Best TWAS P=1.01e-09 · Best GWAS P=1.23e-08 conditioned to 0.552
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | -5.4 | -5.4 | 8.5e-08 | 0.93 | 0.01 | 0.99 | FALSE |
| 2 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABO | 0.27 | 0.31 | blup | 43 | 0.33 | 2.1e-19 | -5.4 | -5.7 | 1.0e-08 | 0.87 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | -5.4 | -5.3 | 9.0e-08 | 0.93 | 0.01 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABO | 0.11 | 0.08 | blup | 43 | 0.12 | 2.5e-13 | -5.4 | -5.3 | 1.3e-07 | 0.78 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ABO | 0.31 | 0.38 | lasso | 5 | 0.42 | 3.1e-26 | -5.7 | -5.3 | 8.9e-08 | 0.97 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABO | 0.26 | 0.23 | enet | 10 | 0.26 | 6.0e-29 | -5.4 | -5.7 | 9.7e-09 | 0.87 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | -5.7 | -5.7 | 1.2e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | -5.4 | -5.5 | 3.1e-08 | 0.97 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | -5.4 | -5.5 | 4.3e-08 | 0.94 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ABO | 0.23 | 0.21 | lasso | 5 | 0.20 | 6.7e-09 | -5.7 | -5.6 | 2.1e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ABO | 0.23 | 0.23 | lasso | 3 | 0.23 | 2.0e-09 | -5.4 | -5.3 | 1.4e-07 | 0.95 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | -5.6 | -6.1 | 1.0e-09 | 0.89 | 0.00 | 0.98 | TRUE |
| 13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ABO | 0.20 | 0.10 | blup | 42 | 0.18 | 5.8e-13 | -5.4 | -5.6 | 2.4e-08 | 0.83 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | ABO | 0.44 | 0.57 | enet | 18 | 0.60 | 1.9e-73 | -5.4 | -5.4 | 6.1e-08 | 0.97 | 0.00 | 1.00 | FALSE |