Best TWAS P=1.43e-09 · Best GWAS P=5.07e-08 conditioned to 0.904
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | RASIP1 | 0.19 | 0.14 | lasso | 6 | 0.20 | 6.1e-15 | 4.9 | 5.2 | 2.1e-07 | 0.93 | 0.04 | 0.96 | FALSE |
2 | GTEx | Esophagus Mucosa | RASIP1 | 0.13 | 0.13 | lasso | 4 | 0.13 | 9.0e-09 | -4.5 | 5.2 | 2.1e-07 | 0.78 | 0.19 | 0.80 | FALSE |
3 | GTEx | Heart Atrial Appendage | MAMSTR | 0.24 | 0.13 | lasso | 2 | 0.13 | 1.3e-06 | -5.1 | 5.4 | 8.1e-08 | 0.74 | 0.03 | 0.96 | FALSE |
4 | GTEx | Heart Left Ventricle | MAMSTR | 0.26 | 0.18 | lasso | 6 | 0.21 | 3.4e-11 | -5.2 | 5.5 | 4.9e-08 | 0.80 | 0.04 | 0.96 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | NTN5 | 0.19 | 0.07 | lasso | 5 | 0.08 | 2.5e-05 | 5.2 | 5.5 | 5.0e-08 | 0.94 | 0.02 | 0.97 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | FUT2 | 0.18 | 0.22 | enet | 12 | 0.18 | 6.8e-11 | 5.2 | -5.3 | 1.4e-07 | -0.95 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FUT2 | 0.10 | 0.01 | blup | 51 | 0.05 | 9.8e-04 | 5.3 | -5.3 | 1.2e-07 | -0.88 | 0.01 | 0.92 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FUT2 | 0.02 | 0.04 | lasso | 1 | 0.03 | 1.8e-04 | -5.1 | -5.1 | 2.6e-07 | -0.67 | 0.04 | 0.77 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NTN5 | 0.05 | 0.04 | lasso | 2 | 0.02 | 6.7e-04 | 5.4 | 5.4 | 5.1e-08 | 1.00 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FUT2 | 0.05 | 0.08 | lasso | 2 | 0.08 | 6.7e-09 | 5.3 | -5.4 | 7.4e-08 | -0.96 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FUT2 | 0.26 | 0.28 | lasso | 10 | 0.22 | 5.2e-06 | 5.4 | -5.5 | 3.3e-08 | -0.99 | 0.01 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FUT2 | 0.14 | 0.16 | lasso | 8 | 0.14 | 4.9e-10 | 4.9 | -5.1 | 2.8e-07 | -0.95 | 0.02 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | NTN5 | 0.11 | 0.07 | blup | 43 | 0.09 | 2.6e-09 | 5.3 | 6.1 | 1.4e-09 | 0.89 | 0.01 | 0.99 | TRUE |