TWAS
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Models
Genes
Traits
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Traits
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High blood pressure
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chr3:19,382,787-20,893,060
Best TWAS P=3.54e-08 · Best GWAS P=1.26e-08 conditioned to 0.0707
19.4M
19.6M
19.8M
20M
20.2M
20.4M
20.6M
20.8M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Nerve Tibial
KAT2B
0.28
0.27
enet
9
0.29
1.8e-20
-5.0
-5.5
3.5e-08
0.87
0.03
0.97
TRUE
3
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
SGOL1
0.03
0.04
blup
70
0.04
2.6e-04
4.3
5.5
4.9e-08
-0.52
0.05
0.80
FALSE
1
GTEx
Artery Aorta
KAT2B
0.19
0.00
lasso
5
0.00
4.4e-01
-5.7
5.2
2.1e-07
-0.88
0.03
0.51
FALSE