TWAS
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Traits
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Traits
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Vascular/heart problems diagnosed by doctor
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chr6:42,586,058-44,034,691
Best TWAS P=1.87e-12 · Best GWAS P=8.68e-13 conditioned to 1
42.6M
42.8M
43M
43.2M
43.4M
43.6M
43.8M
44M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Lung Adenocarcinoma
ZNF318
0.05
0.06
lasso
3
0.05
1.1e-06
-7.1
7.0
1.9e-12
-0.99
0.00
1.00
TRUE
1
NTR
Blood
ZNF318
0.04
0.03
lasso
8
0.02
1.3e-08
-6.4
-6.4
1.7e-10
0.83
0.49
0.51
FALSE
5
The Cancer Genome Atlas
Soft Tissue Sarcoma
ZNF318
0.04
0.02
blup
48
0.04
2.2e-03
-5.9
-5.7
1.4e-08
0.69
0.04
0.14
FALSE
3
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
CRIP3
0.08
0.08
blup
34
0.07
1.0e-04
-5.9
-5.5
4.3e-08
0.67
0.11
0.78
FALSE
2
YFS
Blood
ZNF318
0.10
0.08
lasso
5
0.10
5.6e-31
-6.7
5.4
7.5e-08
-0.86
0.04
0.96
FALSE