TWAS hub - CRIP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.4630	0.1230	0.00430	-0.008	NA	0.006	NA	-0.004	6.4e-01	NA	0.21000	NA	0.42000
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0770	0.0420	0.00037	0.082	0.067	0.056	NA	0.060	1.9e-05	0.0001	0.00038	NA	0.00024
3	TCGA	Lung Squamous Cell Carcinoma	0.0493	0.0276	0.00220	0.002	0.018	0.019	NA	0.001	1.8e-01	0.0035	0.00280	NA	0.26000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hearing difficulty/problems: Yes	14.4	21.9	47.5	-2.6	-6.9	-3.4
Hearing difficulty/problems with background noise	12.2	19.4	46.4	-1.4	-6.8	-3.2
Waist Hip Ratio (WHR)	8.4	37.7	71.7	5.8	8.5	2.7
Cardiovascular Disease	6.6	21.7	51.4	2.7	7.2	2.6
Medication: Blood pressure	6.5	12.3	28.5	1.9	5.3	2.2
Gout (self-reported)	6.2	8.4	16.6	1.9	4.1	2.2
Medication: Amlodipine	5.6	7.9	16.6	0.1	4.1	2.6
Tinnitus: Yes, now most or all of the time	5.1	5.9	13.0	-1.3	-3.6	-1.8
Comparative body size at age 10	4.9	13.4	30.5	1.8	5.5	2.6
Bipolar Disorder (2018)	4.8	7.6	12.5	-2.6	-3.5	-1.8
High blood pressure (mother)	4.8	6.7	18.7	1.0	4.3	0.6
Hearing aid user	4.7	5.3	7.0	-1.8	-2.6	-2.4
Vascular/heart problems diagnosed by doctor	4.5	12.2	30.0	-2.2	-5.5	-1.3
Wheeze or whistling in the chest in last year	4.4	7.9	13.9	1.6	3.7	2.7
Medication: Gliclazide	4.4	4.9	11.3	3.4	1.4	-1.2
Systolic Blood Pressure	4.3	21.7	54.8	2.5	7.4	2.1
High blood pressure	4.3	11.9	29.1	2.1	5.4	1.5
Medication for cholesterol	4.2	6.3	13.6	-1.9	-3.7	-1.4
Crohns Disease (2017)	4.0	8.9	10.3	-2.7	-3.2	-3.0
Hypertension (Self-reported)	3.8	10.6	27.6	1.6	5.2	1.4
Taking other prescription medications	3.7	5.7	11.7	1.1	3.4	2.1
Depressed Affect (Nagel 2018)	3.5	7.4	15.0	1.3	3.9	2.3
Alzheimer’s Disease (in mother)	3.5	4.1	8.7	-0.1	-3.0	-1.9
Cholesterol lowering medication	3.5	5.2	13.4	1.0	3.7	1.1
Medication: Atenolol	3.4	4.3	5.2	1.7	2.3	2.2
Average weekly red wine intake	3.4	4.9	9.2	-3.0	-1.4	-2.0
Back pain experienced in last month	3.4	4.9	10.2	-0.2	3.2	2.1
Medication: Bendroflumethiazide	3.3	5.1	12.7	1.1	3.6	1.2
Alzheimer’s Disease (including proxy)	3.2	4.6	11.6	-0.2	-3.4	-1.5
Migraine (self-reported)	3.2	4.0	6.1	-2.1	-1.2	-2.5
Alcohol drinker status: Previous	3.2	3.6	5.7	0.6	2.4	2.2
Number of incorrect matches in round	3.0	5.1	8.9	-3.0	-1.7	-1.9
Type 2 Diabetes (T2D) (2018)	2.9	5.3	11.6	3.4	1.9	1.0
Number of self-reported non-cancer illnesses	2.9	5.1	14.4	0.5	3.8	0.8
Average weekly beer plus cider intake	2.9	4.2	9.4	-1.8	0.3	3.1
Crohns Disease (2012)	2.8	4.5	5.0	-2.1	-2.2	-2.0
Bipolar Disorder or Schizophrenia	2.7	6.6	12.5	-2.1	-3.5	-1.6
Neuroticism (Nagel 2018)	2.7	6.4	16.2	0.7	4.0	1.6
Heel T-Score	2.7	21.6	41.2	3.4	6.4	3.4
Neuroticism	2.7	6.6	14.8	1.6	3.9	1.5
Chronotype (morning person)	2.7	6.3	13.1	1.2	3.6	2.1
