Hub : Traits :

Mouth/teeth dental problems

30 significantly associated models · 17 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 154401972 155887772 6 1 5.2e-08 1.4e-07 0.097 90 THBS3
2 1 243298257 243910067 1 1 1.1e-09 1.1e-06 0.538 98 SDCCAG8
3 3 45262393 46728659 4 2 3.1e-10 1.5e-09 1.000 100 CCR3 FYCO1
4 14 103161201 104866687 3 1 1.1e-07 4.3e-06 0.680 99 KLC1
5 22 45736153 47135205 1 1 1.8e-07 2.1e-07 0.415 98 LINC00899

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.21 1 0 0.0 0.00 1.00 KLC1
Bipolar Disorder or Schizophrenia 3.61 1 1 2.2 0.00 1.00 KLC1
Depressed Affect (Nagel 2018) 3.52 2 0 0.0 0.00 1.00 SDCCAG8 THBS3
Intelligence (Savage-Jansen 2018) 0.78 1 0 0.0 0.00 1.00 KLC1
Schizophrenia (2018) 3.37 1 1 2.2 0.00 1.00 KLC1
Crohns Disease (2017) 2.15 1 0 0.0 0.00 1.00 THBS3
Irritable Bowel Disease (IBD) 3.71 1 1 2.2 0.00 1.00 THBS3
Ulcerative Colitis (UC) 4.25 1 0 0.0 0.00 1.00 THBS3
Reaction Time 1.25 1 0 0.0 0.00 1.00 SDCCAG8
Breast Cancer 3.09 1 1 2.2 0.00 1.00 THBS3
Prostate Cancer 2.45 1 0 0.0 0.00 1.00 KLC1
Crohns Disease (2012) 1.92 1 0 0.0 0.00 1.00 THBS3
Schizophrenia (2014) 3.28 1 1 2.2 0.00 1.00 KLC1
Ulcerative Colitis 2.61 1 0 0.0 0.00 1.00 THBS3
Blood Eosinophil Count 0.84 1 0 0.0 0.00 1.00 KLC1
Blood Platelet Count 1.04 1 1 2.2 0.00 1.00 THBS3
Blood Red Count 2.21 3 1 2.2 0.00 1.00 KLC1 SDCCAG8 THBS3
Blood White Count 1.35 2 1 2.2 0.00 1.00 KLC1 SDCCAG8
Heel T-Score 5.58 4 4 8.9 -0.15 0.85 FYCO1 KLC1 LINC00899 THBS3
BMI 3.18 3 1 2.2 0.00 1.00 KLC1 SDCCAG8 THBS3
Height 1.21 3 1 2.2 0.00 1.00 CCR3 KLC1 THBS3
Waist Hip Ratio (WHR) 1.08 1 0 0.0 0.00 1.00 THBS3
Systolic Blood Pressure 0.45 1 0 0.0 0.00 1.00 SDCCAG8
Smoking Status 4.59 2 1 2.2 0.00 1.00 KLC1 LINC00899
Allergy or Eczema 1.22 1 0 0.0 0.00 1.00 THBS3
Cardiovascular Disease 2.57 2 1 2.2 0.00 1.00 KLC1 SDCCAG8
Lung FEV1/FVC ratio 0.70 1 0 0.0 0.00 1.00 KLC1
Lung FVC 1.11 1 0 0.0 0.00 1.00 THBS3
Neuroticism 2.14 1 0 0.0 0.00 1.00 THBS3
Chronotype (morning person) 1.57 1 0 0.0 0.00 1.00 SDCCAG8
Hair Pigment 0.80 2 2 4.4 0.00 1.00 KLC1 THBS3
Tanning 0.46 2 0 0.0 0.00 1.00 SDCCAG8 THBS3
Number of treatments/medications taken 2.62 1 0 0.0 0.00 1.00 SDCCAG8
Hearing difficulty/problems: Yes 2.18 1 0 0.0 0.00 1.00 KLC1
Other serious medical condition/disability diagnosed by doctor 2.89 1 0 0.0 0.00 1.00 KLC1
Pack years adult smoking proportion 3.85 1 0 0.0 0.00 1.00 KLC1
Impedance of leg (right) 4.33 4 3 6.7 0.53 0.47 CCR3 FYCO1 KLC1 THBS3
Leg fat-free mass (left) 2.04 3 1 2.2 0.00 1.00 CCR3 FYCO1 THBS3
Trunk fat percentage 2.08 3 0 0.0 0.00 1.00 KLC1 SDCCAG8 THBS3
Current tobacco smoking 4.17 2 0 0.0 0.00 1.00 KLC1 LINC00899
