TWAS
hub
About
Usage
Models
Genes
Traits
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Traits
:
High blood pressure
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chr1:230,142,626-231,548,480
Best TWAS P=6.39e-12 · Best GWAS P=3.66e-10 conditioned to 0.0637
230.2M
230.4M
230.6M
230.8M
231M
231.2M
231.4M
231.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
AGT
0.07
0.02
enet
12
0.04
1.8e-05
5.3
6.9
6.4e-12
0.73
0.02
0.97
TRUE
2
GTEx
Brain Cerebellum
AGT
0.60
0.40
lasso
6
0.36
1.4e-11
6.2
6.4
2.0e-10
0.93
0.00
1.00
FALSE
1
GTEx
Brain Cerebellar Hemisphere
AGT
0.67
0.50
enet
12
0.40
3.4e-11
6.2
-6.2
7.5e-10
-0.98
0.00
1.00
FALSE
4
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
AGT
0.11
0.05
blup
125
0.04
1.4e-03
5.6
5.6
1.9e-08
0.68
0.02
0.85
FALSE