Medication: Allopurinol	2.7	3.6	8.9	1.0	3.0	1.0
Eye problems/disorders: Cataract	2.7	3.1	7.9	2.8	0.5	1.0
Supplements: Fish oil (including cod liver oil)	2.7	3.5	9.3	-3.1	-0.7	-0.7
Sitting height	2.6	18.2	33.3	-5.8	-4.3	-1.7
Standing height	2.6	26.2	43.3	-6.6	-5.8	-1.3
Falls in the last year	2.5	3.5	9.8	0.6	3.1	0.5
Schizophrenia (2014)	2.4	5.4	12.4	-1.4	-3.5	-1.3
Type 2 Diabetes (T2D) (2012)	2.4	2.8	5.8	1.4	2.4	0.8
Supplements: Zinc	2.4	2.7	4.7	-1.7	-2.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	4.0	-0.6	2.0	2.0
Height	2.3	44.1	62.3	-7.9	-7.9	-2.9
Stomach or abdominal pain in last month	2.3	2.8	5.7	1.5	2.4	0.7
Medication: Lansoprazole	2.3	2.6	4.4	0.6	1.8	2.1
Depression (Nagel 2018)	2.2	3.3	5.0	1.4	2.2	1.7
Diabetes (mother)	2.2	2.8	6.7	2.6	0.9	-0.8
Illnesses of siblings: Diabetes	2.2	2.7	6.3	2.5	1.2	-0.4
Worry (Nagel 2018)	2.1	4.5	9.9	1.4	3.1	1.3
Had other major operations	2.1	2.6	4.3	-0.2	1.9	-2.1
Diabetes diagnosed by doctor	2.1	3.4	8.5	2.9	1.1	-0.8
Mineral and other dietary supplements	2.1	2.9	3.6	1.9	1.7	1.4
Illnesses of siblings	2.0	2.8	5.2	-1.7	-2.3	0.4
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.9	0.7	2.2	1.4
Neuroticism score	1.9	4.0	11.0	0.9	3.3	0.5
Worrier / anxious feelings	1.9	3.5	8.9	1.3	3.0	0.3
Length of working week for main job	1.9	2.1	5.1	-2.2	-0.3	1.1
Age when periods started (menarche)	1.8	4.3	10.8	0.9	-3.3	-1.1
Time employed in main current job	1.8	2.1	6.0	0.1	-2.5	0.4
Father’s age at death	1.8	2.4	3.4	-1.8	-1.8	-0.6
Mood swings	1.8	3.3	8.7	0.6	2.9	0.9
Blood Platelet Count	1.7	19.2	48.9	1.8	-7.0	-2.3
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.9	2.4	0.6	0.4
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.8	-0.6	1.4	2.0
Comparative height size at age 10	1.7	9.1	23.4	-4.8	-2.0	-0.3
Illnesses of father: High blood pressure	1.7	2.1	3.7	1.3	1.9	0.9
Medication: Metformin	1.6	2.2	5.7	2.4	0.5	-0.8
Diabetes (self-reported)	1.6	2.5	6.3	2.5	1.0	-0.5
Ever highly irritable/argumentative for 2 days	1.6	1.9	2.2	1.2	1.5	1.4
Forced vital capacity (FVC), Best measure	1.6	5.7	9.7	-3.1	-2.1	-1.8
Illnesses of father: Heart disease	1.6	2.3	4.4	2.1	0.8	-1.3
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.5	-2.1	-1.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	4.9	0.3	2.2	0.9
Osteoarthritis (self-reported)	1.6	2.1	4.7	-0.8	-1.0	-2.2
HbA1C	1.5	1.7	2.6	1.2	1.6	0.9
BMI	1.5	8.8	14.1	1.6	3.8	3.1
Number of treatments/medications taken	1.5	2.7	6.1	1.4	2.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	7.6	-1.7	-2.8	-1.9
Medication: Seretide 50 evohaler	1.5	1.7	4.2	0.9	2.0	0.4
Age at last live birth	1.5	2.1	5.1	0.6	-2.3	-1.0
Alzheimer’s Disease (in father)	1.4	1.5	4.1	-0.4	-2.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	2.8	0.1	1.7	1.7
