TWAS
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Genes
Traits
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Traits
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Vascular/heart problems diagnosed by doctor
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chr15:80,377,452-81,936,479
Best TWAS P=4.12e-11 · Best GWAS P=7.84e-14 conditioned to 0.000288
80.4M
80.6M
80.8M
81M
81.2M
81.4M
81.6M
81.8M
82M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
FAM108C1
0.07
0.02
lasso
2
0.02
1.7e-03
5.5
6.6
4.1e-11
-0.81
0.04
0.49
TRUE
2
The Cancer Genome Atlas
Lung Adenocarcinoma
FAM108C1
0.05
0.04
lasso
3
0.04
5.6e-06
-6.5
6.2
4.7e-10
-0.83
0.16
0.82
FALSE
1
CommonMind
Brain Pre-frontal Cortex
KIAA1199
0.06
0.04
bslmm
581
0.03
2.1e-04
4.6
-5.2
1.6e-07
0.58
0.12
0.73
FALSE