Best TWAS P=7.94e-11 · Best GWAS P=5.58e-10 conditioned to 0.0307
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | NCOA1 | 0.11 | 0.02 | enet | 17 | 0.02 | 2.1e-02 | -5.8 | -6.5 | 7.9e-11 | 0.73 | 0.02 | 0.89 | TRUE |
| 2 | GTEx | Artery Aorta | NCOA1 | 0.15 | 0.00 | enet | 15 | 0.01 | 1.4e-01 | -4.0 | -5.4 | 7.2e-08 | 0.60 | 0.03 | 0.60 | FALSE |
| 3 | GTEx | Esophagus Muscularis | NCOA1 | 0.11 | 0.01 | enet | 9 | 0.01 | 5.8e-02 | -6.2 | -5.3 | 1.3e-07 | 0.83 | 0.01 | 0.87 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | EFR3B | 0.07 | 0.03 | bslmm | 348 | 0.03 | 3.5e-05 | 4.2 | -6.0 | 1.9e-09 | 0.34 | 0.17 | 0.39 | FALSE |
| 5 | YFS | Blood | CENPO | 0.09 | 0.06 | lasso | 6 | 0.07 | 6.7e-21 | -5.7 | 5.6 | 1.9e-08 | -0.58 | 0.05 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | ADCY3 | 0.36 | 0.14 | enet | 7 | 0.13 | 8.9e-05 | -6.0 | 5.9 | 4.3e-09 | -0.90 | 0.00 | 0.95 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADCY3 | 0.08 | 0.03 | enet | 16 | 0.03 | 1.5e-04 | -5.4 | 5.4 | 5.3e-08 | -0.51 | 0.01 | 0.61 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EFR3B | 0.26 | 0.01 | lasso | 4 | 0.05 | 3.8e-03 | -6.2 | -6.0 | 2.2e-09 | 0.87 | 0.00 | 0.92 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ADCY3 | 0.09 | 0.02 | enet | 11 | 0.04 | 3.2e-05 | -6.0 | 6.3 | 2.9e-10 | -0.79 | 0.00 | 0.99 | FALSE |