Hub : Genes

PLCB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Spleen 0.5350 0.1180 0.00070 0.002 NA 0.096 NA 0.044 2.8e-01 NA 2.0e-03 NA 2.8e-02
2 ROSMAP Brain Pre-frontal Cortex 0.0618 0.0230 0.00630 0.009 0.009 0.022 0.018 0.030 1.9e-02 2.4e-02 7.3e-04 2.1e-03 7.8e-05
3 YFS Blood 0.0311 0.0108 0.00100 0.039 0.012 0.035 0.036 0.036 9.4e-13 4.6e-05 1.0e-11 7.6e-12 5.0e-12
4 TCGA Ovarian Serous Cystadenocarcinoma 0.2250 0.0600 0.00015 0.090 0.042 0.075 NA 0.087 1.2e-06 8.2e-04 9.3e-06 NA 1.7e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.8 1.3 3.5 1.9 0.4 1.2 -0.5
Bipolar Disorder or Schizophrenia 0.6 1.4 4.0 0.1 -0.3 2.0 -1.2
Depressed Affect (Nagel 2018) 0.7 1.5 3.1 -0.5 -1.8 1.1 -1.2
Depression (Nagel 2018) 1.7 2.5 8.1 -2.8 -1.3 0.4 -0.4
Intelligence (Savage-Jansen 2018) 1.6 5.0 6.6 1.0 2.5 2.6 2.5
Neuroticism (Nagel 2018) 0.9 2.2 3.2 -1.7 -1.8 0.6 -1.5
Schizophrenia (2018) 0.8 1.6 2.5 -1.4 -0.8 1.6 -1.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.5 -0.5 -0.1 1.2 -0.2
Worry (Nagel 2018) 1.2 2.6 5.9 -2.4 -1.8 -0.9 -0.5
Alzheimer’s Disease (in mother) 0.3 0.3 1.3 -0.1 -1.1 -0.1 -0.1
Alzheimer’s Disease (in father) 0.4 0.5 1.4 1.2 0.5 0.5 0.2
Alzheimer’s Disease (including proxy) 0.3 0.4 0.6 0.7 -0.7 0.8 -0.2
Crohns Disease (2017) 0.4 0.8 1.3 -0.9 -1.2 0.6 -0.9
Irritable Bowel Disease (IBD) 0.4 0.9 2.1 -1.4 -0.3 0.9 -0.7
Ulcerative Colitis (UC) 0.4 0.8 1.4 -0.9 0.5 1.2 -0.9
Major Depression (MDD) 0.7 0.9 3.1 -1.8 0.3 -0.5 -0.1
Reaction Time 0.3 0.6 1.4 0.1 0.7 1.2 0.7
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.7 -0.4 1.2 1.9 1.2
Breast Cancer 0.5 1.1 2.9 0.4 -1.7 0.2 -1.2
Ovarian Cancer 0.6 0.7 1.2 1.1 -1.1 -0.7 0.4
Prostate Cancer 0.8 1.2 2.8 1.7 -0.2 -0.6 -1.2
Age at First Birth 0.3 0.4 1.0 0.7 0.3 -1.0 0.5
Bipolar Disorder (2011) 1.5 1.5 4.4 1.1 0.3 2.1 -0.4
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 0.1 0.2 0.7 0.9
Coronary Artery Disease (CAD) 0.7 0.9 2.5 -0.0 -1.0 1.6 -0.3
Crohns Disease (2012) 0.2 0.3 0.4 0.3 -0.7 0.5 -0.6
Mean Putamen Volume 0.8 0.9 2.4 0.3 1.6 1.0 0.2
Fasting Glucose 0.5 0.6 2.1 0.3 -0.1 1.5 -0.4
HbA1C 0.4 0.4 0.7 -0.5 0.8 -0.8 0.5
HDL Cholesterol 1.8 3.1 7.1 -2.7 0.7 -2.1 -0.4
LDL Cholesterol 0.7 1.1 2.2 1.5 -0.5 1.5 -0.1
Lupus 0.3 0.5 2.0 0.2 -0.1 -0.3 -1.4
Neuroticism (2016) 1.9 2.7 5.2 -2.3 -2.0 -1.3 0.4
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.5 0.5 0.7 -0.1
Rheumatoid Arthritis 1.7 2.3 3.0 -1.7 -0.9 -1.6 -1.7
Schizophrenia (2014) 0.4 0.9 2.7 -0.8 -0.1 1.6 -0.6
Triglycerides 1.6 2.6 9.0 3.0 0.3 0.9 0.5
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.5 1.6 -0.2 1.5 -0.1