Maternal smoking around birth 3.70 1 1 2.2 0.00 1.00 KLC1
Heel bone mineral density (BMD) T-score, automated (left) 3.04 2 0 0.0 0.00 1.00 KLC1 THBS3
High blood pressure 1.52 1 0 0.0 0.00 1.00 KLC1
Hayfever, allergic rhinitis or eczema 1.39 1 0 0.0 0.00 1.00 THBS3
Sitting height 1.02 1 0 0.0 0.00 1.00 CCR3
Body mass index (BMI) 3.38 3 1 2.2 0.00 1.00 KLC1 SDCCAG8 THBS3
Impedance of leg (left) 3.93 4 3 6.7 0.48 0.52 CCR3 FYCO1 KLC1 THBS3
Leg predicted mass (left) 1.98 3 1 2.2 0.00 1.00 CCR3 FYCO1 THBS3
Trunk fat mass 1.96 3 0 0.0 0.00 1.00 KLC1 SDCCAG8 THBS3
Waist circumference 2.09 2 0 0.0 0.00 1.00 KLC1 SDCCAG8
Past tobacco smoking 4.91 3 0 0.0 0.00 1.00 KLC1 LINC00899 THBS3
Frequency of tenseness / restlessness in last 2 weeks 2.61 1 0 0.0 0.00 1.00 LINC00899
Hearing difficulty/problems with background noise 4.47 1 0 0.0 0.00 1.00 KLC1
Heel bone mineral density (BMD) T-score, automated (right) 1.91 2 0 0.0 0.00 1.00 KLC1 THBS3
Qualifications: None of the above 1.82 1 0 0.0 0.00 1.00 SDCCAG8
Financial difficulties in last 2 years 5.04 1 1 2.2 0.00 1.00 KLC1
Allergy 1.62 1 0 0.0 0.00 1.00 THBS3
Weight 1.88 3 0 0.0 0.00 1.00 KLC1 SDCCAG8 THBS3
Impedance of arm (right) 0.84 1 0 0.0 0.00 1.00 FYCO1
Arm fat percentage (right) 3.44 3 1 2.2 0.00 1.00 KLC1 SDCCAG8 THBS3
Trunk fat-free mass 0.84 1 0 0.0 0.00 1.00 THBS3
Hip circumference 1.78 2 0 0.0 0.00 1.00 KLC1 THBS3
Frequency of tiredness / lethargy in last 2 weeks 3.74 2 0 0.0 0.00 1.00 KLC1 LINC00899
Forced expiratory volume in 1-second (FEV1) 1.03 1 0 0.0 0.00 1.00 THBS3
Qualifications: A levels/AS levels or equivalent 2.19 1 0 0.0 0.00 1.00 SDCCAG8
Mouth/teeth dental problems: Dentures 6.87 3 1 2.2 0.00 1.00 LINC00899 SDCCAG8 THBS3
Impedance of arm (left) 1.17 2 0 0.0 0.00 1.00 FYCO1 KLC1
Arm fat mass (right) 3.16 3 1 2.2 0.00 1.00 KLC1 SDCCAG8 THBS3
Trunk predicted mass 0.83 1 0 0.0 0.00 1.00 THBS3
Standing height 0.85 2 1 2.2 0.00 1.00 CCR3 KLC1
Tense / 'highly strung' 1.83 1 0 0.0 0.00 1.00 LINC00899
Seen doctor (GP) for nerves, anxiety, tension or depression 2.16 1 0 0.0 0.00 1.00 LINC00899
Hair/balding pattern: Pattern 4 1.82 1 0 0.0 0.00 1.00 THBS3
Mouth/teeth dental problems: Bleeding gums 3.57 1 0 0.0 0.00 1.00 KLC1
Medication: Paracetamol 4.91 2 0 0.0 0.00 1.00 KLC1 SDCCAG8
Gout (self-reported) 3.81 1 0 0.0 0.00 1.00 THBS3
Birth weight 2.34 1 0 0.0 0.00 1.00 LINC00899
High blood pressure (siblings) 2.11 1 0 0.0 0.00 1.00 KLC1
Body fat percentage 2.27 2 0 0.0 0.00 1.00 KLC1 SDCCAG8
Leg fat percentage (right) 1.93 2 0 0.0 0.00 1.00 KLC1 SDCCAG8
Exposure to tobacco smoke outside home 4.25 1 0 0.0 0.00 1.00 SDCCAG8