Hair/balding pattern: Pattern 2	1.4	1.7	3.3	1.8	1.1	-0.8
Hip circumference	1.4	6.1	13.1	-2.3	-3.6	0.2
Hair/balding pattern: Pattern 3	1.4	2.0	3.6	-1.9	-0.8	-1.4
Heart disease (mother)	1.4	1.7	2.1	1.4	1.2	1.3
Ever had bowel cancer screening	1.4	1.6	3.9	0.5	0.9	2.0
High cholesterol (Self-reported)	1.4	2.4	4.8	1.5	2.2	0.5
Sensitivity / hurt feelings	1.3	2.2	4.4	-0.4	2.1	-1.4
Systolic blood pressure, automated reading	1.3	3.9	10.6	0.6	3.2	0.8
Pack years adult smoking proportion	1.3	2.0	4.4	0.9	2.1	0.9
Fed-up feelings	1.3	2.4	5.6	1.2	2.4	0.1
Fluid intelligence score	1.3	2.7	5.4	2.3	1.5	0.7
Exposure to tobacco smoke at home	1.3	1.5	4.2	2.0	-0.4	0.4
Tense / ‘highly strung’	1.3	2.2	4.4	0.6	2.1	1.3
Had major operations	1.3	1.6	3.0	1.2	1.7	-0.5
Illnesses of father: None of the above (group 1)	1.3	1.6	2.7	-1.7	-1.0	1.1
Miserableness	1.3	2.3	5.4	0.7	2.3	1.0
Commuting to job workplace: Cycle	1.3	1.6	4.3	0.3	2.1	0.6
Myopia	1.3	1.9	3.2	1.2	1.8	0.9
Irritable Bowel Disease (IBD)	1.2	2.9	4.5	-1.6	-2.1	-1.3
Allergy or Eczema	1.2	3.1	6.6	2.6	1.6	-0.2
Impedance of leg (right)	1.2	5.9	9.5	-1.9	-3.1	-2.2
Illnesses of mother	1.2	1.4	3.5	-0.7	-1.9	-0.5
Worry too long after embarrassment	1.2	2.0	3.3	-1.1	1.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	6.1	-2.5	-1.2	-0.4
Pack years of smoking	1.2	1.7	4.2	0.5	2.0	0.8
Breast Cancer	1.1	2.5	3.8	1.5	2.0	1.2
Mean Putamen Volume	1.1	1.2	1.6	-1.3	-0.7	-1.3
Lupus	1.1	1.7	4.2	-0.9	2.0	-0.1
Respiratory disease	1.1	2.4	5.1	0.6	2.3	1.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.1	0.6	1.4	1.3
Current tobacco smoking	1.1	1.8	4.0	-0.0	2.0	1.2
Hayfever, allergic rhinitis or eczema	1.1	2.3	6.1	2.5	0.9	0.1
Allergy	1.1	2.6	5.2	-2.3	-1.6	-0.2
Medication: Ramipril	1.1	1.4	3.1	0.6	1.8	0.9
Medication: Simvastatin	1.1	1.6	2.4	1.4	1.5	-0.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	6.8	-1.6	-2.6	-1.1
High blood pressure (siblings)	1.1	1.6	4.6	0.4	2.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.0	0.6	2.0	0.3
Alcohol intake frequency.	1.1	2.5	6.4	0.9	2.5	-0.4
Number of full sisters	1.1	1.4	2.1	0.1	-1.4	-1.4
Chest pain or discomfort	1.1	1.6	2.0	1.4	1.1	1.3
Long-standing illness, disability or infirmity	1.1	1.7	4.8	-0.4	-0.3	-2.2
Medication: Atorvastatin	1.1	1.4	2.8	0.1	1.7	1.1
Risk taking	1.1	1.6	2.8	-0.7	1.7	1.2
Pain experienced in last month	1.1	1.9	2.8	-0.6	-1.7	-1.6
Ovarian Cancer	1.0	1.3	2.9	1.0	0.3	1.7
Neuroticism (2016)	1.0	1.5	2.2	0.5	1.4	1.5
Average weekly spirits intake	1.0	1.3	3.0	-1.7	-0.9	0.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.0	1.5	1.1	1.2	-0.7
Forced vital capacity (FVC)	1.0	4.0	6.1	-2.5	-2.2	-1.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.6	0.2	1.6	1.0
