TWAS
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Traits
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Traits
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Vascular/heart problems diagnosed by doctor
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chr20:7,419,920-9,648,826
Best TWAS P=3.68e-11 · Best GWAS P=2.55e-18 conditioned to 6.3e-07
7.5M
8M
8.5M
9M
9.5M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
PLCB1
0.23
0.09
lasso
9
0.09
1.7e-06
7.21
-6.6
3.7e-11
-0.55
0.66
0.21
TRUE
1
ROSMAP
Brain Pre-frontal Cortex
PLCB1
0.06
0.01
lasso
3
0.03
7.8e-05
-0.62
-5.6
1.9e-08
-0.69
0.01
0.98
TRUE