Ulcerative Colitis 0.8 1.1 3.1 -1.8 0.4 0.9 -0.5
Blood Eosinophil Count 0.4 2.7 6.6 -2.6 0.4 2.0 0.5
Blood Platelet Count 0.7 7.9 14.6 -2.5 3.8 -1.2 3.1
Blood Red Count 0.5 5.3 11.2 -2.0 2.3 -0.8 3.3
Blood White Count 2.0 14.6 23.1 -4.4 3.9 0.7 4.8
Heel T-Score 0.6 4.6 13.1 3.6 0.1 1.0 2.0
BMI 1.1 6.3 19.0 -2.3 0.8 4.4 0.4
Height 0.0 0.4 1.2 -0.1 0.1 -1.1 -0.7
Waist Hip Ratio (WHR) 0.1 0.5 1.3 -0.5 1.1 -0.1 0.8
Systolic Blood Pressure 3.9 19.5 43.7 3.1 5.0 -0.0 6.6
Smoking Status 0.3 0.6 1.3 0.5 -1.1 0.9 0.3
Allergy or Eczema 0.2 0.6 1.7 1.3 1.0 -0.1 0.0
Cardiovascular Disease 8.4 27.8 63.9 1.7 6.5 1.4 8.0
Hypothyroidism (self reported) 1.0 2.2 4.5 1.1 -2.1 1.6 -0.8
Respiratory disease 1.7 3.9 14.2 -0.3 -0.4 3.8 -1.0
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.5 0.2 1.9 1.5 1.0
Lung FEV1/FVC ratio 0.2 1.0 1.8 1.3 0.7 1.3 0.6
Lung FVC 1.2 5.9 10.3 3.2 -1.9 -0.5 -3.1
Neuroticism 2.2 5.2 9.2 -2.1 -3.0 1.6 -2.2
Chronotype (morning person) 0.9 2.0 4.3 1.6 -0.5 -2.1 0.8
Hair Pigment 0.0 0.9 1.7 -1.3 -1.0 -0.7 -0.5
Tanning 0.1 1.5 3.1 0.6 -1.8 -1.1 1.3
Hand grip strength (left) 0.5 1.2 3.4 -1.8 0.1 -0.6 -1.1
Number of treatments/medications taken 2.6 4.6 8.7 1.3 2.5 2.9 1.3
Average weekly spirits intake 3.0 3.7 7.7 1.6 -1.6 1.3 -2.8
Sensitivity / hurt feelings 1.6 2.8 8.7 -3.0 -0.1 1.5 0.4
Frequency of depressed mood in last 2 weeks 1.7 2.4 5.8 -2.4 -1.7 0.9 -0.2
Hearing difficulty/problems: Yes 1.2 1.9 4.3 1.1 -1.0 1.0 -2.1
Relative age of first facial hair 0.9 1.8 5.5 2.4 -0.5 -1.2 0.2
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 2.4 -1.2 1.5 0.4 1.5
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.3 1.1 0.9 -0.2 -0.1
Ever had hysterectomy (womb removed) 0.6 0.7 2.3 1.5 -0.7 0.1 0.0
Systolic blood pressure, automated reading 0.7 2.0 6.4 2.5 -0.0 0.8 0.9
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 6.0 2.5 -1.0 0.5 -1.4
Angina 0.6 0.8 2.2 -0.5 0.3 1.5 0.8
Medication for hormone replacement therapy 1.5 1.6 4.0 2.0 1.5 -0.0 0.6
Vitamin and mineral supplements 0.7 0.9 2.1 -0.5 0.8 -0.8 1.4
Supplements: Zinc 0.6 0.7 2.1 0.6 0.4 0.2 -1.4
Medication: Co-codamol 0.7 0.8 3.1 0.0 -1.8 -0.3 0.3
Medication: Metformin 0.1 0.2 0.3 0.1 0.0 0.6 0.6
Diabetes (father) 0.5 0.6 0.7 -0.8 -0.7 -0.7 -0.8
Diabetes (mother) 0.5 0.6 1.1 -0.2 -0.5 1.0 -1.1
Severe depression (siblings) 0.8 0.9 2.0 -0.4 -0.5 -1.4 1.1
Pack years adult smoking proportion 0.3 0.5 1.7 -0.3 1.3 -0.3 -0.3
Impedance of leg (right) 1.5 7.2 18.1 -1.0 -0.5 -4.3 3.0
Leg fat-free mass (left) 0.7 3.5 9.6 -1.2 1.3 3.1 -1.1
Trunk fat percentage 1.2 4.7 8.6 -2.4 1.3 1.8 2.9
