TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Vascular/heart problems diagnosed by doctor
:
←
→
chr1:230,142,626-231,548,480
Best TWAS P=2.53e-12 · Best GWAS P=7.08e-11 conditioned to 0.0541
230.2M
230.4M
230.6M
230.8M
231M
231.2M
231.4M
231.6M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
AGT
0.07
0.02
enet
12
0.04
1.8e-05
-5.3
-7.0
2.5e-12
0.75
0.03
0.97
TRUE
2
GTEx
Brain Cerebellum
AGT
0.60
0.40
lasso
6
0.36
1.4e-11
-6.4
-6.6
4.0e-11
0.90
0.00
1.00
FALSE
1
GTEx
Brain Cerebellar Hemisphere
AGT
0.67
0.50
enet
12
0.40
3.4e-11
-6.4
6.3
2.2e-10
-0.93
0.00
1.00
FALSE
4
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
AGT
0.11
0.05
blup
125
0.04
1.4e-03
-5.9
-5.9
4.1e-09
0.71
0.02
0.87
FALSE