Best TWAS P=6.3e-09 · Best GWAS P=1.33e-09 conditioned to 0.246
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SENP1 | 0.05 | 0.02 | blup | 555 | 0.04 | 1.7e-05 | 5.4 | -5.5 | 4.2e-08 | 0.12 | 0.23 | 0.77 | TRUE |
| 2 | GTEx | Lung | ZNF641 | 0.08 | 0.10 | lasso | 2 | 0.08 | 8.0e-07 | 5.3 | 5.2 | 1.6e-07 | -0.07 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | ZNF641 | 0.14 | 0.11 | lasso | 4 | 0.08 | 2.3e-06 | 5.1 | 5.3 | 1.2e-07 | -0.07 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HDAC7 | 0.05 | 0.02 | blup | 85 | 0.01 | 7.5e-03 | -5.8 | -5.8 | 6.3e-09 | 0.82 | 0.00 | 0.97 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF641 | 0.11 | 0.12 | enet | 10 | 0.12 | 5.2e-12 | 5.2 | 5.5 | 4.4e-08 | -0.08 | 0.00 | 1.00 | FALSE |