Number of live births	1.0	1.4	3.0	1.1	-0.2	-1.7
Depression (self-reported)	1.0	1.1	2.8	0.2	1.7	0.8
Prospective memory result	1.0	1.2	3.2	-1.8	-0.2	-0.5
Birth weight of first child	1.0	1.8	2.9	-1.6	-0.1	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.5	0.7	1.6	0.8
Mean time to correctly identify matches	1.0	1.8	4.0	-2.0	-1.0	-0.7
Suffer from ‘nerves’	1.0	1.6	4.4	0.4	2.1	0.6
Medication: Aspirin	1.0	1.4	3.7	0.4	1.9	-0.4
Medication: Aspirin	1.0	1.2	2.8	0.4	1.7	-0.9
Smoking status: Current	1.0	1.5	3.6	-0.1	1.9	1.0
Mother’s age at death	1.0	1.3	3.5	0.1	-1.9	-0.6
Number of operations (self-reported)	1.0	1.5	2.6	0.8	1.6	-1.2
Unable to work because of sickness or disability	1.0	1.4	3.0	1.7	1.0	0.2
Heart disease (siblings)	1.0	1.3	2.0	1.4	1.2	-0.7
Medication: Levothyroxine sodium	0.9	1.6	3.2	-1.8	1.1	-0.4
Medication: Paracetamol	0.9	1.5	3.8	2.0	-0.0	-0.8
Overall health rating	0.9	1.8	5.0	2.2	-0.3	-0.7
Family relationship satisfaction	0.9	1.1	2.9	1.7	0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.8	1.7	0.5	-0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.9	-1.4	-1.0	-0.7
Breast cancer (self-reported)	0.9	1.1	2.9	-0.5	1.7	0.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.8	1.9	1.4	0.1
Fasting Glucose	0.8	1.0	2.0	-0.6	1.4	0.7
Triglycerides	0.8	1.2	3.5	1.9	0.1	0.4
Hand grip strength (left)	0.8	2.0	3.2	-1.2	-1.1	-1.8
Impedance of leg (left)	0.8	3.7	6.2	-1.6	-2.5	-1.5
Qualifications: None of the above	0.8	1.7	3.2	-0.6	-1.2	-1.8
Trunk fat-free mass	0.8	4.4	8.9	-3.0	-2.0	-0.3
Pulse rate	0.8	1.3	3.0	-0.6	-0.7	-1.7
Trunk predicted mass	0.8	4.4	9.3	-3.0	-1.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.8	-0.4	1.3	-1.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.1	-1.8	0.6	-1.0
Exposure to tobacco smoke outside home	0.8	1.1	2.2	0.2	1.5	1.0
Wears glasses or contact lenses	0.8	0.9	2.2	0.6	-0.5	-1.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.3	1.5	0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.0	2.0	1.7	-0.2
Schizophrenia (2018)	0.7	1.4	2.8	-1.0	-1.7	-0.6
Schizophrenia vs Biploar Disorder	0.7	1.0	1.9	0.4	-1.4	-0.9
Lung FEV1/FVC ratio	0.7	3.4	9.1	0.8	-3.0	-0.7
Relative age of first facial hair	0.7	1.5	3.0	-1.7	-0.7	0.9
Medication for hormone replacement therapy	0.7	0.8	1.8	-0.7	-1.3	-0.3
Hand grip strength (right)	0.7	2.0	2.5	-1.2	-1.6	-1.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	-0.1	1.2	1.1
Impedance of arm (right)	0.7	3.5	6.7	-2.6	-1.9	-0.1
Loud music exposure frequency	0.7	0.8	1.4	0.9	-0.2	-1.2
Birth weight	0.7	1.4	3.3	-1.8	-0.4	-0.9
Emphysema/chronic bronchitis	0.7	0.8	1.5	1.0	1.2	-0.1
Asthma (self-reported)	0.7	1.4	2.6	1.0	1.6	0.7
Medication: Lisinopril	0.7	0.9	1.4	-1.1	1.2	-0.3
Impedance of whole body	0.7	3.5	6.2	-1.9	-2.5	-0.7
