Best TWAS P=1.07e-07 · Best GWAS P=4.31e-06 conditioned to 0.68
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | XRCC3 | 0.06 | 0.08 | lasso | 3 | 0.03 | 1.4e-03 | -4.4 | -5.1 | 2.8e-07 | 0.76 | 0.06 | 0.86 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | KLC1 | 0.12 | 0.02 | enet | 26 | 0.07 | 2.9e-04 | -4.3 | -5.3 | 1.1e-07 | 0.82 | 0.06 | 0.86 | TRUE |
| 3 | GTEx | Muscle Skeletal | KLC1 | 0.11 | 0.07 | lasso | 7 | 0.08 | 3.3e-08 | 4.4 | -5.1 | 3.0e-07 | 0.72 | 0.06 | 0.89 | FALSE |
| 4 | METSIM | Adipose | MARK3 | 0.03 | 0.02 | lasso | 6 | 0.03 | 6.3e-05 | -4.6 | 5.3 | 1.1e-07 | -0.89 | 0.06 | 0.89 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | KLC1 | 0.04 | 0.01 | blup | 82 | 0.03 | 5.4e-04 | -4.6 | -5.2 | 1.9e-07 | 0.86 | 0.02 | 0.61 | FALSE |