Hub : Traits :

Mouth/teeth dental problems: Dentures

137 significantly associated models · 29 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	154238383	155910830	12	1	9.5e-10	1.9e-09	2.2e-02	85	GBAP1
2	3	49016056	50833360	5	1	1.4e-08	2.2e-08	6.7e-02	89	RBM6
3	6	25296606	26689223	1	3	3.6e-14	1.1e-23	7.5e-12	53	U91328.19
4	14	73459917	73990117	1	1	1.3e-07	1.3e-05	2.8e-02	75	PAPLN
5	15	62716641	64367745	4	4	4.4e-13	8.8e-16	2.1e-12	24	APH1B CA12 LACTB
6	17	45312813	46899254	2	2	5.5e-08	7.3e-07	6.4e-01	99	RP11-6N17.3 SNX11
7	19	48464978	49935001	4	1	1.4e-09	5.1e-08	9.0e-01	100	NTN5

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Leg fat mass (left)	6.99	3	2	4.4	0.96	0.01077	RBM6 SNX11 U91328.19
Leg fat mass (right)	6.87	3	2	4.4	0.96	0.01057	RBM6 SNX11 U91328.19
Hip circumference	6.43	3	3	6.7	0.98	0.00425	RBM6 SNX11 U91328.19
Weight	6.15	5	3	6.7	0.82	0.02270	GBAP1 RBM6 RP11-6N17.3 SNX11 U91328.19
Whole body fat mass	6.13	4	2	4.4	0.97	0.00132	RBM6 RP11-6N17.3 SNX11 U91328.19
Arm fat mass (right)	6.04	5	2	4.4	0.79	0.03527	GBAP1 RBM6 RP11-6N17.3 SNX11 U91328.19
Arm fat mass (left)	5.97	5	2	4.4	0.78	0.03908	GBAP1 RBM6 RP11-6N17.3 SNX11 U91328.19
Body mass index (BMI)	5.91	3	2	4.4	0.69	0.19809	GBAP1 RBM6 U91328.19
Mouth/teeth dental problems	5.86	2	1	2.2	0.00	1.00000	GBAP1 NTN5
Trunk fat mass	5.71	5	3	6.7	0.84	0.01671	GBAP1 RBM6 RP11-6N17.3 SNX11 U91328.19
Leg fat percentage (left)	5.58	2	2	4.4	0.99	0.01378	RBM6 U91328.19
Leg fat percentage (right)	5.51	2	2	4.4	0.99	0.01338	RBM6 U91328.19
Age at last live birth	5.39	1	1	2.2	0.00	1.00000	RBM6
Hayfever, allergic rhinitis or eczema	5.01	2	1	2.2	-0.83	0.16698	GBAP1 U91328.19
Body fat percentage	4.89	4	2	4.4	0.97	0.00102	RBM6 RP11-6N17.3 SNX11 U91328.19
Age at first live birth	4.85	1	1	2.2	0.00	1.00000	RBM6
Medication: Atorvastatin	4.63	1	0	0.0	0.00	1.00000	NTN5
High cholesterol (Self-reported)	4.62	1	1	2.2	0.00	1.00000	NTN5
Medication: Levothyroxine sodium	4.57	1	1	2.2	0.00	1.00000	U91328.19
Trunk fat percentage	4.56	4	2	4.4	0.99	0.00019	RBM6 RP11-6N17.3 SNX11 U91328.19
Arm fat-free mass (left)	4.52	4	2	4.4	0.80	0.05400	NTN5 RBM6 SNX11 U91328.19
Arm predicted mass (left)	4.50	4	2	4.4	0.80	0.05497	NTN5 RBM6 SNX11 U91328.19
Arm predicted mass (right)	4.46	4	2	4.4	0.79	0.06148	NTN5 RBM6 SNX11 U91328.19
Hypothyroidism/myxoedema (self-reported)	4.41	1	1	2.2	0.00	1.00000	U91328.19
Arm fat percentage (right)	4.37	4	2	4.4	0.72	0.10380	GBAP1 RBM6 RP11-6N17.3 U91328.19
Arm fat percentage (left)	4.35	4	2	4.4	0.72	0.10617	GBAP1 RBM6 RP11-6N17.3 U91328.19
Cholesterol lowering medication	4.34	1	1	2.2	0.00	1.00000	NTN5
Basal metabolic rate	4.29	4	3	6.7	0.79	0.06149	GBAP1 RBM6 SNX11 U91328.19
BMI	4.27	4	1	2.2	-0.45	0.55198	GBAP1 RBM6 RP11-6N17.3 SNX11
Arm fat-free mass (right)	4.22	4	2	4.4	0.79	0.06436	NTN5 RBM6 SNX11 U91328.19