Lung FVC	0.6	3.1	4.0	-1.9	-1.3	-2.0
Angina	0.6	0.8	1.5	1.2	0.8	-0.6
Townsend deprivation index at recruitment	0.6	0.8	1.9	0.7	-1.4	-0.3
Financial difficulties in last 2 years	0.6	0.8	1.4	1.2	0.9	0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.3	1.1	0.7	0.7
Mouth/teeth dental problems: Dentures	0.6	1.1	2.3	-1.5	0.1	-1.0
Lung cancer (father)	0.6	0.7	1.1	-0.5	1.0	0.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.8	-1.3	0.3	-0.4
Impedance of arm (left)	0.6	2.6	4.7	-2.2	-1.8	0.1
Angina (self-reported)	0.6	0.8	1.5	1.2	0.7	-0.6
Pulse rate, automated reading	0.6	2.1	4.1	0.8	-1.2	-2.0
Smoking status: Previous	0.6	0.8	0.9	-0.9	0.9	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.7	-0.4	1.3	-0.2
Guilty feelings	0.6	0.9	2.6	-0.3	1.6	-0.2
Irritability	0.6	1.0	1.5	1.2	1.2	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	-0.8	-0.5	-1.2
Age at First Birth	0.5	0.7	1.1	1.0	-1.0	0.2
Bipolar Disorder (2011)	0.5	0.5	1.1	0.0	-1.1	0.6
Coronary Artery Disease (CAD)	0.5	0.5	1.1	1.1	0.6	0.3
Smoking Status	0.5	1.3	3.6	-0.5	1.9	-0.3
Hypothyroidism (self reported)	0.5	1.2	2.3	-1.5	1.1	-0.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	0.3	1.3	-0.4
Diabetes (father)	0.5	0.6	1.8	1.4	-0.1	-0.1
Waist circumference	0.5	1.8	2.3	1.5	1.5	0.9
Alcohol usually taken with meals	0.5	0.8	2.2	-0.0	-0.5	-1.5
Nervous feelings	0.5	1.0	2.4	0.6	1.5	0.3
Heart attack	0.5	0.6	1.0	-0.7	-0.5	-1.0
Alcohol intake versus 10 years previously	0.5	0.7	1.2	-0.2	1.0	-1.1
Asthma	0.5	1.1	2.2	0.8	1.5	0.6
Glaucoma (self-reported)	0.5	0.6	1.0	-1.0	-0.9	-0.2
Number of children fathered	0.5	0.5	0.9	0.8	1.0	-0.2
Age at first live birth	0.5	0.9	1.5	0.2	-1.2	1.1
Shortness of breath walking on level ground	0.5	0.6	1.3	-1.1	-0.5	-0.4
Eye problems/disorders: None of the above	0.5	0.6	1.4	-1.2	-0.6	0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.8	1.3	0.2	-0.1
Medication: Blood pressure	0.5	1.0	2.8	0.1	1.7	0.2
Whole body fat-free mass	0.5	2.7	6.1	-2.5	-1.4	-0.1
Friendships satisfaction	0.5	0.7	1.1	1.1	0.9	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	-1.0	-1.2	0.4
Whole body water mass	0.5	2.7	5.9	-2.4	-1.4	-0.1
Average weekly champagne plus white wine intake	0.5	0.7	1.4	-0.6	-1.2	-0.5
Medication: Paracetamol	0.5	0.8	2.0	1.4	0.6	0.4
Basal metabolic rate	0.5	2.6	5.6	-2.4	-1.5	-0.0
Diastolic blood pressure, automated reading	0.5	1.7	3.5	-0.0	1.9	1.2
Arm predicted mass (left)	0.5	2.7	5.9	-2.4	-1.4	-0.6
Rheumatoid Arthritis	0.4	0.5	1.0	-0.6	-1.0	-0.5
Blood Red Count	0.4	3.6	4.2	-1.6	-2.0	-2.0
Blood White Count	0.4	3.2	7.5	0.7	-2.7	-1.2
Vitamin and mineral supplements	0.4	0.5	0.8	0.7	0.3	0.9
Medication: Co-codamol	0.4	0.5	1.1	1.1	-0.0	0.7