Hand grip strength (right) 0.4 1.0 2.1 -1.2 -0.9 -0.0 -1.4
Townsend deprivation index at recruitment 0.4 0.5 1.5 0.7 -0.2 1.2 -0.3
Current tobacco smoking 0.4 0.7 1.2 -0.9 -0.8 -1.1 -0.4
Average weekly fortified wine intake 0.5 0.6 1.9 0.3 -1.4 -0.1 -0.7
Maternal smoking around birth 1.3 1.8 5.5 0.2 -2.4 -0.2 -1.3
Fed-up feelings 1.4 2.5 3.9 -1.5 -2.0 0.9 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 7.6 -2.8 -1.1 0.4 -0.0
Relative age voice broke 1.6 2.4 6.7 2.6 -0.8 -1.3 -0.8
Taking other prescription medications 1.0 1.6 5.1 0.7 -0.4 2.3 -0.6
Age when periods started (menarche) 1.1 2.5 4.8 -2.2 -2.1 -0.8 0.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.1 -0.0 0.3 -1.1 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.3 0.0 0.4 0.4 1.5
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 1.3 0.7 -0.9 1.1 -1.1
Qualifications: CSEs or equivalent 0.5 0.7 1.3 -0.6 1.1 -1.0 -0.3
Serious illness, injury or assault to yourself 0.5 0.6 2.2 -0.0 -0.2 0.3 1.5
High blood pressure 7.6 21.3 41.1 2.2 6.0 1.8 6.4
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.9 -0.3 0.0 -0.4 -0.9
Multivitamins +/- minerals 0.3 0.4 0.7 -0.6 -0.7 -0.1 -0.8
Stomach or abdominal pain in last month 0.6 0.7 1.5 0.5 0.6 0.8 -1.2
Supplements: Glucosamine 0.7 0.9 2.3 1.5 -0.1 -1.1 0.2
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 2.7 -1.6 -1.3 -1.2 -0.3
Medication: Atenolol 5.8 7.2 11.3 0.9 3.4 2.8 3.0
Medication: Levothyroxine sodium 1.2 2.1 7.5 0.1 -0.3 2.7 0.9
Sitting height 0.4 3.1 10.4 -0.3 3.2 -1.1 -1.0
Chronic bronchitis/emphysema (father) 2.2 2.6 5.2 0.7 -2.3 1.6 -1.5
High blood pressure (mother) 1.9 2.6 4.4 -0.5 1.4 2.0 2.1
Body mass index (BMI) 0.9 4.0 13.0 -0.8 1.4 3.6 0.6
Impedance of leg (left) 1.5 7.1 17.5 -1.3 -0.3 -4.2 3.0
Leg predicted mass (left) 0.7 3.6 9.7 -1.3 1.3 3.1 -1.1
Trunk fat mass 0.9 3.9 5.3 -2.1 1.4 2.3 2.0
Waist circumference 0.5 2.0 4.7 -0.6 1.6 2.2 0.6
Number of incorrect matches in round 2.2 3.7 9.7 -0.0 -3.1 -1.8 -1.3
Past tobacco smoking 1.2 2.2 7.2 -0.4 0.7 -2.7 -1.1
Alcohol usually taken with meals 1.0 1.6 5.4 2.3 -0.9 -0.2 0.5
Nervous feelings 1.4 2.6 6.5 -2.5 -1.7 -0.3 1.0
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 4.8 -2.2 -1.4 0.7 0.7
Hearing difficulty/problems with background noise 1.5 2.4 4.6 0.3 -0.8 2.1 -2.1
Hair/balding pattern: Pattern 2 0.6 0.7 1.5 -0.1 1.2 -1.1 0.3
Had menopause 2.2 2.7 7.6 2.8 1.2 -1.1 -0.8
Had other major operations 2.3 2.8 7.2 2.7 -1.7 0.2 -1.1
Forced vital capacity (FVC) 0.9 3.4 5.2 -2.2 -1.2 -1.5 -2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 -0.2 -0.1 0.9 0.6
