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chr3:47,204,518-49,365,269

Best TWAS P=3.75e-11 · Best GWAS P=2.49e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ZNF589	0.15	0.14	bslmm	254	0.16	1.3e-19	-5.0	-5.6	1.8e-08	0.89	0.97	0.03	FALSE
2	GTEx	Adipose Subcutaneous	FCF1P2	0.17	0.07	enet	18	0.09	9.8e-08	-4.9	5.4	7.0e-08	-0.77	0.63	0.36	FALSE
3	GTEx	Adipose Visceral Omentum	CDC25A	0.12	0.09	lasso	13	0.08	7.2e-05	-5.0	-5.1	2.8e-07	0.86	0.18	0.82	FALSE
4	GTEx	Adipose Visceral Omentum	MRPS18AP1	0.26	0.31	enet	16	0.31	9.1e-17	-4.8	-5.3	1.3e-07	0.93	0.15	0.85	FALSE
5	GTEx	Adrenal Gland	ZNF589	0.38	0.35	lasso	15	0.36	9.6e-14	-4.8	-5.4	6.1e-08	0.89	0.58	0.42	FALSE
6	GTEx	Adrenal Gland	NME6	0.12	0.07	lasso	9	0.08	6.1e-04	-6.7	6.3	2.4e-10	-0.97	0.03	0.90	FALSE
7	GTEx	Adrenal Gland	MRPS18AP1	0.49	0.45	enet	20	0.46	1.7e-18	-4.8	-5.4	7.0e-08	0.86	0.25	0.75	FALSE
8	GTEx	Artery Aorta	ZNF589	0.32	0.43	lasso	4	0.44	4.6e-26	-5.0	-5.4	7.2e-08	0.88	0.97	0.03	FALSE
9	GTEx	Artery Aorta	MRPS18AP1	0.45	0.37	lasso	8	0.42	5.4e-25	-5.0	-5.2	2.4e-07	0.89	0.91	0.09	FALSE
10	GTEx	Artery Tibial	CDC25A	0.23	0.27	lasso	5	0.27	5.8e-21	-5.0	-5.2	2.0e-07	0.86	0.98	0.02	FALSE
11	GTEx	Artery Tibial	FCF1P2	0.17	0.24	enet	23	0.25	1.7e-19	-5.0	5.3	1.3e-07	-0.89	0.96	0.04	FALSE
12	GTEx	Brain Cerebellum	MRPS18AP1	0.56	0.51	lasso	24	0.50	4.8e-17	-4.8	-5.3	1.4e-07	0.91	0.57	0.43	FALSE
13	GTEx	Breast Mammary Tissue	ZNF589	0.29	0.25	lasso	20	0.30	4.9e-16	-4.8	-5.3	1.3e-07	0.86	0.96	0.04	FALSE
14	GTEx	Breast Mammary Tissue	NME6	0.11	0.08	enet	21	0.12	5.6e-07	-5.0	5.3	1.2e-07	-0.70	0.46	0.30	FALSE
15	GTEx	Breast Mammary Tissue	FCF1P2	0.07	0.04	lasso	7	0.02	5.1e-02	-6.7	6.6	3.7e-11	-1.00	0.01	0.96	TRUE
16	GTEx	Breast Mammary Tissue (Male)	ZNF589	0.15	0.15	lasso	17	0.11	1.5e-03	-5.0	-5.4	6.1e-08	0.83	0.12	0.59	FALSE
17	GTEx	Breast Mammary Tissue (Male)	FCF1P2	0.09	0.01	lasso	4	0.03	8.6e-02	-3.9	5.5	3.1e-08	-0.88	0.03	0.71	FALSE
18	GTEx	Breast Mammary Tissue (Female)	ZNF589	0.29	0.21	lasso	8	0.20	1.3e-06	-4.8	-5.5	2.8e-08	0.91	0.14	0.83	FALSE
19	GTEx	Breast Mammary Tissue (Female)	NME6	0.05	-0.01	lasso	2	0.03	3.5e-02	-5.0	5.5	2.8e-08	-0.70	0.04	0.21	FALSE