Wheeze or whistling in the chest in last year 3.44 1 0 0.0 0.00 1.00 LINC00899
Health satisfaction 1.70 1 0 0.0 0.00 1.00 KLC1
Qualifications: College or University degree 2.12 1 1 2.2 0.00 1.00 SDCCAG8
Emphysema/chronic bronchitis 4.15 2 0 0.0 0.00 1.00 KLC1 LINC00899
Medication for pain relief, constipation, heartburn 4.13 1 0 0.0 0.00 1.00 SDCCAG8
Medication: Allopurinol 3.05 1 0 0.0 0.00 1.00 THBS3
Whole body fat mass 2.14 3 0 0.0 0.00 1.00 KLC1 SDCCAG8 THBS3
Leg fat mass (right) 2.02 2 0 0.0 0.00 1.00 KLC1 SDCCAG8
Pulse rate, automated reading 1.44 1 0 0.0 0.00 1.00 KLC1
Comparative height size at age 10 1.09 1 1 2.2 0.00 1.00 KLC1
Number of full sisters 2.21 1 0 0.0 0.00 1.00 LINC00899
Overall health rating 4.47 2 1 2.2 0.00 1.00 KLC1 SDCCAG8
Qualifications: NVQ or HND or HNC or equivalent 2.67 1 0 0.0 0.00 1.00 SDCCAG8
Illness, injury, bereavement, stress in last 2 years 2.39 1 0 0.0 0.00 1.00 KLC1
Hypertension (Self-reported) 1.42 1 0 0.0 0.00 1.00 KLC1
Smoking status: Previous 3.66 1 0 0.0 0.00 1.00 THBS3
Whole body fat-free mass 1.20 1 0 0.0 0.00 1.00 THBS3
Leg fat-free mass (right) 2.28 3 1 2.2 0.00 1.00 CCR3 FYCO1 THBS3
Arm fat percentage (left) 3.18 3 1 2.2 0.00 1.00 KLC1 SDCCAG8 THBS3
Mood swings 1.63 1 0 0.0 0.00 1.00 THBS3
Long-standing illness, disability or infirmity 2.60 1 0 0.0 0.00 1.00 KLC1
Qualifications: nursing, teaching 2.16 1 0 0.0 0.00 1.00 SDCCAG8
Mouth/teeth dental problems: Mouth ulcers 37.76 3 2 4.4 0.00 1.00 CCR3 FYCO1 SDCCAG8
Smoking status: Current 4.06 2 0 0.0 0.00 1.00 KLC1 LINC00899
Whole body water mass 1.31 3 0 0.0 0.00 1.00 CCR3 FYCO1 THBS3
Leg predicted mass (right) 2.21 3 1 2.2 0.00 1.00 CCR3 FYCO1 THBS3
Arm fat mass (left) 3.12 3 1 2.2 0.00 1.00 KLC1 SDCCAG8 THBS3
Number of self-reported non-cancer illnesses 2.85 1 0 0.0 0.00 1.00 KLC1
Miserableness 2.93 2 0 0.0 0.00 1.00 SDCCAG8 THBS3
Mother's age at death 3.56 2 0 0.0 0.00 1.00 KLC1 SDCCAG8
High cholesterol (Self-reported) 2.39 1 0 0.0 0.00 1.00 FYCO1
Medication: Paracetamol 3.85 2 0 0.0 0.00 1.00 KLC1 SDCCAG8
Medication: Atorvastatin 2.27 1 0 0.0 0.00 1.00 THBS3
Ever smoked 4.33 2 0 0.0 0.00 1.00 LINC00899 THBS3
Basal metabolic rate 1.42 1 0 0.0 0.00 1.00 THBS3
Leg fat percentage (left) 2.12 2 1 2.2 0.00 1.00 KLC1 SDCCAG8
Arm fat-free mass (left) 0.93 1 0 0.0 0.00 1.00 THBS3
Risk taking 6.44 2 0 0.0 0.00 1.00 KLC1 LINC00899
Diastolic blood pressure, automated reading 3.29 2 1 2.2 0.00 1.00 KLC1 SDCCAG8
Ever depressed for a whole week 1.70 1 0 0.0 0.00 1.00 KLC1
Unable to work because of sickness or disability 1.94 1 0 0.0 0.00 1.00 KLC1
Vascular/heart problems diagnosed by doctor 1.83 1 0 0.0 0.00 1.00 KLC1