Qualifications: College or University degree	4.09	2	1	2.2	0.00	1.00000	RBM6 U91328.19
Leg fat-free mass (left)	4.01	4	4	8.9	0.74	0.09215	GBAP1 RBM6 SNX11 U91328.19
Leg predicted mass (left)	4.00	4	4	8.9	0.74	0.09287	GBAP1 RBM6 SNX11 U91328.19
Allergy	3.95	2	1	2.2	0.46	0.54049	GBAP1 U91328.19
Irritable Bowel Disease (IBD)	3.85	3	1	2.2	0.00	1.00000	GBAP1 NTN5 RBM6
Waist circumference	3.71	4	2	4.4	0.97	0.00730	RBM6 RP11-6N17.3 SNX11 U91328.19
Age at First Birth	3.65	1	1	2.2	0.00	1.00000	RBM6
Whole body fat-free mass	3.56	4	3	6.7	0.79	0.06423	GBAP1 RBM6 SNX11 U91328.19
Leg fat-free mass (right)	3.52	4	3	6.7	0.71	0.11071	GBAP1 RBM6 SNX11 U91328.19
Whole body water mass	3.51	4	3	6.7	0.78	0.06649	GBAP1 RBM6 SNX11 U91328.19
Leg predicted mass (right)	3.50	4	3	6.7	0.72	0.10859	GBAP1 RBM6 SNX11 U91328.19
Crohns Disease (2017)	3.44	2	2	4.4	0.00	1.00000	GBAP1 NTN5
Seen a psychiatrist for nerves, anxiety, tension or depression	3.39	1	0	0.0	0.00	1.00000	U91328.19
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.24	1	1	2.2	0.00	1.00000	U91328.19
Hayfever/allergic rhinitis (self-reported)	3.23	1	0	0.0	0.00	1.00000	U91328.19
Hypothyroidism (self reported)	3.22	2	0	0.0	0.00	1.00000	CA12 NTN5
Schizophrenia vs Biploar Disorder	3.16	1	0	0.0	0.00	1.00000	RBM6
Impedance of arm (right)	3.13	2	1	2.2	0.00	1.00000	RBM6 U91328.19
Systolic blood pressure, automated reading	3.08	2	1	2.2	0.00	1.00000	LACTB SNX11
Trunk fat-free mass	3.05	4	2	4.4	0.78	0.06958	NTN5 RBM6 SNX11 U91328.19
Impedance of arm (left)	3.05	2	1	2.2	0.00	1.00000	RBM6 U91328.19
Qualifications: A levels/AS levels or equivalent	3.04	1	1	2.2	0.00	1.00000	RBM6
Ulcerative Colitis (UC)	3.03	2	1	2.2	0.00	1.00000	GBAP1 RBM6
Trunk predicted mass	3.02	4	2	4.4	0.77	0.07077	NTN5 RBM6 SNX11 U91328.19
Crohns Disease (2012)	2.99	1	0	0.0	0.00	1.00000	GBAP1
Nervous feelings	2.87	1	1	2.2	0.00	1.00000	U91328.19
Medication: Cholesterol lowering	2.86	1	1	2.2	0.00	1.00000	NTN5
HDL Cholesterol	2.84	2	0	0.0	0.00	1.00000	APH1B LACTB
Systolic Blood Pressure	2.79	4	3	6.7	-0.42	0.57814	LACTB NTN5 RP11-6N17.3 SNX11
Qualifications: None of the above	2.76	1	1	2.2	0.00	1.00000	RBM6
Schizophrenia (2018)	2.70	1	0	0.0	0.00	1.00000	U91328.19
Cardiovascular Disease	2.68	1	1	2.2	0.00	1.00000	NTN5
Impedance of whole body	2.67	2	1	2.2	0.00	1.00000	RBM6 U91328.19
Comparative body size at age 10	2.66	3	1	2.2	0.00	1.00000	NTN5 RBM6 U91328.19
Number of children fathered	2.63	1	0	0.0	0.00	1.00000	NTN5
Miserableness	2.62	2	1	2.2	0.00	1.00000	GBAP1 RBM6
Medication for cholesterol	2.57	1	1	2.2	0.00	1.00000	NTN5
Medication: Simvastatin	2.53	1	1	2.2	0.00	1.00000	NTN5
Hearing difficulty/problems with background noise	2.52	1	0	0.0	0.00	1.00000	U91328.19
Heel bone mineral density (BMD) T-score, automated (left)	2.51	2	0	0.0	0.00	1.00000	GBAP1 U91328.19