Average weekly fortified wine intake	0.4	0.4	1.2	1.1	0.3	0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.1	1.0	0.3	-0.7
Serious illness, injury or assault to yourself	0.4	0.5	0.8	0.4	-0.9	-0.7
Multivitamins +/- minerals	0.4	0.5	0.9	-0.7	-0.9	-0.6
Supplements: Glucosamine	0.4	0.5	0.8	-0.7	-0.9	0.5
Trunk fat mass	0.4	1.7	3.1	-1.8	-1.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.0	-1.0	0.8	-0.7
Weight	0.4	2.2	4.8	-2.2	-1.4	0.1
Noisy workplace	0.4	0.5	0.8	0.7	0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	1.0	0.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	0.8	0.9	-0.8	0.5
Medication: Cholesterol lowering	0.4	0.7	1.6	1.3	0.2	-0.6
Blood clot in the leg (DVT)	0.4	0.5	1.2	0.2	0.5	-1.1
Headache pain in last month	0.4	0.7	1.7	1.3	0.5	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	-1.0	-0.6	0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	-0.4	0.9	0.8
Health satisfaction	0.4	0.5	1.3	-0.5	-0.2	-1.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	-1.2	-0.6	0.5
Neck or shoulder pain in last month	0.4	0.5	1.0	0.3	0.8	1.0
Medication: Ibuprofen	0.4	0.5	0.6	0.6	-0.7	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	0.3	1.1	0.3
Loneliness, isolation	0.4	0.5	1.0	0.8	1.0	0.1
Osteoporosis (self-reported)	0.4	0.4	1.2	1.1	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	-0.5	-0.5	-1.4
Ever taken oral contraceptive pill	0.4	0.4	1.0	0.3	-0.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.6	-0.0	-0.3	1.3
Alcohol drinker status: Never	0.4	0.5	1.3	1.1	-0.2	-0.3
Arm fat-free mass (left)	0.4	2.1	3.8	-2.0	-1.4	-0.6
Ever depressed for a whole week	0.4	0.5	1.4	0.1	1.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	-0.0	0.4	-1.2
Major Depression (MDD)	0.3	0.3	0.8	0.9	-0.1	-0.3
Reaction Time	0.3	0.6	1.2	-1.1	-0.6	0.3
Ulcerative Colitis	0.3	0.5	0.7	-0.8	-0.8	-0.2
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	-0.8	0.7	0.1
Leg fat-free mass (left)	0.3	1.3	3.2	-1.8	-0.9	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	0.8	-0.5	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.9	0.9	0.5	-0.1
Leg predicted mass (left)	0.3	1.3	3.0	-1.7	-0.9	0.3
Past tobacco smoking	0.3	0.6	1.6	-0.0	-1.3	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	0.1	1.2	0.7
Happiness	0.3	0.3	0.9	0.1	1.0	-0.1
Breastfed as a baby	0.3	0.4	0.9	0.1	-0.9	-0.6
Arm fat-free mass (right)	0.3	1.8	3.3	-1.8	-1.4	-0.2
Pulse wave peak to peak time	0.3	0.3	0.7	0.8	-0.5	0.3
Whole body fat mass	0.3	1.1	1.8	-1.4	-1.3	-0.1
Arm predicted mass (right)	0.3	1.6	2.9	-1.7	-1.4	-0.3
Leg pain on walking	0.3	0.4	0.8	-0.9	0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	-0.9	-0.5	-0.3
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.9	-0.5	-0.4
Commuting to job workplace: Public transport	0.3	0.3	0.9	-0.2	-1.0	-0.1
