Hub : Traits :

Mouth/teeth dental problems

30 significantly associated models · 17 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	154401972	155887772	6	1	5.2e-08	1.4e-07	0.097	90	THBS3
2	1	243298257	243910067	1	1	1.1e-09	1.1e-06	0.538	98	SDCCAG8
3	3	45262393	46728659	4	2	3.1e-10	1.5e-09	1.000	100	CCR3 FYCO1
4	14	103161201	104866687	3	1	1.1e-07	4.3e-06	0.680	99	KLC1
5	22	45736153	47135205	1	1	1.8e-07	2.1e-07	0.415	98	LINC00899

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Mouth/teeth dental problems: Mouth ulcers	37.76	3	2	4.4	0.00	1.00	CCR3 FYCO1 SDCCAG8
Mouth/teeth dental problems: Dentures	6.87	3	1	2.2	0.00	1.00	LINC00899 SDCCAG8 THBS3
Risk taking	6.44	2	0	0.0	0.00	1.00	KLC1 LINC00899
Heel T-Score	5.58	4	4	8.9	-0.15	0.85	FYCO1 KLC1 LINC00899 THBS3
Financial difficulties in last 2 years	5.04	1	1	2.2	0.00	1.00	KLC1
Past tobacco smoking	4.91	3	0	0.0	0.00	1.00	KLC1 LINC00899 THBS3
Medication: Paracetamol	4.91	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Smoking Status	4.59	2	1	2.2	0.00	1.00	KLC1 LINC00899
Hearing difficulty/problems with background noise	4.47	1	0	0.0	0.00	1.00	KLC1
Overall health rating	4.47	2	1	2.2	0.00	1.00	KLC1 SDCCAG8
Impedance of leg (right)	4.33	4	3	6.7	0.53	0.47	CCR3 FYCO1 KLC1 THBS3
Ever smoked	4.33	2	0	0.0	0.00	1.00	LINC00899 THBS3
Ulcerative Colitis (UC)	4.25	1	0	0.0	0.00	1.00	THBS3
Exposure to tobacco smoke outside home	4.25	1	0	0.0	0.00	1.00	SDCCAG8
Current tobacco smoking	4.17	2	0	0.0	0.00	1.00	KLC1 LINC00899
Emphysema/chronic bronchitis	4.15	2	0	0.0	0.00	1.00	KLC1 LINC00899
Medication for pain relief, constipation, heartburn	4.13	1	0	0.0	0.00	1.00	SDCCAG8
Smoking status: Current	4.06	2	0	0.0	0.00	1.00	KLC1 LINC00899
Impedance of leg (left)	3.93	4	3	6.7	0.48	0.52	CCR3 FYCO1 KLC1 THBS3
Alcohol drinker status: Previous	3.91	1	0	0.0	0.00	1.00	KLC1
Pack years adult smoking proportion	3.85	1	0	0.0	0.00	1.00	KLC1
Medication: Paracetamol	3.85	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Gout (self-reported)	3.81	1	0	0.0	0.00	1.00	THBS3
Frequency of tiredness / lethargy in last 2 weeks	3.74	2	0	0.0	0.00	1.00	KLC1 LINC00899
Irritable Bowel Disease (IBD)	3.71	1	1	2.2	0.00	1.00	THBS3
Maternal smoking around birth	3.70	1	1	2.2	0.00	1.00	KLC1
Smoking status: Previous	3.66	1	0	0.0	0.00	1.00	THBS3
Pack years of smoking	3.63	1	0	0.0	0.00	1.00	KLC1
Bipolar Disorder or Schizophrenia	3.61	1	1	2.2	0.00	1.00	KLC1
Medication: Omeprazole (e.g. Zanprol)	3.61	1	0	0.0	0.00	1.00	CCR3
Mouth/teeth dental problems: Bleeding gums	3.57	1	0	0.0	0.00	1.00	KLC1
Mother's age at death	3.56	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Depressed Affect (Nagel 2018)	3.52	2	0	0.0	0.00	1.00	SDCCAG8 THBS3
