[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr15:73,933,444-76,108,550

Best TWAS P=3.67e-22 · Best GWAS P=5.37e-22 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	YFS	Blood	CSK	0.13	0.15	lasso	11	0.16	6.7e-51	-9.5	-9.7	3.7e-22	0.93	0.01	0.99	TRUE
33	GTEx	Lung	CSK	0.09	0.06	lasso	3	0.05	1.4e-04	-9.4	-9.6	6.6e-22	0.97	0.01	0.99	TRUE
30	GTEx	Esophagus Mucosa	MPI	0.11	0.11	lasso	7	0.10	2.3e-07	-6.3	7.1	1.0e-12	-0.69	0.62	0.37	TRUE
52	METSIM	Adipose	RPP25	0.04	0.06	lasso	7	0.05	1.4e-08	-5.2	-6.5	1.1e-10	0.68	0.60	0.40	TRUE
88	The Cancer Genome Atlas	Soft Tissue Sarcoma	ULK3	0.04	0.03	blup	49	0.02	3.3e-02	-8.3	-6.5	1.1e-10	0.76	0.01	0.63	TRUE
31	GTEx	Heart Left Ventricle	UBL7	0.06	-0.01	enet	11	0.00	5.5e-01	-4.1	6.3	2.5e-10	-0.55	0.06	0.22	TRUE
56	YFS	Blood	COX5A	0.01	0.01	lasso	3	0.01	1.9e-05	6.4	6.2	6.7e-10	-0.62	0.86	0.09	TRUE
14	GTEx	Brain Frontal Cortex BA9	ARID3B	0.20	0.13	lasso	6	0.14	2.0e-04	-5.9	6.0	2.0e-09	-0.34	0.15	0.07	TRUE
22	GTEx	Breast Mammary Tissue (Male)	MPI	0.06	0.01	enet	4	0.03	5.7e-02	-4.2	5.7	1.4e-08	-0.60	0.03	0.11	TRUE
50	METSIM	Adipose	ARID3B	0.03	0.03	lasso	3	0.03	5.3e-05	-5.3	5.1	2.8e-07	-0.13	0.56	0.03	TRUE
36	GTEx	Muscle Skeletal	UBL7	0.06	0.02	lasso	6	0.01	3.7e-02	-9.3	9.5	1.9e-21	-0.96	0.02	0.89	FALSE
6	GTEx	Adipose Visceral Omentum	ULK3	0.13	0.12	enet	8	0.11	3.3e-06	-9.5	-9.5	3.2e-21	0.95	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	ULK3	0.02	0.02	blup	49	0.02	1.1e-05	-8.8	-9.4	6.7e-21	0.91	0.04	0.96	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ULK3	0.03	0.03	lasso	3	0.03	5.3e-04	-8.8	-9.2	3.1e-20	0.91	0.02	0.96	FALSE
60	YFS	Blood	ULK3	0.09	0.11	lasso	6	0.11	1.1e-33	-8.8	-9.2	4.2e-20	0.91	0.86	0.14	FALSE
47	GTEx	Vagina	COX5A	0.38	0.02	lasso	7	0.02	9.3e-02	-9.6	9.2	5.5e-20	-0.94	0.02	0.83	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	ULK3	0.08	0.11	lasso	5	0.10	4.6e-10	-8.8	-9.2	5.8e-20	0.91	0.04	0.96	FALSE
54	METSIM	Adipose	ULK3	0.14	0.14	lasso	10	0.15	3.2e-22	-8.8	-9.1	8.7e-20	0.92	0.08	0.92	FALSE
39	GTEx	Pancreas	ULK3	0.12	0.10	lasso	4	0.07	6.9e-04	-8.7	-9.0	2.6e-19	0.89	0.04	0.95	FALSE
85	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ULK3	0.04	0.06	lasso	4	0.04	7.6e-06	-8.8	-8.9	3.7e-19	0.88	0.05	0.95	FALSE
13	GTEx	Brain Frontal Cortex BA9	MPI	0.29	0.12	lasso	10	0.19	9.7e-06	-8.1	8.9	4.7e-19	-0.84	0.06	0.93	FALSE
41	GTEx	Stomach	ULK3	0.16	0.13	lasso	2	0.11	9.7e-06	-8.7	-8.9	7.1e-19	0.86	0.09	0.90	FALSE
23	GTEx	Breast Mammary Tissue (Female)	ULK3	0.08	0.01	lasso	2	0.01	1.8e-01	-8.8	-8.8	1.5e-18	0.87	0.03	0.36	FALSE
