Best TWAS P=2.97e-16 · Best GWAS P=1.57e-17 conditioned to 0.0107
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NEK10 | 0.04 | 0.03 | blup | 450 | 0.03 | 9.5e-05 | -5.4 | 6.9 | 6.5e-12 | 0.57 | 0.60 | 0.15 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC4A7 | 0.09 | 0.00 | enet | 27 | 0.04 | 2.9e-05 | -7.2 | 5.4 | 6.3e-08 | 0.40 | 0.09 | 0.59 | FALSE |
| 3 | GTEx | Artery Aorta | SLC4A7 | 0.10 | 0.08 | enet | 15 | 0.08 | 5.4e-05 | 8.5 | 8.2 | 3.0e-16 | 0.92 | 0.00 | 0.99 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | SLC4A7 | 0.15 | 0.02 | enet | 21 | 0.04 | 4.0e-04 | 8.5 | 7.4 | 1.8e-13 | 0.80 | 0.00 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK10 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.3e-05 | 5.4 | -5.5 | 3.6e-08 | -0.69 | 0.60 | 0.36 | FALSE |