Arm fat percentage (right)	3.44	3	1	2.2	0.00	1.00	KLC1 SDCCAG8 THBS3
Wheeze or whistling in the chest in last year	3.44	1	0	0.0	0.00	1.00	LINC00899
Body mass index (BMI)	3.38	3	1	2.2	0.00	1.00	KLC1 SDCCAG8 THBS3
Schizophrenia (2018)	3.37	1	1	2.2	0.00	1.00	KLC1
Diastolic blood pressure, automated reading	3.29	2	1	2.2	0.00	1.00	KLC1 SDCCAG8
Schizophrenia (2014)	3.28	1	1	2.2	0.00	1.00	KLC1
BMI	3.18	3	1	2.2	0.00	1.00	KLC1 SDCCAG8 THBS3
Arm fat percentage (left)	3.18	3	1	2.2	0.00	1.00	KLC1 SDCCAG8 THBS3
Arm fat mass (right)	3.16	3	1	2.2	0.00	1.00	KLC1 SDCCAG8 THBS3
Arm fat mass (left)	3.12	3	1	2.2	0.00	1.00	KLC1 SDCCAG8 THBS3
Breast Cancer	3.09	1	1	2.2	0.00	1.00	THBS3
Medication: Allopurinol	3.05	1	0	0.0	0.00	1.00	THBS3
Heel bone mineral density (BMD) T-score, automated (left)	3.04	2	0	0.0	0.00	1.00	KLC1 THBS3
Miserableness	2.93	2	0	0.0	0.00	1.00	SDCCAG8 THBS3
Other serious medical condition/disability diagnosed by doctor	2.89	1	0	0.0	0.00	1.00	KLC1
Number of self-reported non-cancer illnesses	2.85	1	0	0.0	0.00	1.00	KLC1
Qualifications: NVQ or HND or HNC or equivalent	2.67	1	0	0.0	0.00	1.00	SDCCAG8
Number of treatments/medications taken	2.62	1	0	0.0	0.00	1.00	SDCCAG8
Ulcerative Colitis	2.61	1	0	0.0	0.00	1.00	THBS3
Frequency of tenseness / restlessness in last 2 weeks	2.61	1	0	0.0	0.00	1.00	LINC00899
Long-standing illness, disability or infirmity	2.60	1	0	0.0	0.00	1.00	KLC1
Cardiovascular Disease	2.57	2	1	2.2	0.00	1.00	KLC1 SDCCAG8
Prostate Cancer	2.45	1	0	0.0	0.00	1.00	KLC1
Illness, injury, bereavement, stress in last 2 years	2.39	1	0	0.0	0.00	1.00	KLC1
High cholesterol (Self-reported)	2.39	1	0	0.0	0.00	1.00	FYCO1
Birth weight	2.34	1	0	0.0	0.00	1.00	LINC00899
Leg fat-free mass (right)	2.28	3	1	2.2	0.00	1.00	CCR3 FYCO1 THBS3
Body fat percentage	2.27	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Medication: Atorvastatin	2.27	1	0	0.0	0.00	1.00	THBS3
Leg fat mass (left)	2.26	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Impedance of whole body	2.22	3	1	2.2	0.00	1.00	FYCO1 KLC1 THBS3
Bipolar Disorder (2018)	2.21	1	0	0.0	0.00	1.00	KLC1
Blood Red Count	2.21	3	1	2.2	0.00	1.00	KLC1 SDCCAG8 THBS3
Number of full sisters	2.21	1	0	0.0	0.00	1.00	LINC00899
Leg predicted mass (right)	2.21	3	1	2.2	0.00	1.00	CCR3 FYCO1 THBS3
Qualifications: A levels/AS levels or equivalent	2.19	1	0	0.0	0.00	1.00	SDCCAG8
Hearing difficulty/problems: Yes	2.18	1	0	0.0	0.00	1.00	KLC1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.16	1	0	0.0	0.00	1.00	LINC00899
Qualifications: nursing, teaching	2.16	1	0	0.0	0.00	1.00	SDCCAG8
Crohns Disease (2017)	2.15	1	0	0.0	0.00	1.00	THBS3
