[Hub]/) : Traits : High blood pressure :

chr3:47,204,518-49,365,269

Best TWAS P=3.75e-11 · Best GWAS P=2.49e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ZNF589 0.15 0.14 bslmm 254 0.16 1.3e-19 -5.0 -5.6 1.8e-08 0.89 0.97 0.03 FALSE
2 GTEx Adipose Subcutaneous FCF1P2 0.17 0.07 enet 18 0.09 9.8e-08 -4.9 5.4 7.0e-08 -0.77 0.63 0.36 FALSE
3 GTEx Adipose Visceral Omentum CDC25A 0.12 0.09 lasso 13 0.08 7.2e-05 -5.0 -5.1 2.8e-07 0.86 0.18 0.82 FALSE
4 GTEx Adipose Visceral Omentum MRPS18AP1 0.26 0.31 enet 16 0.31 9.1e-17 -4.8 -5.3 1.3e-07 0.93 0.15 0.85 FALSE
5 GTEx Adrenal Gland ZNF589 0.38 0.35 lasso 15 0.36 9.6e-14 -4.8 -5.4 6.1e-08 0.89 0.58 0.42 FALSE
6 GTEx Adrenal Gland NME6 0.12 0.07 lasso 9 0.08 6.1e-04 -6.7 6.3 2.4e-10 -0.97 0.03 0.90 FALSE
7 GTEx Adrenal Gland MRPS18AP1 0.49 0.45 enet 20 0.46 1.7e-18 -4.8 -5.4 7.0e-08 0.86 0.25 0.75 FALSE
8 GTEx Artery Aorta ZNF589 0.32 0.43 lasso 4 0.44 4.6e-26 -5.0 -5.4 7.2e-08 0.88 0.97 0.03 FALSE
9 GTEx Artery Aorta MRPS18AP1 0.45 0.37 lasso 8 0.42 5.4e-25 -5.0 -5.2 2.4e-07 0.89 0.91 0.09 FALSE
10 GTEx Artery Tibial CDC25A 0.23 0.27 lasso 5 0.27 5.8e-21 -5.0 -5.2 2.0e-07 0.86 0.98 0.02 FALSE
11 GTEx Artery Tibial FCF1P2 0.17 0.24 enet 23 0.25 1.7e-19 -5.0 5.3 1.3e-07 -0.89 0.96 0.04 FALSE
12 GTEx Brain Cerebellum MRPS18AP1 0.56 0.51 lasso 24 0.50 4.8e-17 -4.8 -5.3 1.4e-07 0.91 0.57 0.43 FALSE
13 GTEx Breast Mammary Tissue ZNF589 0.29 0.25 lasso 20 0.30 4.9e-16 -4.8 -5.3 1.3e-07 0.86 0.96 0.04 FALSE
14 GTEx Breast Mammary Tissue NME6 0.11 0.08 enet 21 0.12 5.6e-07 -5.0 5.3 1.2e-07 -0.70 0.46 0.30 FALSE
15 GTEx Breast Mammary Tissue FCF1P2 0.07 0.04 lasso 7 0.02 5.1e-02 -6.7 6.6 3.7e-11 -1.00 0.01 0.96 TRUE
16 GTEx Breast Mammary Tissue (Male) ZNF589 0.15 0.15 lasso 17 0.11 1.5e-03 -5.0 -5.4 6.1e-08 0.83 0.12 0.59 FALSE
17 GTEx Breast Mammary Tissue (Male) FCF1P2 0.09 0.01 lasso 4 0.03 8.6e-02 -3.9 5.5 3.1e-08 -0.88 0.03 0.71 FALSE
18 GTEx Breast Mammary Tissue (Female) ZNF589 0.29 0.21 lasso 8 0.20 1.3e-06 -4.8 -5.5 2.8e-08 0.91 0.14 0.83 FALSE
19 GTEx Breast Mammary Tissue (Female) NME6 0.05 -0.01 lasso 2 0.03 3.5e-02 -5.0 5.5 2.8e-08 -0.70 0.04 0.21 FALSE
