TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Vascular/heart problems diagnosed by doctor
:
←
→
chr2:24,021,231-26,068,509
Best TWAS P=1.4e-08 · Best GWAS P=1.22e-06 conditioned to 0.5
24M
24.5M
25M
25.5M
26M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
EFR3B
0.07
0.03
bslmm
348
0.03
3.5e-05
-3.9
5.7
1.4e-08
0.34
0.07
0.43
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
ADCY3
0.09
0.02
enet
11
0.04
3.2e-05
4.7
-5.3
9.0e-08
-0.79
0.00
0.89
TRUE
1
GTEx
Adipose Visceral Omentum
NCOA1
0.11
0.02
enet
17
0.02
2.1e-02
4.7
5.4
5.7e-08
0.73
0.02
0.79
FALSE