Neuroticism	2.14	1	0	0.0	0.00	1.00	THBS3
Whole body fat mass	2.14	3	0	0.0	0.00	1.00	KLC1 SDCCAG8 THBS3
Qualifications: College or University degree	2.12	1	1	2.2	0.00	1.00	SDCCAG8
Leg fat percentage (left)	2.12	2	1	2.2	0.00	1.00	KLC1 SDCCAG8
High blood pressure (siblings)	2.11	1	0	0.0	0.00	1.00	KLC1
Waist circumference	2.09	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Trunk fat percentage	2.08	3	0	0.0	0.00	1.00	KLC1 SDCCAG8 THBS3
Leg fat-free mass (left)	2.04	3	1	2.2	0.00	1.00	CCR3 FYCO1 THBS3
Leg fat mass (right)	2.02	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Leg predicted mass (left)	1.98	3	1	2.2	0.00	1.00	CCR3 FYCO1 THBS3
Trunk fat mass	1.96	3	0	0.0	0.00	1.00	KLC1 SDCCAG8 THBS3
Unable to work because of sickness or disability	1.94	1	0	0.0	0.00	1.00	KLC1
Leg fat percentage (right)	1.93	2	0	0.0	0.00	1.00	KLC1 SDCCAG8
Crohns Disease (2012)	1.92	1	0	0.0	0.00	1.00	THBS3
Heel bone mineral density (BMD) T-score, automated (right)	1.91	2	0	0.0	0.00	1.00	KLC1 THBS3
Weight	1.88	3	0	0.0	0.00	1.00	KLC1 SDCCAG8 THBS3
Tense / 'highly strung'	1.83	1	0	0.0	0.00	1.00	LINC00899
Vascular/heart problems diagnosed by doctor	1.83	1	0	0.0	0.00	1.00	KLC1
Qualifications: None of the above	1.82	1	0	0.0	0.00	1.00	SDCCAG8
Hair/balding pattern: Pattern 4	1.82	1	0	0.0	0.00	1.00	THBS3
Hip circumference	1.78	2	0	0.0	0.00	1.00	KLC1 THBS3
Health satisfaction	1.70	1	0	0.0	0.00	1.00	KLC1
Ever depressed for a whole week	1.70	1	0	0.0	0.00	1.00	KLC1
Mood swings	1.63	1	0	0.0	0.00	1.00	THBS3
Allergy	1.62	1	0	0.0	0.00	1.00	THBS3
Chronotype (morning person)	1.57	1	0	0.0	0.00	1.00	SDCCAG8
High blood pressure	1.52	1	0	0.0	0.00	1.00	KLC1
Pulse rate, automated reading	1.44	1	0	0.0	0.00	1.00	KLC1
Hypertension (Self-reported)	1.42	1	0	0.0	0.00	1.00	KLC1
Basal metabolic rate	1.42	1	0	0.0	0.00	1.00	THBS3
Hayfever, allergic rhinitis or eczema	1.39	1	0	0.0	0.00	1.00	THBS3
Blood White Count	1.35	2	1	2.2	0.00	1.00	KLC1 SDCCAG8
Whole body water mass	1.31	3	0	0.0	0.00	1.00	CCR3 FYCO1 THBS3
Reaction Time	1.25	1	0	0.0	0.00	1.00	SDCCAG8
Allergy or Eczema	1.22	1	0	0.0	0.00	1.00	THBS3
Height	1.21	3	1	2.2	0.00	1.00	CCR3 KLC1 THBS3
Whole body fat-free mass	1.20	1	0	0.0	0.00	1.00	THBS3
Impedance of arm (left)	1.17	2	0	0.0	0.00	1.00	FYCO1 KLC1
Lung FVC	1.11	1	0	0.0	0.00	1.00	THBS3
Comparative height size at age 10	1.09	1	1	2.2	0.00	1.00	KLC1
Waist Hip Ratio (WHR)	1.08	1	0	0.0	0.00	1.00	THBS3
Blood Platelet Count	1.04	1	1	2.2	0.00	1.00	THBS3
Forced expiratory volume in 1-second (FEV1)	1.03	1	0	0.0	0.00	1.00	THBS3
Sitting height	1.02	1	0	0.0	0.00	1.00	CCR3
Arm fat-free mass (left)	0.93	1	0	0.0	0.00	1.00	THBS3
Standing height	0.85	2	1	2.2	0.00	1.00	CCR3 KLC1