Vitamin and mineral supplements	2.47	1	0	0.0	0.00	1.00000	U91328.19
Ulcerative Colitis	2.46	1	0	0.0	0.00	1.00000	RBM6
Supplements: Vitamin C	2.46	1	0	0.0	0.00	1.00000	U91328.19
Heel bone mineral density (BMD) T-score, automated (right)	2.43	1	0	0.0	0.00	1.00000	U91328.19
Number of treatments/medications taken	2.41	2	0	0.0	0.00	1.00000	NTN5 RBM6
Alcohol intake frequency.	2.40	2	1	2.2	0.00	1.00000	NTN5 RBM6
Medication: Co-codamol	2.37	1	0	0.0	0.00	1.00000	RBM6
Intelligence (Savage-Jansen 2018)	2.34	1	1	2.2	0.00	1.00000	RBM6
Peak expiratory flow (PEF)	2.31	1	1	2.2	0.00	1.00000	NTN5
Verbal and Numeric Reasoning (VNR)	2.29	2	1	2.2	0.00	1.00000	RBM6 U91328.19
Alcohol intake versus 10 years previously	2.22	2	0	0.0	0.00	1.00000	NTN5 RBM6
Blood Platelet Count	2.21	4	4	8.9	0.98	0.02268	APH1B GBAP1 LACTB NTN5
Ever highly irritable/argumentative for 2 days	2.19	1	1	2.2	0.00	1.00000	RBM6
Forced expiratory volume in 1-second (FEV1), predicted	2.19	1	0	0.0	0.00	1.00000	SNX11
Guilty feelings	2.18	1	0	0.0	0.00	1.00000	RBM6
Number of live births	2.17	1	0	0.0	0.00	1.00000	RBM6
Ovarian Cancer	2.16	1	0	0.0	0.00	1.00000	RP11-6N17.3
Impedance of leg (left)	2.16	2	2	4.4	0.00	1.00000	GBAP1 RBM6
Gout (self-reported)	2.16	1	0	0.0	0.00	1.00000	GBAP1
Medication for cholesterol, blood pressure or diabetes	2.14	1	0	0.0	0.00	1.00000	NTN5
Pulse rate, automated reading	2.12	1	0	0.0	0.00	1.00000	U91328.19
LDL Cholesterol	2.10	1	0	0.0	0.00	1.00000	NTN5
Fluid intelligence score	2.10	1	1	2.2	0.00	1.00000	RBM6
Headache pain in last month	2.09	1	0	0.0	0.00	1.00000	U91328.19
Overall health rating	2.09	1	1	2.2	0.00	1.00000	RBM6
Serious illness, injury or assault of a close relative in last 2 years	2.08	1	0	0.0	0.00	1.00000	NTN5
Impedance of leg (right)	2.03	2	2	4.4	0.00	1.00000	GBAP1 RBM6
Exposure to tobacco smoke outside home	2.01	1	0	0.0	0.00	1.00000	RBM6
Average weekly spirits intake	1.96	1	0	0.0	0.00	1.00000	NTN5
Taking other prescription medications	1.96	1	0	0.0	0.00	1.00000	RBM6
Ever depressed for a whole week	1.94	1	0	0.0	0.00	1.00000	RBM6
Average weekly red wine intake	1.91	1	0	0.0	0.00	1.00000	RBM6
Depressed Affect (Nagel 2018)	1.90	2	0	0.0	0.00	1.00000	GBAP1 RBM6
Wheeze or whistling in the chest in last year	1.89	1	1	2.2	0.00	1.00000	RBM6
Mood swings	1.89	1	0	0.0	0.00	1.00000	RBM6
Forced expiratory volume in 1-second (FEV1)	1.87	2	0	0.0	0.00	1.00000	RBM6 U91328.19
Supplements: Fish oil (including cod liver oil)	1.86	1	0	0.0	0.00	1.00000	U91328.19
Number of self-reported non-cancer illnesses	1.85	1	0	0.0	0.00	1.00000	NTN5
Hearing aid user	1.82	1	0	0.0	0.00	1.00000	RP11-6N17.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.81	1	0	0.0	0.00	1.00000	RBM6
Past tobacco smoking	1.79	1	0	0.0	0.00	1.00000	GBAP1
Exposure to tobacco smoke at home	1.77	1	0	0.0	0.00	1.00000	RBM6