38	GTEx	Ovary	ULK3	0.19	0.23	lasso	1	0.23	3.0e-06	-8.8	-8.8	1.5e-18	0.87	0.08	0.54	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	ULK3	0.19	0.04	lasso	2	0.08	1.2e-03	-8.7	-8.8	2.2e-18	0.86	0.04	0.88	FALSE
46	GTEx	Uterus	ULK3	0.40	0.16	lasso	16	0.12	2.2e-03	-8.8	-8.7	2.8e-18	0.78	0.04	0.74	FALSE
5	GTEx	Adipose Subcutaneous	CTD-2235H24.2	0.09	0.01	lasso	13	0.01	1.2e-01	-8.8	8.7	4.9e-18	-0.77	0.27	0.28	FALSE
44	GTEx	Thyroid	ULK3	0.11	0.09	lasso	4	0.13	5.9e-10	-8.8	-8.6	8.3e-18	0.79	0.17	0.82	FALSE
9	GTEx	Brain Caudate basal ganglia	MPI	0.23	0.25	lasso	4	0.23	3.1e-07	-8.3	8.5	1.7e-17	-0.84	0.09	0.89	FALSE
79	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ULK3	0.10	0.02	blup	49	0.07	2.5e-04	-9.5	-8.5	2.6e-17	0.90	0.02	0.97	FALSE
15	GTEx	Brain Hippocampus	MPI	0.13	0.07	lasso	3	0.06	1.7e-02	-8.8	8.4	2.9e-17	-0.86	0.04	0.45	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MPI	0.06	0.04	blup	35	0.05	8.5e-04	-8.3	8.4	2.9e-17	-0.80	0.01	0.95	FALSE
69	The Cancer Genome Atlas	Glioblastoma Multiforme	MPI	0.11	0.03	blup	36	0.02	8.4e-02	-8.0	8.4	4.6e-17	-0.78	0.01	0.71	FALSE
18	GTEx	Breast Mammary Tissue	ULK3	0.15	0.11	lasso	3	0.09	1.6e-05	-8.3	-8.4	4.9e-17	0.84	0.07	0.92	FALSE
58	YFS	Blood	MPI	0.02	0.02	lasso	4	0.03	1.2e-09	-8.4	8.4	5.1e-17	-0.78	0.65	0.35	FALSE
26	GTEx	Cells Transformed fibroblasts	ULK3	0.12	0.04	lasso	5	0.10	8.4e-08	-8.8	-8.3	7.6e-17	0.80	0.43	0.57	FALSE
48	GTEx	Whole Blood	ULK3	0.14	0.06	lasso	5	0.04	8.3e-05	-8.8	-8.3	1.3e-16	0.85	0.05	0.94	FALSE
27	GTEx	Cells Transformed fibroblasts	MPI	0.21	0.16	enet	15	0.22	1.1e-16	-8.1	8.2	1.9e-16	-0.85	0.25	0.75	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	MPI	0.07	0.03	blup	36	0.04	2.1e-03	-8.0	8.2	2.1e-16	-0.77	0.01	0.94	FALSE
7	GTEx	Artery Tibial	ULK3	0.06	0.04	enet	12	0.03	1.7e-03	-9.3	-8.1	6.2e-16	0.86	0.03	0.88	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	C15orf17	0.02	0.03	lasso	1	0.02	1.5e-03	-8.1	8.1	6.4e-16	-0.76	0.01	0.86	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	C15orf17	0.02	0.02	lasso	1	0.02	1.9e-05	-8.1	8.1	6.8e-16	-0.75	0.01	0.98	FALSE
92	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MPI	0.12	0.11	lasso	7	0.12	5.3e-05	-8.1	8.1	7.4e-16	-0.76	0.03	0.92	FALSE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MPI	0.02	0.01	blup	36	0.01	1.2e-02	-8.1	8.0	1.2e-15	-0.76	0.02	0.64	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	MPI	0.07	0.09	lasso	4	0.10	2.4e-11	-8.1	8.0	1.3e-15	-0.77	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	FAM219B	0.07	0.01	lasso	6	0.02	1.4e-02	-6.6	8.0	1.9e-15	-0.71	0.27	0.38	FALSE
49	GTEx	Whole Blood	MPI	0.04	0.04	lasso	2	0.01	1.7e-02	-8.0	7.9	2.1e-15	-0.70	0.19	0.23	FALSE
42	GTEx	Testis	ULK3	0.15	0.03	enet	24	0.06	1.6e-03	-9.3	-7.8	4.5e-15	0.75	0.03	0.94	FALSE
