Best TWAS P=2.95e-15 · Best GWAS P=4.14e-17 conditioned to 7.87e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | WNT2B | 0.10 | 0.10 | enet | 19 | 0.06 | 1.2e-05 | 4.5 | 5.9 | 4.5e-09 | -0.12 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | WNT2B | 0.15 | 0.01 | enet | 7 | 0.01 | 1.0e-01 | 5.6 | 5.6 | 2.0e-08 | -0.16 | 0.23 | 0.07 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | WNT2B | 0.18 | 0.07 | lasso | 6 | 0.05 | 2.3e-02 | 5.5 | 5.9 | 3.7e-09 | -0.16 | 0.08 | 0.05 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | WNT2B | 0.01 | -0.01 | enet | 24 | 0.00 | 3.4e-01 | -1.5 | 5.5 | 2.9e-08 | -0.11 | 0.03 | 0.07 | FALSE |
| 5 | GTEx | Muscle Skeletal | WNT2B | 0.06 | 0.02 | lasso | 7 | 0.03 | 9.4e-04 | 5.5 | 6.7 | 2.6e-11 | -0.14 | 0.56 | 0.02 | FALSE |
| 6 | GTEx | Nerve Tibial | RP4-671G15.2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 2.9e-05 | 4.8 | -5.1 | 2.9e-07 | 0.17 | 0.94 | 0.00 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RHOC | 0.07 | 0.02 | lasso | 3 | 0.02 | 1.5e-02 | 5.3 | 5.2 | 2.7e-07 | -0.16 | 0.51 | 0.08 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | CAPZA1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.1e-07 | 5.3 | 5.2 | 1.9e-07 | -0.16 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CTTNBP2NL | 0.04 | 0.00 | blup | 53 | 0.02 | 2.1e-03 | 5.8 | 6.0 | 2.4e-09 | -0.27 | 0.03 | 0.19 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | WNT2B | 0.05 | 0.02 | blup | 46 | 0.05 | 4.7e-04 | 5.4 | 7.2 | 6.8e-13 | -0.30 | 0.06 | 0.10 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | RHOC | 0.04 | 0.03 | enet | 9 | 0.04 | 1.4e-04 | 7.2 | 7.9 | 2.9e-15 | -0.30 | 0.00 | 0.98 | TRUE |