Blood Eosinophil Count	0.84	1	0	0.0	0.00	1.00	KLC1
Impedance of arm (right)	0.84	1	0	0.0	0.00	1.00	FYCO1
Trunk fat-free mass	0.84	1	0	0.0	0.00	1.00	THBS3
Trunk predicted mass	0.83	1	0	0.0	0.00	1.00	THBS3
Hair Pigment	0.80	2	2	4.4	0.00	1.00	KLC1 THBS3
Intelligence (Savage-Jansen 2018)	0.78	1	0	0.0	0.00	1.00	KLC1
Lung FEV1/FVC ratio	0.70	1	0	0.0	0.00	1.00	KLC1
Tanning	0.46	2	0	0.0	0.00	1.00	SDCCAG8 THBS3
Systolic Blood Pressure	0.45	1	0	0.0	0.00	1.00	SDCCAG8

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	1	0.217	1.8
GTEx	Colon Transverse	0	0.000	1.7
GTEx	Prostate	1	0.120	1.7
GTEx	Spleen	1	0.071	1.7
The Cancer Genome Atlas	Rectum Adenocarcinoma	3	0.434	1.7
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.7
GTEx	Adipose Subcutaneous	1	0.029	1.6
GTEx	Adipose Visceral Omentum	0	0.000	1.6
GTEx	Artery Coronary	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.6
GTEx	Brain Cerebellum	2	0.101	1.6
GTEx	Brain Cortex	0	0.000	1.6
GTEx	Brain Frontal Cortex BA9	0	0.000	1.6
GTEx	Brain Hippocampus	0	0.000	1.6
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.6
GTEx	Breast Mammary Tissue	1	0.051	1.6
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.6
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.6
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.6
GTEx	Cells Transformed fibroblasts	1	0.024	1.6
GTEx	Colon Sigmoid	0	0.000	1.6
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.6
GTEx	Esophagus Mucosa	0	0.000	1.6
GTEx	Esophagus Muscularis	1	0.031	1.6
GTEx	Heart Atrial Appendage	0	0.000	1.6
GTEx	Heart Left Ventricle	0	0.000	1.6
GTEx	Muscle Skeletal	2	0.069	1.6
GTEx	Ovary	0	0.000	1.6
GTEx	Pituitary	0	0.000	1.6
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.6
GTEx	Stomach	0	0.000	1.6
GTEx	Testis	0	0.000	1.6
GTEx	Thyroid	1	0.025	1.6
GTEx	Whole Blood	0	0.000	1.6
NTR	Blood	1	0.042	1.6
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.6
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.6
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Artery Tibial	2	0.053	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Putamen basal ganglia	0	0.000	1.5
GTEx	Lung	0	0.000	1.5
GTEx	Nerve Tibial	0	0.000	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.5
GTEx	Uterus	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.5
YFS	Blood	0	0.000	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.5
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	3	0.070	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.5
GTEx	Liver	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
METSIM	Adipose	1	0.022	1.4
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4