20 GTEx Esophagus Mucosa MAP4 0.05 0.04 lasso 4 0.02 2.3e-02 -4.8 5.4 7.3e-08 -0.91 0.09 0.81 FALSE
21 GTEx Esophagus Mucosa FCF1P2 0.13 0.14 lasso 11 0.14 1.7e-09 -4.8 5.1 2.9e-07 -0.87 0.83 0.17 FALSE
22 GTEx Esophagus Muscularis FCF1P2 0.17 0.10 lasso 19 0.09 6.3e-06 -4.8 5.1 2.8e-07 -0.89 0.24 0.75 FALSE
23 GTEx Esophagus Muscularis MRPS18AP1 0.45 0.51 lasso 8 0.57 6.3e-42 -4.9 -5.2 2.6e-07 0.89 0.99 0.01 FALSE
24 GTEx Heart Atrial Appendage CDC25A 0.23 0.26 enet 23 0.26 4.0e-12 -5.0 -5.2 1.5e-07 0.84 0.87 0.13 FALSE
25 GTEx Lung ZNF589 0.13 0.12 enet 23 0.13 3.1e-10 -4.9 -5.3 1.3e-07 0.90 0.10 0.90 FALSE
26 GTEx Lung MRPS18AP1 0.33 0.35 lasso 9 0.36 3.3e-28 -4.8 -5.4 5.5e-08 0.94 0.72 0.28 FALSE
27 GTEx Ovary ZNF589 0.28 0.29 lasso 3 0.26 4.0e-07 -4.8 -5.4 6.2e-08 0.90 0.08 0.91 FALSE
28 GTEx Ovary MRPS18AP1 0.53 0.33 lasso 8 0.43 7.8e-12 -5.0 -5.8 5.7e-09 0.94 0.05 0.95 FALSE
29 GTEx Pancreas CDC25A 0.29 0.27 lasso 3 0.27 1.2e-11 -5.0 -5.2 1.9e-07 0.86 0.70 0.30 FALSE
30 GTEx Pituitary SLC26A6 0.16 0.18 lasso 8 0.14 2.0e-04 -6.4 -6.5 9.0e-11 0.98 0.02 0.85 FALSE
31 GTEx Prostate CDC25A 0.18 0.14 lasso 4 0.16 7.9e-05 -6.5 -6.1 1.0e-09 0.95 0.03 0.91 FALSE
32 GTEx Prostate MRPS18AP1 0.29 0.32 lasso 5 0.36 6.8e-10 -5.0 -5.7 1.3e-08 0.91 0.05 0.95 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic NME6 0.24 0.18 enet 20 0.18 6.0e-10 -5.0 5.5 4.4e-08 -0.82 0.98 0.02 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic MRPS18AP1 0.47 0.44 lasso 9 0.50 2.3e-31 -4.8 -5.2 2.2e-07 0.90 0.99 0.01 FALSE
35 GTEx Skin Sun Exposed Lower leg ZNF589 0.43 0.39 enet 35 0.40 1.7e-35 -4.8 -5.4 6.4e-08 0.91 0.90 0.10 FALSE
36 GTEx Skin Sun Exposed Lower leg NME6 0.16 0.17 lasso 11 0.20 1.5e-16 -5.0 5.1 2.9e-07 -0.88 0.94 0.06 FALSE
37 GTEx Skin Sun Exposed Lower leg FCF1P2 0.09 0.09 lasso 9 0.10 5.5e-09 -5.0 5.1 2.7e-07 -0.84 0.94 0.06 FALSE
38 GTEx Spleen ZNF589 0.29 0.13 lasso 13 0.16 5.1e-05 -4.4 -5.4 7.0e-08 0.93 0.08 0.90 FALSE
39 GTEx Spleen MRPS18AP1 0.36 0.20 lasso 18 0.31 8.5e-09 -6.6 -5.7 1.6e-08 0.95 0.05 0.95 FALSE
40 GTEx Stomach CDC25A 0.29 0.05 lasso 3 0.00 2.5e-01 -5.0 -5.1 3.0e-07 0.88 0.05 0.84 FALSE
