Best TWAS P=1.35e-08 · Best GWAS P=8.92e-09 conditioned to 0.0599
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Frontal Cortex BA9 | NRBF2 | 0.25 | 0.17 | lasso | 6 | 0.16 | 6.1e-05 | 5.4 | -5.3 | 9.3e-08 | -0.88 | 0.03 | 0.95 | FALSE |
2 | GTEx | Nerve Tibial | NRBF2 | 0.08 | 0.09 | enet | 11 | 0.06 | 5.0e-05 | 4.9 | -5.7 | 1.4e-08 | -0.83 | 0.04 | 0.96 | TRUE |
3 | GTEx | Thyroid | NRBF2 | 0.11 | 0.05 | lasso | 3 | 0.07 | 2.5e-06 | -3.2 | -5.6 | 2.6e-08 | -0.66 | 0.05 | 0.94 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | NRBF2 | 0.34 | 0.46 | lasso | 5 | 0.46 | 3.1e-66 | 5.4 | -5.2 | 1.7e-07 | -0.89 | 0.02 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NRBF2 | 0.05 | 0.06 | lasso | 2 | 0.06 | 5.5e-12 | 5.4 | -5.4 | 5.5e-08 | -0.89 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Glioblastoma Multiforme | JMJD1C | 0.11 | 0.02 | blup | 87 | 0.05 | 1.4e-02 | 5.3 | -5.6 | 2.8e-08 | -0.80 | 0.02 | 0.66 | FALSE |
7 | The Cancer Genome Atlas | Glioblastoma Multiforme | NRBF2 | 0.17 | 0.09 | enet | 10 | 0.13 | 1.1e-04 | 5.4 | -5.4 | 7.9e-08 | -0.80 | 0.00 | 0.94 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NRBF2 | 0.08 | 0.08 | enet | 6 | 0.08 | 4.3e-09 | 5.4 | -5.2 | 2.1e-07 | -0.90 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NRBF2 | 0.18 | 0.13 | enet | 11 | 0.08 | 2.5e-04 | 5.3 | -5.4 | 7.3e-08 | -0.87 | 0.00 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | NRBF2 | 0.14 | 0.10 | enet | 16 | 0.09 | 8.1e-09 | 5.3 | -5.3 | 1.4e-07 | -0.89 | 0.00 | 1.00 | FALSE |