2	GTEx	Adipose Subcutaneous	ULK3	0.22	0.10	enet	19	0.12	2.9e-10	-9.3	-7.8	5.5e-15	0.77	0.03	0.97	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCAMP2	0.18	0.04	enet	5	0.06	6.1e-07	-9.5	7.8	6.5e-15	-0.63	0.00	1.00	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	MPI	0.04	0.02	blup	36	0.03	1.7e-03	-8.2	7.8	8.0e-15	-0.75	0.04	0.83	FALSE
21	GTEx	Breast Mammary Tissue (Male)	ULK3	0.19	0.19	lasso	2	0.15	2.4e-04	-8.1	-7.8	8.1e-15	0.71	0.07	0.22	FALSE
84	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MPI	0.04	0.03	blup	36	0.05	8.8e-07	-8.1	7.7	1.0e-14	-0.73	0.04	0.96	FALSE
17	GTEx	Brain Putamen basal ganglia	MPI	0.31	0.18	enet	26	0.23	2.9e-06	-8.3	7.7	1.1e-14	-0.79	0.04	0.94	FALSE
37	GTEx	Nerve Tibial	MPI	0.10	0.12	enet	12	0.15	1.5e-10	-5.9	7.7	1.5e-14	-0.78	0.54	0.46	FALSE
67	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ULK3	0.21	0.02	enet	8	0.07	1.9e-04	-9.3	-7.6	3.3e-14	0.77	0.01	0.70	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CSK	0.02	0.00	blup	57	0.01	1.8e-02	-9.0	-7.6	3.5e-14	0.67	0.02	0.60	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	MPI	0.07	0.07	blup	36	0.10	3.3e-10	-6.3	7.4	1.5e-13	-0.74	0.08	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MPI	0.13	0.11	blup	277	0.14	1.6e-16	-8.0	7.4	1.7e-13	-0.64	1.00	0.00	FALSE
40	GTEx	Skin Sun Exposed Lower leg	MPI	0.04	0.01	lasso	4	0.02	7.4e-03	-5.9	7.4	1.9e-13	-0.76	0.34	0.44	FALSE
11	GTEx	Brain Cerebellum	MPI	0.14	0.09	enet	13	0.09	9.7e-04	4.0	7.3	2.0e-13	-0.75	0.04	0.90	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	MPI	0.13	0.18	enet	10	0.16	3.7e-15	-6.3	7.3	2.0e-13	-0.70	0.98	0.02	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	CSK	0.04	0.04	blup	57	0.04	4.6e-05	-9.4	-7.2	6.1e-13	0.79	0.01	0.97	FALSE
45	GTEx	Thyroid	MPI	0.06	0.07	enet	12	0.07	5.1e-06	-6.2	7.2	7.2e-13	-0.71	0.43	0.56	FALSE
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	COX5A	0.03	0.03	blup	32	0.03	2.9e-03	5.1	7.1	9.3e-13	-0.69	0.02	0.64	FALSE
12	GTEx	Brain Cortex	MPI	0.13	0.04	enet	27	0.06	9.3e-03	-8.7	7.1	1.5e-12	-0.66	0.07	0.55	FALSE
43	GTEx	Testis	MPI	0.09	0.08	enet	12	0.04	6.0e-03	-6.2	7.0	1.8e-12	-0.71	0.14	0.52	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPP25	0.02	0.01	blup	23	0.02	6.8e-05	-8.0	-7.0	1.9e-12	0.65	0.01	0.98	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	MPI	0.04	0.07	enet	13	0.06	5.8e-13	-6.3	7.0	3.2e-12	-0.68	0.92	0.08	FALSE
51	METSIM	Adipose	MPI	0.08	0.06	blup	273	0.07	3.1e-11	-8.1	6.9	3.8e-12	-0.65	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	ULK3	0.03	0.00	blup	50	0.00	8.1e-02	-8.1	-6.9	5.7e-12	0.77	0.03	0.34	FALSE
