TWAS
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Traits
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Traits
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Vascular/heart problems diagnosed by doctor
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chr12:89,116,708-90,799,212
Best TWAS P=3.2e-13 · Best GWAS P=2.93e-22 conditioned to 4.83e-14
89.2M
89.4M
89.6M
89.8M
90M
90.2M
90.4M
90.6M
90.8M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Tibial
ATP2B1
0.08
0.01
enet
10
0.03
0.0035
8.3
7.3
3.2e-13
0.37
0.12
0.54
TRUE
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
LOC338758
0.14
0.00
enet
6
0.01
0.0619
-1.6
5.6
1.8e-08
0.31
0.00
0.18
FALSE
2
GTEx
Prostate
POC1B
0.25
0.00
enet
37
0.01
0.1640
9.4
-5.3
1.1e-07
-0.54
0.03
0.58
FALSE