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chr10:63,856,856-65,606,229

Best TWAS P=9.91e-13 · Best GWAS P=6.7e-12 conditioned to 0.328

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cortex NRBF2 0.30 0.26 enet 24 0.21 1.4e-06 5.1 5.2 1.9e-07 -0.06 0.92 0.01 FALSE
2 GTEx Muscle Skeletal ADO 0.15 0.16 lasso 8 0.16 1.1e-15 5.4 5.9 3.5e-09 -0.76 0.77 0.23 FALSE
3 GTEx Muscle Skeletal RP11-436D10.3 0.08 0.04 enet 13 0.06 3.2e-06 -6.8 7.0 1.9e-12 -0.87 0.00 1.00 TRUE
4 GTEx Skin Sun Exposed Lower leg NRBF2 0.06 0.01 lasso 3 0.00 4.0e-01 -5.9 7.1 9.9e-13 -0.68 0.08 0.15 TRUE
5 GTEx Testis ADO 0.21 0.23 lasso 7 0.22 6.6e-10 5.4 -5.5 4.3e-08 0.74 0.68 0.32 FALSE
6 ROSMAP Brain Pre-frontal Cortex ADO 0.06 0.04 lasso 2 0.06 3.1e-08 -6.8 5.5 3.1e-08 -0.89 0.00 1.00 FALSE
7 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NRBF2 0.04 0.04 enet 5 0.03 1.3e-04 -4.7 5.2 2.4e-07 -0.06 0.01 0.93 FALSE
8 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADO 0.10 0.03 enet 6 0.06 4.6e-07 5.1 5.6 2.7e-08 -0.79 0.00 0.99 FALSE
9 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NRBF2 0.10 0.06 lasso 7 0.08 3.5e-09 5.0 5.2 1.6e-07 -0.04 0.00 0.99 FALSE
10 The Cancer Genome Atlas Lung Adenocarcinoma ADO 0.14 0.05 blup 53 0.05 3.8e-06 -5.9 6.8 8.3e-12 -0.85 0.01 0.99 FALSE
11 The Cancer Genome Atlas Lung Squamous Cell Carcinoma NRBF2 0.09 0.02 enet 6 0.04 1.4e-05 4.4 5.7 1.0e-08 -0.03 0.01 0.98 TRUE
12 The Cancer Genome Atlas Pancreatic Adenocarcinoma ADO 0.06 0.04 blup 55 0.01 1.4e-01 -6.8 6.0 1.7e-09 -0.84 0.00 0.86 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma ADO 0.12 0.10 lasso 5 0.09 5.2e-09 -6.8 6.7 1.7e-11 -0.97 0.00 1.00 FALSE