Pain experienced in last month	1.76	1	0	0.0	0.00	1.00000	RBM6
Average weekly beer plus cider intake	1.74	1	0	0.0	0.00	1.00000	RBM6
Chronic bronchitis/emphysema (mother)	1.70	1	0	0.0	0.00	1.00000	RBM6
Smoking status: Previous	1.68	1	0	0.0	0.00	1.00000	GBAP1
Blood Red Count	1.64	2	2	4.4	0.00	1.00000	GBAP1 RP11-6N17.3
Fed-up feelings	1.62	1	0	0.0	0.00	1.00000	RBM6
Sitting height	1.62	2	1	2.2	0.35	0.65425	NTN5 U91328.19
Chronic bronchitis/emphysema (father)	1.62	1	0	0.0	0.00	1.00000	RBM6
Waist Hip Ratio (WHR)	1.61	2	1	2.2	0.00	1.00000	GBAP1 NTN5
Lung FEV1/FVC ratio	1.61	3	1	2.2	0.00	1.00000	LACTB NTN5 SNX11
Neuroticism score	1.61	1	0	0.0	0.00	1.00000	U91328.19
Tense / 'highly strung'	1.59	1	0	0.0	0.00	1.00000	U91328.19
Forced vital capacity (FVC)	1.58	1	0	0.0	0.00	1.00000	RBM6
Hair Pigment	1.56	3	3	6.7	0.00	1.00000	GBAP1 RP11-6N17.3 SNX11
Neuroticism (Nagel 2018)	1.54	1	0	0.0	0.00	1.00000	U91328.19
Comparative height size at age 10	1.54	3	2	4.4	0.00	1.00000	NTN5 RBM6 SNX11
Standing height	1.53	4	3	6.7	0.35	0.49720	NTN5 RBM6 SNX11 U91328.19
Forced vital capacity (FVC), Best measure	1.52	1	0	0.0	0.00	1.00000	RBM6
Medication: Allopurinol	1.51	1	0	0.0	0.00	1.00000	GBAP1
Breast Cancer	1.50	1	1	2.2	0.00	1.00000	GBAP1
Diabetes (mother)	1.47	1	0	0.0	0.00	1.00000	SNX11
Number of full brothers	1.45	1	0	0.0	0.00	1.00000	RBM6
Medication: Blood pressure	1.44	1	0	0.0	0.00	1.00000	NTN5
Number of operations (self-reported)	1.44	1	0	0.0	0.00	1.00000	RBM6
Hypertension (Self-reported)	1.43	1	1	2.2	0.00	1.00000	NTN5
Number of full sisters	1.41	1	0	0.0	0.00	1.00000	RBM6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.40	1	0	0.0	0.00	1.00000	GBAP1
Vascular/heart problems diagnosed by doctor	1.38	1	1	2.2	0.00	1.00000	NTN5
Smoking Status	1.36	1	0	0.0	0.00	1.00000	RBM6
Heel T-Score	1.35	2	2	4.4	0.00	1.00000	GBAP1 SNX11
Qualifications: O levels/GCSEs or equivalent	1.28	1	0	0.0	0.00	1.00000	RBM6
Blood White Count	1.26	2	1	2.2	0.00	1.00000	RBM6 RP11-6N17.3
Age when periods started (menarche)	1.26	1	0	0.0	0.00	1.00000	NTN5
Chronotype (morning person)	1.23	1	0	0.0	0.00	1.00000	NTN5
Hair/balding pattern: Pattern 4	1.23	1	0	0.0	0.00	1.00000	GBAP1
Lung FVC	1.21	1	1	2.2	0.00	1.00000	GBAP1
Respiratory disease	1.18	1	0	0.0	0.00	1.00000	RBM6
Worry (Nagel 2018)	1.15	1	0	0.0	0.00	1.00000	U91328.19
Knee pain experienced in last month	1.15	1	0	0.0	0.00	1.00000	RBM6
Pain all over the body in last month	1.13	1	0	0.0	0.00	1.00000	RBM6
High blood pressure	1.10	1	0	0.0	0.00	1.00000	NTN5
Medication: Bendroflumethiazide	1.10	1	0	0.0	0.00	1.00000	NTN5
Neuroticism	1.04	1	0	0.0	0.00	1.00000	RBM6
Height	1.01	4	3	6.7	-0.40	0.60310	GBAP1 NTN5 RBM6 SNX11
Blood Eosinophil Count	0.90	2	0	0.0	0.00	1.00000	LACTB RP11-6N17.3
Birth weight	0.90	1	0	0.0	0.00	1.00000	NTN5
Tanning	0.49	1	1	2.2	0.00	1.00000	SNX11

