Best TWAS P=7.35e-11 · Best GWAS P=5.74e-12 conditioned to 4.33e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SIPA1 | 0.19 | 0.00 | enet | 30 | 0.05 | 2.5e-04 | 4.4 | 5.4 | 8.1e-08 | -0.48 | 0.05 | 0.82 | FALSE |
| 2 | GTEx | Nerve Tibial | SIPA1 | 0.17 | 0.01 | enet | 19 | 0.06 | 6.8e-05 | -5.1 | 6.0 | 1.9e-09 | -0.42 | 0.07 | 0.79 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | 2.8 | -6.0 | 1.9e-09 | 0.46 | 0.47 | 0.24 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RNASEH2C | 0.05 | 0.00 | blup | 32 | 0.02 | 1.1e-04 | 1.2 | -6.5 | 7.4e-11 | 0.42 | 0.00 | 0.80 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIPA1 | 0.06 | 0.04 | blup | 43 | 0.05 | 4.6e-06 | -3.6 | 5.4 | 6.1e-08 | -0.52 | 0.02 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RNASEH2C | 0.15 | 0.05 | blup | 32 | 0.05 | 3.1e-06 | 1.2 | -5.3 | 9.0e-08 | 0.48 | 0.36 | 0.02 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIPA1 | 0.04 | 0.00 | blup | 43 | 0.02 | 6.2e-03 | -5.2 | 5.7 | 1.1e-08 | -0.59 | 0.00 | 0.39 | FALSE |