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.6 1.0 0.0 0.6 -1.6
Qualifications: None of the above 0.3 0.7 1.4 -0.3 -1.2 -0.9 -0.6
Financial difficulties in last 2 years 0.8 1.1 1.8 -0.8 1.3 1.4 0.3
Mouth/teeth dental problems 0.4 0.6 2.2 -0.4 0.0 -0.1 1.5
Heart attack 2.3 3.0 9.3 1.4 -0.3 3.0 0.7
Allergy 0.3 0.7 1.9 -0.1 0.3 -0.8 1.4
Pain all over the body in last month 1.5 1.6 4.4 2.1 0.3 1.4 0.0
Diabetes (self-reported) 0.4 0.7 1.5 0.8 0.2 1.2 0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.0 -0.7 0.2 -0.1 -1.0
Medication: Ramipril 4.2 5.4 10.8 1.0 3.3 1.0 3.0
Medication: Simvastatin 2.5 3.7 7.3 1.4 2.7 1.8 1.5
Fluid intelligence score 2.0 4.2 7.6 0.1 2.1 2.8 2.2
Illnesses of siblings 1.2 1.7 4.2 -1.2 -0.6 1.0 -2.0
Neuroticism score 1.7 3.5 6.8 -2.6 -1.7 1.9 -0.5
Weight 0.6 2.8 7.2 -1.2 1.5 2.7 0.4
Impedance of arm (right) 1.9 8.9 14.8 -3.8 -0.9 -3.2 3.1
Arm fat percentage (right) 1.4 5.6 9.8 -3.1 0.9 2.9 1.9
Trunk fat-free mass 0.5 3.1 7.0 1.0 1.3 2.6 -1.7
Hip circumference 0.5 2.1 4.4 -1.1 1.2 2.1 1.2
Time employed in main current job 0.6 0.7 2.7 1.7 -0.4 -0.2 -0.1
Alcohol intake versus 10 years previously 0.6 1.0 1.9 1.2 1.4 0.5 0.4
Father’s age at death 0.5 0.7 0.8 -0.6 -0.9 -0.9 -0.9
Worrier / anxious feelings 1.3 2.5 8.8 -3.0 -1.1 -0.1 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.8 -1.3 -0.9 1.2 -0.5
Falls in the last year 2.0 2.8 6.0 -0.0 -2.5 1.6 -1.6
Hair/balding pattern: Pattern 3 0.2 0.4 0.9 0.9 -0.6 -0.5 -0.1
Number of live births 0.5 0.7 1.3 0.4 0.0 1.1 1.2
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 5.0 -2.2 -0.5 -0.9 -1.7
Pulse rate 0.6 1.0 3.7 -0.3 -0.2 -0.5 -1.9
Happiness 0.7 0.9 2.8 -0.4 0.6 1.7 0.5
Noisy workplace 0.4 0.5 1.1 1.1 0.4 -0.4 -0.8
Qualifications: A levels/AS levels or equivalent 0.8 1.8 2.5 0.6 1.3 1.6 1.5
Serious illness, injury or assault of a close relative in last 2 years 3.1 3.6 9.9 -0.6 -3.1 1.4 -1.4
Mouth/teeth dental problems: Dentures 0.3 0.6 1.5 0.6 0.1 -1.2 0.5
Asthma 1.8 3.5 11.4 -0.5 -0.7 3.4 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.4 -0.3 0.1 -0.5 -0.6
Medication: Cholesterol lowering 3.5 5.5 11.5 -0.0 3.4 2.6 1.9
Depression (self-reported) 2.6 3.1 8.0 -2.8 -2.0 -0.7 -0.1
Medication: Lansoprazole 0.5 0.5 1.5 -0.7 1.2 -0.3 0.3
Prospective memory result 0.7 0.9 2.5 1.6 -0.0 -0.7 -0.7
Lung cancer (father) 4.2 4.9 14.3 0.8 -0.8 -3.8 -2.0
Illnesses of mother 2.7 3.3 8.6 -0.4 -2.0 -0.7 -2.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 1.5 -1.2 0.0 -0.9 -0.9
Pulse wave Arterial Stiffness index 1.4 1.7 5.2 2.3 -1.1 0.3 -0.4
Impedance of arm (left) 1.6 7.5 10.5 -3.2 -1.4 -3.2 2.6
