.0	-0.6
Average weekly red wine intake	8.6	12.7	20.3	2.1	-3.9	-4.5	-4.5	-4.2	2.0	2.7
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.1	-1.0	0.2	-0.2	1.0	0.9	0.3	-0.1
Mood swings	1.6	2.9	4.9	-1.5	2.1	2.0	1.7	1.5	0.2	-2.2
Loneliness, isolation	1.4	1.9	4.4	-2.1	0.8	0.1	-1.0	-0.5	2.0	-1.8
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.3	0.7	0.4	0.6	0.8	-0.5	-0.5
Ever had bowel cancer screening	2.0	2.4	4.8	0.7	1.5	1.9	2.2	1.8	-1.5	-0.2
Diabetes diagnosed by doctor	0.6	1.0	3.2	-0.3	0.4	1.3	1.4	1.8	-0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	3.8	0.9	-1.3	-1.1	-0.1	-0.0	-1.1	1.9
Friendships satisfaction	8.7	10.7	22.3	1.3	-3.9	-3.6	-4.7	-4.0	1.8	2.1
Qualifications: nursing, teaching	4.8	7.5	16.0	-1.0	-1.6	-3.0	-3.7	-4.0	3.2	-0.4
Commuting to job workplace: Walk	2.8	3.0	6.0	-0.7	-1.7	-1.2	-2.4	-2.1	2.3	0.8
Eye problems/disorders: Cataract	0.4	0.4	1.5	0.5	-0.5	-0.6	-0.7	-1.2	0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	5.3	8.4	22.1	-0.4	-2.3	-2.7	-4.7	-4.4	2.3	0.0
Medication for cholesterol	1.8	2.7	6.0	-1.2	-0.9	-1.7	-2.4	-2.2	1.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.0	7.5	-0.6	1.7	1.5	2.7	2.1	-1.7	-1.1
Back pain experienced in last month	3.0	4.3	7.3	2.0	1.8	2.4	2.3	2.7	-2.2	-0.1
Mineral and other dietary supplements	1.0	1.3	4.5	-1.7	-0.4	0.3	-1.1	-0.7	2.1	-0.5
Breast cancer (self-reported)	0.3	0.3	0.8	0.5	-0.6	-0.1	-0.9	0.1	-0.4	0.8
Asthma (self-reported)	1.6	3.1	4.7	1.4	1.9	2.0	2.2	2.2	-1.5	-0.5
Osteoporosis (self-reported)	0.5	0.7	1.2	0.7	1.0	0.8	0.6	1.1	-1.0	0.1
Osteoarthritis (self-reported)	2.1	2.7	6.2	0.3	1.2	1.1	2.3	2.1	-2.5	-0.4
Medication: Aspirin	0.6	0.7	1.4	0.7	0.8	0.6	1.2	1.1	-1.0	0.2
Medication: Gliclazide	0.3	0.4	1.0	-0.3	-1.0	-0.6	-0.6	0.1	-0.3	1.0
Illnesses of father: None of the above (group 1)	0.6	0.7	1.8	0.6	-1.4	-0.7	-0.9	-0.5	0.5	1.0
Smoking status: Current	1.6	2.6	4.2	-1.2	2.0	2.0	1.8	1.4	-0.5	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.1	0.8	-0.7	-0.4	-1.0	-1.0	1.0	0.5
Whole body water mass	0.9	4.9	11.0	-0.5	-1.0	-0.7	-3.3	-3.3	3.1	-1.2
Leg predicted mass (right)	1.1	6.0	12.6	-0.3	-1.4	-1.5	-3.5	-3.5	3.5	-0.6
Arm fat mass (left)	0.2	0.7	1.3	-0.6	0.8	1.1	0.9	0.6	0.2	-1.0
Number of self-reported non-cancer illnesses	2.2	3.9	11.0	1.4	1.2	1.6	2.0	2.5	-3.3	-0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.8	-0.5	0.3	-0.1	-0.4	-0.5	0.3	-0.9
Miserableness	0.1	0.1	0.3	-0.5	0.2	0.1	-0.1	0.1	-0.2	-0.6
Guilty feelings	0.6	0.8	1.8	-0.1	0.4	-1.1	-0.9	-1.1	1.3	-0.9
Wears glasses or contact lenses	1.0	1.2	2.6	-1.6	0.9	1.1	1.3	0.6	-0.9	-0.9
Ever taken oral contraceptive pill	1.2	1.3	2.6	0.6	1.5	1.6	0.9	0.3	-0.8	-1.6
Hearing aid user	0.9	1.1	1.8	1.3	-1.1	-1.0	-0.2	0.1	-1.3	1.3
Mother’s age at death	1.5	1.9	4.3	-0.0	-1.3	-2.1	-2.0	-1.6	0.6	0.6
Financial situation satisfaction	8.2	10.2	17.1	-0.0	-4.0	-3.9	-4.1	-3.5	2.6	2.0
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.9	1.5	-0.8	-1.2	-2.0	-1.2	-0.0	0.5
Commuting to job workplace: Public transport	0.2	0.3	1.0	0.8	-0.0	0.3	-1.0	-0.4	-0.2	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	2.2	-0.7	-0.2	0.5	-0.7	-0.5	1.5	-0.2
