TWAS
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Traits
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Traits
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High blood pressure
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chr10:18,221,643-19,601,824
Best TWAS P=8.76e-13 · Best GWAS P=1.24e-16 conditioned to 5.16e-14
18.2M
18.4M
18.6M
18.8M
19M
19.2M
19.4M
19.6M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
CACNB2
0.05
0.05
enet
4
0.04
8.8e-06
6.0
7.2
8.8e-13
-0.03
0.98
0.01
TRUE
2
GTEx
Esophagus Gastroesophageal Junction
NSUN6
0.22
0.03
lasso
7
0.03
3.1e-02
-3.5
5.1
3.1e-07
-0.11
0.20
0.10
TRUE
1
GTEx
Artery Tibial
NSUN6
0.18
0.11
lasso
8
0.10
4.9e-08
-3.6
5.6
1.7e-08
-0.14
1.00
0.00
FALSE