20	GTEx	Breast Mammary Tissue (Male)	PPCDC	0.07	0.00	enet	8	-0.01	7.9e-01	-5.1	-6.9	6.2e-12	0.63	0.04	0.16	FALSE
34	GTEx	Lung	CYP11A1	0.10	0.01	enet	21	0.02	9.5e-03	-5.5	6.8	7.7e-12	-0.50	0.15	0.56	FALSE
4	GTEx	Adipose Subcutaneous	MPI	0.05	0.05	lasso	7	0.04	6.6e-04	-6.3	6.6	4.4e-11	-0.65	0.14	0.64	FALSE
86	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MPI	0.09	0.07	blup	36	0.08	3.9e-06	6.3	6.6	5.1e-11	-0.60	0.50	0.49	FALSE
76	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPP25	0.05	0.03	blup	23	0.04	3.7e-03	5.1	-6.6	5.2e-11	0.61	0.01	0.70	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MPI	0.09	0.00	blup	36	0.02	7.9e-03	-8.0	6.5	6.9e-11	-0.52	0.01	0.42	FALSE
55	NTR	Blood	SCAMP2	0.01	0.01	blup	290	0.01	1.6e-03	2.6	6.3	2.6e-10	-0.46	0.21	0.11	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	MPI	0.33	0.12	enet	29	0.34	8.6e-10	-8.4	6.2	4.6e-10	-0.70	0.07	0.91	FALSE
10	GTEx	Brain Cerebellum	SCAMP2	0.12	0.01	lasso	8	-0.01	5.9e-01	6.1	6.2	5.4e-10	-0.58	0.13	0.21	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MPI	0.04	0.04	enet	2	0.03	7.8e-05	6.1	6.2	7.1e-10	-0.60	0.79	0.12	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	SCAMP2	0.04	0.05	lasso	2	0.05	2.0e-04	6.1	6.2	7.5e-10	-0.60	0.19	0.50	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	MPI	0.02	0.02	lasso	1	0.02	4.7e-03	-6.1	6.1	1.1e-09	-0.61	0.08	0.68	FALSE
62	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ULK3	0.06	0.03	enet	6	0.05	6.2e-05	-6.8	-5.9	3.2e-09	0.59	0.11	0.25	FALSE
35	GTEx	Lung	MPI	0.12	0.08	lasso	5	0.10	8.8e-08	-6.3	5.9	4.3e-09	-0.59	0.99	0.01	FALSE
29	GTEx	Esophagus Mucosa	COX5A	0.11	0.02	enet	23	0.03	6.9e-03	-8.1	5.8	5.2e-09	-0.55	0.10	0.24	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	MPI	0.25	0.16	lasso	5	0.15	1.5e-05	-6.3	5.8	7.9e-09	-0.58	0.22	0.06	FALSE
28	GTEx	Esophagus Mucosa	SCAMP2	0.36	0.20	enet	20	0.27	1.8e-18	-6.3	5.8	8.6e-09	-0.49	1.00	0.00	FALSE
8	GTEx	Artery Tibial	MPI	0.08	0.03	lasso	5	0.04	8.3e-04	-6.3	5.7	9.7e-09	-0.58	0.37	0.37	FALSE
19	GTEx	Breast Mammary Tissue	MPI	0.16	0.00	lasso	8	0.01	1.4e-01	-5.9	5.7	1.5e-08	-0.64	0.06	0.29	FALSE
32	GTEx	Liver	PPCDC	0.26	0.02	lasso	12	0.01	1.4e-01	-6.6	-5.6	2.4e-08	0.41	0.09	0.21	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPP25	0.04	0.07	lasso	3	0.06	2.2e-07	5.1	-5.5	3.4e-08	0.55	0.96	0.04	FALSE
59	YFS	Blood	SCAMP2	0.04	0.03	blup	287	0.03	6.2e-11	6.4	5.5	4.2e-08	-0.40	1.00	0.00	FALSE
53	METSIM	Adipose	SCAMP2	0.05	0.02	enet	21	0.07	3.9e-10	3.6	5.2	1.9e-07	-0.30	0.79	0.20	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC33	0.05	0.02	blup	93	0.04	4.0e-05	-4.2	-5.2	2.2e-07	0.18	0.60	0.23	FALSE