20	GTEx	Esophagus Mucosa	MAP4	0.05	0.04	lasso	4	0.02	2.3e-02	-4.8	5.4	7.3e-08	-0.91	0.09	0.81	FALSE
21	GTEx	Esophagus Mucosa	FCF1P2	0.13	0.14	lasso	11	0.14	1.7e-09	-4.8	5.1	2.9e-07	-0.87	0.83	0.17	FALSE
22	GTEx	Esophagus Muscularis	FCF1P2	0.17	0.10	lasso	19	0.09	6.3e-06	-4.8	5.1	2.8e-07	-0.89	0.24	0.75	FALSE
23	GTEx	Esophagus Muscularis	MRPS18AP1	0.45	0.51	lasso	8	0.57	6.3e-42	-4.9	-5.2	2.6e-07	0.89	0.99	0.01	FALSE
24	GTEx	Heart Atrial Appendage	CDC25A	0.23	0.26	enet	23	0.26	4.0e-12	-5.0	-5.2	1.5e-07	0.84	0.87	0.13	FALSE
25	GTEx	Lung	ZNF589	0.13	0.12	enet	23	0.13	3.1e-10	-4.9	-5.3	1.3e-07	0.90	0.10	0.90	FALSE
26	GTEx	Lung	MRPS18AP1	0.33	0.35	lasso	9	0.36	3.3e-28	-4.8	-5.4	5.5e-08	0.94	0.72	0.28	FALSE
27	GTEx	Ovary	ZNF589	0.28	0.29	lasso	3	0.26	4.0e-07	-4.8	-5.4	6.2e-08	0.90	0.08	0.91	FALSE
28	GTEx	Ovary	MRPS18AP1	0.53	0.33	lasso	8	0.43	7.8e-12	-5.0	-5.8	5.7e-09	0.94	0.05	0.95	FALSE
29	GTEx	Pancreas	CDC25A	0.29	0.27	lasso	3	0.27	1.2e-11	-5.0	-5.2	1.9e-07	0.86	0.70	0.30	FALSE
30	GTEx	Pituitary	SLC26A6	0.16	0.18	lasso	8	0.14	2.0e-04	-6.4	-6.5	9.0e-11	0.98	0.02	0.85	FALSE
31	GTEx	Prostate	CDC25A	0.18	0.14	lasso	4	0.16	7.9e-05	-6.5	-6.1	1.0e-09	0.95	0.03	0.91	FALSE
32	GTEx	Prostate	MRPS18AP1	0.29	0.32	lasso	5	0.36	6.8e-10	-5.0	-5.7	1.3e-08	0.91	0.05	0.95	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	NME6	0.24	0.18	enet	20	0.18	6.0e-10	-5.0	5.5	4.4e-08	-0.82	0.98	0.02	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	MRPS18AP1	0.47	0.44	lasso	9	0.50	2.3e-31	-4.8	-5.2	2.2e-07	0.90	0.99	0.01	FALSE
35	GTEx	Skin Sun Exposed Lower leg	ZNF589	0.43	0.39	enet	35	0.40	1.7e-35	-4.8	-5.4	6.4e-08	0.91	0.90	0.10	FALSE
36	GTEx	Skin Sun Exposed Lower leg	NME6	0.16	0.17	lasso	11	0.20	1.5e-16	-5.0	5.1	2.9e-07	-0.88	0.94	0.06	FALSE
37	GTEx	Skin Sun Exposed Lower leg	FCF1P2	0.09	0.09	lasso	9	0.10	5.5e-09	-5.0	5.1	2.7e-07	-0.84	0.94	0.06	FALSE
38	GTEx	Spleen	ZNF589	0.29	0.13	lasso	13	0.16	5.1e-05	-4.4	-5.4	7.0e-08	0.93	0.08	0.90	FALSE
39	GTEx	Spleen	MRPS18AP1	0.36	0.20	lasso	18	0.31	8.5e-09	-6.6	-5.7	1.6e-08	0.95	0.05	0.95	FALSE
40	GTEx	Stomach	CDC25A	0.29	0.05	lasso	3	0.00	2.5e-01	-5.0	-5.1	3.0e-07	0.88	0.05	0.84	FALSE