Arm fat mass (right) 1.0 4.3 10.4 -2.1 1.0 3.2 1.1
Trunk predicted mass 0.6 3.2 7.1 1.0 1.2 2.7 -1.8
Standing height 0.1 0.8 2.7 -0.6 0.3 -1.6 -0.3
Length of working week for main job 0.5 0.6 0.8 -0.5 0.8 0.8 0.9
Exposure to tobacco smoke at home 0.7 0.7 1.5 -0.3 -1.2 0.5 -1.0
Breastfed as a baby 2.3 2.9 5.9 1.7 -0.3 -2.4 -1.7
Tense / ‘highly strung’ 1.5 2.5 7.6 -2.8 -1.5 0.4 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.1 7.5 -2.7 -1.6 1.2 0.9
Hair/balding pattern: Pattern 4 0.3 0.7 1.8 -1.3 0.7 0.6 -0.5
Birth weight of first child 1.6 2.9 3.8 -1.6 1.9 1.9 1.3
Peak expiratory flow (PEF) 0.4 0.9 3.0 -1.7 -0.5 0.7 0.1
Pulse wave reflection index 1.5 1.9 4.5 1.7 -2.1 0.3 -0.2
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.2 -0.1 -1.1 0.6 0.5
Loud music exposure frequency 0.6 0.6 2.5 -0.2 -0.1 1.6 -0.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 3.1 0.9 0.9 1.8 0.1
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.3 0.3 1.4 1.5 -1.5
Blood clot in the leg (DVT) 0.7 0.9 2.9 1.7 -0.3 0.4 -0.5
Medication: Paracetamol 0.9 1.5 4.1 -0.6 -0.5 2.0 -1.1
Headache pain in last month 2.0 3.4 11.2 -0.7 1.3 3.4 0.3
Medication for cholesterol, blood pressure or diabetes 7.3 12.1 23.6 -1.1 -4.9 -2.2 -4.3
Glaucoma (self-reported) 1.3 1.6 4.5 2.1 1.1 -0.7 0.1
Gout (self-reported) 0.8 1.0 2.3 0.8 1.5 -0.5 1.0
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.7 0.5 -1.9 1.8 -0.2
Medication: Amlodipine 2.5 3.5 4.7 1.5 2.1 1.7 2.2
Medication: Ventolin 100micrograms inhaler 2.3 3.0 5.3 0.0 -1.3 2.2 -2.3
Birth weight 0.1 0.2 0.6 -0.3 0.8 0.1 0.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.8 -1.3 -0.7 0.1 0.3
High blood pressure (siblings) 2.6 3.8 8.3 0.6 2.4 0.8 2.9
Forced vital capacity (FVC), Best measure 0.4 1.4 2.7 -1.6 -0.5 -0.9 -1.3
Body fat percentage 1.1 4.2 6.4 -2.2 1.4 1.9 2.5
Leg fat percentage (right) 0.9 3.2 6.0 -0.6 1.5 2.0 2.5
Arm fat-free mass (right) 0.6 3.1 6.6 1.0 1.1 2.6 -1.9
Exposure to tobacco smoke outside home 0.2 0.2 0.4 0.3 0.6 0.5 -0.4
Comparative body size at age 10 0.1 0.3 0.9 -0.9 0.2 0.6 0.0
Number of full brothers 1.4 1.7 3.6 -1.5 -1.0 0.1 -1.9
Worry too long after embarrassment 0.8 1.3 2.1 -1.1 -0.3 1.3 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.3 -1.8 -0.5 0.6 0.5
Wheeze or whistling in the chest in last year 2.1 3.7 5.8 -2.2 -1.2 2.4 -1.6
Number of children fathered 1.5 1.6 3.6 0.1 1.7 -1.9 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.5 0.7 -0.4 0.1 -0.2
Age at first live birth 0.3 0.6 1.2 -0.8 0.3 -1.1 0.6
Pulse wave peak to peak time 1.5 1.7 5.0 -2.2 1.3 -0.4 0.5