Age started oral contraceptive pill	0.3	0.3	0.5	-0.7	-0.7	-0.0
Supplements: Calcium	0.3	0.4	1.0	-1.0	-0.2	0.1
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.6	0.8	-0.4
HDL Cholesterol	0.2	0.3	0.6	-0.5	-0.8	-0.1
LDL Cholesterol	0.2	0.3	0.6	-0.6	0.8	-0.2
Hair Pigment	0.2	5.5	7.8	-2.8	-2.2	-1.9
Trunk fat percentage	0.2	0.7	1.4	-1.2	-0.9	0.2
Maternal smoking around birth	0.2	0.2	0.4	0.5	-0.1	0.7
Body mass index (BMI)	0.2	0.9	1.8	0.7	1.4	0.6
Pain all over the body in last month	0.2	0.2	0.4	0.3	0.7	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	0.5	-0.6	-1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	1.1	0.2	-0.1
Number of full brothers	0.2	0.2	0.5	-0.3	-0.0	-0.7
Qualifications: College or University degree	0.2	0.5	0.6	-0.8	0.6	0.7
Knee pain experienced in last month	0.2	0.3	0.6	-0.6	0.8	0.1
Leg fat-free mass (right)	0.2	1.2	2.9	-1.7	-0.5	0.7
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	-0.5	0.1
Leg predicted mass (right)	0.2	1.3	3.2	-1.8	-0.5	0.6
Financial situation satisfaction	0.2	0.2	0.5	-0.2	0.7	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.8	0.3	-0.2
Ulcerative Colitis (UC)	0.1	0.2	0.6	-0.1	-0.8	0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	-0.5	0.4	-0.3
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.3	-0.2	-0.6
Blood Eosinophil Count	0.1	1.0	3.0	1.7	-0.2	0.2
Tanning	0.1	1.5	2.5	-1.0	-1.6	-0.9
Relative age voice broke	0.1	0.1	0.4	-0.2	0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.2	0.5	0.8
Had menopause	0.1	0.1	0.2	-0.3	0.5	-0.1
Mouth/teeth dental problems	0.1	0.1	0.3	-0.6	-0.2	-0.0
Arm fat percentage (right)	0.1	0.2	0.4	-0.5	0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.3	-0.5	-0.1
Arm fat mass (right)	0.1	0.3	0.9	-0.9	-0.3	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.1	-0.8	0.5
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.7	-0.4	0.3
Pulse wave reflection index	0.1	0.1	0.1	-0.3	-0.4	0.1
Body fat percentage	0.1	0.3	0.4	-0.6	-0.6	0.1
Leg fat percentage (right)	0.1	0.2	0.4	0.3	-0.4	-0.6
Medication: Omeprazole	0.1	0.2	0.4	0.4	-0.1	-0.6
Leg fat mass (right)	0.1	0.2	0.4	-0.4	-0.6	-0.3
Arm fat percentage (left)	0.1	0.3	0.7	-0.2	0.3	0.9
Arm fat mass (left)	0.1	0.3	0.8	-0.9	-0.4	0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.5	0.0	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.7	-0.1	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Severe depression (siblings)	0.0	0.0	0.1	0.1	-0.2	0.0
Chronic bronchitis/emphysema (father)	0.0	0.1	0.1	-0.3	0.2	-0.2
Supplements: Vitamin C	0.0	0.0	0.0	0.1	-0.2	0.1
Ever smoked	0.0	0.1	0.1	0.3	0.3	-0.0
Leg fat percentage (left)	0.0	0.0	0.1	0.4	-0.0	-0.0
Leg fat mass (left)	0.0	0.1	0.2	-0.2	-0.5	-0.1

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