Medication: Blood pressure	1.5	2.8	5.9	-0.3	1.4	2.0	2.4	2.1	-1.5	-0.8
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.7	-0.4	1.6	1.4	1.2	0.4	-1.1	-1.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.6	0.8	0.7	-0.1	1.3	0.9	-1.9	-0.2
High cholesterol (Self-reported)	1.0	1.8	5.8	-1.0	1.5	0.7	2.4	1.4	-0.8	-1.0
Medication: Bendroflumethiazide	1.8	2.8	6.4	-0.2	1.4	1.4	2.5	2.3	-1.8	-0.9
Medication: Paracetamol	2.8	4.3	10.8	-1.5	2.0	1.6	3.3	2.9	-1.2	-0.8
Medication: Lisinopril	0.5	0.7	3.0	0.8	0.2	0.6	0.5	0.5	-1.7	-0.1
Medication: Atorvastatin	1.5	1.8	3.6	-1.5	1.4	1.6	1.9	1.0	-0.3	-1.1
Illnesses of father: High blood pressure	0.8	0.9	2.5	-0.5	1.6	0.5	1.2	0.4	-0.4	-1.3
Alcohol drinker status: Never	2.2	2.7	8.8	2.1	-1.9	-1.1	-0.1	0.0	0.9	3.0
Ever smoked	0.5	0.9	3.0	-1.7	0.9	0.4	0.7	0.2	-0.2	-1.3
Basal metabolic rate	0.7	3.6	8.1	-0.7	-0.7	-0.4	-2.7	-2.7	2.8	-1.2
Leg fat percentage (left)	1.7	6.1	13.1	-1.4	2.3	2.6	3.6	3.3	-1.8	-1.4
Arm fat-free mass (left)	0.5	2.6	5.7	-0.3	-0.7	-0.0	-2.4	-2.3	2.3	-1.1
Number of operations (self-reported)	0.4	0.6	1.3	0.6	-0.8	-0.6	-1.0	-1.1	0.2	0.8
Average weekly beer plus cider intake	3.0	4.3	10.7	-1.2	1.7	2.5	3.3	2.7	-1.1	-0.5
Irritability	0.1	0.2	0.7	-0.4	-0.5	-0.1	-0.8	-0.1	0.5	0.3
Risk taking	0.2	0.3	0.8	0.9	0.3	0.3	-0.5	-0.6	-0.2	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	-0.2	0.5	-0.3	-0.6	-0.7	-0.1	-0.9
Fractured/broken bones in last 5 years	0.8	1.1	2.2	-1.2	1.0	1.5	0.8	1.2	-0.2	-0.8
Age started oral contraceptive pill	0.2	0.2	1.0	0.2	-0.1	0.1	-1.0	0.0	-0.7	-0.1
Diastolic blood pressure, automated reading	0.6	1.8	7.5	0.2	0.9	2.7	1.4	1.4	-0.6	-0.5
Ever depressed for a whole week	0.5	0.7	1.4	-0.7	0.9	1.0	-0.1	0.6	0.8	-1.2
Unable to work because of sickness or disability	4.8	6.2	11.2	-0.9	3.2	2.3	3.3	3.4	-1.3	-1.8
Commuting to job workplace: Cycle	3.9	4.7	10.7	-0.5	-2.0	-2.9	-3.3	-2.8	0.8	0.9
Myopia	0.4	0.5	1.8	-0.1	-1.0	-0.4	-0.4	0.2	0.6	1.4
Vascular/heart problems diagnosed by doctor	1.2	3.1	7.4	-0.9	-0.9	-1.3	-2.7	-2.3	2.4	-0.0
Cholesterol lowering medication	4.2	6.1	11.0	-1.1	3.1	2.9	3.3	3.2	-0.7	-1.4
Medication: Omeprazole (e.g. Zanprol)	3.3	4.0	9.8	-1.7	2.0	1.6	3.1	2.6	-1.0	-1.1
Pain experienced in last month	1.9	3.2	7.1	-0.1	-2.7	-1.9	-2.4	-1.8	0.4	1.6
Supplements: Calcium	3.5	3.8	9.1	0.3	-1.7	-3.0	-2.2	-2.7	1.6	0.2
Basal cell carcinoma (self-reported)	1.1	1.3	2.5	0.8	-1.1	-1.0	-1.5	-1.6	0.7	0.9
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.1	2.0	-0.9	-0.6	-0.5	-0.3	-1.1	1.2
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	5.5	2.4	-1.0	-0.1	0.3	0.5	-2.0	2.1
Heart disease (siblings)	0.4	0.5	1.3	-0.6	0.6	0.7	1.1	0.7	-0.4	-0.5
Alcohol drinker status: Previous	1.0	1.1	2.0	-1.1	1.4	1.3	0.3	0.6	1.0	-1.2
Pack years of smoking	3.8	5.6	9.2	-3.0	2.6	2.8	2.0	2.0	0.2	-2.8
Impedance of whole body	1.0	5.2	11.1	0.7	1.4	1.3	3.3	3.2	-3.1	1.0
Leg fat mass (left)	0.6	2.1	3.8	-1.2	1.5	2.0	1.8	1.5	-0.3	-1.4
Arm predicted mass (left)	0.6	2.8	6.3	-0.5	-0.7	-0.0	-2.5	-2.5	2.3	-1.1