Health satisfaction 0.1 0.1 0.3 0.3 0.1 0.5 -0.2
Shortness of breath walking on level ground 0.6 0.7 1.7 1.3 0.5 -0.8 -0.5
Qualifications: College or University degree 1.0 3.2 5.6 -1.4 2.0 2.4 1.3
Eye problems/disorders: None of the above 0.3 0.3 0.9 -0.9 0.4 -0.5 -0.2
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.4 -0.1 1.5 1.5 0.7
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.2 -0.3 0.2 -0.3
Medication for pain relief, constipation, heartburn 0.9 1.5 4.0 -0.1 -1.3 -2.0 -0.0
Neck or shoulder pain in last month 1.0 1.4 4.2 -0.5 -0.9 2.0 -0.8
Medication: Blood pressure 11.3 20.0 38.2 1.5 6.2 1.8 6.0
Angina (self-reported) 0.6 0.8 2.3 -0.3 0.3 1.5 0.7
Migraine (self-reported) 1.3 1.6 3.5 -1.9 -0.2 1.7 -0.2
Medication: Ibuprofen 0.3 0.4 1.0 -0.8 1.0 -0.0 0.1
Medication: Allopurinol 1.3 1.7 3.8 0.5 1.6 0.2 2.0
Medication: Omeprazole 1.4 1.7 3.1 0.7 -0.6 1.8 -1.7
Medication: Seretide 50 evohaler 0.6 0.7 1.4 0.4 0.3 1.2 1.0
Mean time to correctly identify matches 0.8 1.6 4.1 2.0 0.5 1.4 -0.4
Heart disease (mother) 0.7 0.8 1.8 0.3 1.0 -0.5 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.1 5.6 -2.4 -0.8 0.3 1.4
Whole body fat mass 0.9 3.9 6.6 -2.1 1.5 2.6 1.5
Leg fat mass (right) 0.9 3.3 6.9 -1.5 1.4 2.6 1.5
Arm predicted mass (right) 0.7 3.6 7.1 1.4 1.0 2.7 -2.0
Pulse rate, automated reading 0.2 0.7 1.2 1.1 0.6 0.1 -1.1
Alcohol intake frequency. 0.6 1.4 5.2 0.3 2.3 0.1 -0.4
Comparative height size at age 10 0.2 0.8 1.1 0.9 0.8 -0.8 -1.1
Number of full sisters 0.4 0.5 1.6 0.2 1.3 0.4 0.4
Suffer from ‘nerves’ 1.2 1.9 3.2 -1.8 -1.8 0.2 1.1
Overall health rating 0.3 0.7 2.2 -0.2 0.6 0.6 1.5
Chest pain or discomfort 1.6 2.4 4.1 -0.9 -2.0 1.7 -1.2
Had major operations 1.0 1.2 3.3 1.1 -0.5 0.1 1.8
Age at last live birth 0.4 0.6 1.1 -1.1 0.2 -1.0 0.3
Family relationship satisfaction 1.1 1.4 3.0 -1.5 0.3 1.7 0.2
Leg pain on walking 1.3 1.6 3.1 1.5 0.8 -0.6 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.5 0.3 -0.1 -0.4 -0.7
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.4 1.5 0.3 -0.3 0.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.3 1.1 1.0 -1.0 0.0
Medication: Aspirin 4.9 6.5 12.3 0.8 3.5 1.6 3.2
Supplements: Vitamin C 1.6 1.9 5.3 1.3 0.6 2.3 -0.6
Knee pain experienced in last month 0.7 1.1 4.1 -0.6 -0.3 -0.1 -2.0
Hypertension (Self-reported) 8.2 22.8 44.9 2.5 6.2 1.2 6.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.7 -0.5 -0.3 -0.6 -1.3
Illnesses of father: Heart disease 0.4 0.5 1.2 0.1 -0.1 1.0 1.1
Illnesses of siblings: Diabetes 2.0 2.4 5.7 -0.3 -2.4 -0.7 -1.9
Smoking status: Previous 1.6 2.3 8.6 0.5 -0.1 2.9 0.7