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	2	0.434	2.0
GTEx	Spleen	5	0.354	1.9
GTEx	Artery Coronary	0	0.000	1.8
GTEx	Brain Cerebellar Hemisphere	4	0.269	1.8
GTEx	Brain Cerebellum	3	0.151	1.8
GTEx	Brain Cortex	2	0.193	1.8
GTEx	Brain Frontal Cortex BA9	3	0.325	1.8
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.8
GTEx	Cells Transformed fibroblasts	4	0.095	1.8
GTEx	Colon Transverse	2	0.097	1.8
GTEx	Esophagus Gastroesophageal Junction	2	0.138	1.8
GTEx	Esophagus Mucosa	5	0.151	1.8
GTEx	Esophagus Muscularis	1	0.031	1.8
GTEx	Heart Atrial Appendage	2	0.127	1.8
GTEx	Heart Left Ventricle	2	0.131	1.8
GTEx	Liver	2	0.279	1.8
GTEx	Lung	3	0.104	1.8
GTEx	Muscle Skeletal	1	0.035	1.8
GTEx	Ovary	1	0.110	1.8
GTEx	Pituitary	0	0.000	1.8
GTEx	Prostate	2	0.240	1.8
GTEx	Skin Not Sun Exposed Suprapubic	5	0.203	1.8
GTEx	Stomach	1	0.069	1.8
GTEx	Testis	1	0.032	1.8
GTEx	Thyroid	4	0.100	1.8
GTEx	Whole Blood	2	0.100	1.8
GTEx	Adipose Subcutaneous	2	0.057	1.7
GTEx	Adipose Visceral Omentum	2	0.098	1.7
GTEx	Adrenal Gland	2	0.137	1.7
GTEx	Artery Tibial	3	0.080	1.7
GTEx	Brain Caudate basal ganglia	0	0.000	1.7
GTEx	Brain Hypothalamus	0	0.000	1.7
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.7
GTEx	Brain Putamen basal ganglia	1	0.160	1.7
GTEx	Breast Mammary Tissue	2	0.101	1.7
GTEx	Breast Mammary Tissue (Female)	2	0.122	1.7
GTEx	Colon Sigmoid	2	0.137	1.7
GTEx	Nerve Tibial	4	0.093	1.7
GTEx	Pancreas	2	0.123	1.7
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.7
NTR	Blood	1	0.042	1.7
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.7
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.7
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.7
The Cancer Genome Atlas	Brain Lower Grade Glioma	6	0.139	1.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.7
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.7
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.7
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.126	1.7
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.7
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.7
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.7
The Cancer Genome Atlas	Stomach Adenocarcinoma	3	0.178	1.7
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.7
GTEx	Artery Aorta	3	0.101	1.6
GTEx	Brain Hippocampus	0	0.000	1.6
GTEx	Uterus	0	0.000	1.6
GTEx	Vagina	1	0.157	1.6
METSIM	Adipose	3	0.065	1.6
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.6
YFS	Blood	1	0.022	1.6
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.6
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	5	0.122	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.6
The Cancer Genome Atlas	Thyroid Carcinoma	4	0.078	1.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.6
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5