TWAS
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Models
Genes
Traits
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Traits
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High blood pressure
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chr4:80,407,869-82,578,407
Best TWAS P=4.27e-20 · Best GWAS P=1.11e-65 conditioned to 1.84e-42
80.5M
81M
81.5M
82M
82.5M
0
20
40
60
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
C4orf22
0.09
0.08
lasso
5
0.07
4.5e-09
8.5
9.2
4.3e-20
0.59
1.00
0.00
TRUE
3
GTEx
Nerve Tibial
PRDM8
0.14
0.14
lasso
3
0.13
1.0e-09
-5.2
-5.2
2.4e-07
-0.19
1.00
0.00
TRUE
2
CommonMind
Brain Pre-frontal Cortex
FGF5
0.07
0.06
lasso
2
0.05
5.4e-07
8.5
8.0
9.2e-16
0.53
0.76
0.14
FALSE