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.3 11.6 -3.4 1.5 -1.7 0.4
Whole body fat-free mass 0.6 3.4 9.1 0.2 1.4 3.0 -1.6
Leg fat-free mass (right) 0.7 3.8 10.1 -1.2 1.2 3.2 -1.4
Arm fat percentage (left) 1.1 4.6 8.1 -2.7 0.6 2.9 1.6
Average weekly red wine intake 0.8 1.1 3.4 1.8 -1.0 -0.1 0.3
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.6 1.6 0.7 0.4 0.9
Mood swings 0.7 1.2 2.3 -1.5 -1.4 0.8 -0.2
Loneliness, isolation 1.6 2.2 4.9 -0.1 -1.8 2.2 0.6
Long-standing illness, disability or infirmity 0.7 1.0 2.3 0.7 0.5 1.5 1.0
Ever had bowel cancer screening 0.6 0.7 1.5 1.2 -0.5 -0.6 -0.8
Diabetes diagnosed by doctor 0.8 1.4 5.0 0.1 0.5 2.2 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.2 0.4 0.6 0.9 1.8
Friendships satisfaction 0.6 0.7 1.6 -1.3 1.0 -0.0 0.6
Qualifications: nursing, teaching 1.5 2.4 5.8 1.4 2.4 1.4 -0.0
Commuting to job workplace: Walk 0.4 0.4 0.9 -0.6 0.4 1.0 -0.4
Eye problems/disorders: Cataract 0.3 0.3 0.8 -0.3 0.4 0.9 0.5
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 3.1 -1.1 -1.0 -0.6 -1.8
Medication for cholesterol 7.4 11.2 18.4 -3.0 -4.3 -0.2 -4.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.5 0.5 -0.2 -0.7 0.5
Back pain experienced in last month 0.6 0.9 2.6 -0.9 -1.6 0.1 -0.2
Mineral and other dietary supplements 0.9 1.2 2.3 -1.5 0.3 0.8 1.3
Breast cancer (self-reported) 3.9 4.6 8.7 -0.1 2.5 -3.0 1.9
Asthma (self-reported) 1.7 3.3 10.4 -0.3 -0.7 3.2 -1.5
Osteoporosis (self-reported) 1.1 1.3 3.4 0.3 1.9 1.1 0.8
Osteoarthritis (self-reported) 0.4 0.5 0.9 -0.2 -0.7 0.8 -0.9
Medication: Aspirin 4.5 5.9 11.1 0.6 3.3 1.7 3.1
Medication: Gliclazide 0.2 0.2 0.8 0.9 0.2 0.2 -0.1
Illnesses of father: None of the above (group 1) 1.5 1.9 2.7 -1.6 -1.6 -1.0 -1.2
Smoking status: Current 0.5 0.8 1.6 -0.5 -1.2 -0.9 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 0.6 0.1 0.1 -0.6
Whole body water mass 0.6 3.4 9.1 0.2 1.3 3.0 -1.7
Leg predicted mass (right) 0.7 3.8 10.2 -1.3 1.3 3.2 -1.4
Arm fat mass (left) 0.9 3.7 8.9 -2.0 0.9 3.0 0.9
Number of self-reported non-cancer illnesses 1.8 3.0 7.8 1.1 0.9 1.5 2.8
Average weekly champagne plus white wine intake 3.6 4.9 9.2 1.4 -2.9 3.0 -0.6
Miserableness 0.4 0.6 1.5 -1.2 -0.5 0.5 -0.8
Guilty feelings 1.3 2.0 5.6 -2.4 -0.5 0.5 -1.4
Wears glasses or contact lenses 0.8 0.9 2.6 1.6 0.1 -0.0 1.0
Ever taken oral contraceptive pill 0.5 0.6 1.3 0.8 -0.4 -1.1 -0.5
Hearing aid user 0.5 0.5 1.8 -0.2 -0.1 -1.3 0.5
Mother’s age at death 0.4 0.5 0.9 1.0 0.7 -0.5 0.4
Financial situation satisfaction 0.7 0.8 1.6 -0.2 0.6 1.3 1.1
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 0.1 -0.6 0.5 -0.8
