Best TWAS P=6.21e-22 · Best GWAS P=4.43e-20 conditioned to 0.0108
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PPP5C | 0.13 | 0.06 | enet | 8 | 0.10 | 1.2e-08 | 7.2 | -7.1 | 8.9e-13 | 0.39 | 0.99 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | PPP5C | 0.19 | 0.04 | enet | 17 | 0.05 | 1.0e-03 | 7.9 | -5.5 | 5.0e-08 | 0.38 | 0.12 | 0.38 | FALSE |
| 3 | GTEx | Spleen | PPP5C | 0.33 | 0.44 | lasso | 1 | 0.43 | 1.8e-12 | 7.9 | -7.9 | 3.0e-15 | 0.61 | 0.48 | 0.50 | FALSE |
| 4 | GTEx | Spleen | AC007193.9 | 0.49 | 0.07 | lasso | 5 | 0.20 | 7.8e-06 | 7.9 | -9.6 | 6.2e-22 | 0.79 | 0.01 | 0.94 | TRUE |
| 5 | GTEx | Whole Blood | PPP5C | 0.16 | 0.12 | enet | 18 | 0.12 | 3.0e-11 | 7.2 | -8.1 | 3.6e-16 | 0.72 | 0.22 | 0.78 | FALSE |
| 6 | METSIM | Adipose | PPP5C | 0.23 | 0.18 | lasso | 8 | 0.18 | 3.8e-26 | 7.9 | -8.0 | 1.1e-15 | 0.63 | 0.98 | 0.02 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | CCDC8 | 0.11 | 0.02 | blup | 46 | 0.07 | 1.7e-07 | 4.4 | -6.3 | 3.5e-10 | 0.43 | 0.00 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP5C | 0.06 | 0.03 | enet | 10 | 0.01 | 1.4e-02 | 7.9 | -8.6 | 5.2e-18 | 0.57 | 0.00 | 0.95 | FALSE |