41	GTEx	Stomach	ZNF589	0.25	0.27	lasso	18	0.33	2.5e-16	-4.9	-5.4	7.9e-08	0.91	0.22	0.78	FALSE
42	GTEx	Stomach	NME6	0.14	0.17	lasso	8	0.17	1.8e-08	-5.0	5.3	1.2e-07	-0.83	0.89	0.10	FALSE
43	GTEx	Stomach	FCF1P2	0.12	0.05	enet	5	0.03	1.3e-02	-6.7	6.2	7.4e-10	-0.96	0.03	0.90	FALSE
44	GTEx	Stomach	MRPS18AP1	0.29	0.35	lasso	4	0.42	7.0e-22	-4.9	-5.3	1.4e-07	0.90	0.33	0.67	FALSE
45	GTEx	Testis	ZNF589	0.48	0.42	enet	33	0.48	4.0e-24	-5.0	-5.3	1.1e-07	0.91	0.67	0.33	FALSE
46	GTEx	Testis	NME6	0.06	0.06	lasso	5	0.04	8.7e-03	-5.0	5.4	8.3e-08	-0.89	0.05	0.84	FALSE
47	GTEx	Thyroid	MAP4	0.07	0.05	lasso	12	0.05	1.6e-04	-6.4	-6.1	1.0e-09	0.96	0.03	0.97	FALSE
48	GTEx	Thyroid	CDC25A	0.24	0.33	enet	28	0.34	2.3e-26	-5.0	-5.5	3.6e-08	0.89	0.94	0.06	FALSE
49	GTEx	Thyroid	ZNF589	0.19	0.32	lasso	8	0.34	1.5e-26	-5.0	-5.3	1.4e-07	0.89	0.98	0.02	FALSE
50	GTEx	Thyroid	FCF1P2	0.07	0.05	lasso	3	0.05	1.6e-04	-4.9	5.3	1.1e-07	-0.88	0.08	0.91	FALSE
51	GTEx	Thyroid	MRPS18AP1	0.33	0.44	lasso	9	0.52	2.5e-46	-5.0	-5.5	3.2e-08	0.91	0.98	0.02	FALSE
52	NTR	Blood	ZNF589	0.02	0.02	lasso	8	0.02	2.8e-06	-6.6	-6.5	6.4e-11	0.97	0.01	0.99	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	NME6	0.09	0.17	lasso	5	0.18	7.1e-23	-5.0	5.2	2.0e-07	-0.87	0.97	0.03	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NME6	0.04	0.04	blup	33	0.04	1.6e-05	-4.9	5.2	1.8e-07	-0.87	0.02	0.97	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC25A	0.05	0.04	blup	19	0.04	3.7e-03	-4.8	-5.7	9.4e-09	0.94	0.01	0.78	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF589	0.09	0.05	blup	32	0.04	1.6e-03	-5.0	-5.3	1.0e-07	0.82	0.02	0.89	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDC25A	0.02	0.00	blup	20	0.01	5.0e-02	-6.4	-6.1	1.1e-09	0.97	0.01	0.64	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	CDC25A	0.02	0.01	blup	20	0.01	6.7e-03	-4.8	-5.9	2.8e-09	0.91	0.01	0.71	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF589	0.13	0.10	blup	32	0.11	3.2e-11	-5.0	-5.2	1.7e-07	0.87	0.03	0.97	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	CDC25A	0.11	0.19	lasso	3	0.19	8.3e-18	-5.0	-5.2	2.0e-07	0.86	0.81	0.19	FALSE