Commuting to job workplace: Public transport 0.5 0.6 0.9 -0.5 1.0 -0.6 -0.9
Eye problems/disorders: Glaucoma 0.9 1.0 1.8 1.4 1.3 0.6 0.5
Medication: Blood pressure 8.6 16.4 36.0 1.4 5.2 0.8 6.0
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.5 -0.4 -1.6 0.8 0.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.8 1.3 -0.0 -0.4 -1.1
High cholesterol (Self-reported) 1.0 1.7 3.3 0.5 1.5 1.8 1.1
Medication: Bendroflumethiazide 8.0 12.1 26.8 1.3 4.4 0.7 5.2
Medication: Paracetamol 2.2 3.4 13.1 -0.5 0.2 3.6 -0.5
Medication: Lisinopril 3.6 4.6 12.1 -0.7 3.5 0.5 2.4
Medication: Atorvastatin 0.8 1.0 3.2 -0.0 0.3 1.8 0.9
Illnesses of father: High blood pressure 8.4 10.4 25.3 0.9 5.0 0.1 4.0
Alcohol drinker status: Never 1.1 1.4 4.6 0.0 2.1 0.8 0.5
Ever smoked 0.8 1.4 3.0 -0.4 -1.3 1.7 0.9
Basal metabolic rate 0.6 3.1 8.8 -0.4 1.5 3.0 -1.0
Leg fat percentage (left) 0.9 3.4 5.7 -0.8 1.7 2.1 2.4
Arm fat-free mass (left) 0.6 3.2 9.1 0.7 1.2 3.0 -1.3
Number of operations (self-reported) 2.5 3.7 11.0 3.3 -0.2 1.5 1.2
Average weekly beer plus cider intake 0.4 0.6 1.3 -1.0 0.6 0.1 1.1
Irritability 1.8 3.1 6.5 -2.2 -0.9 2.5 -0.5
Risk taking 0.1 0.1 0.3 0.6 -0.1 0.3 -0.0
Ever had prostate specific antigen (PSA) test 2.0 2.4 5.4 2.3 -0.4 0.8 -1.8
Fractured/broken bones in last 5 years 0.6 0.8 1.3 1.2 -1.0 0.9 -0.3
Age started oral contraceptive pill 1.3 1.6 3.1 1.8 -0.2 -1.0 -1.5
Diastolic blood pressure, automated reading 1.1 3.5 6.7 1.7 2.6 -0.1 2.1
Ever depressed for a whole week 1.3 1.7 3.3 1.8 0.1 -0.1 -1.8
Unable to work because of sickness or disability 0.8 1.0 2.1 -0.3 -1.4 1.3 -0.2
Commuting to job workplace: Cycle 1.1 1.3 2.8 0.2 1.7 1.5 0.5
Myopia 1.2 1.7 3.3 1.5 0.2 -1.8 1.1
Vascular/heart problems diagnosed by doctor 7.9 21.4 43.8 -2.4 -5.6 -2.2 -6.6
Cholesterol lowering medication 0.5 0.7 1.6 1.3 0.6 0.3 0.8
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 2.5 1.0 -1.0 1.6 -1.1
Pain experienced in last month 0.8 1.3 2.4 0.4 1.5 -1.4 0.7
Supplements: Calcium 1.0 1.1 2.0 0.1 1.0 1.1 1.4
Basal cell carcinoma (self-reported) 0.4 0.5 1.3 0.3 -0.6 0.3 -1.2
Heart attack/myocardial infarction (self-reported) 2.5 3.2 9.6 1.6 -0.5 3.1 0.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.3 1.8 -0.3 0.3 -0.5
Heart disease (siblings) 0.7 0.8 1.4 0.6 1.1 -0.4 1.2
Alcohol drinker status: Previous 0.7 0.8 1.7 -0.7 -1.3 0.5 -0.8
Pack years of smoking 0.5 0.7 2.0 0.6 1.4 -0.3 -0.5
Impedance of whole body 1.5 7.9 15.2 -2.4 -0.7 -3.9 3.2
Leg fat mass (left) 0.9 3.4 7.0 -1.4 1.7 2.7 1.4
Arm predicted mass (left) 0.6 2.9 7.1 1.0 1.2 2.7 -1.5