TWAS
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Traits
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Traits
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Vascular/heart problems diagnosed by doctor
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chr1:88,621,347-90,134,392
Best TWAS P=2.84e-12 · Best GWAS P=5.66e-12 conditioned to 0.0898
88.6M
88.8M
89M
89.2M
89.4M
89.6M
89.8M
90M
90.2M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
YFS
Blood
GTF2B
0.01
0.00
lasso
3
0.01
2.3e-04
-6.9
-7.0
2.8e-12
0.86
0.01
0.98
TRUE
1
GTEx
Brain Cerebellar Hemisphere
CCBL2
0.31
0.18
lasso
5
0.23
1.7e-06
-6.0
5.6
2.2e-08
-0.85
0.04
0.94
FALSE
2
GTEx
Pancreas
CCBL2
0.26
0.21
lasso
4
0.23
5.3e-10
-6.0
5.4
7.1e-08
-0.70
0.14
0.86
FALSE