Best TWAS P=4.82e-12 · Best GWAS P=1.06e-10 conditioned to 0.885
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | IL12RB1 | 0.05 | 0.05 | lasso | 3 | 0.04 | 2.8e-07 | -6.2 | 6.4 | 2.1e-10 | -0.97 | 0.00 | 1.00 | FALSE |
2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL12RB1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 6.4e-02 | -6.2 | 6.3 | 2.2e-10 | -0.97 | 0.00 | 0.97 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL12RB1 | 0.06 | 0.03 | lasso | 5 | 0.05 | 3.9e-10 | -6.3 | 6.8 | 1.5e-11 | -0.84 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL12RB1 | 0.05 | 0.03 | enet | 11 | 0.05 | 2.3e-06 | 4.4 | 6.7 | 2.5e-11 | -0.79 | 0.00 | 0.99 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL12RB1 | 0.10 | 0.08 | blup | 58 | 0.09 | 6.9e-10 | -6.1 | 5.9 | 4.1e-09 | -0.89 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IL12RB1 | 0.05 | 0.03 | lasso | 3 | 0.03 | 1.3e-04 | -6.2 | 6.9 | 4.8e-12 | -0.94 | 0.00 | 0.99 | TRUE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | IL12RB1 | 0.10 | 0.08 | enet | 13 | 0.07 | 3.9e-08 | -6.1 | 6.3 | 2.5e-10 | -0.89 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | -3.8 | 5.7 | 1.1e-08 | -0.82 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IL12RB1 | 0.09 | 0.01 | blup | 58 | 0.05 | 1.2e-05 | -6.5 | 5.7 | 9.6e-09 | -0.81 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | -6.3 | 5.9 | 3.6e-09 | -0.71 | 0.01 | 0.73 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | IL12RB1 | 0.08 | 0.04 | lasso | 3 | 0.05 | 8.9e-06 | -4.1 | 6.1 | 9.2e-10 | -0.84 | 0.00 | 0.99 | FALSE |