Best TWAS P=2.69e-35 · Best GWAS P=1.35e-33 conditioned to 0.181
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARHGAP42 | 0.08 | 0.03 | enet | 14 | 0.05 | 2.8e-06 | -6.1 | -5.9 | 3.4e-09 | 0.50 | 0.98 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | ARHGAP42 | 0.22 | 0.15 | enet | 18 | 0.19 | 1.7e-10 | -11.6 | -10.9 | 1.6e-27 | 0.86 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | TMEM133 | 0.30 | 0.15 | enet | 34 | 0.19 | 7.1e-11 | -12.1 | -9.8 | 6.7e-23 | 0.72 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Tibial | ARHGAP42 | 0.24 | 0.24 | lasso | 4 | 0.24 | 2.4e-18 | -12.1 | -12.2 | 5.6e-34 | 0.98 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | TMEM133 | 0.26 | 0.25 | enet | 28 | 0.27 | 1.3e-21 | -12.1 | -12.4 | 2.7e-35 | 0.94 | 0.00 | 1.00 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | ARHGAP42 | 0.15 | 0.10 | enet | 20 | 0.08 | 2.6e-06 | 5.0 | -5.6 | 1.8e-08 | 0.46 | 0.71 | 0.23 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | ARHGAP42 | 0.04 | 0.00 | lasso | 2 | 0.00 | 1.9e-01 | -5.7 | -5.4 | 6.4e-08 | 0.51 | 0.11 | 0.19 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ARHGAP42 | 0.04 | 0.01 | blup | 266 | 0.02 | 1.1e-04 | 6.0 | -7.7 | 1.8e-14 | 0.57 | 0.04 | 0.88 | FALSE |