41 GTEx Stomach ZNF589 0.25 0.27 lasso 18 0.33 2.5e-16 -4.9 -5.4 7.9e-08 0.91 0.22 0.78 FALSE
42 GTEx Stomach NME6 0.14 0.17 lasso 8 0.17 1.8e-08 -5.0 5.3 1.2e-07 -0.83 0.89 0.10 FALSE
43 GTEx Stomach FCF1P2 0.12 0.05 enet 5 0.03 1.3e-02 -6.7 6.2 7.4e-10 -0.96 0.03 0.90 FALSE
44 GTEx Stomach MRPS18AP1 0.29 0.35 lasso 4 0.42 7.0e-22 -4.9 -5.3 1.4e-07 0.90 0.33 0.67 FALSE
45 GTEx Testis ZNF589 0.48 0.42 enet 33 0.48 4.0e-24 -5.0 -5.3 1.1e-07 0.91 0.67 0.33 FALSE
46 GTEx Testis NME6 0.06 0.06 lasso 5 0.04 8.7e-03 -5.0 5.4 8.3e-08 -0.89 0.05 0.84 FALSE
47 GTEx Thyroid MAP4 0.07 0.05 lasso 12 0.05 1.6e-04 -6.4 -6.1 1.0e-09 0.96 0.03 0.97 FALSE
48 GTEx Thyroid CDC25A 0.24 0.33 enet 28 0.34 2.3e-26 -5.0 -5.5 3.6e-08 0.89 0.94 0.06 FALSE
49 GTEx Thyroid ZNF589 0.19 0.32 lasso 8 0.34 1.5e-26 -5.0 -5.3 1.4e-07 0.89 0.98 0.02 FALSE
50 GTEx Thyroid FCF1P2 0.07 0.05 lasso 3 0.05 1.6e-04 -4.9 5.3 1.1e-07 -0.88 0.08 0.91 FALSE
51 GTEx Thyroid MRPS18AP1 0.33 0.44 lasso 9 0.52 2.5e-46 -5.0 -5.5 3.2e-08 0.91 0.98 0.02 FALSE
52 NTR Blood ZNF589 0.02 0.02 lasso 8 0.02 2.8e-06 -6.6 -6.5 6.4e-11 0.97 0.01 0.99 FALSE
53 ROSMAP Brain Pre-frontal Cortex NME6 0.09 0.17 lasso 5 0.18 7.1e-23 -5.0 5.2 2.0e-07 -0.87 0.97 0.03 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NME6 0.04 0.04 blup 33 0.04 1.6e-05 -4.9 5.2 1.8e-07 -0.87 0.02 0.97 FALSE
55 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CDC25A 0.05 0.04 blup 19 0.04 3.7e-03 -4.8 -5.7 9.4e-09 0.94 0.01 0.78 FALSE
56 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ZNF589 0.09 0.05 blup 32 0.04 1.6e-03 -5.0 -5.3 1.0e-07 0.82 0.02 0.89 FALSE
57 The Cancer Genome Atlas Brain Lower Grade Glioma CDC25A 0.02 0.00 blup 20 0.01 5.0e-02 -6.4 -6.1 1.1e-09 0.97 0.01 0.64 FALSE
58 The Cancer Genome Atlas Lung Adenocarcinoma CDC25A 0.02 0.01 blup 20 0.01 6.7e-03 -4.8 -5.9 2.8e-09 0.91 0.01 0.71 FALSE
59 The Cancer Genome Atlas Prostate Adenocarcinoma ZNF589 0.13 0.10 blup 32 0.11 3.2e-11 -5.0 -5.2 1.7e-07 0.87 0.03 0.97 FALSE
60 The Cancer Genome Atlas Thyroid Carcinoma CDC25A 0.11 0.19 lasso 3 0.19 8.3e-18 -5.0 -5.2 2.0e-07 0.86 0.81 0.19 FALSE