Best TWAS P=3.09e-10 · Best GWAS P=1.53e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | FYCO1 | 0.18 | 0.12 | lasso | 4 | 0.12 | 9.8e-10 | 5.1 | 5.3 | 1.3e-07 | -0.35 | 0.27 | 0.72 | FALSE |
| 2 | GTEx | Esophagus Muscularis | FYCO1 | 0.17 | 0.06 | lasso | 8 | 0.08 | 1.7e-05 | 5.1 | 5.9 | 4.5e-09 | -0.37 | 0.39 | 0.52 | TRUE |
| 3 | GTEx | Thyroid | FYCO1 | 0.20 | 0.13 | lasso | 9 | 0.13 | 2.0e-10 | 4.8 | 5.9 | 3.8e-09 | -0.43 | 0.43 | 0.56 | FALSE |
| 4 | NTR | Blood | CXCR6 | 0.02 | 0.02 | lasso | 5 | 0.02 | 2.4e-06 | 4.9 | -5.6 | 2.7e-08 | 0.34 | 0.41 | 0.57 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCR3 | 0.23 | 0.13 | enet | 8 | 0.13 | 8.3e-05 | 5.6 | -5.6 | 1.6e-08 | 0.48 | 0.02 | 0.66 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CCR1 | 0.03 | 0.02 | blup | 28 | 0.02 | 1.5e-03 | 5.6 | 5.4 | 6.3e-08 | -0.40 | 0.00 | 0.92 | FALSE |
| 7 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CCR3 | 0.20 | 0.11 | lasso | 3 | 0.10 | 2.7e-03 | -6.0 | -6.3 | 3.1e-10 | 0.97 | 0.00 | 0.87 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | CCR3 | 0.07 | 0.01 | blup | 76 | 0.01 | 1.3e-02 | 5.5 | -5.8 | 5.4e-09 | 0.53 | 0.02 | 0.43 | FALSE |