Medication: Omeprazole (e.g. Zanprol) 3.61 1 0 0.0 0.00 1.00 CCR3
Alcohol drinker status: Previous 3.91 1 0 0.0 0.00 1.00 KLC1
Pack years of smoking 3.63 1 0 0.0 0.00 1.00 KLC1
Impedance of whole body 2.22 3 1 2.2 0.00 1.00 FYCO1 KLC1 THBS3
Leg fat mass (left) 2.26 2 0 0.0 0.00 1.00 KLC1 SDCCAG8

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.6
GTEx Adipose Visceral Omentum 0 0.000 1.6
GTEx Adrenal Gland 0 0.000 1.5
GTEx Artery Aorta 0 0.000 1.5
GTEx Artery Coronary 0 0.000 1.6
GTEx Artery Tibial 2 0.053 1.5
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 0 0.000 1.6
GTEx Brain Cerebellum 2 0.101 1.6
GTEx Brain Cortex 0 0.000 1.6
GTEx Brain Frontal Cortex BA9 0 0.000 1.6
GTEx Brain Hippocampus 0 0.000 1.6
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.6
GTEx Brain Putamen basal ganglia 0 0.000 1.5
GTEx Breast Mammary Tissue 1 0.051 1.6
GTEx Breast Mammary Tissue (Male) 0 0.000 1.6
GTEx Breast Mammary Tissue (Female) 0 0.000 1.6
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.6
GTEx Cells Transformed fibroblasts 1 0.024 1.6
GTEx Colon Sigmoid 0 0.000 1.6
GTEx Colon Transverse 0 0.000 1.7
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.6
GTEx Esophagus Mucosa 0 0.000 1.6
GTEx Esophagus Muscularis 1 0.031 1.6
GTEx Heart Atrial Appendage 0 0.000 1.6
GTEx Heart Left Ventricle 0 0.000 1.6
GTEx Liver 0 0.000 1.4
GTEx Lung 0 0.000 1.5
GTEx Muscle Skeletal 2 0.069 1.6
GTEx Nerve Tibial 0 0.000 1.5
GTEx Ovary 0 0.000 1.6
GTEx Pancreas 0 0.000 1.5
GTEx Pituitary 0 0.000 1.6
GTEx Prostate 1 0.120 1.7
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.6
GTEx Skin Sun Exposed Lower leg 0 0.000 1.5
GTEx Small Intestine Terminal Ileum 1 0.217 1.8
GTEx Spleen 1 0.071 1.7
GTEx Stomach 0 0.000 1.6
GTEx Testis 0 0.000 1.6
GTEx Thyroid 1 0.025 1.6
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.6
METSIM Adipose 1 0.022 1.4
NTR Blood 1 0.042 1.6
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.5
YFS Blood 0 0.000 1.5
CommonMind Brain Pre-frontal Cortex 0 0.000 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.5
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.6
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.5
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Brain Lower Grade Glioma 3 0.070 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.6
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.6
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.5
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 3 0.434 1.7
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.7
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.5
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.6